SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1592-1599

Amino acid derived quinazolines as Rock/PKA inhibitors

(13) Chowdhury, Sarwat a Chen, Yen Ting a Fang, Xingang a Grant, Wayne a Pocas, Jennifer a Cameron, Michael D a Ruiz, Claudia a Lin, Li a Park, Hajeung a Schröter, Thomas a Bannister, Thomas D a Lograsso, Philip V a Feng, Yangbo a

a SCRIPPS RESEARCH INSTITUTE (United States)

Author keywords

Kinase inhibitor; PKA; Quinazoline; Rock

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450; PHENYLALANINE DERIVATIVE; PHENYLGLYCINE; PYRROLIDINE 2 CARBOXYLIC ACID; PYRROLIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; RHO FACTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME STABILITY; HUMAN; HYDROGEN BOND; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; BINDING SITES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; MICROSOMES; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; RHO-ASSOCIATED KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874666204 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.01.109 Document Type: Article

Times cited : (14)

References (32)

1
- 9244257348
- T. Matsui, M. Amano, T. Yamamoto, K. Chihara, M. Nakafuku, M. Ito, T. Nakano, K. Okawa, A. Iwamatsu, and K. Kaibuchi EMBO J. 15 1996 2208
- (1996) EMBO J. , vol.15 , pp. 2208
- Matsui, T.¹ Amano, M.² Yamamoto, T.³ Chihara, K.⁴ Nakafuku, M.⁵ Ito, M.⁶ Nakano, T.⁷ Okawa, K.⁸ Iwamatsu, A.⁹ Kaibuchi, K.¹⁰

2
- 0030603119
- O. Nakagawa, K. Fujisawa, T. Ishizaki, Y. Saito, K. Nakao, and S. Narumiya FEBS Lett. 392 1996 189
- (1996) FEBS Lett. , vol.392 , pp. 189
- Nakagawa, O.¹ Fujisawa, K.² Ishizaki, T.³ Saito, Y.⁴ Nakao, K.⁵ Narumiya, S.⁶

3
- 0038024241
- K. Riento, and A.J.J. Ridley Nat. Rev. Mol. Cell Biol. 4 2003 446
- (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 446
- Riento, K.¹ Ridley, A.J.J.²

4
- 27944458787
- A. Muranyi, D. Derkach, F. Erdodi, A. Kiss, M. Ito, and D.J. Hartshorne FEBS Lett. 579 2005 6611
- (2005) FEBS Lett. , vol.579 , pp. 6611
- Muranyi, A.¹ Derkach, D.² Erdodi, F.³ Kiss, A.⁴ Ito, M.⁵ Hartshorne, D.J.⁶

5
- 34249887660
- R.W. Scott, and M.F. Olson J. Mol. Med. 85 2007 555
- (2007) J. Mol. Med. , vol.85 , pp. 555
- Scott, R.W.¹ Olson, M.F.²

6
- 33947537278
- L. Hagerty, D.H. Weitzel, J. Chambers, C.N. Fortner, M.H. Brush, D. Loiselle, H. Hosoya, and T.A. Haystead J. Biol. Chem. 282 2007 4884
- (2007) J. Biol. Chem. , vol.282 , pp. 4884
- Hagerty, L.¹ Weitzel, D.H.² Chambers, J.³ Fortner, C.N.⁴ Brush, M.H.⁵ Loiselle, D.⁶ Hosoya, H.⁷ Haystead, T.A.⁸

7
- 0030615004
- T. Ishizaki, M. Naito, K. Fujisawa, M. Maekawa, N. Watanabe, Y. Saito, and S. Narumiya FEBS Lett. 404 2-3 1997 118
- (1997) FEBS Lett. , vol.404 , Issue.23 , pp. 118
- Ishizaki, T.¹ Naito, M.² Fujisawa, K.³ Maekawa, M.⁴ Watanabe, N.⁵ Saito, Y.⁶ Narumiya, S.⁷

8
- 0030977123
- Y. Kureishi, S. Kobayashi, M. Amano, K. Kimura, and H. Kanaide J. Biol. Chem. 272 1997 12257
- (1997) J. Biol. Chem. , vol.272 , pp. 12257
- Kureishi, Y.¹ Kobayashi, S.² Amano, M.³ Kimura, K.⁴ Kanaide, H.⁵

9
- 0030656619
- M. Uehata, T. Ishizaki, H. Satoh, T. Ono, T. Kawahara, T. Morishita, H. Tamakawa, K. Yamagami, J. Inui, M. Maekawa, and Narumiya Nature 389 1997 990
- (1997) Nature , vol.389 , pp. 990
- Uehata, M.¹ Ishizaki, T.² Satoh, H.³ Ono, T.⁴ Kawahara, T.⁵ Morishita, T.⁶ Tamakawa, H.⁷ Yamagami, K.⁸ Inui, J.⁹ Maekawa, M.¹⁰ Narumiya¹¹

