메뉴 건너뛰기




Volumn 10, Issue 2, 2013, Pages 165-175

TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Author keywords

graft versus host disease; hematopoietic stem cell transplantation; knockout mouse; Toll like receptor 4

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TOLL LIKE RECEPTOR 4;

EID: 84874586924     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2012.58     Document Type: Article
Times cited : (37)

References (43)
  • 3
    • 23044472871 scopus 로고    scopus 로고
    • In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets
    • Beilhack A, Schulz S, Baker J, Beilhack GF, Wieland CB, Herman EI et al. In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood 2005; 106: 1113-1122.
    • (2005) Blood , vol.106 , pp. 1113-1122
    • Beilhack, A.1    Schulz, S.2    Baker, J.3    Beilhack, G.F.4    Wieland, C.B.5    Herman, E.I.6
  • 4
    • 0037082478 scopus 로고    scopus 로고
    • Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipients
    • Auffermann-Gretzinger S, Lossos IS, Vayntrub TA, Leong W, Grumet FC, Blume KG et al. Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipients. Blood 2002; 99: 1442-1448.
    • (2002) Blood , vol.99 , pp. 1442-1448
    • Auffermann-Gretzinger, S.1    Lossos, I.S.2    Vayntrub, T.A.3    Leong, W.4    Grumet, F.C.5    Blume, K.G.6
  • 5
  • 6
    • 33846288929 scopus 로고    scopus 로고
    • New directions in the genomics of allogeneic hematopoietic stem cell transplantation
    • Mullighan CG, Bardy PG. New directions in the genomics of allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2007; 13: 127-144.
    • (2007) Biol Blood Marrow Transplant , vol.13 , pp. 127-144
    • Mullighan, C.G.1    Bardy, P.G.2
  • 7
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 2008; 42: 145-151.
    • (2008) Cytokine , vol.42 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 8
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 2010; 327: 291-295.
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 9
    • 30344461633 scopus 로고    scopus 로고
    • Pathophysiology of graft-versus-host disease
    • Ferrara JL, Reddy P. Pathophysiology of graft-versus-host disease. Semin Hematol 2006; 43: 3-10.
    • (2006) Semin Hematol , vol.43 , pp. 3-10
    • Ferrara, J.L.1    Reddy, P.2
  • 10
    • 0038500966 scopus 로고    scopus 로고
    • The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease
    • Sect
    • Cooke KR, Olkiewicz K, Erickson N, Ferrara JL. The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease. J Endotoxin Res 2002; Sect. 441-448.
    • (2002) J Endotoxin Res , pp. 441-448
    • Cooke, K.R.1    Olkiewicz, K.2    Erickson, N.3    Ferrara, J.L.4
  • 12
    • 0035064830 scopus 로고    scopus 로고
    • The sole gateway to endotoxin response: How LPS was identified as Tlr4, and its role in innate immunity
    • Beutler B, Poltorak A. The sole gateway to endotoxin response: how LPS was identified as Tlr4, and its role in innate immunity. Drug Metab Dispos 2001; 29: 474-478.
    • (2001) Drug Metab Dispos , vol.29 , pp. 474-478
    • Beutler, B.1    Poltorak, A.2
  • 14
    • 0036893595 scopus 로고    scopus 로고
    • Polymorphisms in Toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    • Raby BA, Klimecki WT, Laprise C, Renaud Y, Faith J, Lemire M et al. Polymorphisms in Toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med 2002; 166: 1449-1456.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1449-1456
    • Raby, B.A.1    Klimecki, W.T.2    Laprise, C.3    Renaud, Y.4    Faith, J.5    Lemire, M.6
  • 15
    • 34248176306 scopus 로고    scopus 로고
    • Study of diseaserelevant polymorphisms in the TLR4 and TLR9 genes: A novel method applied to the analysis of the Portuguese population
    • Carvalho A, Marques A, Maciel P, Rodrigues F. Study of diseaserelevant polymorphisms in the TLR4 and TLR9 genes: a novel method applied to the analysis of the Portuguese population. Mol Cell Probes 2007; 21: 316-320.
