CD4+ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis

Journal of Clinical Investigation

Volumn 109, Issue 4, 2002, Pages 517-524

  Wu, Jean ^a   Hicks, John ^b   Borillo, Jason ^a   Glass Ii, William F ^c   Lou, Ya Huan ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BASEMENT MEMBRANE ANTIGEN; CD4 ANTIGEN; CYTOKINE; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL TRANSFER; CONTROLLED STUDY; GLOMERULONEPHRITIS; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; IMMUNOFLUORESCENCE; INTERSTITIUM; KIDNEY CAPSULE; KIDNEY CORTEX; KIDNEY TUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TISSUE DISTRIBUTION;

EID: 0036182188     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI13876     Document Type: Article

References (40)

1. Renal response to immunologic glomerular injury
2. Experimental allergic glomerulonephritis induced in the rabbit with heterologous renal antigens
3. The α3(IV) chain of type IV collagen induces autoimmune Goodpasture syndrome
4. Immune complexes in human diseases: A review
5. Amelioration of lupus-like autoimmune disease in NZB/W F1 mice after treatment with a blocking monoclonal antibody specific for complement component C5
6. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis
7. Prominence of cell-mediated immunity effectors in "pauci-immune" glomerulonephritis
8. Cell-mediated immunity in glomerular disease
9. Intraglomerular T cells and monocytes in nephritis: Study with monoclonal antibodies
10. T-cells and macrophages in rapidly progressive glomerulonephritis: Clinicopathologic correlations
11. Evidence for a pathogenic role of a cell-mediated immune mechanism in experimental glomerulonephritis
12. Activated (IL-2R+) intraglomerular mononuclear cells in crescentic glomerulonephritis
13. Antibody independent crescentic glomerulonephritis in μ chain deficient mice
14. Crescentic glomerulonephritis in CD4- and CD8-deficient mice
15. CD28-B7 blockage prevents the development of experimental autoimmune glomerulonephritis
16. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
17. Analysis of T cell response to the autoantigen in Goodpasture's disease
18. New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity
19. Collagen IV α3, α4 and α5 chains in rodent basal laminae: Sequence, distribution, association with laminins, and developmental switches
20. Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen
21. Experimental Goodpasture's syndrome in Wistar-Kyoto rats immunized with α3 chain of type IV collagen
22. Induction of anti-GBM nephritis in rats by recombinant α3(IV)NC1 and α4(IV)NC1 of type IV collagen
23. Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice
24. Glomerulonephritis induced by recombinant Col4a3NC1 is not associated with GBM antibody: A potential T cell mediated mechanism
25. Analysis of cytokine gene expression during fetal thymic ontogeny using polymerase chain reaction
26. Structural and functional consequences of alveolar cell recognition by CD8(+) T lymphocytes in experimental lung disease
27. Intratracheal priming with ovalbumin-and ovalbumin 323-339 peptide-pulsed dendritic cells induces airway hyperresponsiveness, lung eosinophilia, goblet cell hyperplasia, and inflammation
28. Autoimmune ovarian disease: Mechanism of disease induction and prevention
29. Induction of autoreactive B cells allows priming of autoreactive T cells
30. null mice
31. Chronicity of tissue-specific experimental antoimmune disease: A role for B cells?
32. The role of somatic mutation in the pathogenic anti-DNA response
33. Experimental anti-GBM glomerulonephritis induced in rats by immunization with synthetic peptides based on six α chains of human type IV collagen
34. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
35. Origin of the rat mesangial phagocyte and its expression of the leukocyte common antigen
36. In vivo induction of Ia antigen in resident leukocytes in the normal rat renal glomerulus
37. Glomerular mesangial cells in local inflammation. Induction of the expression of MHC class II antigens by IFN-gamma
38. Activation of autoreactive T-lymphocytes by cultured syngeneic glomerular mesangial cells
39. Does truly 'idiopathic' crescentic glomerulonephritis exist?
40. Anti-GBM glomerulonephritis including Goodpasture disease