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Volumn 8, Issue 2, 2013, Pages

Astrocytes Protect Neurons against Methylmercury via ATP/P2Y1 Receptor-Mediated Pathways in Astrocytes

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE TRIPHOSPHATE; CALCIUM ION; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; MESSENGER RNA; METHYLMERCURY; MITOGEN ACTIVATED PROTEIN KINASE P38; PURINERGIC P2Y1 RECEPTOR; RECOMBINANT INTERLEUKIN 6;

EID: 84874557357     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057898     Document Type: Article
Times cited : (45)

References (73)
  • 1
    • 0030865205 scopus 로고    scopus 로고
    • The toxicology of mercury
    • Clarkson TW, (1997) The toxicology of mercury. Crit Rev Clin Lab Sci 34: 369-403.
    • (1997) Crit Rev Clin Lab Sci , vol.34 , pp. 369-403
    • Clarkson, T.W.1
  • 2
    • 0029562840 scopus 로고
    • An analysis of autopsy brain tissue from infants prenatally exposed to methymercury
    • Lapham LW, Cernichiari E, Cox C, Myers GJ, Baggs RB, et al. (1995) An analysis of autopsy brain tissue from infants prenatally exposed to methymercury. Neurotoxicology 16: 689-704.
    • (1995) Neurotoxicology , vol.16 , pp. 689-704
    • Lapham, L.W.1    Cernichiari, E.2    Cox, C.3    Myers, G.J.4    Baggs, R.B.5
  • 3
    • 77956458798 scopus 로고    scopus 로고
    • Methylmercury-induced neurotoxicity and apoptosis
    • Ceccatelli S, Dare E, Moors M, (2010) Methylmercury-induced neurotoxicity and apoptosis. Chem Biol Interact 188: 301-308.
    • (2010) Chem Biol Interact , vol.188 , pp. 301-308
    • Ceccatelli, S.1    Dare, E.2    Moors, M.3
  • 4
    • 0142213730 scopus 로고    scopus 로고
    • The toxicology of mercury-current exposures and clinical manifestations
    • Clarkson TW, Magos L, Myers GJ, (2003) The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med 349: 1731-1737.
    • (2003) N Engl J Med , vol.349 , pp. 1731-1737
    • Clarkson, T.W.1    Magos, L.2    Myers, G.J.3
  • 5
    • 84984580627 scopus 로고    scopus 로고
    • Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies
    • Farina M, Rocha JB, Aschner M, (2011) Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci 89: 555-563.
    • (2011) Life Sci , vol.89 , pp. 555-563
    • Farina, M.1    Rocha, J.B.2    Aschner, M.3
  • 6
    • 84855802185 scopus 로고    scopus 로고
    • Methylmercury: a potential environmental risk factor contributing to epileptogenesis
    • Yuan Y, (2012) Methylmercury: a potential environmental risk factor contributing to epileptogenesis. Neurotoxicology 33: 119-126.
    • (2012) Neurotoxicology , vol.33 , pp. 119-126
    • Yuan, Y.1
  • 7
    • 0035287432 scopus 로고    scopus 로고
    • GLIA: listening and talking to the synapse
    • Haydon PG, (2001) GLIA: listening and talking to the synapse. Nat Rev Neurosci 2: 185-193.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 185-193
    • Haydon, P.G.1
  • 8
    • 84984559567 scopus 로고    scopus 로고
    • Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity
    • Ni M, Li X, Yin Z, Sidoryk-Wegrzynowicz M, Jiang H, et al. (2011) Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity. Glia 59: 810-820.
    • (2011) Glia , vol.59 , pp. 810-820
    • Ni, M.1    Li, X.2    Yin, Z.3    Sidoryk-Wegrzynowicz, M.4    Jiang, H.5
  • 9
    • 58049198418 scopus 로고    scopus 로고
    • Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes
    • Wang L, Jiang H, Yin Z, Aschner M, Cai J, (2009) Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes. Toxicol Sci 107: 135-143.
