Methylmercury-induced IL-6 release requires phospholipase C activities

Neuroscience Letters

Volumn 496, Issue 3, 2011, Pages 152-156

  Chang, Jason Y ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Calcium; Cytokine; IL 6; Methylmercury; Phospholipase C

Indexed keywords

ARACHIDONIC ACID; INTERLEUKIN 6; LYSOPHOSPHATIDYLCHOLINE; METHYLMERCURY; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; BRAIN DAMAGE; CALCIUM SIGNALING; CEREBELLUM; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; FETUS DEVELOPMENT; GLIA; GRANULE CELL; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM SIGNALING; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-6; METHYLMERCURY COMPOUNDS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROGLIA; PHOSPHOLIPASES A2; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; TYPE C PHOSPHOLIPASES;

EID: 79955774958     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.04.004     Document Type: Article

References (31)

1. Andrei C., Margiocco P., Poggi A., Lotti L.V., Torrisi M.R., Rubartelli A. Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:9745-9750.
2. Bootman M.D., Collins T.J., Mackenzie L., Roderick H.L., Berridge M.J., Peppiatt C.M. 2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release. FASEB J. 2002, 16:1145-1150.
3. Bordin L., Priante G., Musacchio E., Giunco S., Tibaldi E., Clari G., Baggio B. Arachidonic acid-induced IL-6 expression is mediated by PKC alpha activation in osteoblastic cells. Biochemistry 2003, 42:4485-4491.
4. Castoldi A.F., Barni S., Turin I., Gandini C., Manzo L. Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J. Neurosci. Res. 2000, 59:775-787.
5. Chang J.Y. Methylmercury causes glial IL-6 release. Neurosci. Lett. 2007, 416:217-220.
6. Chang J.Y., Tsai P.F. IL-6 release from mouse glia caused by MeHg requires cytosolic phospholipase A(2) activation. Neurosci. Lett. 2009, 461:85-89.
7. Chang J.Y., Tsai P.F. Prevention of methylmercury-induced mitochondrial depolarization, glutathione depletion and cell death by 15-deoxy-delta-12,14-prostaglandin J(2). Neurotoxicology 2008, 29:1054-1061.
8. Dong Y., Benveniste E.N. Immune function of astrocytes. Glia 2001, 36:180-190.
9. Edwards J.R., Marty M.S., Atchison W.D. Comparative sensitivity of rat cerebellar neurons to dysregulation of divalent cation homeostasis and cytotoxicity caused by methylmercury. Toxicol. Appl. Pharmacol. 2005, 208:222-232.
10. Garg T.K., Chang J.Y. 15-Deoxy-delta 12,14-prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress,. BMC Pharmacol. 2004, 4:6.
11. Garg T.K., Chang J.Y. Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12,14-prostaglandin J2. J. Neuroimmunol. 2006, 171:17-28.
12. Hare M.F., Atchison W.D. Methylmercury mobilizes Ca++ from intracellular stores sensitive to inositol 1,4,5-trisphosphate in NG108-15 cells. J. Pharmacol. Exp. Ther. 1995, 272:1016-1023.
13. Hare M.F., McGinnis K.M., Atchison W.D. Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells. J. Pharmacol. Exp. Ther. 1993, 266:1626-1635.
14. Holliday J., Parsons K., Curry J., Lee S.Y., Gruol D.L. Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture. Brain Res. 1995, 673:141-148.
15. Ihara H., Hirukawa K., Goto S., Togari A. ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. Biochem. Biophys. Res. Commun. 2005, 326:329-334.
16. Kang M.S., Jeong J.Y., Seo J.H., Jeon H.J., Jung K.M., Chin M.R., Moon C.K., Bonventre J.V., Jung S.Y., Kim D.K. Methylmercury-induced toxicity is mediated by enhanced intracellular calcium through activation of phosphatidylcholine-specific phospholipase C. Toxicol. Appl. Pharmacol. 2006, 216:206-215.
17. Kobayashi D., Ohkubo S., Nakahata N. Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in HaCaT keratinocytes. J. Pharmacol. Sci. 2006, 102:368-376.
18. Kondo A., Koshihara Y., Togari A. Signal transduction system for interleukin-6 synthesis stimulated by lipopolysaccharide in human osteoblasts. J. Interferon Cytokine Res. 2001, 21:943-950.
19. Leslie C.C. Properties and regulation of cytosolic phospholipase A2. J. Biol. Chem. 1997, 272:16709-16712.
20. Mazerik J.N., Hagele T., Sherwani S., Ciapala V., Butler S., Kuppusamy M.L., Hunter M., Kuppusamy P., Marsh C.B., Parinandi N.L. Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells. Int. J. Toxicol. 2007, 26:553-569.
21. Monick M.M., Carter A.B., Gudmundsson G., Mallampalli R., Powers L.S., Hunninghake G.W. A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages. J. Immunol. 1999, 162:3005-3012.
22. Qiu Z., Sweeney D.D., Netzeband J.G., Gruol D.L. Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons. J. Neurosci. 1998, 18:10445-10456.
23. Rees D.A., Lewis B.M., Lewis M.D., Francis K., Scanlon M.F., Ham J. Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. Br. J. Pharmacol. 2003, 140:764-772.
24. Sarafian T.A. Methyl mercury increases intracellular Ca2+ and inositol phosphate levels in cultured cerebellar granule neurons. J. Neurochem. 1993, 61:648-657.
25. Shanker G., Mutkus L.A., Walker S.J., Aschner M. Methylmercury enhances arachidonic acid release and cytosolic phospholipase A2 expression in primary cultures of neonatal astrocytes. Brain Res. Mol. Brain Res. 2002, 106:1-11.
26. Snetkov V.A., Hapgood K.J., McVicker C.G., Lee T.H., Ward J.P. Mechanisms of leukotriene D4-induced constriction in human small bronchioles. Br. J. Pharmacol. 2001, 133:243-252.
27. Spangelo B.L., Jarvis W.D. Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. Endocrinology 1996, 137:4419-4426.
28. Sun G.Y., Xu J., Jensen M.D., Yu S., Wood W.G., Gonzalez F.A., Simonyi A., Sun A.Y., Weisman G.A. Phospholipase A2 in astrocytes: responses to oxidative stress, inflammation, and G protein-coupled receptor agonists. Mol. Neurobiol. 2005, 31:27-41.
29. Tao F.C., Shah S., Pradhan A.A., Tolloczko B., Martin J.G. Enhanced calcium signaling to bradykinin in airway smooth muscle from hyperresponsive inbred rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 2003, 284:L90-L99.
30. Venkatachalam K., van Rossum D.B., Patterson R.L., Ma H.T., Gill D.L. The cellular and molecular basis of store-operated calcium entry. Nat. Cell Biol. 2002, 4:E263-E272.
31. Verity M.A., Sarafian T., Pacifici E.H., Sevanian A. Phospholipase A2 stimulation by methyl mercury in neuron culture. J. Neurochem. 1994, 62:705-714.