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Volumn 13, Issue 1, 2012, Pages 46-58

Targeting the endocannabinod system to limit myocardial and cerebral ischemic and reperfusion injury

Author keywords

Cannabinoid receptors; Endocannabinoids; Excitotoxicity; Fibrosis; Inflammation; Ischemia reperfusion injury; Remodeling

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ADENOSINE A2 RECEPTOR AGONIST; ALTEPLASE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BAY 387271; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; DEXANABINOL; ENDOCANNABINOID; O 1966; PALMIDROL; RIMONABANT; UNCLASSIFIED DRUG; WIN 55212A;

EID: 84855857001     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920112798868665     Document Type: Review
Times cited : (36)

References (161)
  • 1
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby, P. Inflammation in atherosclerosis. Nature, 2002, 420, 868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 3
    • 0037187866 scopus 로고    scopus 로고
    • Reperfusion therapy in acute myocardial infarction
    • Lange, R.A.; Hillis, L.D. Reperfusion therapy in acute myocardial infarction. N. Engl. J. Med., 2002, 346, 954-955.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 954-955
    • Lange, R.A.1    Hillis, L.D.2
  • 4
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • Yellon, D.M.; Hausenloy, D.J. Myocardial reperfusion injury. N. Engl. J. Med., 2007, 357, 1121-1135.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 5
    • 34249008096 scopus 로고    scopus 로고
    • Chemokines in ischemia and reperfusion
    • Frangogiannis, N.G. Chemokines in ischemia and reperfusion. Thromb. Haemost., 2007, 97, 738-747.
    • (2007) Thromb. Haemost. , vol.97 , pp. 738-747
    • Frangogiannis, N.G.1
  • 6
    • 70350462045 scopus 로고    scopus 로고
    • The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury
    • Steffens, S.; Montecucco, F.; Mach, F. The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury. Thromb. Haemost., 2009, 102, 240-247.
    • (2009) Thromb. Haemost. , vol.102 , pp. 240-247
    • Steffens, S.1    Montecucco, F.2    Mach, F.3
  • 7
    • 1142309740 scopus 로고    scopus 로고
    • Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
    • Vinten-Johansen, J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc. Res., 2004, 61, 481-497.
    • (2004) Cardiovasc. Res. , vol.61 , pp. 481-497
    • Vinten-Johansen, J.1
  • 9
    • 67349229765 scopus 로고    scopus 로고
    • Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?
    • Lecour, S. Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway? J. Mol. Cell Cardiol., 2009, 47, 32-40.
    • (2009) J. Mol. Cell Cardiol. , vol.47 , pp. 32-40
    • Lecour, S.1
  • 11
    • 0346059584 scopus 로고    scopus 로고
    • Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection
    • Murphy, E. Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection. Circ. Res., 2004, 94, 7-16.
    • (2004) Circ. Res. , vol.94 , pp. 7-16
    • Murphy, E.1
  • 12
    • 57149142506 scopus 로고    scopus 로고
    • Cardioprotection: Nitric oxide, protein kinases, and mitochondria
    • Heusch, G.; Boengler, K.; Schulz, R. Cardioprotection: nitric oxide, protein kinases, and mitochondria, Circulation, 2008, 118, 1915-1919.
    • (2008) Circulation , vol.118 , pp. 1915-1919
    • Heusch, G.1    Boengler, K.2    Schulz, R.3
  • 13
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    • Halestrap, A.P.; Clarke, S.J.; Javadov, S.A. Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection. Cardiovasc. Res., 2004, 61, 372-385.
    • (2004) Cardiovasc. Res. , vol.61 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 14
    • 59449107442 scopus 로고    scopus 로고
    • Myocardial repair/remodelling following infarction: Roles of local factors
    • Sun, Y. Myocardial repair/remodelling following infarction: roles of local factors. Cardiovasc. Res., 2009, 81, 482-490.
    • (2009) Cardiovasc. Res. , vol.81 , pp. 482-490
    • Sun, Y.1
  • 15
    • 0026354053 scopus 로고
    • Ventricular enlargement and remodeling following acute myocardial infarction: Mechanisms and management
    • Braunwald, E.; Pfeffer, M. A. Ventricular enlargement and remodeling following acute myocardial infarction: mechanisms and management. Am. J. Cardiol., 1991, 68, 1D-6D.
    • (1991) Am. J. Cardiol. , vol.68
    • Braunwald, E.1    Pfeffer, M.A.2
  • 17
    • 71049180369 scopus 로고    scopus 로고
    • Inflammatory mechanisms in ischemic stroke: Therapeutic approaches
    • Lakhan, S. E.; Kirchgessner, A.; Hofer, M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J. Transl. Med., 2009, 7, 97.
    • (2009) J. Transl. Med. , vol.7 , pp. 97
    • Lakhan, S.E.1    Kirchgessner, A.2    Hofer, M.3
  • 18
    • 62949144759 scopus 로고    scopus 로고
    • Endovascular therapy for acute ischemic stroke
    • Broderick, J.P. Endovascular therapy for acute ischemic stroke. Stroke, 2009, 40, S103-106.
    • (2009) Stroke , vol.40
    • Broderick, J.P.1
  • 20
    • 43249112515 scopus 로고    scopus 로고
    • Role of inflammatory markers in brain ischemia
    • Rodriguez-Yanez, M.; Castillo, J. Role of inflammatory markers in brain ischemia. Curr. Opin. Neurol., 2008, 21, 353-357.
    • (2008) Curr. Opin. Neurol. , vol.21 , pp. 353-357
    • Rodriguez-Yanez, M.1    Castillo, J.2
  • 21
    • 33847644971 scopus 로고    scopus 로고
    • The inflammatory response in stroke
    • Wang, Q.; Tang, X.N.; Yenari, M.A. The inflammatory response in stroke. J. Neuroimmunol., 2007, 184, 53-68.
    • (2007) J. Neuroimmunol. , vol.184 , pp. 53-68
    • Wang, Q.1    Tang, X.N.2    Yenari, M.A.3
  • 22
    • 26844435654 scopus 로고    scopus 로고
    • Rodent models of focal stroke: Size, mechanism, and purpose
    • Carmichael, S.T. Rodent models of focal stroke: size, mechanism, and purpose. NeuroRx, 2005, 2, 396-409.
    • (2005) NeuroRx , vol.2 , pp. 396-409
    • Carmichael, S.T.1
  • 23
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • Lipton, P. Ischemic cell death in brain neurons. Physiol. Rev., 1999, 79, 1431-1568.
