The Shigella Type Three Secretion System Effector OspG Directly and Specifically Binds to Host Ubiquitin for Activation

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Zhou, Yan ^a,b   Dong, Na ^b   Hu, Liyan ^b   Shao, Feng ^b  

^a BEIJING NORMAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSPG PROTEIN; PROTEIN NLEH1; PROTEIN NLEH2; PROTEIN SERINE THREONINE KINASE; SUMO PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ENTEROPATHOGENIC ESCHERICHIA COLI; ENZYME ACTIVATION; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SHIGELLA; TYPE III SECRETION SYSTEM;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 10; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SHIGELLA; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84874573643     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057558     Document Type: Article

References (38)

1. Sansonetti PJ, (1998) Pathogenesis of shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation and vaccine development. Jpn J Med Sci Biol 51Suppl: S69-80.
2. Sasakawa C, Buysse JM, Watanabe H, (1992) The large virulence plasmid of Shigella. Curr Top Microbiol Immunol 180: 21-44.
3. Phalipon A, Sansonetti PJ, (2007) Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival? Immunol Cell Biol 85: 119-129.
4. Ogawa M, Handa Y, Ashida H, Suzuki M, Sasakawa C, (2008) The versatility of Shigella effectors. Nat Rev Microbiol 6: 11-16.
5. Li H, Xu H, Zhou Y, Zhang J, Long C, et al. (2007) The phosphothreonine lyase activity of a bacterial type III effector family. Science 315: 1000-1003.
6. Arbibe L, Kim DW, Batsche E, Pedron T, Mateescu B, et al. (2007) An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses. Nat Immunol 8: 47-56.
7. Kramer RW, Slagowski NL, Eze NA, Giddings KS, Morrison MF, et al. (2007) Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLoS Pathog 3: e21.
8. Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, et al. (2009) Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics. Nat Struct Mol Biol 16: 853-860.
9. Ohya K, Handa Y, Ogawa M, Suzuki M, Sasakawa C, (2005) IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells. Its activity to promote membrane ruffling via Rac1 and Cdc42 activation. J Biol Chem 280: 24022-24034.
10. Handa Y, Suzuki M, Ohya K, Iwai H, Ishijima N, et al. (2007) Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery. Nat Cell Biol 9: 121-128.
11. Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, et al. (2012) Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses. Cell 150: 1029-1041.
12. Schwartz AL, Ciechanover A, (1999) The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50: 57-74.
13. Komander D, Rape M, (2012) The ubiquitin code. Annu Rev Biochem 81: 203-229.
14. Rytkonen A, Holden DW, (2007) Bacterial interference of ubiquitination and deubiquitination. Cell Host Microbe 1: 13-22.
15. Jiang X, Chen ZJ, (2012) The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol 12: 35-48.
16. Cui J, Yao Q, Li S, Ding X, Lu Q, et al. (2010) Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science 329: 1215-1218.
17. Sanada T, Kim M, Mimuro H, Suzuki M, Ogawa M, et al. (2012) The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature 483: 623-626.
18. Rohde JR, Breitkreutz A, Chenal A, Sansonetti PJ, Parsot C, (2007) Type III secretion effectors of the IpaH family are E3 ubiquitin ligases. Cell Host Microbe 1: 77-83.
19. Singer AU, Rohde JR, Lam R, Skarina T, Kagan O, et al. (2008) Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases. Nat Struct Mol Biol 15: 1293-1301.
20. Zhu Y, Li H, Hu L, Wang J, Zhou Y, et al. (2008) Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nat Struct Mol Biol 15: 1302-1308.
21. Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, et al. (2010) A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat Cell Biol 12: 66-73; sup 61-69.
22. Buchrieser C, Glaser P, Rusniok C, Nedjari H, D'Hauteville H, et al. (2000) The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri. Mol Microbiol 38: 760-771.
23. Le Gall T, Mavris M, Martino MC, Bernardini ML, Denamur E, et al. (2005) Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri. Microbiology 151: 951-962.
24. Kim DW, (2005) The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proceedings of the National Academy of Sciences 102: 14046-14051.
25. Hurley JH, Lee S, Prag G, (2006) Ubiquitin-binding domains. Biochem J 399: 361-372.
26. Husnjak K, Dikic I, (2012) Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem 81: 291-322.
27. Hochstrasser M, (2009) Origin and function of ubiquitin-like proteins. Nature 458: 422-429.
28. van der Veen AG, Ploegh HL, (2012) Ubiquitin-like proteins. Annu Rev Biochem 81: 323-357.
29. Cheek S, Zhang H, Grishin NV, (2002) Sequence and structure classification of kinases. J Mol Biol 320: 855-881.
30. Taylor SS, Radzio-Andzelm E, (1994) Three protein kinase structures define a common motif. Structure 2: 345-355.
31. Hemrajani C, Berger CN, Robinson KS, Marches O, Mousnier A, et al. (2010) NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection. Proc Natl Acad Sci U S A 107: 3129-3134.
32. Chen G, Porter MD, Bristol JR, Fitzgibbon MJ, Pazhanisamy S, (2000) Kinetic mechanism of the p38-alpha MAP kinase: phosphoryl transfer to synthetic peptides. Biochemistry 39: 2079-2087.
33. Mendelow M, Prorok M, Salerno A, Lawrence DS, (1993) ATPase-promoting dead end inhibitors of the cAMP-dependent protein kinase. J Biol Chem 268: 12289-12296.
34. Young PR, McLaughlin MM, Kumar S, Kassis S, Doyle ML, et al. (1997) Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem 272: 12116-12121.
35. Ward NE, O'Brian CA, (1992) The intrinsic ATPase activity of protein kinase C is catalyzed at the active site of the enzyme. Biochemistry 31: 5905-5911.
36. Juris SJ, Rudolph AE, Huddler D, Orth K, Dixon JE, (2000) A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption. Proc Natl Acad Sci U S A 97: 9431-9436.
37. Coaker G, Falick A, Staskawicz B, (2005) Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin. Science 308: 548-550.
38. Mittal R, Peak-Chew SY, Sade RS, Vallis Y, McMahon HT, (2010) The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate. J Biol Chem 285: 19927-19934.