Stereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans

Xenobiotica

Volumn 42, Issue 3, 2012, Pages 231-237

  Song, Y L ^a   Jing, W H ^a   Zhao, H Y ^a   Yan, R ^a   Li, P T ^b   Wang, Y T ^a,c  

^a University of Macau   (Macao)

^b University of Chinese Medicine   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

( ) Praeruptorin A; Acyl migration; Hydrolysis; Liver microsomes; Metabolism; Stereoselectivity

Indexed keywords

3' ANGELOYL KHELLACTONE; 4' ANGELOYL KHELLACTONE; CALCIUM CHANNEL BLOCKING AGENT; CARBOXYLESTERASE; DRUG METABOLITE; KHELLACTONE; PLANT MEDICINAL PRODUCT; PRAERUPTORIN A; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PEUCEDANI RADIX; PLASMA; RAT; STEREOCHEMISTRY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84863012860     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.609250     Document Type: Article

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