CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis

Journal of Clinical Investigation

Volumn 105, Issue 5, 2000, Pages 643-651

  Reynolds, John ^a   Tam, Frederick W K ^a   Chandraker, Anil ^b   Smith, Jennifer ^a   Karkar, Ayman M ^a   Cross, Jane ^a   Peach, Robert ^c   Sayegh, Mohamed H ^b   Pusey, Charles D ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLOMERULUS BASEMENT MEMBRANE ANTIBODY;

ALLERGIC GLOMERULONEPHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE SEVERITY; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT;

EID: 0034101827     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI6710     Document Type: Article

References (46)

1. Mueller, D.L., Jenkins, M.K., and Schwartz, R.H. 1989. Clonal expansion versus functional clonal inactivation: a costimulation signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445-480.
2. June, C.H., Ledbetter, J.A., Linsley, P.S., and Thompson, C.B. 1990. Role of CD28 receptor in T cell activation. Immunol. Today 11:211-216.
3. Linsley, P.S., et al. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. Exp. Med. 174:561-569.
4. Linsley, PS., et al. 1992. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 176:1595-1604.
5. Lance, P., Gerhard, W., Hubele, S., Lanzavecchia, A., and McConnell, J. 1993. Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTA-4 and human IgG1. Immunology, 80:56-61.
6. Linsley, P.S., and Ledbetter, J.A. 1993. The role of CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191-212.
7. Bluestone, J.A. 1995. New perspectives of CD28-B7 mediated T cell costimalation. Immunity. 2:555-559.
8. Thompson, C.B. 1995. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation. Cell. 81:979-982.
9. Sayegh, M.H., et al. 1995. CD28-B7 Blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181:1869-1874.
10. Harris, N., et al. 1997. CD80 costimulation is essential for the induction of airway cosinophilia. J. Exp. Med. 185:177-182.
11. Sayegh, M.H., and Turka, L.A. 1998. The role of T-cell costimulatory activation pathways in transplant rejection. N. Engl. J. Med. 338:1813-1821.
12. Finck, B.K., Linsley, P.S., and Wolsy, D. 1994, Treatment of murine lupus with CTLA41g. Science. 265:1225-1227.
13. Cross, A.H., et al. 1995. Long-term inhibition of murine experimental allergic encephalomyelitis. Using CTA4-Fc supports a key role for CD28 costimulation. J. Clin. Invest. 95:2783-2789.
14. Khoury, S.J., et al. 1995 CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J. Immunol. 155:4521-4524.
15. Lenschow, D.J., et al. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1145-1155.
16. Perrin, P.J., et al. 1995. Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental a allergic encephalomyelitis J. Immunol. 154:1481-1490.
17. Akalin, E., Chandraker, A., Sayegh, M.H., and Turka, L.A. 1997. Role of CD28-B7 costimulatory interaction in alloimmune responses. Kidney Int. 58(Suppl.):S8-S10.
18. Pusey, C.D., et al. 1991. Experimental autoimmune glomerulonephritis induced by homologous and isologous glomerular basement membrane in Brown-Norway rats. Nephrol. Dial. Transplant. 6:457-465.
19. Sado, Y., and Naito, I. 1987. Experimental autoimmune glomerulonephritis induced in rats by soluble isologous or homologous antigens from glomerular and tubular basement membranes. Br. J. Exp. pathol. 68:695-704.
20. Bolton, W.K., May, W.J., and Sturgill, B.C. 1993. Proliferative autoimmune glomerulonephritis in rats: a model for autoimmune glomerulonephritis in humans. Kidney Int. 44:294-306.
21. Reynolds, J., Mavronmatidis, R., Cashman, S.J., Evans, D.J., and Pusey, C.D. 1998. Experimental autoimmune glomerulonephrites (EAG) induced by homologous and heterologous glomerular basement membrane in two substrains of Wistar Kyoto rat. Nephrol. Dial. Transplant. 13:44-52.
22. Reynolds, J., Syrganis, C., Derry, C.J., and Pusey, C.D. 1994. Comparison of the spicificity of anti-GBM antibodies in EAG and Goodpasture's syndrome. Nephrol. Dial. Transplant 9:849. (Abstr.)
23. Sado, Y., Kagawa, M., Naito, I., and Okigaki, T. 1991. Properties of bovine nephritogenic antigen that induces anti-GBM nephritis in rats and its similarity to the Goodpasture antigen. Virchows Arch. B Cell Pathol. Ind. Mol. Pathol. 60:345-351.
