Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: Inhibitory effects and occurrence in A7r5 cells

FEBS Letters

Volumn 579, Issue 29, 2005, Pages 6611-6615

  Murányi, Andrea ^a   Derkach, Dmitry ^a   Erdodi, Ferenc ^b   Kiss, Andrea ^b   Ito, Masaaki ^c   Hartshorne, David J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c MIE UNIVERSITY   (Japan)

Author keywords

A7r5 cells; Lysophosphatidic acid; Myosin phosphatase; Myosin target subunit; Rho kinase; Type 1 phosphatase

Indexed keywords

MYOSIN PHOSPHATASE; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN SUBUNIT; RHO KINASE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT;

ANIMALS; BINDING SITES; CELL LINE; CHICKENS; KINETICS; MUTATION; MYOCYTES, SMOOTH MUSCLE; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN SUBUNITS; RATS; RHO GTP-BINDING PROTEINS; SUBSTRATE SPECIFICITY; THREONINE;

ANIMALIA;

EID: 27944458787     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.10.055     Document Type: Article

References (37)

1. D.J. Hartshorne L.R. Johnson Physiology of the Gastrointestinal Tract 1987 Raven Press NY 423 482
2. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase Physiol. Rev. 83 2003 1325 1358
3. J.R. Sellers, and R.S. Adelstein The mechanism of regulation of smooth muscle myosin by phosphorylation Curr. Top. Cell Regul. 27 1985 51 62
4. K.E. Kamm, and J.T. Stull Dedicated myosin light chain kinases with diverse cellular functions J. Biol. Chem. 276 2001 4527 4530
5. D.J. Hartshorne, M. Ito, and F. Erdõdi Role of protein phosphatase type 1 in contractile functions: myosin phosphatase J. Biol. Chem. 279 2004 37211 37214
6. M. Eto, S. Senba, F. Morita, and M. Yazawa Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle FEBS Lett. 410 1997 356 360
7. K. Ichikawa, M. Ito, and D.J. Hartshorne Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity J. Biol. Chem. 271 1996 4733 4740
8. J. Feng, M. Ito, K. Ichikawa, N. Isaka, M. Nishikawa, D.J. Hartshorne, and T. Nakano Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase J. Biol. Chem. 274 1999 37385 37390
9. M. Ito, T. Nakano, F. Erdõdi, and D.J. Hartshorne Myosin phosphatase: structure, regulation and function Mol. Cell Biochem. 259 2004 197 209
10. A.P. Somlyo, and A.V. Somlyo Signal transduction and regulation in smooth muscle Nature 372 1994 231 236
11. D.J. Hartshorne, M. Ito, and F. Erdõdi Myosin light chain phosphatase: subunit composition, interactions and regulation J. Muscle Res. Cell Motil. 19 1998 325 431
12. Y. Kawano, Y. Fukata, N. Oshiro, M. Amano, T. Nakamura, M. Ito, F. Matsumura, M. Inagaki, and K. Kaibuchi Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo J. Cell Biol. 147 1999 1023 1038
13. H. Shimizu, M. Ito, M. Miyahara, K. Ichikawa, S. Okubo, T. Konishi, M. Naka, T. Tanaka, K. Hirano, and D.J. Hartshorne Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase J. Biol. Chem. 269 1994 30407 30411
14. O.A. Sandu, M. Ito, and N. Begum Selected contribution: insulin utilizes NO/cGMP pathway to activate myosin phosphatase via Rho inhibition in vascular smooth muscle J. Appl. Physiol. 91 2001 1475 1482
15. H.M. Shin, H.D. Je, C. Gallant, T.C. Tao, D.J. Hartshorne, M. Ito, and K.G. Morgan Differential association and localization of myosin phosphatase subunits during agonist-induced signal transduction in smooth muscle Circ. Res. 90 2002 546 553
