Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS -/- mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 299, Issue 3, 2010, Pages

  Steed, Mesia M ^a   Tyagi, Neetu ^a   Sen, Utpal ^a   Schuschke, Dale A ^a   Joshua, Irving G ^a   Tyagi, Suresh C ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Aorta stiffness; Endothelial function; Hypertension; Matrix metalloproteinase; Nitrotyrosine; NOX4; Reactive oxygen species; Superoxide dismutase; Thioredoxin; Tissue inhibitor of metalloproteinase

Indexed keywords

3 NITROTYROSINE; COLLAGEN; ELASTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATIN; GELATINASE A; GELATINASE B; HYDROETHIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE; SUPEROXIDE; 3-NITROTYROSINE; DRUG DERIVATIVE; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; NOS3 PROTEIN, MOUSE; TISSUE INHIBITOR OF METALLOPROTEINASE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA VALVE; ARTICLE; BLOOD VESSEL FUNCTION; ECHOCARDIOGRAPHY; ECHOGRAPHY; ENZYME ACTIVITY; HISTOLOGY; HYPERHOMOCYSTEINEMIA; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; AORTA; BIOSYNTHESIS; BLOOD FLOW VELOCITY; C57BL MOUSE; COMPLIANCE (PHYSICAL); EXTRACELLULAR MATRIX; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY;

ANIMALS; AORTA; BLOOD FLOW VELOCITY; COLLAGEN; COMPLIANCE; ELASTIN; EXTRACELLULAR MATRIX; HYPERHOMOCYSTEINEMIA; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; TISSUE INHIBITOR OF METALLOPROTEINASES; TYROSINE;

EID: 77956694480     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00065.2010     Document Type: Article

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