The HLA-DRB1*15:01-restricted goodpasture's T cell epitope induces GN

Journal of the American Society of Nephrology

Volumn 24, Issue 3, 2013, Pages 419-431

  Ooi, Joshua D ^a   Chang, Janet ^a   O'Sullivan, Kim M ^a   Pedchenko, Vadim ^b   Hudson, Billy G ^b   Vandenbark, Arthur A ^c   Fugger, Lars ^d   Holdsworth, Stephen R ^a,e   Kitching, A Richard ^a,e  

^a MONASH UNIVERSITY   (Australia)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e MONASH MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; HLA DRB1 ANTIGEN; TUMSTATIN; AUTOANTIGEN; COLLAGEN TYPE 4; EPITOPE; FC RECEPTOR IIB; HLA DRB1*15:01 ANTIGEN; HLA-DRB1*15:01 ANTIGEN; HYBRID PROTEIN; TYPE IV COLLAGEN ALPHA3 CHAIN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CD3+ T LYMPHOCYTE; CELL CLONE; CONTROLLED STUDY; DISEASE PREDISPOSITION; GLOMERULUS; GOODPASTURE SYNDROME; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; DISEASE MODEL; GENETICS; GLOMERULONEPHRITIS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE MUTANT; PATHOLOGY; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; AUTOANTIGENS; AUTOIMMUNITY; COLLAGEN TYPE IV; DISEASE MODELS, ANIMAL; EPITOPES, T-LYMPHOCYTE; HLA-DRB1 CHAINS; HUMANS; IMMUNIZATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS;

MLCS; MLOWN;

EID: 84874587957     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012070705     Document Type: Article

References (53)