    • (1999) Physiol. Rev. , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 24
    • 0031759682 scopus 로고    scopus 로고
    • Reperfusion injury after focal cerebral ischemia: The role of inflammation and the therapeutic horizon
    • discussion 1396-1387
    • Jean, W.C.; Spellman, S.R.; Nussbaum, E.S.; Low, W.C. Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. Neurosurgery, 1998, 43, 1382-1396; discussion 1396-1387.
    • (1998) Neurosurgery , vol.43 , pp. 1382-1396
    • Jean, W.C.1    Spellman, S.R.2    Nussbaum, E.S.3    Low, W.C.4
  • 25
    • 0035376112 scopus 로고    scopus 로고
    • The role of the complement cascade in ischemia/reperfusion injury: Implications for neuroprotection
    • D'Ambrosio, A.L.; Pinsky, D.J.; Connolly, E.S. The role of the complement cascade in ischemia/reperfusion injury: implications for neuroprotection. Mol. Med., 2001, 7, 367-382.
    • (2001) Mol. Med. , vol.7 , pp. 367-382
    • D'Ambrosio, A.L.1    Pinsky, D.J.2    Connolly, E.S.3
  • 26
    • 39049169272 scopus 로고    scopus 로고
    • Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemiareperfusion injury
    • Wong, C.H.; Crack, P.J. Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemiareperfusion injury. Curr. Med. Chem., 2008, 15, 1-14.
    • (2008) Curr. Med. Chem. , vol.15 , pp. 1-14
    • Wong, C.H.1    Crack, P.J.2
  • 27
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • Klein, T.W. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat. Rev. Immunol., 2005, 5, 400-411.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 28
    • 33947128224 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of their levels in health and disease
    • Di Marzo, V.; Petrosino, S. Endocannabinoids and the regulation of their levels in health and disease. Curr. Opin. Lipidol., 2007, 18, 129-140.
    • (2007) Curr. Opin. Lipidol. , vol.18 , pp. 129-140
    • di Marzo, V.1    Petrosino, S.2
  • 29
    • 33645796477 scopus 로고    scopus 로고
    • Cannabinoid receptor signaling
    • Howlett, A.C. Cannabinoid receptor signaling. Handb. Exp. Pharmacol., 2005, 53-79.
    • (2005) Handb. Exp. Pharmacol. , pp. 53-79
    • Howlett, A.C.1
  • 30
    • 77950644306 scopus 로고    scopus 로고
    • CB(1) cannabinoid receptors and their associated proteins
    • Howlett, A.C.; Blume, L.C.; Dalton, G.D. CB(1) cannabinoid receptors and their associated proteins. Curr. Med. Chem., 17, 1382-1393.
    • Curr. Med. Chem. , vol.17 , pp. 1382-1393
    • Howlett, A.C.1    Blume, L.C.2    Dalton, G.D.3
  • 31
    • 75749126604 scopus 로고    scopus 로고
    • Signal transduction of the CB1 cannabinoid receptor
    • Turu, G.; Hunyady, L. Signal transduction of the CB1 cannabinoid receptor. J. Mol. Endocrinol., 2010, 44, 75-85.
    • (2010) J. Mol. Endocrinol. , vol.44 , pp. 75-85
    • Turu, G.1    Hunyady, L.2
  • 32
    • 67749086243 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in cardiovascular disease
    • Pacher, P.; Steffens, S. The emerging role of the endocannabinoid system in cardiovascular disease. Semin. Immunopathol, 2009, 31, 63-77.
    • (2009) Semin. Immunopathol , vol.31 , pp. 63-77
    • Pacher, P.1    Steffens, S.2
  • 34
    • 67449119913 scopus 로고    scopus 로고
    • The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
    • Di Marzo, V. The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacol. Res., 2009, 60, 77-84.
    • (2009) Pharmacol. Res. , vol.60 , pp. 77-84
    • di Marzo, V.1
  • 35
    • 20444460345 scopus 로고    scopus 로고
    • The endocannabinoid signalling system: Biochemical aspects
    • Bisogno, T.; Ligresti, A.; Di Marzo, V. The endocannabinoid signalling system: biochemical aspects. Pharmacol. Biochem. Behav., 2005, 81, 224-238.
    • (2005) Pharmacol. Biochem. Behav. , vol.81 , pp. 224-238
    • Bisogno, T.1    Ligresti, A.2    di Marzo, V.3
  • 36
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di Marzo, V. Targeting the endocannabinoid system: to enhance or reduce? Nat. Rev. Drug Discov., 2008, 7, 438-455.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 438-455
    • di Marzo, V.1
  • 37
    • 0033989891 scopus 로고    scopus 로고
    • A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols
    • Schmid, P.C.; Schwartz, K.D.; Smith, C.N.; Krebsbach, R.J.; Berdyshev, E.V.; Schmid, H.H. A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols. Chem. Phys. Lipids., 2000, 104, 185-191.
    • (2000) Chem. Phys. Lipids. , vol.104 , pp. 185-191
    • Schmid, P.C.1    Schwartz, K.D.2    Smith, C.N.3    Krebsbach, R.J.4    Berdyshev, E.V.5    Schmid, H.H.6
  • 39
    • 0037424211 scopus 로고    scopus 로고
    • Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart
    • Bouchard, J.F.; Lepicier, P.; Lamontagne, D. Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart. Life Sci., 2003, 72, 1859-1870.
    • (2003) Life Sci. , vol.72 , pp. 1859-1870
    • Bouchard, J.F.1    Lepicier, P.2    Lamontagne, D.3
  • 40
    • 35348983991 scopus 로고    scopus 로고
    • Endothelial CB1-receptors limit infarct size through NO formation in rat isolated hearts
    • Lepicier, P.; Lagneux, C.; Sirois, M. G.; Lamontagne, D. Endothelial CB1-receptors limit infarct size through NO formation in rat isolated hearts. Life Sci., 2007, 81, 1373-1380.
    • (2007) Life Sci. , vol.81 , pp. 1373-1380
    • Lepicier, P.1    Lagneux, C.2    Sirois, M.G.3    Lamontagne, D.4
  • 41
    • 0035120753 scopus 로고    scopus 로고
    • Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide
    • Lagneux, C.; Lamontagne, D. Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide. Br. J. Pharmacol., 2001, 132, 793-796.
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 793-796
    • Lagneux, C.1    Lamontagne, D.2
  • 42
    • 0036023638 scopus 로고    scopus 로고
    • Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts
    • Joyeux, M.; Arnaud, C.; Godin-Ribuot, D.; Demenge, P.; Lamontagne, D.; Ribuot, C. Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts. Cardiovasc. Res., 2002, 55, 619-625.