    • (2009) Toxicol Sci , vol.107 , pp. 135-143
    • Wang, L.1    Jiang, H.2    Yin, Z.3    Aschner, M.4    Cai, J.5
  • 10
    • 0036905468 scopus 로고    scopus 로고
    • The consequences of methylmercury exposure on interactive functions between astrocytes and neurons
    • Allen JW, Shanker G, Tan KH, Aschner M, (2002) The consequences of methylmercury exposure on interactive functions between astrocytes and neurons. Neurotoxicology 23: 755-759.
    • (2002) Neurotoxicology , vol.23 , pp. 755-759
    • Allen, J.W.1    Shanker, G.2    Tan, K.H.3    Aschner, M.4
  • 11
    • 0026483404 scopus 로고
    • Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity
    • Ali SF, LeBel CP, Bondy SC, (1992) Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology 13: 637-648.
    • (1992) Neurotoxicology , vol.13 , pp. 637-648
    • Ali, S.F.1    LeBel, C.P.2    Bondy, S.C.3
  • 12
    • 0035476890 scopus 로고    scopus 로고
    • Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity
    • Gasso S, Cristofol RM, Selema G, Rosa R, Rodriguez-Farre E, et al. (2001) Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity. J Neurosci Res 66: 135-145.
    • (2001) J Neurosci Res , vol.66 , pp. 135-145
    • Gasso, S.1    Cristofol, R.M.2    Selema, G.3    Rosa, R.4    Rodriguez-Farre, E.5
  • 13
    • 0034474266 scopus 로고    scopus 로고
    • Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium
    • Mundy WR, Freudenrich TM, (2000) Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium. Neurotoxicology 21: 1135-1144.
    • (2000) Neurotoxicology , vol.21 , pp. 1135-1144
    • Mundy, W.R.1    Freudenrich, T.M.2
  • 14
    • 0029953552 scopus 로고    scopus 로고
    • Oxidative stress in neurotoxic effects of methylmercury poisoning
    • Yee S, Choi BH, (1996) Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology 17: 17-26.
    • (1996) Neurotoxicology , vol.17 , pp. 17-26
    • Yee, S.1    Choi, B.H.2
  • 15
    • 33947730851 scopus 로고    scopus 로고
    • Methylmercury causes glial IL-6 release
    • Chang JY, (2007) Methylmercury causes glial IL-6 release. Neurosci Lett 416: 217-220.
    • (2007) Neurosci Lett , vol.416 , pp. 217-220
    • Chang, J.Y.1
  • 16
    • 79955774958 scopus 로고    scopus 로고
    • Methylmercury-induced IL-6 release requires phospholipase C activities
    • Chang JY, (2011) Methylmercury-induced IL-6 release requires phospholipase C activities. Neurosci Lett 496: 152-156.
    • (2011) Neurosci Lett , vol.496 , pp. 152-156
    • Chang, J.Y.1
  • 17
    • 67649662199 scopus 로고    scopus 로고
    • IL-6 release from mouse glia caused by MeHg requires cytosolic phospholipase A2 activation
    • Chang JY, Tsai PF, (2009) IL-6 release from mouse glia caused by MeHg requires cytosolic phospholipase A2 activation. Neurosci Lett 461: 85-89.
    • (2009) Neurosci Lett , vol.461 , pp. 85-89
    • Chang, J.Y.1    Tsai, P.F.2
  • 18
    • 77049092091 scopus 로고    scopus 로고
    • Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms
    • Fujishita K, Ozawa T, Shibata K, Tanabe S, Sato Y, et al. (2009) Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms. Cell Mol Neurobiol 29: 1121-1129.
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 1121-1129
    • Fujishita, K.1    Ozawa, T.2    Shibata, K.3    Tanabe, S.4    Sato, Y.5
  • 19
    • 61349130664 scopus 로고    scopus 로고
    • Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects
    • Suzuki S, Tanaka K, Suzuki N, (2009) Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects. J Cereb Blood Flow Metab 29: 464-479.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 464-479
    • Suzuki, S.1    Tanaka, K.2    Suzuki, N.3
  • 20
    • 0141814615 scopus 로고    scopus 로고
    • Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures
    • Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K, (2003) Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Proc Natl Acad Sci U S A 100: 11023-11028.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11023-11028
    • Koizumi, S.1    Fujishita, K.2    Tsuda, M.3    Shigemoto-Mogami, Y.4    Inoue, K.5
  • 21
    • 0342723744 scopus 로고    scopus 로고
    • Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice
    • Leon C, Hechler B, Freund M, Eckly A, Vial C, et al. (1999) Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J Clin Invest 104: 1731-1737.