10
- 10444246505
- Y. Hirooka, H. Shimokawa, and A. Takeshita Drug News Perspect. 17 2004 523
- (2004) Drug News Perspect. , vol.17 , pp. 523
- Hirooka, Y.¹ Shimokawa, H.² Takeshita, A.³

11
- 24344442067
- S.A. Doggrell Opin. Invest. Drug 14 2005 1157
- (2005) Opin. Invest. Drug , vol.14 , pp. 1157
- Doggrell, S.A.¹

12
- 0035726683
- M. Waki, Y. Yoshida, T. Oka, and M. Azuma Curr. Eye Res. 2 2001 470
- (2001) Curr. Eye Res. , vol.2 , pp. 470
- Waki, M.¹ Yoshida, Y.² Oka, T.³ Azuma, M.⁴

13
- 0242298683
- M. Nakajima, K. Hayashi, Y. Egi, K. Katayama, Y. Amano, M. Uehata, M. Ohtsuki, A. Fujii, K. Oshita, H. Kataoka, K. Chiba, N. Goto, and T. Kondo Cancer Chemother. Pharmacol. 52 2003 319
- (2003) Cancer Chemother. Pharmacol. , vol.52 , pp. 319
- Nakajima, M.¹ Hayashi, K.² Egi, Y.³ Katayama, K.⁴ Amano, Y.⁵ Uehata, M.⁶ Ohtsuki, M.⁷ Fujii, A.⁸ Oshita, K.⁹ Kataoka, H.¹⁰ Chiba, K.¹¹ Goto, N.¹² Kondo, T.¹³

14
- 0037449474
- M. Nakajima, K. Hayashi, K. Katayama, Y. Amano, Y. Egi, M. Uehata, N. Goto, and T. Kondo Eur. J. Pharmacol. 459 2003 113
- (2003) Eur. J. Pharmacol. , vol.459 , pp. 113
- Nakajima, M.¹ Hayashi, K.² Katayama, K.³ Amano, Y.⁴ Egi, Y.⁵ Uehata, M.⁶ Goto, N.⁷ Kondo, T.⁸

15
- 33750618507
- X.J. Sun, M. Minohara, H. Kikuchi, T. Ishizu, M. Tanaka, H. Piao, M. Osoegawa, Y. Ohyagi, H. Shimokawa, and J. Kira J. Neuroimmunol. 180 2006 126
- (2006) J. Neuroimmunol. , vol.180 , pp. 126
- Sun, X.J.¹ Minohara, M.² Kikuchi, H.³ Ishizu, T.⁴ Tanaka, M.⁵ Piao, H.⁶ Osoegawa, M.⁷ Ohyagi, Y.⁸ Shimokawa, H.⁹ Kira, J.¹⁰

16
- 0023359056
- T. Asano, I. Ikegaki, S.I. Satoh, Y. Suzuki, M. Shibuya, M. Takayasu, and H. Hidaka J. Pharmacol. Exp. Ther. 241 1987 1033
- (1987) J. Pharmacol. Exp. Ther. , vol.241 , pp. 1033
- Asano, T.¹ Ikegaki, I.² Satoh, S.I.³ Suzuki, Y.⁴ Shibuya, M.⁵ Takayasu, M.⁶ Hidaka, H.⁷

17
- 70350125752
- For a recent review, see
- For a recent review, see: P. LoGrasso, and Y. Feng Curr. Top. Med. Chem. 9 2009 704
- (2009) Curr. Top. Med. Chem. , vol.9 , pp. 704
- Lograsso, P.¹ Feng, Y.²

18
- 56249140110
- Y. Feng, Y. Yin, A. Weiser, E. Griffin, M.D. Cameron, L. Lin, C. Ruiz, S.C. Schurer, T. Inoue, P.V. Rao, T. Schroter, and P. LoGrasso J. Med. Chem. 51 2008 6642
- (2008) J. Med. Chem. , vol.51 , pp. 6642
- Feng, Y.¹ Yin, Y.² Weiser, A.³ Griffin, E.⁴ Cameron, M.D.⁵ Lin, L.⁶ Ruiz, C.⁷ Schurer, S.C.⁸ Inoue, T.⁹ Rao, P.V.¹⁰ Schroter, T.¹¹ Lograsso, P.¹²