    • (2002) Cardiovasc. Res. , vol.55 , pp. 619-625
    • Joyeux, M.1    Arnaud, C.2    Godin-Ribuot, D.3    Demenge, P.4    Lamontagne, D.5    Ribuot, C.6
  • 43
    • 0038002221 scopus 로고    scopus 로고
    • Endocannabinoids protect the rat isolated heart against ischaemia
    • Lepicier, P.; Bouchard, J.F.; Lagneux, C.; Lamontagne, D. Endocannabinoids protect the rat isolated heart against ischaemia. Br. J. Pharmacol., 2003, 139, 805-815.
    • (2003) Br. J. Pharmacol. , vol.139 , pp. 805-815
    • Lepicier, P.1    Bouchard, J.F.2    Lagneux, C.3    Lamontagne, D.4
  • 44
    • 27744478054 scopus 로고    scopus 로고
    • Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism
    • Underdown, N.J.; Hiley, C.R.; Ford, W.R. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. Br. J. Pharmacol., 2005, 146, 809-816.
    • (2005) Br. J. Pharmacol. , vol.146 , pp. 809-816
    • Underdown, N.J.1    Hiley, C.R.2    Ford, W.R.3
  • 45
    • 33748164344 scopus 로고    scopus 로고
    • 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts
    • Wagner, J.A.; Abesser, M.; Harvey-White, J.; Ertl, G. 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. J. Cardiovasc. Pharmacol., 2006, 47, 650-655.
    • (2006) J. Cardiovasc. Pharmacol. , vol.47 , pp. 650-655
    • Wagner, J.A.1    Abesser, M.2    Harvey-White, J.3    Ertl, G.4
  • 46
    • 33645783755 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia via CB2 receptor activation and nitric oxide production
    • Shmist, Y.A.; Goncharov, I.; Eichler, M.; Shneyvays, V.; Isaac, A.; Vogel, Z.; Shainberg, A. Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia via CB2 receptor activation and nitric oxide production. Mol. Cell Biochem., 2006, 283, 75-83.
    • (2006) Mol. Cell Biochem. , vol.283 , pp. 75-83
    • Shmist, Y.A.1    Goncharov, I.2    Eichler, M.3    Shneyvays, V.4    Isaac, A.5    Vogel, Z.6    Shainberg, A.7
  • 47
    • 1542283728 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: Involvement of cytokine/chemokines and PMN
    • Di Filippo, C.; Rossi, F.; Rossi, S.; D'Amico, M. Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN. J. Leukoc Biol., 2004, 75, 453-459.
    • (2004) J. Leukoc Biol. , vol.75 , pp. 453-459
    • di Filippo, C.1    Rossi, F.2    Rossi, S.3    D'Amico, M.4
  • 50
    • 70349652198 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist, rimonabant, protects against acute myocardial infarction
    • Lim, S.Y.; Davidson, S.M.; Yellon, D.M.; Smith, C.C. The cannabinoid CB1 receptor antagonist, rimonabant, protects against acute myocardial infarction. Basic Res. Cardiol., 2009, 104, 781-792.
    • (2009) Basic Res. Cardiol. , vol.104 , pp. 781-792
    • Lim, S.Y.1    Davidson, S.M.2    Yellon, D.M.3    Smith, C.C.4
  • 53
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
    • Carrier, E.J.; Auchampach, J.A.; Hillard, C.J. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc. Natl. Acad Sci. U S A., 2006, 103, 7895-7900.
    • (2006) Proc. Natl. Acad Sci. U S A. , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 54
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • Hasko, G.; Linden, J.; Cronstein, B.; Pacher, P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov., 2008, 7, 759-770.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 759-770
    • Hasko, G.1    Linden, J.2    Cronstein, B.3    Pacher, P.4
  • 56
  • 57
    • 0031823187 scopus 로고    scopus 로고
    • Platelet-and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension
    • Varga, K.; Wagner, J.A.; Bridgen, D.T.; Kunos, G. Platelet-and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J., 1998, 12, 1035-1044.
    • (1998) FASEB J. , vol.12 , pp. 1035-1044
    • Varga, K.1    Wagner, J.A.2    Bridgen, D.T.3    Kunos, G.4
  • 60
    • 0038753984 scopus 로고    scopus 로고
    • CB(1) cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction
    • Wagner, J.A.; Hu, K.; Karcher, J.; Bauersachs, J.; Schafer, A.; Laser, M.; Han, H.; Ertl, G. CB(1) cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction. Br. J. Pharmacol., 2003, 138, 1251-1258.
    • (2003) Br. J. Pharmacol. , vol.138 , pp. 1251-1258
    • Wagner, J.A.1    Hu, K.2    Karcher, J.3    Bauersachs, J.4    Schafer, A.5    Laser, M.6    Han, H.7    Ertl, G.8
  • 62
    • 27144472559 scopus 로고    scopus 로고
    • Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats
    • Gaskari, S.A.; Liu, H.; Moezi, L.; Li, Y.; Baik, S.K.; Lee, S.S. Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Br. J. Pharmacol., 2005, 146, 315-323.
    • (2005) Br. J. Pharmacol. , vol.146 , pp. 315-323
    • Gaskari, S.A.1    Liu, H.2    Moezi, L.3    Li, Y.4    Baik, S.K.5    Lee, S.S.6
  • 64
    • 76749118468 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes
    • Mukhopadhyay, P.; Rajesh, M.; Batkai, S.; Patel, V.; Kashiwaya, Y.; Liaudet, L.; Evgenov, O. V.; Mackie, K.; Hasko, G.; Pacher, P. CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovasc. Res., 2010, 85, 773-784.
    • (2010) Cardiovasc. Res. , vol.85 , pp. 773-784
    • Mukhopadhyay, P.1    Rajesh, M.2    Batkai, S.3    Patel, V.4    Kashiwaya, Y.5    Liaudet, L.6    Evgenov, O.V.7    McKie, K.8    Hasko, G.9    Pacher, P.10
  • 67
    • 77956552524 scopus 로고    scopus 로고
    • Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure
    • Weis, F.; Beiras-Fernandez, A.; Sodian, R.; Kaczmarek, I.; Reichart, B.; Beiras, A.; Schelling, G.; Kreth, S. Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. J. Mol. Cell Cardiol., 2010, 48, 1187-1193.
    • (2010) J. Mol. Cell Cardiol. , vol.48 , pp. 1187-1193
    • Weis, F.1    Beiras-Fernandez, A.2    Sodian, R.3    Kaczmarek, I.4    Reichart, B.5    Beiras, A.6    Schelling, G.7    Kreth, S.8
  • 68
    • 0028837562 scopus 로고
    • Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain
    • Schmid, P.C.; Krebsbach, R.J.; Perry, S.R.; Dettmer, T.M.; Maasson, J.L.; Schmid, H.H. Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain. FEBS Lett., 1995, 375, 117-120.