    • (2007) Mol Cell Probes , vol.21 , pp. 316-320
    • Carvalho, A.1    Marques, A.2    MacIel, P.3    Rodrigues, F.4
  • 16
    • 34249983550 scopus 로고    scopus 로고
    • TLR2 Arg753Gly TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population
    • Berdeli A, Emingil G, Han Saygan B, Gurkan A, Atilla G, Kose T et al. TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population. J Clin Periodontol 2007; 34: 551-557.
    • (2007) J Clin Periodontol , vol.34 , pp. 551-557
    • Berdeli, A.1    Emingil, G.2    Han Saygan, B.3    Gurkan, A.4    Atilla, G.5    Kose, T.6
  • 17
    • 34347375715 scopus 로고    scopus 로고
    • Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men
    • Nebel A, Flachsbart F, Schafer A, Nothnagel M, Nikolaus S, Mokhtari NE et al. Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. Mech Ageing Dev 2007; 128: 409-411.
    • (2007) Mech Ageing Dev , vol.128 , pp. 409-411
    • Nebel, A.1    Flachsbart, F.2    Schafer, A.3    Nothnagel, M.4    Nikolaus, S.5    Mokhtari, N.E.6
  • 18
    • 38449087761 scopus 로고    scopus 로고
    • Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children
    • Awomoyi AA, Rallabhandi P, Pollin TI, Lorenz E, Sztein MB, Boukhvalova MS et al. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol 2007; 179: 3171-3177.
    • (2007) J Immunol , vol.179 , pp. 3171-3177
    • Awomoyi, A.A.1    Rallabhandi, P.2    Pollin, T.I.3    Lorenz, E.4    Sztein, M.B.5    Boukhvalova, M.S.6
  • 20
    • 18244366407 scopus 로고    scopus 로고
    • Simple genotype analysis of the Asp299Gly polymorphismof the Toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsiveness
    • Okayama N, Fujimura K, Suehiro Y, Hamanaka Y, Fujiwara M, Matsubara T et al. Simple genotype analysis of the Asp299Gly polymorphismof the Toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsiveness. J Clin Lab Anal 2002; 16: 56-58.
    • (2002) J Clin Lab Anal , vol.16 , pp. 56-58
    • Okayama, N.1    Fujimura, K.2    Suehiro, Y.3    Hamanaka, Y.4    Fujiwara, M.5    Matsubara, T.6
  • 21
    • 41949114511 scopus 로고    scopus 로고
    • Rarity of TLR4 Asp299Gly and Thr399Ile polymorphisms in the Korean population
    • Kim YS, Hwang YJ, Kim SY, Yang SM, Lee KY, Park Ie B. Rarity of TLR4 Asp299Gly and Thr399Ile polymorphisms in the Korean population. Yonsei Med J 2008; 49: 58-62.
    • (2008) Yonsei Med J , vol.49 , pp. 58-62
    • Kim, Y.S.1    Hwang, Y.J.2    Kim, S.Y.3    Yang, S.M.4    Lee, K.Y.5    Park Ie, B.6
  • 22
    • 33644859324 scopus 로고    scopus 로고
    • Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graftversus-host disease in patients who underwent an allogeneic transplantation
    • Elmaagacli AH, Koldehoff M, Hindahl H, Steckel NK, Trenschel R, Peceny R et al. Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graftversus-host disease in patients who underwent an allogeneic transplantation. Transplantation 2006; 81: 247-254.
    • (2006) Transplantation , vol.81 , pp. 247-254
    • Elmaagacli, A.H.1    Koldehoff, M.2    Hindahl, H.3    Steckel, N.K.4    Trenschel, R.5    Peceny, R.6
  • 23
    • 78650275424 scopus 로고    scopus 로고
    • The protective role of host Toll-like receptor-4 in acute graft-versushost disease
    • Imado T, Iwasaki T, Kitano S, Satake A, Kuroiwa T, Tsunemi S et al. The protective role of host Toll-like receptor-4 in acute graft-versushost disease. Transplantation 2010; 90: 1063-1070.