    • (1999) J Clin Invest , vol.104 , pp. 1731-1737
    • Leon, C.1    Hechler, B.2    Freund, M.3    Eckly, A.4    Vial, C.5
  • 22
    • 0030882658 scopus 로고    scopus 로고
    • Inhibition by ATP of calcium oscillations in rat cultured hippocampal neurones
    • Koizumi S, Inoue K, (1997) Inhibition by ATP of calcium oscillations in rat cultured hippocampal neurones. Br J Pharmacol 122: 51-58.
    • (1997) Br J Pharmacol , vol.122 , pp. 51-58
    • Koizumi, S.1    Inoue, K.2
  • 23
    • 0032125217 scopus 로고    scopus 로고
    • Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat
    • Braun N, Zhu Y, Krieglstein J, Culmsee C, Zimmermann H, (1998) Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat. J Neurosci 18: 4891-4900.
    • (1998) J Neurosci , vol.18 , pp. 4891-4900
    • Braun, N.1    Zhu, Y.2    Krieglstein, J.3    Culmsee, C.4    Zimmermann, H.5
  • 24
    • 0033153149 scopus 로고    scopus 로고
    • Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway
    • Neary JT, Kang Y, Bu Y, Yu E, Akong K, et al. (1999) Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway. J Neurosci 19: 4211-4220.
    • (1999) J Neurosci , vol.19 , pp. 4211-4220
    • Neary, J.T.1    Kang, Y.2    Bu, Y.3    Yu, E.4    Akong, K.5
  • 25
    • 0035884937 scopus 로고    scopus 로고
    • P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
    • Panenka W, Jijon H, Herx LM, Armstrong JN, Feighan D, et al. (2001) P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J Neurosci 21: 7135-7142.
    • (2001) J Neurosci , vol.21 , pp. 7135-7142
    • Panenka, W.1    Jijon, H.2    Herx, L.M.3    Armstrong, J.N.4    Feighan, D.5
  • 26
    • 13244272004 scopus 로고    scopus 로고
    • Cytoprotection against oxidative stress-induced damage of astrocytes by extracellular ATP via P2Y1 receptors
    • Shinozaki Y, Koizumi S, Ishida S, Sawada J, Ohno Y, et al. (2005) Cytoprotection against oxidative stress-induced damage of astrocytes by extracellular ATP via P2Y1 receptors. Glia 49: 288-300.
    • (2005) Glia , vol.49 , pp. 288-300
    • Shinozaki, Y.1    Koizumi, S.2    Ishida, S.3    Sawada, J.4    Ohno, Y.5
  • 27
    • 33745146834 scopus 로고    scopus 로고
    • Purinergic signaling induces thrombospondin-1 expression in astrocytes
    • Tran MD, Neary JT, (2006) Purinergic signaling induces thrombospondin-1 expression in astrocytes. Proc Natl Acad Sci U S A 103: 9321-9326.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 9321-9326
    • Tran, M.D.1    Neary, J.T.2
  • 28
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR, (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494.
    • (1995) J Biol Chem , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 30
    • 0029923193 scopus 로고    scopus 로고
    • Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
    • McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, et al. (1996) Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J Biol Chem 271: 8488-8492.
    • (1996) J Biol Chem , vol.271 , pp. 8488-8492
    • McLaughlin, M.M.1    Kumar, S.2    McDonnell, P.C.3    Van Horn, S.4    Lee, J.C.5
  • 31
    • 0037162496 scopus 로고    scopus 로고
    • Intercellular calcium signaling mediated by point-source burst release of ATP
    • Arcuino G, Lin JH, Takano T, Liu C, Jiang L, et al. (2002) Intercellular calcium signaling mediated by point-source burst release of ATP. Proc Natl Acad Sci U S A 99: 9840-9845.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9840-9845
    • Arcuino, G.1    Lin, J.H.2    Takano, T.3    Liu, C.4    Jiang, L.5
  • 32
    • 44649092806 scopus 로고    scopus 로고
    • Connexin 43 hemichannels are permeable to ATP
    • Kang J, Kang N, Lovatt D, Torres A, Zhao Z, et al. (2008) Connexin 43 hemichannels are permeable to ATP. J Neurosci 28: 4702-4711.
