Quantitative structure-activity relationships in a series of endogenous and synthetic steroids exhibiting induction of CYP3A activity and hepatomegaly associated with increased DNA synthesis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 74, Issue 4, 2000, Pages 179-185

  Lewis, D F V ^a   Ioannides, C ^a   Parke, D V ^a   Schulte Hermann, R ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

CYP3A; Ethylmorphine N demethylase; QSAR

Indexed keywords

CELL NUCLEUS RECEPTOR; CYPROTERONE ACETATE; CYTOCHROME P450 3A; DEXAMETHASONE; DNA; ESTRADIOL; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; ETHYLMORPHINE N DEMETHYLASE; GESTODENE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; METHYLTESTOSTERONE; NORETHISTERONE ACETATE; NORETYNODREL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PREGNANE X RECEPTOR; PROGESTERONE; SPIRONOLACTONE; STEROID; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DNA CONTENT; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HEPATOMEGALY; LIVER WEIGHT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEQUENCE HOMOLOGY;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DNA; HEPATOMEGALY; HUMANS; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROIDS;

BACTERIA (MICROORGANISMS);

EID: 0034668719     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(00)00121-7     Document Type: Article

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