Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats

British Journal of Pharmacology

Volumn 165, Issue 8, 2012, Pages 2425-2435

  Sticht, Martin A ^a   Long, Jonathan Z ^b   Rock, Erin M ^a   Limebeer, Cheryl L ^a   Mechoulam, Raphael ^c   Cravatt, Benjamin F ^b   Parker, Linda A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

2AG; CB 1 receptor; Cyclooxygenase; Gaping; Learning; MAGL; Nausea; Taste reactivity; Vomiting

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2 ARACHIDONOYLGLYCEROL; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ACYLGLYCEROL LIPASE; ARACHIDONIC ACID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; ESTERASE INHIBITOR; INDOMETACIN; JZL 184; LITHIUM CHLORIDE; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIEMETIC ACTIVITY; ANTINAUSEA ACTIVITY; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; ELECTRIC SHOCK; ENZYME INHIBITION; FEMALE; FREEZING; IN VIVO STUDY; LEARNING; MALE; NAUSEA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; SHREW; SUNCUS MURINUS; VOMITING;

ANIMALS; ARACHIDONIC ACIDS; BEHAVIOR, ANIMAL; BENZODIOXOLES; BRAIN; ENZYME INHIBITORS; FEAR; GLYCERIDES; LITHIUM CHLORIDE; MALE; MONOACYLGLYCEROL LIPASES; NAUSEA; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; SHREWS; VOMITING;

EID: 84859067302     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01407.x     Document Type: Article

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