Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK) Complete inhibition of the potentiated toxicity by U0126 an ERK1/2 and p38 kinase inhibitor

Biochemical Pharmacology

Volumn 62, Issue 10, 2001, Pages 1379-1390

  Son, Moon Ho ^a,b   Kang, Keon Wook ^a   Lee, Chang Ho ^c   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Cadmium; Cytotoxicity; ERK1 2; Glutathione; JNK; MKK1 2; P38 kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CADMIUM; CYSTEINE; ENZYME INHIBITOR; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; SULFUR AMINO ACID; SYNAPTOPHYSIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME SUBUNIT; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AMINO ACIDS; AMINO ACIDS, SULFUR; ANIMALS; BUTADIENES; CADMIUM; CYSTEINE; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; TUMOR CELLS, CULTURED;

EID: 0035892367     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00780-8     Document Type: Article

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