Chroman-3-amides as potent Rho kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6406-6409

  Chen, Yen Ting ^a   Bannister, Thomas D ^a   Weiser, Amiee ^a   Griffin, Evelyn ^a   Lin, Li ^a   Ruiz, Claudia ^a   Cameron, Michael D ^a   Schürer, Stephan ^a   Duckett, Derek ^a   Schröter, Thomas ^a   LoGrasso, Philip ^a   Feng, Yangbo ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Chromans; Glaucoma; Kinase; Rho kinase; ROCK; ROCK II

Indexed keywords

CHROMAN 3 AMIDE DERIVATIVE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GLAUCOMA; HUMAN; HUMAN CELL; HYPERTENSION; LIVER MICROSOME; NEOPLASM; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMANS; DRUG DESIGN; GLAUCOMA; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PROTEIN KINASE INHIBITORS; RATS; RHO-ASSOCIATED KINASES; TIME FACTORS;

EID: 56249104835     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.080     Document Type: Article

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