Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6686-6690

  Yin, Yan ^a   Lin, Li ^a   Ruiz, Claudia ^a   Cameron, Michael D ^a   Pocas, Jennifer ^a   Grant, Wayne ^a   Schröter, Thomas ^a   Chen, Weimin ^a   Duckett, Derek ^a   Schürer, Stephan ^b   LoGrasso, Philip ^a   Feng, Yangbo ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

Benzothiazole; Chroman; Glaucoma; Pyrazole; Rho; ROCK

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; RHO KINASE INHIBITOR;

ARTICLE; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; IC 50; STRUCTURE ACTIVITY RELATION;

BENZOTHIAZOLES; DRUG DESIGN; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049085036     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.115     Document Type: Article

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