    • (1995) FEBS Lett. , vol.375 , pp. 117-120
    • Schmid, P.C.1    Krebsbach, R.J.2    Perry, S.R.3    Dettmer, T.M.4    Maasson, J.L.5    Schmid, H.H.6
  • 71
    • 0030016343 scopus 로고    scopus 로고
    • Isotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post mortem but is contained at low levels in or is absent from fresh tissue
    • Kempe, K.; Hsu, F.F.; Bohrer, A.; Turk, J. Isotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post mortem but is contained at low levels in or is absent from fresh tissue. J. Biol. Chem., 1996, 271, 17287-17295.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17287-17295
    • Kempe, K.1    Hsu, F.F.2    Bohrer, A.3    Turk, J.4
  • 72
    • 0035910626 scopus 로고    scopus 로고
    • Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation
    • Sugiura, T.; Yoshinaga, N.; Waku, K. Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation. Neurosci. Lett., 2001, 297, 175-178.
    • (2001) Neurosci. Lett. , vol.297 , pp. 175-178
    • Sugiura, T.1    Yoshinaga, N.2    Waku, K.3
  • 73
    • 52949119940 scopus 로고    scopus 로고
    • Role of cannabinoids and endocannabinoids in cerebral ischemia
    • Hillard, C.J. Role of cannabinoids and endocannabinoids in cerebral ischemia. Curr. Pharm. Des., 2008, 14, 2347-2361.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 2347-2361
    • Hillard, C.J.1
  • 74
    • 0034087481 scopus 로고    scopus 로고
    • Synthesis and characterization of a fluorescent substrate for the Narachidonoylethanolamine (anandamide) transmembrane carrier
    • Muthian, S.; Nithipatikom, K.; Campbell, W.B.; Hillard, C.J. Synthesis and characterization of a fluorescent substrate for the Narachidonoylethanolamine (anandamide) transmembrane carrier. J. Pharmacol. Exp. Ther., 2000, 293, 289-295.
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 289-295
    • Muthian, S.1    Nithipatikom, K.2    Campbell, W.B.3    Hillard, C.J.4
  • 79
    • 0033863179 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor induction in experimental stroke
    • Jin, K.L.; Mao, X.O.; Goldsmith, P.C.; Greenberg, D.A. CB1 cannabinoid receptor induction in experimental stroke. Ann. Neurol., 2000, 48, 257-261.
    • (2000) Ann. Neurol. , vol.48 , pp. 257-261
    • Jin, K.L.1    Mao, X.O.2    Goldsmith, P.C.3    Greenberg, D.A.4
  • 80
    • 40949116660 scopus 로고    scopus 로고
    • Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury
    • Zhang, M.; Martin, B.R.; Adler, M.W.; Razdan, R.K.; Ganea, D.; Tuma, R.F. Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury. Neuroscience, 2008, 152, 753-760.
    • (2008) Neuroscience , vol.152 , pp. 753-760
    • Zhang, M.1    Martin, B.R.2    Adler, M.W.3    Razdan, R.K.4    Ganea, D.5    Tuma, R.F.6
  • 81
    • 33846047809 scopus 로고    scopus 로고
    • Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain
    • Ashton, J.C.; Rahman, R.M.; Nair, S.M.; Sutherland, B.A.; Glass, M.; Appleton, I. Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neurosci. Lett., 2007, 412, 114-117.
    • (2007) Neurosci. Lett. , vol.412 , pp. 114-117
    • Ashton, J.C.1    Rahman, R.M.2    Nair, S.M.3    Sutherland, B.A.4    Glass, M.5    Appleton, I.6
  • 82
    • 33747759356 scopus 로고    scopus 로고
    • Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra
    • Sommer, C.; Schomacher, M.; Berger, C.; Kuhnert, K.; Muller, H.D.; Schwab, S.; Schabitz, W.R. Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra. Acta Neuropathol., 2006, 112, 277-286.
    • (2006) Acta Neuropathol. , vol.112 , pp. 277-286
    • Sommer, C.1    Schomacher, M.2    Berger, C.3    Kuhnert, K.4    Muller, H.D.5    Schwab, S.6    Schabitz, W.R.7
  • 84
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl, U.; Iadecola, C.; Moskowitz, M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci., 1999, 22, 391-397.
    • (1999) Trends Neurosci. , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 85
    • 0032749166 scopus 로고    scopus 로고
    • Neuronal death after brain injury. Models, mechanisms, and therapeutic strategies in vivo
    • Kermer, P.; Klocker, N.; Bahr, M. Neuronal death after brain injury. Models, mechanisms, and therapeutic strategies in vivo. Cell Tissue Res., 1999, 298, 383-395.
    • (1999) Cell Tissue Res. , vol.298 , pp. 383-395
    • Kermer, P.1    Klocker, N.2    Bahr, M.3
  • 86
    • 0026603679 scopus 로고
    • Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
    • Mackie, K.; Hille, B. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells, Proc. Natl. Acad Sci. U S A., 1992, 89, 3825-3829.
    • (1992) Proc. Natl. Acad Sci. U S A. , vol.89 , pp. 3825-3829
    • McKie, K.1    Hille, B.2
  • 87
    • 0031706164 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity
    • Shen, M.; Thayer, S.A. Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity. Mol. Pharmacol., 1998, 54, 459-462.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 459-462
    • Shen, M.1    Thayer, S.A.2
  • 88
    • 0029937282 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures
    • Shen, M.; Piser, T.M.; Seybold, V.S.; Thayer, S.A. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures. J. Neurosci., 1996, 16, 4322-4334.
    • (1996) J. Neurosci. , vol.16 , pp. 4322-4334
    • Shen, M.1    Piser, T.M.2    Seybold, V.S.3    Thayer, S.A.4
  • 89
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • Nagayama, T.; Sinor, A.D.; Simon, R.P.; Chen, J.; Graham, S.H.; Jin, K.; Greenberg, D.A. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J. Neurosci., 1999, 19, 2987-2995.
    • (1999) J. Neurosci. , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3    Chen, J.4    Graham, S.H.5    Jin, K.6    Greenberg, D.A.7
  • 90
    • 0036082491 scopus 로고    scopus 로고
    • Characterization of the diarylether sulfonylester (-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties
    • Mauler, F.; Mittendorf, J.; Horvath, E.; De Vry, J. Characterization of the diarylether sulfonylester (-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties. J. Pharmacol. Exp. Ther., 2002, 302, 359-368.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 359-368
    • Mauler, F.1    Mittendorf, J.2    Horvath, E.3    de Vry, J.4
  • 91
    • 0034704404 scopus 로고    scopus 로고
    • CP 55,940 protects against ischemia-induced electroencephalographic flattening and hyperlocomotion in Mongolian gerbils
    • Braida, D.; Pozzi, M.; Sala, M. CP 55,940 protects against ischemia-induced electroencephalographic flattening and hyperlocomotion in Mongolian gerbils. Neurosci. Lett., 2000, 296, 69-72.