1. Hudson BG: The molecular basis of Goodpasture and Alport syndromes: Beacons for the discovery of the collagen IV family. J Am Soc Nephrol 15: 2514-2527, 2004 (Pubitemid 41103358)
2. Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG: Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N Engl J Med 363: 343-354, 2010
3. Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG: Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med 348: 2543-2556, 2003 (Pubitemid 36706542)
4. Neale TJ, Tipping PG, Carson SD, Holdsworth SR: Participation of cellmediated immunity in deposition of fibrin in glomerulonephritis. Lancet 2: 421-424, 1988
5. Bolton WK, Tucker FL, Sturgill BC: New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens. J Clin Invest 73: 1263-1276, 1984 (Pubitemid 14139520)
6. Kalluri R, Danoff TM, Okada H, Neilson EG: Susceptibility to antiglomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. J Clin Invest 100: 2263-2275, 1997 (Pubitemid 27500149)
7. Reynolds J, TamFW, Chandraker A, Smith J, Karkar AM, Cross J, Peach R, Sayegh MH, Pusey CD: CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. J Clin Invest 105: 643-651, 2000 (Pubitemid 30146511)
8. Wu J, Hicks J, Borillo J, Glass WF 2nd, Lou YH: CD4(+) T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis. J Clin Invest 109: 517-524, 2002 (Pubitemid 34171783)
9. Dean EG, Wilson GR, Li M, Edgtton KL, O'Sullivan KM, Hudson BG, Holdsworth SR, Kitching AR: Experimental autoimmuneGoodpasture's disease: A pathogenetic role for both effector cells and antibody in injury. Kidney Int 67: 566-575, 2005 (Pubitemid 40139848)
10. Phelps RG, Rees AJ: The HLA complex in Goodpasture's disease: A model for analyzing susceptibility to autoimmunity. Kidney Int 56: 1638-1653, 1999 (Pubitemid 29518164)
11. Netzer KO, Leinonen A, Boutaud A, Borza DB, Todd P, Gunwar S, Langeveld JP, Hudson BG: The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. J Biol Chem274: 11267-11274, 1999
12. Cairns LS, Phelps RG, Bowie L, Hall AM, Saweirs WW, Rees AJ, Barker RN: The fine specificity and cytokine profile of T-helper cells responsive to the alpha3 chain of type IV collagen in Goodpasture's disease. J Am Soc Nephrol 14: 2801-2812, 2003 (Pubitemid 37305643)
13. Luo AM, Fox JW, Chen L, Bolton WK: Synthetic peptides of Goodpasture's antigen in antiglomerular basement membrane nephritis in rats. J Lab Clin Med 139: 303-310, 2002 (Pubitemid 34577482)
14. Wu J, Borillo J, Glass WF, Hicks J, Ou CN, Lou YH: T-cell epitope of alpha3 chain of type IV collagen induces severe glomerulonephritis. Kidney Int 64: 1292-1301, 2003 (Pubitemid 37153794)
15. Robertson J,Wu J, Arends J, GlassWF 2nd, Southwood S, Sette A, Lou YH: Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis. Kidney Int 68: 1061-1070, 2005 (Pubitemid 43246422)
16. Bolton WK, Chen L, Hellmark T, Wieslander J, Fox JW: Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen. J Am SocNephrol 16: 2657-2666, 2005
17. Reynolds J, Haxby J, Juggapah JK,Evans DJ, PuseyCD: Identificationof a nephritogenic immunodominant B and T cell epitope in experimental autoimmune glomerulonephritis. Clin Exp Immunol 155: 311-319, 2009
18. Wu J, Arends J, Borillo J, Zhou C,Merszei J,McMahon J, Lou YH: A self T cell epitope induces autoantibody response: Mechanism for production of antibodies to diverse glomerular basement membrane antigens. J Immunol 172: 4567-4574, 2004 (Pubitemid 38375274)
19. Madsen L, Labrecque N, Engberg J, Dierich A, Svejgaard A, Benoist C, Mathis D, Fugger L: Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A 96: 10338-10343, 1999 (Pubitemid 29422559)
20. Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI, Fugger L: Functional epistasis on a common MHC haplotype associated withmultiple sclerosis. Nature 443: 574-577, 2006 (Pubitemid 44527292)
21. Attfield KE, Dendrou CA, Fugger L: Bridging the gap from genetic association to functional understanding: The next generation ofmouse models of multiple sclerosis. Immunol Rev 248: 10-22, 2012
22. Apostolopoulos J, Ooi JD, Odobasic D, Holdsworth SR, Kitching AR: The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease. J Immunol Methods 308: 167-178, 2006 (Pubitemid 43107963)
23. Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT: Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439: 851-855, 2006 (Pubitemid 43255703)
24. Reynolds J, Cook PR, Behmoaras J, Smith J, BhangalG, Tadros S, Tee J, Salama AD, Evans DJ, Aitman TJ, Cook HT, Pusey CD: Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat. Am J Pathol 180: 1843-1851, 2012
25. Sharp PE, Martin-Ramirez J, Boross P, Mangsbo SM, Reynolds J, Moss J, Pusey CD, Cook HT, Tarzi RM, Verbeek JS: Increased incidence of anti-GBMdisease in Fcgamma receptor 2b deficientmice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone. Mol Immunol 50: 49-56, 2012
26. Robertson J, Wu J, Arends J, Zhou C, McMahon J, Torres L, Lou YH: Activation of glomerular basement membrane-specific B cells in the renal draining lymph node after T cell-mediated glomerular injury.JAm Soc Nephrol 16: 3256-3263, 2005 (Pubitemid 46179331)