24. Sado, Y., et al. 1997. Purification and characterization of human nephritogenic antigen that induces anti-GBM nephritis in rats. J. Pathol. 182:225-232.
25. Sado, Y., et al. 1998 Induction of anti-GBM nephritis in rats by recombinant α3(IV)NCl and α4(IV)NCl of type IV collagen. Kidney Int. 53:664-671.
26. Abbate, M., et al. 1998. Experimental Goodpasture's syndrome in Wistar-Kyoto rats immunized with α3 chain of type IV collagen. Kidney Int. 54:1550-1561.
27. Sado, Y., Naito, I., and Okigaki, T. 1989. Transfer of anti-glomerular basement membrane antibody-induced glomerulonephritis in inbred rats with isologous antibodies from urine of nephritic rats. J. Pathol. 158:325-332.
28. Kalluri, R., Danoff, T.M., Okada, H., and Neilson, E.G. 1997. Susceptibility to anti-glomerular basement membrane disease and Goodpasture's syndrome is linked ro MHC class II genes and the emergence of T cell-mediated immunity in mice. J. Clin. Invest. 100:2263-2275.
29. Reynolds, J., et al. 1998. Ultrastructural abnormalities of kidney and lung in an animal model of Goodpasture's disease. J. Am. Soc. Nephrol. 9:466. (Abstr.)
30. Reynolds, J., Sallie, B.A., Syrganis, C., and Pusey, C.D. 1993. The role of T-helper lymphocytes in priming for experimental autoimmune glomerulonephritis in the BN rat. J. Autoimmun. 6:571-585.
31. Reynold, J., and Pusey, C.D. 1995. T cell responses to autoantigenic components of GBM in EAG. J. Am. Soc. Nephrol. 6:850. (Abstr.)
32. Reynolds, J., Cashman, S.J., Evans, D.J., and Pusey, C.D. 1991. Cyclosporin A in the prevention and treatment of experimental autoimmune glomerulonephritis in the Brown Norway rat. Clin. Exp. Immunol. 85:28-32.
33. Reynolds, J., and Pusey, C.D. 1994. In vivo treatment with a monoclonal antibody to T helper cells in experimental autoimmune glomerulonephristis. Clin. Exp. Immunol. 95:122-127.
34. Reynolds, J., Norgan, V.A., Chana, U., and Pusey, C.D. 1999. Anti-CD8 monoclonal antibody therapy is effective in experimental autoimmune glomerulonepritis. J. Am. Soc. Nephrol. 10:519. (Abstr.)
35. Reynolds, J., Newman, V.O., and Pusey, C.D. 1996. Oral administration of GBM to WKY rats prevents the development of EAG. J. Am. Soc. Nephrol. 7:1717. (Abstr.)
36. Nishikawa, K., et al. 1994. Effect of CTLA-4chimeric protein on rat autoimmune anti-glomerular basement memhrane disease. Eur. J. Immunol. 24:1249-1254.
37. Reynolds, J., et al. 1997. Effect of fusion protein CTLA4-Ig on the development of experimental automimune glomerulonephritis (EAG) in the WKY rat. Kidney Int. 52:117. (Abstr.)
38. Faquim-Mauro, E.L., Coffman, R.L. Abrahamsohn, I.A., and Macedo, M.S. 1999. Mouse IgG1 antibodies comprise two functionally distinct types that are differentially regulated by IL-4 and IL-12. J. Immunol. 163:3572-3576.
39. Laurell, C.B. 1966. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal. Biochem. 15:45-52.
40. Cashman, S.J., Pusey, C.D., and Evans, D.J. 1988. Extraglomerular distribution of immunoreactive Goodpasture antigen. J. Pathol 155:61-70.
41. Cook, H.T. Smith, J., and Cartell, V. 1987. Isolation and characterization of inflammatory leukocytes from glomeruli in an in situ model of glomerulonephritis in rats. Am. J. Pathol. 126: 126-136.
42. Turner, N., et al. 1992. Molecular cloning of the human Goodpasture antigen demonstrates it to be the α3 chain of type IV collagen. J. Clin. Invest. 89:592-601.
43. Turner, N., Forstova, J., Rees, A., Pusey, C.D. and Mason, P.J. 1994. Production and characterization of recombinant Goodpasture antigen in insect cells. J. Biol. Chem. 269:17141-17145.
44. Cohen, S.B., and Weetman, A.P. 1990. Serological analysis of experimental autoimmune thyroiditis in the buffalo strain rat. Int. Arch. Allergy Appl. Immunol. 91:47-53.
45. Gallon, L. et al. 1997. Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model. J. Immunol. 159:4212-4216.
46. Webb, L.M.C., Walmsley, M.J., and Feldmann, M. 1996. Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement tor both B7-1 and B7-2. Eur: J. Immunol. 26: 2320-2328.