    • (2000) Neurosci. Lett. , vol.296 , pp. 69-72
    • Braida, D.1    Pozzi, M.2    Sala, M.3
  • 92
    • 0037111836 scopus 로고    scopus 로고
    • Increased severity of stroke in CB1 cannabinoid receptor knock-out mice
    • Parmentier-Batteur, S.; Jin, K.; Mao, X.O.; Xie, L.; Greenberg, D.A. Increased severity of stroke in CB1 cannabinoid receptor knock-out mice. J. Neurosci., 2002, 22, 9771-9775.
    • (2002) J. Neurosci. , vol.22 , pp. 9771-9775
    • Parmentier-Batteur, S.1    Jin, K.2    Mao, X.O.3    Xie, L.4    Greenberg, D.A.5
  • 93
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson, A.J.; Grimaldi, M.; Axelrod, J.; Wink, D. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc. Natl. Acad. Sci. U S A., 1998, 95, 8268-8273.
    • (1998) Proc. Natl. Acad. Sci. U S A. , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 94
    • 0033988703 scopus 로고    scopus 로고
    • Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats
    • Sinor, A.D.; Irvin, S.M.; Greenberg, D.A. Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats. Neurosci Lett., 2000, 278, 157-160.
    • (2000) Neurosci Lett. , vol.278 , pp. 157-160
    • Sinor, A.D.1    Irvin, S.M.2    Greenberg, D.A.3
  • 95
    • 0034046970 scopus 로고    scopus 로고
    • Cannabinoids protect cells from oxidative cell death: A receptor-independent mechanism
    • Chen, Y.; Buck, J. Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism. J. Pharmacol. Exp. Ther., 2000, 293, 807-812.
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 807-812
    • Chen, Y.1    Buck, J.2
  • 96
    • 2542566701 scopus 로고    scopus 로고
    • Therapeutic hypothermia for acute ischemic stroke: What do laboratory studies teach us?
    • Krieger, D.W.; Yenari, M.A. Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us? Stroke, 2004, 35, 1482-1489.
    • (2004) Stroke , vol.35 , pp. 1482-1489
    • Krieger, D.W.1    Yenari, M.A.2
  • 97
    • 37349130510 scopus 로고    scopus 로고
    • Therapeutic hypothermia for global and focal ischemic brain injury--a cool way to improve neurologic outcomes
    • Hoesch, R.E.; Geocadin, R.G. Therapeutic hypothermia for global and focal ischemic brain injury--a cool way to improve neurologic outcomes. Neurologist, 2007, 13, 331-342.
    • (2007) Neurologist , vol.13 , pp. 331-342
    • Hoesch, R.E.1    Geocadin, R.G.2
  • 98
  • 99
    • 0345563285 scopus 로고    scopus 로고
    • Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: Effects on neurologic outcome, infarct size, apoptosis, and inflammation
    • Maier, C.M.; Ahern, K.; Cheng, M.L.; Lee, J.E.; Yenari, M.A.; Steinberg, G.K. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation. Stroke, 1998, 29, 2171-2180.
    • (1998) Stroke , vol.29 , pp. 2171-2180
    • Maier, C.M.1    Ahern, K.2    Cheng, M.L.3    Lee, J.E.4    Yenari, M.A.5    Steinberg, G.K.6
  • 100
    • 0013694986 scopus 로고
    • Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain
    • Busto, R.; Globus, M.Y.; Dietrich, W.D.; Martinez, E.; Valdes, I.; Ginsberg, M.D. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke, 1989, 20, 904-910.
    • (1989) Stroke , vol.20 , pp. 904-910
    • Busto, R.1    Globus, M.Y.2    Dietrich, W.D.3    Martinez, E.4    Valdes, I.5    Ginsberg, M.D.6
  • 101
    • 0027982029 scopus 로고
    • Effect of mild hypothermia on nitric oxide synthesis during focal cerebral ischemia
    • discussion 277
    • Kader, A.; Frazzini, V.I.; Baker, C.J.; Solomon, R.A.; Trifiletti, R.R. Effect of mild hypothermia on nitric oxide synthesis during focal cerebral ischemia. Neurosurgery, 1994, 35, 272-277; discussion 277.
    • (1994) Neurosurgery , vol.35 , pp. 272-277
    • Kader, A.1    Frazzini, V.I.2    Baker, C.J.3    Solomon, R.A.4    Trifiletti, R.R.5
  • 102
    • 0028338840 scopus 로고
    • Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats
    • Karibe, H.; Chen, S.F.; Zarow, G.J.; Gafni, J.; Graham, S.H.; Chan, P.H.; Weinstein, P.R. Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats. Brain Res., 1994, 649, 12-18.
    • (1994) Brain Res. , vol.649 , pp. 12-18
    • Karibe, H.1    Chen, S.F.2    Zarow, G.J.3    Gafni, J.4    Graham, S.H.5    Chan, P.H.6    Weinstein, P.R.7
  • 103
    • 0029907713 scopus 로고    scopus 로고
    • Intraischemic hypothermia attenuates neutrophil infiltration in the rat neocortex after focal ischemia-reperfusion injury
    • Toyoda, T.; Suzuki, S.; Kassell, N.F.; Lee, K.S. Intraischemic hypothermia attenuates neutrophil infiltration in the rat neocortex after focal ischemia-reperfusion injury. Neurosurgery, 1996, 39, 1200-1205.
    • (1996) Neurosurgery , vol.39 , pp. 1200-1205
    • Toyoda, T.1    Suzuki, S.2    Kassell, N.F.3    Lee, K.S.4
  • 104
    • 0031720550 scopus 로고    scopus 로고
    • Hypothermia attenuates hyperglycolysis in the periphery of ischemic core in rat brain
    • Tohyama, Y.; Sako, K.; Yonemasu, Y. Hypothermia attenuates hyperglycolysis in the periphery of ischemic core in rat brain. Exp. Brain Res., 1998, 122, 333-338.
    • (1998) Exp. Brain Res. , vol.122 , pp. 333-338
    • Tohyama, Y.1    Sako, K.2    Yonemasu, Y.3
  • 105
    • 0026969158 scopus 로고
    • Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol
    • Compton, D.R.; Gold, L.H.; Ward, S.J.; Balster, R.L.; Martin, B.R. Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. J. Pharmacol. Exp. Ther., 1992, 263, 1118-1126.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 1118-1126
    • Compton, D.R.1    Gold, L.H.2    Ward, S.J.3    Balster, R.L.4    Martin, B.R.5
  • 106
    • 0015738228 scopus 로고
    • Hypothermic action of delta 9-tetrahydrocannabinol, 11-hydroxy-delta 9-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol in mice
    • Haavik, C.O.; Hardman, H.F. Hypothermic action of delta 9-tetrahydrocannabinol, 11-hydroxy-delta 9-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol in mice. Life Sci., 1973, 13, 1771-1778.
