Connexin43 Hemichannel-Mediated Regulation of Connexin43

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Li, Kai ^a,b   Chi, Yuan ^a   Gao, Kun ^a   Yan, Qiaojing ^a   Matsue, Hiroyuki ^c   Takeda, Masayuki ^a   Kitamura, Masanori ^a   Yao, Jian ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CADMIUM; CONNEXIN 43; GLUTATHIONE; HEPTANOL; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; AUTOREGULATION; CELL LEVEL; CHANNEL GATING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EXTRACELLULAR SPACE; GAP JUNCTION; MEMBRANE PERMEABILITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TRANSPORT; UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CADMIUM; CONNEXIN 43; ENZYME ACTIVATION; GAP JUNCTIONS; GLUTATHIONE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LLC-PK1 CELLS; MODELS, BIOLOGICAL; PEPTIDES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-JUN; RATS; SWINE; UP-REGULATION;

EID: 84874528212     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058057     Document Type: Article

References (47)

1. Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC, (2003) Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 83: 1359-1400.
2. Yao J, Zhu Y, Morioka T, Oite T, Kitamura M, (2007) Pathophysiological roles of gap junction in glomerular mesangial cells. J Membr Biol 217: 123-130.
3. Yao J, Oite T, Kitamura M, (2009) Gap junctional intercellular communication in the juxtaglomerular apparatus. Am J Physiol Renal Physiol 296: F939-946.
4. Berthoud VM, Beyer EC, (2009) Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal 11: 339-353.
5. Upham BL, Trosko JE, (2009) Oxidative-dependent integration of signal transduction with intercellular gap junctional communication in the control of gene expression. Antioxid Redox Signal 11: 297-307.
6. Fang X, Huang T, Zhu Y, Yan Q, Chi Y, et al. (2011) Connexin43 hemichannels contribute to cadmium-induced oxidative stress and cell injury. Antioxid Redox Signal 14: 2427-2439.
7. Ramachandran S, Xie LH, John SA, Subramaniam S, Lal R, (2007) A novel role for connexin hemichannel in oxidative stress and smoking-induced cell injury. PLoS One 2: e712.
8. Evans WH, De Vuyst E, Leybaert L, (2006) The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J 397: 1-14.
9. Stridh MH, Tranberg M, Weber SG, Blomstrand F, Sandberg M, (2008) Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels. J Biol Chem 283: 10347-10356.
10. Cherian PP, Siller-Jackson AJ, Gu S, Wang X, Bonewald LF, et al. (2005) Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell 16: 3100-3106.
11. Thompson RJ, Zhou N, MacVicar BA, (2006) Ischemia opens neuronal gap junction hemichannels. Science 312: 924-927.
12. Liu J, Qu W, Kadiiska MB, (2009) Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 238: 209-214.
13. Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, et al. (2008) Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. J Biol Chem 283: 4252-4260.
14. Gennari A, Cortese E, Boveri M, Casado J, Prieto P, (2003) Sensitive endpoints for evaluating cadmium-induced acute toxicity in LLC-PK1 cells. Toxicology 183: 211-220.
15. Lawal AO, Ellis E, (2010) Differential sensitivity and responsiveness of three human cell lines HepG2, 1321N1 and HEK 293 to cadmium. J Toxicol Sci 35: 465-478.
16. Prozialeck WC, Lamar PC, (1995) Effects of glutathione depletion on the cytotoxic actions of cadmium in LLC-PK1 cells. Toxicol Appl Pharmacol 134: 285-295.
17. Son MH, Kang KW, Lee CH, Kim SG, (2001) Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK). Complete inhibition of the potentiated toxicity by U0126 an ERK1/2 and p38 kinase inhibitor. Biochem Pharmacol 62: 1379-1390.
18. Thevenod F, Friedmann JM, Katsen AD, Hauser IA, (2000) Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J Biol Chem 275: 1887-1896.
19. Upham BL, Kang KS, Cho HY, Trosko JE, (1997) Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells. Carcinogenesis 18: 37-42.
20. Loch-Caruso R, Upham BL, Harris C, Trosko JE, (2005) Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85: 694-702.
21. Gao FH, Wang Q, Wu YL, Li X, Zhao KW, et al. (2007) c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochem Biophys Res Commun 356: 505-511.
