Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7113-7118

  Sessions, E Hampton ^a   Chowdhury, Sarwat ^a   Yin, Yan ^a   Pocas, Jennifer R ^a   Grant, Wayne ^a   Schröter, Thomas ^a   Lin, Li ^a   Ruiz, Claudia ^a   Cameron, Michael D ^a   Lograsso, Philip ^a   Bannister, Thomas D ^a   Feng, Yangbo ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Azaindole; Indole; Kinase inhibitor; Pyrazole; Rho kinase; ROCK

Indexed keywords

7 AZAINDOLE DERIVATIVE; INDOLE DERIVATIVE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL ACTIVITY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT;

ANIMALS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DISCOVERY; ENZYME ACTIVATION; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RHO-ASSOCIATED KINASES; SOLUBILITY; WATER;

EID: 80255129420     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.084     Document Type: Article

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