    • (2008) J Neurosci , vol.28 , pp. 4702-4711
    • Kang, J.1    Kang, N.2    Lovatt, D.3    Torres, A.4    Zhao, Z.5
  • 33
    • 43049105822 scopus 로고    scopus 로고
    • Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture
    • Liu HT, Toychiev AH, Takahashi N, Sabirov RZ, Okada Y, (2008) Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture. Cell Res 18: 558-565.
    • (2008) Cell Res , vol.18 , pp. 558-565
    • Liu, H.T.1    Toychiev, A.H.2    Takahashi, N.3    Sabirov, R.Z.4    Okada, Y.5
  • 34
    • 33745755958 scopus 로고    scopus 로고
    • Purinergic transmission in the central nervous system
    • North RA, Verkhratsky A, (2006) Purinergic transmission in the central nervous system. Pflugers Arch 452: 479-485.
    • (2006) Pflugers Arch , vol.452 , pp. 479-485
    • North, R.A.1    Verkhratsky, A.2
  • 36
    • 32544448639 scopus 로고    scopus 로고
    • P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling
    • Suadicani SO, Brosnan CF, Scemes E, (2006) P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci 26: 1378-1385.
    • (2006) J Neurosci , vol.26 , pp. 1378-1385
    • Suadicani, S.O.1    Brosnan, C.F.2    Scemes, E.3
  • 37
    • 34547562467 scopus 로고    scopus 로고
    • Regulated ATP release from astrocytes through lysosome exocytosis
    • Zhang Z, Chen G, Zhou W, Song A, Xu T, et al. (2007) Regulated ATP release from astrocytes through lysosome exocytosis. Nat Cell Biol 9: 945-953.
    • (2007) Nat Cell Biol , vol.9 , pp. 945-953
    • Zhang, Z.1    Chen, G.2    Zhou, W.3    Song, A.4    Xu, T.5
  • 38
    • 14844334146 scopus 로고    scopus 로고
    • Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes
    • Bruzzone R, Barbe MT, Jakob NJ, Monyer H, (2005) Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem 92: 1033-1043.
    • (2005) J Neurochem , vol.92 , pp. 1033-1043
    • Bruzzone, R.1    Barbe, M.T.2    Jakob, N.J.3    Monyer, H.4
  • 39
    • 33646748700 scopus 로고    scopus 로고
    • Pannexin 1 in erythrocytes: function without a gap
    • Locovei S, Bao L, Dahl G, (2006) Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A 103: 7655-7659.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7655-7659
    • Locovei, S.1    Bao, L.2    Dahl, G.3
  • 40
    • 0028069674 scopus 로고
    • Proteolysis of SNAP-25 by types E and A botulinal neurotoxins
    • Binz T, Blasi J, Yamasaki S, Baumeister A, Link E, et al. (1994) Proteolysis of SNAP-25 by types E and A botulinal neurotoxins. J Biol Chem 269: 1617-1620.
    • (1994) J Biol Chem , vol.269 , pp. 1617-1620
    • Binz, T.1    Blasi, J.2    Yamasaki, S.3    Baumeister, A.4    Link, E.5
  • 41
    • 0027219725 scopus 로고
    • Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
    • Blasi J, Chapman ER, Link E, Binz T, Yamasaki S, et al. (1993) Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. Nature 365: 160-163.
    • (1993) Nature , vol.365 , pp. 160-163
    • Blasi, J.1    Chapman, E.R.2    Link, E.3    Binz, T.4    Yamasaki, S.5
  • 42
    • 4744365084 scopus 로고    scopus 로고
    • ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks
    • Bowser DN, Khakh BS, (2004) ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks. J Neurosci 24: 8606-8620.
    • (2004) J Neurosci , vol.24 , pp. 8606-8620
    • Bowser, D.N.1    Khakh, B.S.2
  • 43
    • 34249828210 scopus 로고    scopus 로고
    • Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes
    • Bowser DN, Khakh BS, (2007) Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes. J Gen Physiol 129: 485-491.
