Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2355-2360

  Feng, Yangbo ^a   Cameron, Michael D ^a   Frackowiak, Bozena ^a   Griffin, Evelyn ^a   Lin, Li ^a   Ruiz, Claudia ^a   Schröter, Thomas ^a   LoGrasso, Philip ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Inhibitor; Kinase; Pharmacokinetics; Rho kinase; ROCK II

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CYTOCHROME P450 3A4; FASUDIL; RHO KINASE; SR 1349; SR 1351; SR 1353; SR 1357; SR 1360; SR 1362; SR 1448; SR 1450; SR 1452; SR 1457; SR 1459; SR 705; SR 706; SR 709; SR 710; SR 715; SR 887; SR 889; SR 890; SR 895; SR 897; SR 899; SR 902; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HALF LIFE TIME; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG STABILITY; HUMANS; INDAZOLES; INHIBITORY CONCENTRATION 50; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PIPERAZINES; PIPERIDINES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947595177     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.043     Document Type: Article

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