19
- 56249104835
- Y.T. Chen, T.D. Bannister, A. Weiser, E. Griffin, L. Lin, C. Ruiz, M.D. Cameron, S. Schurer, D. Duckett, T. Schroter, P. LoGrasso, and Y. Feng Bioorg. Med. Chem. Lett. 18 2008 6406
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 6406
- Chen, Y.T.¹ Bannister, T.D.² Weiser, A.³ Griffin, E.⁴ Lin, L.⁵ Ruiz, C.⁶ Cameron, M.D.⁷ Schurer, S.⁸ Duckett, D.⁹ Schroter, T.¹⁰ Lograsso, P.¹¹ Feng, Y.¹²

20
- 77955387235
- X. Fang, Y. Yin, Y.T. Chen, L. Yao, B. Wang, M.D. Cameron, L. Lin, S. Khan, C. Ruiz, T. Schroter, W. Grant, A. Weiser, J. Pocas, A. Pachori, S.C. Schurer, P. LoGrasso, and Y. Feng J. Med. Chem. 53 2010 5727
- (2010) J. Med. Chem. , vol.53 , pp. 5727
- Fang, X.¹ Yin, Y.² Chen, Y.T.³ Yao, L.⁴ Wang, B.⁵ Cameron, M.D.⁶ Lin, L.⁷ Khan, S.⁸ Ruiz, C.⁹ Schroter, T.¹⁰ Grant, W.¹¹ Weiser, A.¹² Pocas, J.¹³ Pachori, A.¹⁴ Schurer, S.C.¹⁵ Lograsso, P.¹⁶ Feng, Y.¹⁷

21
- 56249124570
- E.H. Sessions, Y. Yin, T.D. Bannister, A. Weiser, E. Griffin, J. Pocas, M.D. Cameron, C. Ruiz, L. Lin, S.C. Schurer, T. Schroter, P. LoGrasso, and Y. Feng Bioorg. Med. Chem. Lett. 18 2008 6390
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 6390
- Sessions, E.H.¹ Yin, Y.² Bannister, T.D.³ Weiser, A.⁴ Griffin, E.⁵ Pocas, J.⁶ Cameron, M.D.⁷ Ruiz, C.⁸ Lin, L.⁹ Schurer, S.C.¹⁰ Schroter, T.¹¹ Lograsso, P.¹² Feng, Y.¹³

22
- 77649181943
- E.H. Sessions, M. Smolinksi, B. Wang, B. Frackowiak, S. Chowdhury, Y. Yin, Y.T. Chen, C. Ruiz, L. Lin, J. Pocas, T. Schröter, M. Cameron, P. LoGrasso, Y. Feng, and T. Bannister Bioorg. Med. Chem. Lett. 20 2010 1939
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1939
- Sessions, E.H.¹ Smolinksi, M.² Wang, B.³ Frackowiak, B.⁴ Chowdhury, S.⁵ Yin, Y.⁶ Chen, Y.T.⁷ Ruiz, C.⁸ Lin, L.⁹ Pocas, J.¹⁰ Schröter, T.¹¹ Cameron, M.¹² Lograsso, P.¹³ Feng, Y.¹⁴ Bannister, T.¹⁵

23
- 72049085036
- Y. Yin, L. Lin, C. Ruiz, M.D. Cameron, J. Pocas, W. Grant, T. Schroter, W.M. Chen, D. Duckett, S. Schurer, P. LoGrasso, and Y. Feng Bioorg. Med. Chem. Lett. 19 2009 6686
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 6686
- Yin, Y.¹ Lin, L.² Ruiz, C.³ Cameron, M.D.⁴ Pocas, J.⁵ Grant, W.⁶ Schroter, T.⁷ Chen, W.M.⁸ Duckett, D.⁹ Schurer, S.¹⁰ Lograsso, P.¹¹ Feng, Y.¹²

24
- 77955369160
- Y. Yin, M.D. Cameron, L. Lin, S. Khan, T. Schroter, W. Grant, J. Pocas, Y.T. Chen, S. Schurer, A. Pachori, P. LoGrasso, and Y. Feng ACS Med. Chem. Lett. 1 2010 175
- (2010) ACS Med. Chem. Lett. , vol.1 , pp. 175
- Yin, Y.¹ Cameron, M.D.² Lin, L.³ Khan, S.⁴ Schroter, T.⁵ Grant, W.⁶ Pocas, J.⁷ Chen, Y.T.⁸ Schurer, S.⁹ Pachori, A.¹⁰ Lograsso, P.¹¹ Feng, Y.¹²

