The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion

Biochemical Journal

Volumn 450, Issue 3, 2013, Pages 511-521

  García Blesa, Antonio ^a,b   Klossowicz, Mikolaj ^c   López Osuna, Carmen ^a,b   Martínez Florensa, Mario ^d   Malissen, Bernard ^e   García Cózar, Francisco J ^a,b   Miazek, Arkadiusz ^c   Aguado, Enrique ^a,b  

^a UNIVERSITY OF CÁDIZ   (Spain)

^b HOSPITAL UNIVERSITARIO DE PUERTO REAL   (Spain)

^c INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^d INST D INVESTIGACIONS B   (Spain)

^e CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

Caspase; CD3; Granzyme B; Membrane adaptors; Signalling; T cell receptor (TCR)

Indexed keywords

ADAPTOR PROTEIN; ASPARTIC ACID; FAS ANTIGEN; GRANZYME B; LAT PROTEIN; LENTIVIRUS VECTOR; PERVANADATE; TYROSINE;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DEATH; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LEUKEMIA CELL LINE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; THYMOCYTE; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD95; CELLS, CULTURED; HEK293 CELLS; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEOLYSIS; T-LYMPHOCYTES; TYROSINE;

EID: 84874592242     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121135     Document Type: Article

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