    • (1973) Life Sci. , vol.13 , pp. 1771-1778
    • Haavik, C.O.1    Hardman, H.F.2
  • 107
    • 0015730382 scopus 로고
    • Evaluation of the hypothermic action of tetrahydrocannabinols in mice and squirrel monkeys
    • Haavik, C.O.; Hardman, H.F. Evaluation of the hypothermic action of tetrahydrocannabinols in mice and squirrel monkeys. J. Pharmacol Exp. Ther., 1973, 187, 568-574.
    • (1973) J. Pharmacol Exp. Ther. , vol.187 , pp. 568-574
    • Haavik, C.O.1    Hardman, H.F.2
  • 109
    • 0035136559 scopus 로고    scopus 로고
    • Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse
    • Azad, S.C.; Marsicano, G.; Eberlein, I.; Putzke, J.; Zieglgansberger, W.; Spanagel, R.; Lutz, B. Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse. Eur. J. Neurosci., 2001, 13, 561-568.
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 561-568
    • Azad, S.C.1    Marsicano, G.2    Eberlein, I.3    Putzke, J.4    Zieglgansberger, W.5    Spanagel, R.6    Lutz, B.7
  • 112
    • 1442348425 scopus 로고    scopus 로고
    • Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?
    • Berger, C.; Schmid, P.C.; Schabitz, W.R.; Wolf, M.; Schwab, S.; Schmid, H.H. Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia? J. Neurochem., 2004, 88, 1159-1167.
    • (2004) J. Neurochem. , vol.88 , pp. 1159-1167
    • Berger, C.1    Schmid, P.C.2    Schabitz, W.R.3    Wolf, M.4    Schwab, S.5    Schmid, H.H.6
  • 113
    • 8444250235 scopus 로고    scopus 로고
    • Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia
    • Muthian, S.; Rademacher, D.J.; Roelke, C.T.; Gross, G.J.; Hillard, C.J. Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. Neuroscience, 2004, 129, 743-750.
    • (2004) Neuroscience , vol.129 , pp. 743-750
    • Muthian, S.1    Rademacher, D.J.2    Roelke, C.T.3    Gross, G.J.4    Hillard, C.J.5
  • 115
    • 33644830973 scopus 로고    scopus 로고
    • Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection
    • Pegorini, S.; Zani, A.; Braida, D.; Guerini-Rocco, C.; Sala, M. Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection. Br. J. Pharmacol., 2006, 147, 552-559.
    • (2006) Br. J. Pharmacol. , vol.147 , pp. 552-559
    • Pegorini, S.1    Zani, A.2    Braida, D.3    Guerini-Rocco, C.4    Sala, M.5
  • 117
    • 0033969895 scopus 로고    scopus 로고
    • The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat
    • Louw, D.F.; Yang, F.W.; Sutherland, G.R. The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat. Brain Res., 2000, 857, 183-187.
    • (2000) Brain Res. , vol.857 , pp. 183-187
    • Louw, D.F.1    Yang, F.W.2    Sutherland, G.R.3
  • 119
    • 0035979606 scopus 로고    scopus 로고
    • Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity
    • Abood, M.E.; Rizvi, G.; Sallapudi, N.; McAllister, S.D. Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity. Neurosci. Lett., 2001, 309, 197-201.
    • (2001) Neurosci. Lett. , vol.309 , pp. 197-201
    • Abood, M.E.1    Rizvi, G.2    Sallapudi, N.3    McAllister, S.D.4
  • 120
    • 33846066404 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
    • Gilbert, G.L.; Kim, H.J.; Waataja, J.J.; Thayer, S.A. Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity. Brain Res., 2007, 1128, 61-69.
    • (2007) Brain Res. , vol.1128 , pp. 61-69
    • Gilbert, G.L.1    Kim, H.J.2    Waataja, J.J.3    Thayer, S.A.4
  • 121
    • 0035499974 scopus 로고    scopus 로고
    • Modulation of transmitter release via presynaptic cannabinoid receptors
    • Schlicker, E.; Kathmann, M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol. Sci., 2001, 22, 565-572.
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 565-572
    • Schlicker, E.1    Kathmann, M.2
  • 123
    • 0035893233 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus
    • Varma, N.; Carlson, G.C.; Ledent, C.; Alger, B.E. Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus. J. Neurosci., 2001, 21, RC188.
    • (2001) J. Neurosci. , vol.21
    • Varma, N.1    Carlson, G.C.2    Ledent, C.3    Alger, B.E.4
  • 125
    • 0345621691 scopus 로고    scopus 로고
    • Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
    • Katona, I.; Sperlagh, B.; Sik, A.; Kafalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F. Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J. Neurosci., 1999, 19, 4544-4558.
    • (1999) J. Neurosci. , vol.19 , pp. 4544-4558
    • Katona, I.1    Sperlagh, B.2    Sik, A.3    Kafalvi, A.4    Vizi, E.S.5    McKie, K.6    Freund, T.F.7
  • 126
    • 33947628060 scopus 로고    scopus 로고
    • Molecular targets in cerebral ischemia for developing novel therapeutics
    • Mehta, S.L.; Manhas, N.; Raghubir, R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res. Rev., 2007, 54, 34-66.
    • (2007) Brain Res. Rev. , vol.54 , pp. 34-66
    • Mehta, S.L.1    Manhas, N.2    Raghubir, R.3
  • 127
    • 0023254680 scopus 로고
    • A brief episode of severe arterial hypertension induces delayed deterioration of brain function and worsens blood flow after transient multifocal cerebral ischemia
    • Dutka, A.J.; Hallenbeck, J.M.; Kochanek, P. A brief episode of severe arterial hypertension induces delayed deterioration of brain function and worsens blood flow after transient multifocal cerebral ischemia. Stroke, 1987, 18, 386-395.
    • (1987) Stroke , vol.18 , pp. 386-395
    • Dutka, A.J.1    Hallenbeck, J.M.2    Kochanek, P.3
  • 128
  • 129
    • 0024542144 scopus 로고
    • Influence of granulocytopenia on canine cerebral ischemia induced by air embolism
    • Dutka, A.J.; Kochanek, P.M.; Hallenbeck, J.M. Influence of granulocytopenia on canine cerebral ischemia induced by air embolism. Stroke, 1989, 20, 390-395.