27. Zou J, Henderson L, Thomas V, Swan P, Turner AN, Phelps RG: Presentation of the Goodpasture autoantigen requires proteolytic unlocking steps that destroy prominent T cell epitopes. J AmSocNephrol 18: 771-779, 2007 (Pubitemid 46434494)
28. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES: Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307: 1630-1634, 2005 (Pubitemid 40354746)
29. DayhoffMO, Schwartz RM,Orcutt BC: A model of evolutionary change in proteins. In: Atlas of Protein Sequence and Structure, edited by Dayhoff MO, Washington, DC, National Biomedical Research Foundation, 1978, pp 345-352
30. WongD, Phelps RG, TurnerAN: TheGoodpasture antigen is expressed in the human thymus. Kidney Int 60: 1777-1783, 2001 (Pubitemid 32999982)
31. Salama AD, Chaudhry AN, Holthaus KA, Mosley K, Kalluri R, Sayegh MH, Lechler RI, Pusey CD, Lightstone L: Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. Kidney Int 64: 1685-1694, 2003 (Pubitemid 37323697)
32. Zhang Y, Su SC,HecoxDB, Brady GF,Mackin KM, Clark AG, FosterMH: Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. J Immunol 181: 6092-6100, 2008
33. Clark AG, Mackin KM, Foster MH: Genetic elimination of a3(IV) collagen fails to rescue anti-collagen B cells. Immunol Lett 141: 134-139, 2011
34. Lerner RA,Glassock RJ, Dixon FJ: The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J ExpMed 126: 989-1004, 1967
35. Kohda T, Okada S, Hayashi A, Kanzaki S, Ninomiya Y, Taki M, Sado Y: High nephritogenicity of monoclonal antibodies belonging to IgG2a and IgG2b subclasses in rat anti-GBMnephritis. Kidney Int 66: 177-186, 2004 (Pubitemid 38870093)
36. Kitching AR, Holdsworth SR, Tipping PG: IFN-gamma mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis. J Am Soc Nephrol 10: 752-759, 1999 (Pubitemid 29149525)
37. Timoshanko JR, Holdsworth SR, Kitching AR, Tipping PG: IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol 168: 4135-4141, 2002 (Pubitemid 34298422)
38. Kitching AR, Turner AL, Semple T, Li M, Edgtton KL, Wilson GR, Timoshanko JR, Hudson BG, Holdsworth SR: Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: A protective role for IFN-gamma. J Am Soc Nephrol 15: 1764-1774, 2004 (Pubitemid 38822055)
39. Ooi JD, Phoon RK, Holdsworth SR, Kitching AR: IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J AmSoc Nephrol 20: 980-989, 2009
40. Chen L, Hellmark T, Pedchenko V, Hudson BG, Pusey CD, Fox JW, Bolton WK: A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. J Am Soc Nephrol 17: 3076-3081, 2006 (Pubitemid 44707768)
41. Zhao J, Cui Z, Yang R, Jia XY, Zhang Y, Zhao MH: Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity. Kidney Int 76: 1108-1115, 2009
42. Steblay RW, Rudofsky UH: Experimental autoimmune glomerulonephritis induced by anti-glomerular basement membrane antibody. II. Effects of injecting heterologous, homologous, or autologous glomerular basement membranes and complete Freund's adjuvant into sheep. Am J Pathol 113: 125-133, 1983 (Pubitemid 13023448)
43. Sado Y, Okigaki T, Takamiya H, Seno S: Experimental autoimmune glomerulonephritis with pulmonary hemorrhage in rats. The doseeffect relationship of the nephritogenic antigen from bovine glomerular basement membrane. J Clin Lab Immunol 15: 199-204, 1984 (Pubitemid 15196432)
44. Hopfer H, Holzer J, Hünemörder S, Paust HJ, Sachs M, Meyer-Schwesinger C, Turner JE, Panzer U,MittrückerHW: Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis. Kidney Int 82: 60-71, 2012
45. Goodnow CC: Multistep pathogenesis of autoimmune disease. Cell 130: 25-35, 2007 (Pubitemid 47031326)
46. Smith KG, Clatworthy MR: FcgammaRIIB in autoimmunity and infection: Evolutionary and therapeutic implications. Nat Rev Immunol 10: 328-343, 2010
47. Boross P, Arandhara VL,Martin-Ramirez J, Santiago-RaberML, Carlucci F, Flierman R, van der Kaa J,Breukel C, Claassens JW, CampsM, Lubberts E, Salvatori D, Rastaldi MP, Ossendorp F, Daha MR, Cook HT, Izui S, Botto M, Verbeek JS: The inhibiting Fc receptor for IgG, FcgRIIB, is amodifier of autoimmune susceptibility. J Immunol 187: 1304-1313, 2011
48. Kalluri R, Cantley LG, Kerjaschki D, Neilson EG: Reactive oxygen species expose cryptic epitopes associatedwith autoimmune goodpasture syndrome. J Biol Chem275: 20027-20032, 2000 (Pubitemid 30441611)
49. Miner JH, Sanes JR: Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: Sequence, distribution, association with laminins, and developmental switches. J Cell Biol 127: 879-891, 1994
50. Rich C, Link JM, Zamora A, Jacobsen H, Meza-Romero R, Offner H, Jones R, Burrows GG, Fugger L, Vandenbark AA: Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol 34: 1251-1261, 2004 (Pubitemid 39256004)
51. Rosloniec EF, Brand DD,Myers LK,Whittington KB, Gumanovskaya M, Zaller DM, Woods A, Altmann DM, Stuart JM, Kang AH: An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J ExpMed 185: 1113-1122, 1997 (Pubitemid 27136803)
52. Woods A,ChenHY, TrumbauerME, Sirotina A, Cummings R, ZallerDM: Human major histocompatibility complex class II-restricted T cell responses in transgenic mice. J ExpMed 180: 173-181, 1994 (Pubitemid 24181066)
53. Takai T, OnoM, HikidaM,Ohmori H, Ravetch JV: Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379: 346-349, 1996 (Pubitemid 26033077)