    • (2010) Transplantation , vol.90 , pp. 1063-1070
    • Imado, T.1    Iwasaki, T.2    Kitano, S.3    Satake, A.4    Kuroiwa, T.5    Tsunemi, S.6
  • 24
    • 0034858551 scopus 로고    scopus 로고
    • Association of TLR4 mutations and the risk for acute GVHD after HLAmatched-sibling hematopoietic stem cell transplantation
    • Lorenz E, Schwartz DA, Martin PJ, Gooley T, Lin MT, Chien JW et al. Association of TLR4 mutations and the risk for acute GVHD after HLAmatched-sibling hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001; 7: 384-387.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 384-387
    • Lorenz, E.1    Schwartz, D.A.2    Martin, P.J.3    Gooley, T.4    Lin, M.T.5    Chien, J.W.6
  • 26
    • 67849115979 scopus 로고    scopus 로고
    • Toll-like receptor 4 polymorphisms and risk of Gram-negative bacteremia after allogeneic stem cell transplantation A prospective pilot study
    • Yaa MN, Paolo P, Peter S, Eric PG, Jaya S, Papanicolaou GA. Toll-like receptor 4 polymorphisms and risk of Gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study. Biol Blood Marrow Transplant 2009; 15: 1130-1133.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 1130-1133
    • Yaa, M.N.1    Paolo, P.2    Peter, S.3    Eric, P.G.4    Jaya, S.5    Papanicolaou, G.A.6
  • 27
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999; 162: 3749-3752.
    • (1999) J Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6
  • 28
    • 0029909099 scopus 로고    scopus 로고
    • An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation I. The roles of minor H antigens and endotoxin
    • Cooke KR, Kobzik L, Martin TR, Brewer J, Delmonte J Jr, Crawford JM et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 1996; 88: 3230-3239.
    • (1996) Blood , vol.88 , pp. 3230-3239
    • Cooke, K.R.1    Kobzik, L.2    Martin, T.R.3    Brewer, J.4    Delmonte Jr., J.5    Crawford, J.M.6
  • 29
    • 0032080398 scopus 로고    scopus 로고
    • Suppression of graft-versus-host disease and amplification of graftversus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation
    • Asai O, Longo DL, Tian ZG, Hornung RL, Taub DD, Ruscetti FW et al. Suppression of graft-versus-host disease and amplification of graftversus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J Clin Invest 1998; 101: 1835-1842.
    • (1998) J Clin Invest , vol.101 , pp. 1835-1842
    • Asai, O.1    Longo, D.L.2    Tian, Z.G.3    Hornung, R.L.4    Taub, D.D.5    Ruscetti, F.W.6
  • 31
    • 84861233283 scopus 로고    scopus 로고
    • ConstitutiveMHCclass i molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway
    • Xu S, Liu X, Bao Y, Zhu X, Han C, Zhang P et al. ConstitutiveMHCclass I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 2012; 13: 551-559.
    • (2012) Nat Immunol , vol.13 , pp. 551-559
    • Xu, S.1    Liu, X.2    Bao, Y.3    Zhu, X.4    Han, C.5    Zhang, P.6
  • 32
    • 79954997147 scopus 로고    scopus 로고
    • IntracellularMHCclass II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk
    • Liu X, Zhan Z, Li D, Xu L,MaF, Zhang P et al. IntracellularMHCclass II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 2011; 12: 416-424.
    • (2011) Nat Immunol , vol.12 , pp. 416-424
    • Liu, X.1    Zhan, Z.2    Li, D.3    Lmaf, X.4    Zhang, P.5
  • 33
    • 77954946392 scopus 로고    scopus 로고
    • Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
    • Han C, Jin J, Xu S, Liu H, Li N, Cao X. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol 2010; 11: 734-742.
    • (2010) Nat Immunol , vol.11 , pp. 734-742
    • Han, C.1    Jin, J.2    Xu, S.3    Liu, H.4    Li, N.5    Cao, X.6
  • 34
    • 80052033649 scopus 로고    scopus 로고
    • The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma
    • Ma F, Xu S, Liu X, Zhang Q, Xu X, Liu M et al. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nat Immunol 2011; 12: 861-869.
    • (2011) Nat Immunol , vol.12 , pp. 861-869
    • Ma, F.1    Xu, S.2    Liu, X.3    Zhang, Q.4    Xu, X.5    Liu, M.6
  • 35
    • 9244241059 scopus 로고    scopus 로고
    • Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells
    • Zhang M, Tang H, Guo Z, An H, Zhu X, Song W et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol 2004; 5: 1124-1133.