    • (1989) Stroke , vol.20 , pp. 390-395
    • Dutka, A.J.1    Kochanek, P.M.2    Hallenbeck, J.M.3
  • 132
    • 4243157790 scopus 로고    scopus 로고
    • Polymorphonuclear leukocytes and microcirculatory perfusion in acute stroke in the SHR
    • discussion 252-243
    • Dawson, D.A.; Ruetzler, C.A.; Carlos, T.M.; Kochanek, P.M.; Hallenbeck, J.M. Polymorphonuclear leukocytes and microcirculatory perfusion in acute stroke in the SHR. Keio. J. Med., 1996, 45, 248-252; discussion 252-243.
    • (1996) Keio. J. Med. , vol.45 , pp. 248-252
    • Dawson, D.A.1    Ruetzler, C.A.2    Carlos, T.M.3    Kochanek, P.M.4    Hallenbeck, J.M.5
  • 133
    • 0023201871 scopus 로고
    • Indomethacin, prostacyclin, and heparin improve postischemic cerebral blood flow without affecting early postischemic granulocyte accumulation
    • Kochanek, P.M.; Dutka, A.J.; Hallenbeck, J.M. Indomethacin, prostacyclin, and heparin improve postischemic cerebral blood flow without affecting early postischemic granulocyte accumulation. Stroke, 1987, 18, 634-637.
    • (1987) Stroke , vol.18 , pp. 634-637
    • Kochanek, P.M.1    Dutka, A.J.2    Hallenbeck, J.M.3
  • 134
    • 0023637031 scopus 로고
    • Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia
    • Kochanek, P.M.; Dutka, A.J.; Kumaroo, K.K.; Hallenbeck, J.M. Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. Life Sci., 1987, 41, 2639-2644.
    • (1987) Life Sci. , vol.41 , pp. 2639-2644
    • Kochanek, P.M.1    Dutka, A.J.2    Kumaroo, K.K.3    Hallenbeck, J.M.4
  • 135
    • 0023915661 scopus 로고
    • Effects of prostacyclin, indomethacin, and heparin on cerebral blood flow and platelet adhesion after multifocal ischemia of canine brain
    • Kochanek, P.M.; Dutka, A.J.; Kumaroo, K.K.; Hallenbeck, J.M. Effects of prostacyclin, indomethacin, and heparin on cerebral blood flow and platelet adhesion after multifocal ischemia of canine brain. Stroke, 1988, 19, 693-699.
    • (1988) Stroke , vol.19 , pp. 693-699
    • Kochanek, P.M.1    Dutka, A.J.2    Kumaroo, K.K.3    Hallenbeck, J.M.4
  • 136
    • 0026667919 scopus 로고
    • Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
    • Kochanek, P.M.; Hallenbeck, J.M. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke, 1992, 23, 1367-1379.
    • (1992) Stroke , vol.23 , pp. 1367-1379
    • Kochanek, P.M.1    Hallenbeck, J.M.2
  • 137
    • 2642550045 scopus 로고    scopus 로고
    • Leukocyte-endothelium interactions during permanent focal cerebral ischemia in mice
    • Kataoka, H.; Kim, S.W.; Plesnila, N. Leukocyte-endothelium interactions during permanent focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab., 2004, 24, 668-676.
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 668-676
    • Kataoka, H.1    Kim, S.W.2    Plesnila, N.3
  • 138
    • 0028310665 scopus 로고
    • Integrins, ICAMs, and selectins: Role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites
    • Kishimoto, T.K.; Rothlein, R. Integrins, ICAMs, and selectins: role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites. Adv. Pharmacol., 1994, 25, 117-169.
    • (1994) Adv. Pharmacol. , vol.25 , pp. 117-169
    • Kishimoto, T.K.1    Rothlein, R.2
  • 139
    • 2142772632 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and myeloperoxidase expression: Quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia
    • Maier, C.M.; Hsieh, L.; Yu, F.; Bracci, P.; Chan, P.H. Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia. Stroke, 2004, 35, 1169-1174.
    • (2004) Stroke , vol.35 , pp. 1169-1174
    • Maier, C.M.1    Hsieh, L.2    Yu, F.3    Bracci, P.4    Chan, P.H.5
  • 140
    • 20444383156 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in CNS inflammatory disease
    • Jackson, S.J.; Diemel, L.T.; Pryce, G.; Baker, D. Cannabinoids and neuroprotection in CNS inflammatory disease. J. Neurol. Sci., 2005, 233, 21-25.
    • (2005) J. Neurol. Sci. , vol.233 , pp. 21-25
    • Jackson, S.J.1    Diemel, L.T.2    Pryce, G.3    Baker, D.4
  • 141
    • 16544377251 scopus 로고    scopus 로고
    • Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model
    • Ni, X.; Geller, E.B.; Eppihimer, M.J.; Eisenstein, T.K.; Adler, M.W.; Tuma, R.F. Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. Mult. Scler., 2004, 10, 158-164.
    • (2004) Mult. Scler. , vol.10 , pp. 158-164
    • Ni, X.1    Geller, E.B.2    Eppihimer, M.J.3    Eisenstein, T.K.4    Adler, M.W.5    Tuma, R.F.6
  • 142
    • 1842611884 scopus 로고    scopus 로고
    • Cannabinoids and neuroinflammation
    • Walter, L.; Stella, N. Cannabinoids and neuroinflammation. Br. J. Pharmacol., 2004, 141, 775-785.
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 775-785
    • Walter, L.1    Stella, N.2
  • 143
    • 67349193286 scopus 로고    scopus 로고
    • CB(2) receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury
    • Zhang, M.; Adler, M.W.; Abood, M.E.; Ganea, D.; Jallo, J.; Tuma, R.F. CB(2) receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury. Microvasc. Res., 2009.
    • (2009) Microvasc. Res.
    • Zhang, M.1    Adler, M.W.2    Abood, M.E.3    Ganea, D.4    Jallo, J.5    Tuma, R.F.6
  • 146
    • 33744827120 scopus 로고    scopus 로고
    • Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes
    • Ghosh, S.; Preet, A.; Groopman, J.E.; Ganju, R.K. Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes. Mol. Immunol., 2006, 43, 2169-2179.
    • (2006) Mol. Immunol. , vol.43 , pp. 2169-2179
    • Ghosh, S.1    Preet, A.2    Groopman, J.E.3    Ganju, R.K.4
  • 147
    • 37249091964 scopus 로고    scopus 로고
    • Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/ reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
    • Rajesh, M.; Pan, H.; Mukhopadhyay, P.; Batkai, S.; Osei-Hyiaman, D.; Hasko, G.; Liaudet, L.; Gao, B.; Pacher, P. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/ reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. J. Leukoc. Biol., 2007, 82, 1382-1389.
