Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 1, 2012, Pages

  Philbin, Victoria J ^a,b   Dowling, David J ^a,b   Gallington, Leighanne C ^a   Cortés, Guadalupe ^a,b   Tan, Zhen ^a,b,d   Suter, Eugénie E ^a   Chi, Kevin W ^a   Shuckett, Ariel ^a   Stoler Barak, Liat ^a   Tomai, Mark ^c   Miller, Richard L ^c   Mansfield, Keith ^b   Levy, Ofer ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c 3M COMPANY   (United States)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

adenosine; adjuvant; alum; caspase 1; IL 1 ; inflammasome; innate immunity; neonate; newborn; Toll like receptor 8

Indexed keywords

3M 002; 3M 013; ADENOSINE; ALUMINUM POTASSIUM SULFATE; BETA1 INTERFERON; CASPASE 1 INHIBITORY PEPTIDE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMIDAZOQUINOLINE DERIVATIVE; INFLAMMASOME; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; LYMPHOTOXIN; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PROTEIN INHIBITOR; RESIQUIMOD; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR AGONIST; TRANSCRIPTOME; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; INFANT; MONOCYTE; NEWBORN; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; RHESUS MONKEY; TH1 CELL; WESTERN BLOTTING;

EID: 84862900303     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.02.042     Document Type: Article

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