Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 77, Issue , 2013, Pages 175-188

  Jing, Wang Hui ^a   Song, Yue Lin ^a   Yan, Ru ^a   Wang, Yi Tao ^a,b  

^a University of Macau   (Macao)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

(+) Praeruptorin A; Angular type pyranocoumarins; CYP 3A4; Human liver microsomes; UHPLC QT MS MS

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 3A4; PRAERUPTORIN A; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME KINETICS; HEART PROTECTION; HUMAN; HUMAN CELL; HYDROLYSIS; LIVER MICROSOME; OXIDATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROLYSIS; KINETICS; LIVER; MICROSOMES, LIVER; OXIDATION-REDUCTION; TANDEM MASS SPECTROMETRY;

EID: 84874569370     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.01.023     Document Type: Article

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