    • (2007) J Gen Physiol , vol.129 , pp. 485-491
    • Bowser, D.N.1    Khakh, B.S.2
  • 44
    • 0043135256 scopus 로고    scopus 로고
    • Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors
    • Gallagher CJ, Salter MW, (2003) Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors. J Neurosci 23: 6728-6739.
    • (2003) J Neurosci , vol.23 , pp. 6728-6739
    • Gallagher, C.J.1    Salter, M.W.2
  • 45
    • 0032559887 scopus 로고    scopus 로고
    • Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites
    • Moro S, Guo D, Camaioni E, Boyer JL, Harden TK, et al. (1998) Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem 41: 1456-1466.
    • (1998) J Med Chem , vol.41 , pp. 1456-1466
    • Moro, S.1    Guo, D.2    Camaioni, E.3    Boyer, J.L.4    Harden, T.K.5
  • 46
    • 0033215124 scopus 로고    scopus 로고
    • Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways
    • Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, et al. (1999) Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol 163: 3963-3968.
    • (1999) J Immunol , vol.163 , pp. 3963-3968
    • Carlson, N.G.1    Wieggel, W.A.2    Chen, J.3    Bacchi, A.4    Rogers, S.W.5
  • 47
    • 65849220190 scopus 로고    scopus 로고
    • P2Y1 receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures
    • Fujita T, Tozaki-Saitoh H, Inoue K, (2009) P2Y1 receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures. Glia 57: 244-257.
    • (2009) Glia , vol.57 , pp. 244-257
    • Fujita, T.1    Tozaki-Saitoh, H.2    Inoue, K.3
  • 48
    • 0029894833 scopus 로고    scopus 로고
    • Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma
    • Hirota H, Kiyama H, Kishimoto T, Taga T, (1996) Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. J Exp Med 183: 2627-2634.
    • (1996) J Exp Med , vol.183 , pp. 2627-2634
    • Hirota, H.1    Kiyama, H.2    Kishimoto, T.3    Taga, T.4
  • 49
    • 0031894808 scopus 로고    scopus 로고
    • Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat
    • Loddick SA, Turnbull AV, Rothwell NJ, (1998) Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 18: 176-179.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 176-179
    • Loddick, S.A.1    Turnbull, A.V.2    Rothwell, N.J.3
  • 50
    • 12344331668 scopus 로고    scopus 로고
    • Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity
    • Peng YP, Qiu YH, Lu JH, Wang JJ, (2005) Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Neurosci Lett 374: 192-196.
    • (2005) Neurosci Lett , vol.374 , pp. 192-196
    • Peng, Y.P.1    Qiu, Y.H.2    Lu, J.H.3    Wang, J.J.4
  • 51
    • 0033667998 scopus 로고    scopus 로고
    • Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice
    • Penkowa M, Giralt M, Carrasco J, Hadberg H, Hidalgo J, (2000) Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 32: 271-285.
    • (2000) Glia , vol.32 , pp. 271-285
    • Penkowa, M.1    Giralt, M.2    Carrasco, J.3    Hadberg, H.4    Hidalgo, J.5
  • 52
    • 0030744643 scopus 로고    scopus 로고
    • Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells
    • Yamada K, Umegaki H, Maezawa I, Iguchi A, Kameyama T, et al. (1997) Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells. Brain Res Bull 43: 573-577.
    • (1997) Brain Res Bull , vol.43 , pp. 573-577
    • Yamada, K.1    Umegaki, H.2    Maezawa, I.3    Iguchi, A.4    Kameyama, T.5
  • 53
    • 0035212170 scopus 로고    scopus 로고
    • Interleukin-6 enhances expression of adenosine A(1) receptor mRNA and signaling in cultured rat cortical astrocytes and brain slices
    • Biber K, Lubrich B, Fiebich BL, Boddeke HW, van Calker D, (2001) Interleukin-6 enhances expression of adenosine A(1) receptor mRNA and signaling in cultured rat cortical astrocytes and brain slices. Neuropsychopharmacology 24: 86-96.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 86-96
    • Biber, K.1    Lubrich, B.2    Fiebich, B.L.3    Boddeke, H.W.4    van Calker, D.5
  • 54
    • 47249146449 scopus 로고    scopus 로고
    • Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection
    • Biber K, Pinto-Duarte A, Wittendorp MC, Dolga AM, Fernandes CC, et al. (2008) Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection. Neuropsychopharmacology 33: 2237-2250.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2237-2250
    • Biber, K.1    Pinto-Duarte, A.2    Wittendorp, M.C.3    Dolga, A.M.4    Fernandes, C.C.5
  • 55
    • 0030425982 scopus 로고    scopus 로고
    • Astrocytes as modulators of mercury-induced neurotoxicity
    • Aschner M, (1996) Astrocytes as modulators of mercury-induced neurotoxicity. Neurotoxicology 17: 663-669.