    • (2004) Nat Immunol , vol.5 , pp. 1124-1133
    • Zhang, M.1    Tang, H.2    Guo, Z.3    An, H.4    Zhu, X.5    Song, W.6
  • 36
    • 77950909696 scopus 로고    scopus 로고
    • Interleukin 12 a key immunoregulatory cytokine in infection applications
    • Hamza T, Barnett JB, Li B. Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci 2010; 11: 789-806.
    • (2010) Int J Mol Sci , vol.11 , pp. 789-806
    • Hamza, T.1    Barnett, J.B.2    Li, B.3
  • 37
    • 0031012138 scopus 로고    scopus 로고
    • Pand E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
    • Austrup F, Vestweber D, Borges E, Lhning M, Bruer R, Herz U et al. Pand E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 1997; 385: 81-83.
    • (1997) Nature , vol.385 , pp. 81-83
    • Austrup, F.1    Vestweber, D.2    Borges, E.3    Lhning, M.4    Bruer, R.5    Herz, U.6
  • 38
    • 0034103630 scopus 로고    scopus 로고
    • Th1 and Th2 mediate acute graft-versus-host disease, each with distinct endorgan targets
    • Nikolic B, Lee S, Bronson RT, Grusby MJ, Sykes M. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct endorgan targets. J Clin Invest 2000; 105: 1289-1298.
    • (2000) J Clin Invest , vol.105 , pp. 1289-1298
    • Nikolic, B.1    Lee, S.2    Bronson, R.T.3    Grusby, M.J.4    Sykes, M.5
  • 39
    • 34548853119 scopus 로고    scopus 로고
    • Pathophysiology of acute graftversus-host disease: Recent advances
    • Sun Y, Tawara I, Toubai T, Reddy P. Pathophysiology of acute graftversus-host disease: recent advances. Transl Res 2007; 150: 197-214.
    • (2007) Transl Res , vol.150 , pp. 197-214
    • Sun, Y.1    Tawara, I.2    Toubai, T.3    Reddy, P.4
  • 40
    • 47149106660 scopus 로고    scopus 로고
    • Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft versus host disease
    • Tawara I, Maeda Y, Sun Y, Lowler KP, Liu C, Toubai T et al. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft versus host disease. Exp Hematol 2008; 36: 988-996.
    • (2008) Exp Hematol , vol.36 , pp. 988-996
    • Tawara, I.1    Maeda, Y.2    Sun, Y.3    Lowler, K.P.4    Liu, C.5    Toubai, T.6
  • 41
    • 0027333549 scopus 로고
    • Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice
    • Brok HP, Heidt PJ, van der Meide PH, Zurcher C, Vossen JM. Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Immunol 1993; 151: 6451-6459.
    • (1993) J Immunol , vol.151 , pp. 6451-6459
    • Brok, H.P.1    Heidt, P.J.2    Van Der Meide, P.H.3    Zurcher, C.4    Vossen, J.M.5
  • 42
    • 0032535087 scopus 로고    scopus 로고
    • Donor-derived interferon gamma is required for inhibition of acute graft-versushost disease by interleukin 12
    • Yang YG, Dey BR, Sergio JJ, Pearson DA, Sykes M. Donor-derived interferon gamma is required for inhibition of acute graft-versushost disease by interleukin 12. J Clin Invest 1998; 102: 2126-2135.
    • (1998) J Clin Invest , vol.102 , pp. 2126-2135
    • Yang, Y.G.1    Dey, B.R.2    Sergio, J.J.3    Pearson, D.A.4    Sykes, M.5
  • 43
    • 0032211796 scopus 로고    scopus 로고
    • Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice
    • Murphy WJ, Welniak LA, Taub DD, Wiltrout RH, Taylor PA, Vallera DA et al. Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Clin Invest 1998; 102: 1742-1748.
    • (1998) J Clin Invest , vol.102 , pp. 1742-1748
    • Murphy, W.J.1    Welniak, L.A.2    Taub, D.D.3    Wiltrout, R.H.4    Taylor, P.A.5    Vallera, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.