22. Salameh A, Krautblatter S, Baessler S, Karl S, Rojas Gomez D, et al. (2008) Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation. J Pharmacol Exp Ther 326: 315-322.
23. Shyu KG, Wang BW, Yang YH, Tsai SC, Lin S, et al. (2004) Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway. Cardiovasc Res 63: 98-108.
24. Li K, Yao J, Shi L, Sawada N, Chi Y, et al. (2011) Reciprocal regulation between proinflammatory cytokine-induced inducible NO synthase (iNOS) and connexin43 in bladder smooth muscle cells. J Biol Chem 286: 41552-41562.
25. Yao J, Suwa M, Li B, Kawamura K, Morioka T, et al. (2003) ATP-dependent mechanism for coordination of intercellular Ca2+ signaling and renin secretion in rat juxtaglomerular cells. Circ Res 93: 338-345.
26. Huang T, Zhu Y, Fang X, Chi Y, Kitamura M, et al. (2010) Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis. Cancer Sci 101: 713-721.
27. Yao J, Huang T, Fang X, Chi Y, Zhu Y, et al. (2010) Disruption of gap junctions attenuates aminoglycoside-elicited renal tubular cell injury. British Journal of Pharmacology 9999.
28. Retamal MA, Schalper KA, Shoji KF, Bennett MV, Saez JC, (2007) Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A 104: 8322-8327.
29. Tacheau C, Fontaine J, Loy J, Mauviel A, Verrecchia F, (2008) TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways. J Cell Physiol 217: 759-768.
30. Mitchell JA, Lye SJ, (2001) Regulation of connexin43 expression by c-fos and c-jun in myometrial cells. Cell Commun Adhes 8: 299-302.
31. Wilhelm D, Bender K, Knebel A, Angel P, (1997) The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol Cell Biol 17: 4792-4800.
32. Carmeli C, Knyazeva MG, Cuenod M, Do KQ, (2012) Glutathione precursor N-acetyl-cysteine modulates EEG synchronization in schizophrenia patients: a double-blind, randomized, placebo-controlled trial. PLoS One 7: e29341.
33. D'Hondt C, Ponsaerts R, Srinivas SP, Vereecke J, Himpens B, (2007) Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions. Invest Ophthalmol Vis Sci 48: 120-133.
34. Stridh MH, Correa F, Nodin C, Weber SG, Blomstrand F, et al. (2010) Enhanced glutathione efflux from astrocytes in culture by low extracellular Ca2+ and curcumin. Neurochem Res 35: 1231-1238.
35. Prozialeck WC, Lamar PC, (1997) Cadmium (Cd2+) disrupts E-cadherin-dependent cell-cell junctions in MDCK cells. In Vitro Cell Dev Biol Anim 33: 516-526.
36. Prozialeck WC, Lamar PC, (1998) Comparison of the cytotoxic effects of cadmium (Cd(2+)) in high and low resistance strains of MDCK cells that express different levels of E-Cadherin. Toxicol In Vitro 12: 633-647.
37. Giepmans BN, (2004) Gap junctions and connexin-interacting proteins. Cardiovasc Res 62: 233-245.
38. Martin PE, Blundell G, Ahmad S, Errington RJ, Evans WH, (2001) Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels. J Cell Sci 114: 3845-3855.
39. Majoul IV, Onichtchouk D, Butkevich E, Wenzel D, Chailakhyan LM, et al. (2009) Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway. Histochem Cell Biol 132: 263-280.
40. Thomas T, Jordan K, Simek J, Shao Q, Jedeszko C, et al. (2005) Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci 118: 4451-4462.
41. Prozialeck WC, Niewenhuis RJ, (1991) Cadmium (Cd2+) disrupts intercellular junctions and actin filaments in LLC-PK1 cells. Toxicol Appl Pharmacol 107: 81-97.
42. Hew KW, Heath GL, Jiwa AH, Welsh MJ, (1993) Cadmium in vivo causes disruption of tight junction-associated microfilaments in rat Sertoli cells. Biol Reprod 49: 840-849.
43. Chaytor AT, Evans WH, Griffith TM, (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J Physiol 508 (Pt 2): 561-573.
44. Oviedo-Orta E, Gasque P, Evans WH, (2001) Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication. FASEB J 15: 768-774.
45. Mendoza-Naranjo A, Saez PJ, Johansson CC, Ramirez M, Mandakovic D, et al. (2007) Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. J Immunol 178: 6949-6957.
46. Ponsaerts R, De Vuyst E, Retamal M, D'Hondt C, Vermeire D, et al. (2010) Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity. FASEB J 24: 4378-4395.
47. Evans WH, Bultynck G, Leybaert L, (2012) Manipulating connexin communication channels: use of peptidomimetics and the translational outputs. J Membr Biol 245: 437-449.