    • (1996) Neurotoxicology , vol.17 , pp. 663-669
    • Aschner, M.1
  • 56
    • 0034201572 scopus 로고    scopus 로고
    • Astrocytic swelling, phospholipase A2, glutathione and glutamate: interactions in methylmercury-induced neurotoxicity
    • Aschner M, (2000) Astrocytic swelling, phospholipase A2, glutathione and glutamate: interactions in methylmercury-induced neurotoxicity. Cell Mol Biol (Noisy-le-grand) 46: 843-854.
    • (2000) Cell Mol Biol (Noisy-Le-Grand) , vol.46 , pp. 843-854
    • Aschner, M.1
  • 58
    • 0025977602 scopus 로고
    • Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole blood
    • DeForge LE, Remick DG, (1991) Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole blood. Biochem Biophys Res Commun 174: 18-24.
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 18-24
    • DeForge, L.E.1    Remick, D.G.2
  • 59
    • 0029832703 scopus 로고    scopus 로고
    • Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit ligand and interleukin-10 in mouse bone marrow-derived mast cells
    • Lu-Kuo JM, Austen KF, Katz HR, (1996) Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit ligand and interleukin-10 in mouse bone marrow-derived mast cells. J Biol Chem 271: 22169-22174.
    • (1996) J Biol Chem , vol.271 , pp. 22169-22174
    • Lu-Kuo, J.M.1    Austen, K.F.2    Katz, H.R.3
  • 60
    • 77954532398 scopus 로고    scopus 로고
    • IL-17 enhancement of the IL-6 signaling cascade in astrocytes
    • Ma X, Reynolds SL, Baker BJ, Li X, Benveniste EN, et al. (2010) IL-17 enhancement of the IL-6 signaling cascade in astrocytes. J Immunol 184: 4898-4906.
    • (2010) J Immunol , vol.184 , pp. 4898-4906
    • Ma, X.1    Reynolds, S.L.2    Baker, B.J.3    Li, X.4    Benveniste, E.N.5
  • 61
    • 77956289866 scopus 로고    scopus 로고
    • Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections
    • Oberbach A, Schlichting N, Bluher M, Kovacs P, Till H, et al. (2010) Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections. PLoS One 5: e10882.
    • (2010) PLoS One , vol.5
    • Oberbach, A.1    Schlichting, N.2    Bluher, M.3    Kovacs, P.4    Till, H.5
  • 62
    • 0035205575 scopus 로고    scopus 로고
    • Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C
    • Fiebich BL, Schleicher S, Spleiss O, Czygan M, Hull M, (2001) Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. J Neurochem. 79: 950-958.
    • (2001) J Neurochem , vol.79 , pp. 950-958
    • Fiebich, B.L.1    Schleicher, S.2    Spleiss, O.3    Czygan, M.4    Hull, M.5
  • 63
    • 23944461833 scopus 로고    scopus 로고
    • Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element-binding protein in 1321N1 human astrocytoma cells
    • Obara Y, Kurose H, Nakahata N, (2005) Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element-binding protein in 1321N1 human astrocytoma cells. Mol Pharmacol 68: 670-679.
    • (2005) Mol Pharmacol , vol.68 , pp. 670-679
    • Obara, Y.1    Kurose, H.2    Nakahata, N.3
  • 64
    • 0033929853 scopus 로고    scopus 로고
    • Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38
    • Van Wagoner NJ, Choi C, Repovic P, Benveniste EN, (2000) Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38. J Neurochem 75: 563-575.