16. 2α-induced contraction of rabbit aortae J. Physiol. (Lond) 546 2003 823 836
17. T. Seko, M. Ito, Y. Kureishi, R. Okamoto, N. Moriki, K. Onishi, N. Isaka, D.J. Hartshorne, and T. Nakano Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle Circ. Res. 92 2003 411 418
18. Z. Wang, M.C. Lanner, N. Jin, D. Swartz, L. Li, and R.A. Rhoades Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells: role of Rho-kinase Am. J. Respir. Cell Mol. Biol. 29 2003 465 471
19. B Am. J. Physiol. Cell Physiol. 287 2004 C1209 C1218
20. Y. Watanabe, M. Ito, Y. Kataoka, H. Wada, M. Koyama, J. Feng, H. Shiku, and M. Nishikawa Protein kinase C-catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion Blood 97 2001 3798 3805
21. A.V. Somlyo, C. Phelps, C. Dipierro, M. Eto, P. Read, M. Barrett, J.J. Gibson, M.C. Burnitz, C. Myers, and A.P. Somlyo Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants FASEB J. 17 2003 223 234
22. B. Lontay, A. Kiss, P. Gergely, D.J. Hartshorne, and F. Erdõdi Okadaic acid influences phosphorylation and translocation of myosin phosphatase target subunit 1 influencing myosin phosphorylation, stress fiber assembly and cell migration in HepG2 cells Cell Signal 17 2005 1265 1275
23. N. Niiro, Y. Koga, and M. Ikebe Agonist-induced changes in the phosphorylation of the myosin-binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle Biochem. J. 369 2003 117 128
24. 2+ sensitization in rabbit smooth muscle J. Physiol. (Lond) 546 2003 879 889
25. 2+-sensitization of chicken amnion smooth muscle lacking CPI-17 FEBS Lett. 578 2004 73 79
26. 2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697 Biochem. J. 389 2005 763 774
27. X.D. Ren, R. Wang, Q. Li, L.A. Kahek, K. Kaibuchi, and R.A. Clark Disruption of Rho signal transduction upon cell detachment J. Cell. Sci. 117 2004 3511 3518
28. N. Takizawa, N. Niiro, and M. Ikebe Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17 FEBS Lett. 515 2002 127 132
29. M. Ito, P.R. Pierce, R.E. Allen, and D.J. Hartshorne Effect of monoclonal antibodies on the properties of smooth muscle myosin Biochemistry 28 1989 5567 5572
30. A. Tóth, E. Kiss, F.W. Herberg, P. Gergely, D.J. Hartshorne, and F. Erdõdi Study of the subunit interactions in myosin phosphatase by surface plasmon resonance Eur. J. Biochem. 267 2000 1687 1697
31. D.R. Hathaway, and J.R. Haeberle Selective purification of the 20,000-Da light chains of smooth muscle myosin Anal. Biochem. 135 1983 37 43
32. K. Ichikawa, K. Hirano, M. Ito, J. Tanaka, T. Nakano, and D.J. Hartshorne Interactions and properties of smooth muscle myosin phosphatase Biochemistry 35 1996 6313 6320
33. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
34. M. Uehata, T. Ishizaki, H. Satoh, T. Ono, T. Kawahara, T. Morishita, H. Tamakawa, K. Yamagami, J. Inui, M. Maekawa, and S. Narumiya Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension Nature 389 1997 990 994
35. A. Hall Rho GTPases and the actin cytoskeleton Science 279 1998 509 514
36. K. Hirano, L. Chartier, R.G. Taylor, R.E. Allen, N. Fusetani, H. Karaki, and D.J. Hartshorne Changes in the cytoskeleton of 3T3 fibroblasts induced by the phosphatase inhibitor, calyculin-A J. Muscle Res. Cell Motil. 13 1992 341 353
37. W.H. Moolenaar, L.A. van Meeteren, and B.N. Giepmans The ins and outs of lysophosphatidic acid signaling BioEssays 26 2004 870 881