25
- 33947595177
- Y. Feng, M.D. Cameron, B. Frackowiak, E. Griffin, L. Lin, C. Ruiz, T. Schroter, and P. LoGrasso Bioorg. Med. Chem. Lett. 17 2007 2355
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 2355
- Feng, Y.¹ Cameron, M.D.² Frackowiak, B.³ Griffin, E.⁴ Lin, L.⁵ Ruiz, C.⁶ Schroter, T.⁷ Lograsso, P.⁸

26
- 80255127420
- S. Chowdhury, E.H. Sessions, J.R. Pocas, W. Grant, T. Schröter, L. Lin, C. Ruiz, M.D. Cameron, S. Schürer, P. LoGrasso, T.D. Bannister, and Y. Feng Bioorg. Med. Chem. Lett. 21 2011 7107
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 7107
- Chowdhury, S.¹ Sessions, E.H.² Pocas, J.R.³ Grant, W.⁴ Schröter, T.⁵ Lin, L.⁶ Ruiz, C.⁷ Cameron, M.D.⁸ Schürer, S.⁹ Lograsso, P.¹⁰ Bannister, T.D.¹¹ Feng, Y.¹²

27
- 80255129420
- E.H. Sessions, S. Chowdhury, Y. Yin, J.R. Pocas, W. Grant, T. Schröter, L. Lin, C. Ruiz, M.D. Cameron, P. LoGrasso, T.D. Bannister, and Y. Feng Bioorg. Med. Chem. Lett. 21 2011 7113
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 7113
- Sessions, E.H.¹ Chowdhury, S.² Yin, Y.³ Pocas, J.R.⁴ Grant, W.⁵ Schröter, T.⁶ Lin, L.⁷ Ruiz, C.⁸ Cameron, M.D.⁹ Lograsso, P.¹⁰ Bannister, T.D.¹¹ Feng, Y.¹²

28
- 79952361695
- X. Fang, Y.T. Chen, E.H. Sessions, S. Chowdhury, T. Vojkovsky, Y. Yin, J.R. Pocas, W. Grant, T. Schröter, L. Lin, C. Ruiz, M.D. Cameron, P. LoGrasso, T.D. Bannister, and Y. Feng Bioorg. Med. Chem. Lett. 21 2011 1844
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 1844
- Fang, X.¹ Chen, Y.T.² Sessions, E.H.³ Chowdhury, S.⁴ Vojkovsky, T.⁵ Yin, Y.⁶ Pocas, J.R.⁷ Grant, W.⁸ Schröter, T.⁹ Lin, L.¹⁰ Ruiz, C.¹¹ Cameron, M.D.¹² Lograsso, P.¹³ Bannister, T.D.¹⁴ Feng, Y.¹⁵

29
- 85004281985
- Y. Terao, H. Kotaki, N. Imai, and K. Achiwa Chem. Pharm. Bull. 33 1985 2762
- (1985) Chem. Pharm. Bull. , vol.33 , pp. 2762
- Terao, Y.¹ Kotaki, H.² Imai, N.³ Achiwa, K.⁴

30
- 35848963836
- C.W. Chen, J.A. Tran, B.A. Fleck, F.C. Tucci, W. Jiang, and C. Chen Bioorg. Med. Chem. Lett. 17 2007 6825
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 6825
- Chen, C.W.¹ Tran, J.A.² Fleck, B.A.³ Tucci, F.C.⁴ Jiang, W.⁵ Chen, C.⁶

31
- 37749050446
- T. Schroeter, D. Minond, A. Weiser, C. Dao, J. Habel, T. Spicer, P. Chase, P. Baillargeon, L. Scampavia, S. Schuerer, C. Chung, C. Mader, M. Southern, N. Tsinoremas, P. LoGrasso, and P. Hodder J. Biomol. Screen. 13 2008 17
- (2008) J. Biomol. Screen. , vol.13 , pp. 17
- Schroeter, T.¹ Minond, D.² Weiser, A.³ Dao, C.⁴ Habel, J.⁵ Spicer, T.⁶ Chase, P.⁷ Baillargeon, P.⁸ Scampavia, L.⁹ Schuerer, S.¹⁰ Chung, C.¹¹ Mader, C.¹² Southern, M.¹³ Tsinoremas, N.¹⁴ Lograsso, P.¹⁵ Hodder, P.¹⁶

32
- 48549099363
- T. SchrÖter, E. Griffin, A. Weiser, Y. Feng, and P. LoGrasso Biochem. Biophys. Res. Commun. 374 2008 356
- (2008) Biochem. Biophys. Res. Commun. , vol.374 , pp. 356
- Schröter, T.¹ Griffin, E.² Weiser, A.³ Feng, Y.⁴ Lograsso, P.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.