    • (2000) J Neurochem , vol.75 , pp. 563-575
    • Van Wagoner, N.J.1    Choi, C.2    Repovic, P.3    Benveniste, E.N.4
  • 65
    • 0034667895 scopus 로고    scopus 로고
    • ICAM-1-induced expression of proinflammatory cytokines in astrocytes: involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
    • Lee SJ, Drabik K, Van Wagoner NJ, Lee S, Choi C, et al. (2000) ICAM-1-induced expression of proinflammatory cytokines in astrocytes: involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. J Immunol 165: 4658-4666.
    • (2000) J Immunol , vol.165 , pp. 4658-4666
    • Lee, S.J.1    Drabik, K.2    Van Wagoner, N.J.3    Lee, S.4    Choi, C.5
  • 66
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • Bhat NR, Zhang P, Lee JC, Hogan EL, (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18: 1633-1641.
    • (1998) J Neurosci , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 67
    • 33846666943 scopus 로고    scopus 로고
    • Monocytes infected with Mycobacterium tuberculosis regulate MAP kinase-dependent astrocyte MMP-9 secretion
    • Harris JE, Green JA, Elkington PT, Friedland JS, (2007) Monocytes infected with Mycobacterium tuberculosis regulate MAP kinase-dependent astrocyte MMP-9 secretion. J Leukoc Biol 81: 548-556.
    • (2007) J Leukoc Biol , vol.81 , pp. 548-556
    • Harris, J.E.1    Green, J.A.2    Elkington, P.T.3    Friedland, J.S.4
  • 68
    • 0036096284 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFalpha expression in human fetal astrocytes
    • Hua LL, Zhao ML, Cosenza M, Kim MO, Huang H, et al. (2002) Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFalpha expression in human fetal astrocytes. J Neuroimmunol 126: 180-189.
    • (2002) J Neuroimmunol , vol.126 , pp. 180-189
    • Hua, L.L.1    Zhao, M.L.2    Cosenza, M.3    Kim, M.O.4    Huang, H.5
  • 69
    • 77956470952 scopus 로고    scopus 로고
    • Hemin inhibits NO production by IL-1beta-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation
    • Sheng WS, Hu S, Nettles AR, Lokensgard JR, Vercellotti GM, et al. (2010) Hemin inhibits NO production by IL-1beta-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation. J Neuroinflammation 7: 51.
    • (2010) J Neuroinflammation , vol.7 , pp. 51
    • Sheng, W.S.1    Hu, S.2    Nettles, A.R.3    Lokensgard, J.R.4    Vercellotti, G.M.5
  • 70
    • 24944546733 scopus 로고    scopus 로고
    • Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes
    • Zhu D, Tan KS, Zhang X, Sun AY, Sun GY, et al. (2005) Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes. J Cell Sci 118: 3695-3703.
    • (2005) J Cell Sci , vol.118 , pp. 3695-3703
    • Zhu, D.1    Tan, K.S.2    Zhang, X.3    Sun, A.Y.4    Sun, G.Y.5
  • 71
    • 70349267594 scopus 로고    scopus 로고
    • Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo
    • Fellin T, Halassa MM, Terunuma M, Succol F, Takano H, et al. (2009) Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc Natl Acad Sci U S A 106: 15037-15042.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 15037-15042
    • Fellin, T.1    Halassa, M.M.2    Terunuma, M.3    Succol, F.4    Takano, H.5
  • 72
    • 0346599160 scopus 로고    scopus 로고
    • ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression
    • Zhang JM, Wang HK, Ye CQ, Ge W, Chen Y, et al. (2003) ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression. Neuron 40: 971-982.
    • (2003) Neuron , vol.40 , pp. 971-982
    • Zhang, J.M.1    Wang, H.K.2    Ye, C.Q.3    Ge, W.4    Chen, Y.5
  • 73
    • 33749004283 scopus 로고    scopus 로고
    • Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes
    • Shinozaki Y, Koizumi S, Ohno Y, Nagao T, Inoue K, (2006) Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes. Glia 54: 606-618.
    • (2006) Glia , vol.54 , pp. 606-618
    • Shinozaki, Y.1    Koizumi, S.2    Ohno, Y.3    Nagao, T.4    Inoue, K.5


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