Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity

Kidney International

Volumn 76, Issue 10, 2009, Pages 1108-1115

  Zhao, Juan ^a,b   Cui, Zhao ^a,b   Yang, Rui ^a,b   Jia, Xiao Yu ^a,b   Zhang, Ying ^a,b   Zhao, Ming Hui ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b BEIJING HOSPITAL   (China)

Author keywords

Anti GBM autoantibodies; Anti GBM disease; Epitope spreading; Goodpasture; Renal function

Indexed keywords

AUTOANTIBODY; EPITOPE;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSS REACTION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULUS BASEMENT MEMBRANE; HEMOPTYSIS; HUMAN; KIDNEY FUNCTION; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 70350662356     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.348     Document Type: Article

References (25)

1. Zimmerman SW, Varanasi UR, Hoff B. Goodpasture's syndrome with normal renal function. Am J Med 1979; 66: 163-171.
2. Ang C, Savige J, Dawborn J et al. Anti-glomerular basement membrane (GBM)-antibody-mediated disease with normal renal function. Nephrol Dial Transplant 1998; 13: 935-939.
3. Cui Z, Zhao MH, Singh AK et al. Antiglomerular basement membrane disease with normal renal function. Kidney Int 2007; 72: 1403-1408.
4. Min SA, Rutherford P, Ward MK et al. Goodpasture's syndrome with normal renal function. Nephrol Dial Transplant 1996; 11: 2302-2305.
5. Hellmark T, Burkhardt H, Wieslander J. Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies. J Biol Chem 1999; 274: 25862-25868.
6. Lerner RA, Glassock RJ, Dixon FJ. The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med 1967; 126: 989-1004.
7. Turner N, Mason PJ, Brown R et al. Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen. J Clin Invest 1992; 89: 592-601.
8. Yang R, Cui Z, Hellmark T et al. Natural anti-GBM antibodies from normal human sera recognize alpha3(IV)NC1 restrictively and recognize the same epitopes as anti-GBM antibodies from patients with anti-GBM disease. Clin Immunol 2007; 124: 207-212.
9. Kalluri R, Wilson CB, Weber M et al. Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome. J Am Soc Nephrol 1995; 6: 1178-1185.
10. Netzer KO, Leinonen A, Boutaud A et al. The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. J Biol Chem 1999; 274: 11267-11274.
11. Hellmark T, Johansson C, Wieslander J. Characterization of anti-GBM antibodies involved in Goodpasture's syndrome. Kidney Int 1994; 46: 823-829.
12. Johansson C, Butkowski R, Swedenborg P et al. Characterization of a non-Goodpasture autoantibody to type IV collagen. Nephrol Dial Transplant 1993; 8: 1205-1210.
13. Yang R, Hellmark T, Zhao J et al. Antigen and epitope specificity of anti-glomerular basement membrane antibodies in patients with goodpasture disease with or without anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 2007; 18: 1338-1343.
14. Kalluri R, Petrides S, Wilson CB et al. Anti-alpha1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome. Ann Intern Med 1996; 124: 651-653.
15. Ghohestani RF, Hudson BG, Claudy A et al. The alpha 5 chain of type IV collagen is the target of IgG autoantibodies in a novel autoimmune disease with subepidermal blisters and renal insufficiency. J Biol Chem 2000; 275: 16002-16006.
16. Sado Y, Boutaud A, Kagawa M et al. Induction of anti-GBM nephritis in rats by recombinant alpha 3(IV)NC1 and alpha 4(IV)NC1 of type IV collagen. Kidney Int 1989; 53: 664-671.
17. Bolton WK, Chen L, Hellmark T et al. Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen. J Am Soc Nephrol 2005; 16: 2657-2666.
18. Chen L, Hellmark T, Pedchenko V et al. A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. J Am Soc Nephrol 2006; 17: 3076-3081.
19. Wu J, Arends J, Borillo J et al. A self T cell epitope induces autoanti-body response: mechanism for production of antibodies to diverse glomerular basement membrane antigens. J Immunol 2004; 172: 4567-4574.
20. Boutaud A, Borza DB, Bondar O et al. Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network
21. assembly is encoded by the noncollagenous NC1 domains. J Biol Chem 2000; 275: 30716-30724.
22. Kalluri R, Shield CF, Todd P et al. Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis. J Clin Invest 1997; 99: 2470-2478.
23. Harvey SJ, Zheng K, Sado Y et al. Role of distinct type IV collagen networks in glomerular development and function. Kidney Int 1998; 54: 1857-1866.
24. Cui Z, Wang HY, Zhao MH. Natural autoantibodies against glomerular basement membrane exist in normal human sera. Kidney Int 2006; 69: 894-899.
25. Hellmark T, Segelmark M, Unger C et al. Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease. Kidney Int 1999; 55: 936-944.