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1382-1389
    • Rajesh, M.1    Pan, H.2    Mukhopadhyay, P.3    Batkai, S.4    Osei-Hyiaman, D.5    Hasko, G.6    Liaudet, L.7    Gao, B.8    Pacher, P.9
  • 150
    • 0033661798 scopus 로고    scopus 로고
    • Cannabinoid receptors and the regulation of immune response
    • Berdyshev, E.V. Cannabinoid receptors and the regulation of immune response. Chem. Phys. Lipids, 2000, 108, 169-190.
    • (2000) Chem. Phys. Lipids , vol.108 , pp. 169-190
    • Berdyshev, E.V.1
  • 151
    • 26844448746 scopus 로고    scopus 로고
    • Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli
    • Maresz, K.; Carrier, E.J.; Ponomarev, E.D.; Hillard, C.J.; Dittel, B.N. Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. J. Neurochem., 2005, 95, 437-445.
    • (2005) J. Neurochem. , vol.95 , pp. 437-445
    • Maresz, K.1    Carrier, E.J.2    Ponomarev, E.D.3    Hillard, C.J.4    Dittel, B.N.5
  • 152
    • 3843066799 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study
    • Nunez, E.; Benito, C.; Pazos, M.R.; Barbachano, A.; Fajardo, O.; Gonzalez, S.; Tolon, R.M.; Romero, J. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse, 2004, 53, 208-213.
    • (2004) Synapse , vol.53 , pp. 208-213
    • Nunez, E.1    Benito, C.2    Pazos, M.R.3    Barbachano, A.4    Fajardo, O.5    Gonzalez, S.6    Tolon, R.M.7    Romero, J.8
  • 153
    • 0033933546 scopus 로고    scopus 로고
    • Contribution of microglia/ macrophages to expansion of infarction and response of oligodendrocytes after focal cerebral ischemia in rats
    • Mabuchi, T.; Kitagawa, K.; Ohtsuki, T.; Kuwabara, K.; Yagita, Y.; Yanagihara, T.; Hori, M.; Matsumoto, M. Contribution of microglia/ macrophages to expansion of infarction and response of oligodendrocytes after focal cerebral ischemia in rats. Stroke, 2000, 31, 1735-1743.
    • (2000) Stroke , vol.31 , pp. 1735-1743
    • Mabuchi, T.1    Kitagawa, K.2    Ohtsuki, T.3    Kuwabara, K.4    Yagita, Y.5    Yanagihara, T.6    Hori, M.7    Matsumoto, M.8
  • 154
    • 27744561356 scopus 로고    scopus 로고
    • Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: An investigation using green fluorescent protein transgenic bone marrow chimeric mice
    • Schilling, M.; Besselmann, M.; Muller, M.; Strecker, J.K.; Ringelstein, E.B.; Kiefer, R. Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice. Exp. Neurol., 2005, 196, 290-297.
    • (2005) Exp. Neurol. , vol.196 , pp. 290-297
    • Schilling, M.1    Besselmann, M.2    Muller, M.3    Strecker, J.K.4    Ringelstein, E.B.5    Kiefer, R.6
  • 155
    • 70849114191 scopus 로고    scopus 로고
    • CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages
    • Han, K.H.; Lim, S.; Ryu, J.; Lee, C.W.; Kim, Y.; Kang, J.H.; Kang, S.S.; Ahn, Y.K.; Park, C.S.; Kim, J.J. CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages. Cardiovasc. Res., 2009, 84, 378-386.
    • (2009) Cardiovasc. Res. , vol.84 , pp. 378-386
    • Han, K.H.1    Lim, S.2    Ryu, J.3    Lee, C.W.4    Kim, Y.5    Kang, J.H.6    Kang, S.S.7    Ahn, Y.K.8    Park, C.S.9    Kim, J.J.10
  • 156
    • 0033917648 scopus 로고    scopus 로고
    • Endocannabinoids and vascular function
    • Hillard, C.J. Endocannabinoids and vascular function. J. Pharmacol. Exp. Ther., 2000, 294, 27-32.
    • (2000) J. Pharmacol. Exp. Ther. , vol.294 , pp. 27-32
    • Hillard, C.J.1
  • 157
    • 33746492252 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current
    • Gebremedhin, D.; Lange, A.R.; Campbell, W.B.; Hillard, C.J.; Harder, D.R. Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. Am. J. Physiol., 1999, 276, H2085-2093.
    • (1999) Am. J. Physiol. , vol.276
    • Gebremedhin, D.1    Lange, A.R.2    Campbell, W.B.3    Hillard, C.J.4    Harder, D.R.5
  • 158
    • 0035816432 scopus 로고    scopus 로고
    • Hemodynamic effects of cannabinoids: Coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    • Wagner, J.A.; Jarai, Z.; Batkai, S.; Kunos, G. Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors. Eur. J. Pharmacol., 2001, 423, 203-210.
    • (2001) Eur. J. Pharmacol. , vol.423 , pp. 203-210
    • Wagner, J.A.1    Jarai, Z.2    Batkai, S.3    Kunos, G.4
  • 159
    • 29544450347 scopus 로고    scopus 로고
    • Short-term ischemia usually used for ischemic preconditioning down-regulates central cannabinoid receptors in the gerbil hippocampus
    • Schomacher, M.; Muller, H.D.; Sommer, C. Short-term ischemia usually used for ischemic preconditioning down-regulates central cannabinoid receptors in the gerbil hippocampus. Acta. Neuropathol., 2006, 111, 8-14.
    • (2006) Acta. Neuropathol. , vol.111 , pp. 8-14
    • Schomacher, M.1    Muller, H.D.2    Sommer, C.3
  • 160
    • 71649107789 scopus 로고    scopus 로고
    • Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats
    • Su, B.; Dong, H.; Ma, R.; Zhang, X.; Ding, Q.; Xiong, L. Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats. J. Thorac. Cardiovasc. Surg., 2009, 138, 1409-1416.
    • (2009) J. Thorac. Cardiovasc. Surg. , vol.138 , pp. 1409-1416
    • Su, B.1    Dong, H.2    Ma, R.3    Zhang, X.4    Ding, Q.5    Xiong, L.6
  • 161
    • 66849142361 scopus 로고    scopus 로고
    • Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system
    • Wang, Q.; Peng, Y.; Chen, S.; Gou, X.; Hu, B.; Du, J.; Lu, Y.; Xiong, L. Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. Stroke, 2009, 40, 2157-2164.
    • (2009) Stroke , vol.40 , pp. 2157-2164
    • Wang, Q.1    Peng, Y.2    Chen, S.3    Gou, X.4    Hu, B.5    Du, J.6    Lu, Y.7    Xiong, L.8


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