Differential sensitivity and responsiveness of three human cell lines HepG2, 1321N1 and HEK 293 to cadmium

Journal of Toxicological Sciences

Volumn 35, Issue 4, 2010, Pages 465-478

  Lawal, Akeem Olalekan ^a   Ellis, Elizabeth ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Aldehydes; Antioxidants; Cadmium toxicity; Malondialdehyde; Oxidative stress; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; CADMIUM CHLORIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LACTATE DEHYDROGENASE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE;

ARTICLE; ASTROCYTOMA CELL; CANCER CELL CULTURE; CELL STRAIN 1321N1; CELL STRAIN HEK293; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; SENSITIVITY ANALYSIS;

EID: 77956862551     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.465     Document Type: Article

References (49)

1. Aden, D.P., Fogel, A., Plotkin, S., Damjanov, I. and Knowles, B.B. (1979): Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature, 282, 615-616.
2. Aebi, H. (1974): in Methods of Enzymatic Analysis (H.U. Bergmeyer, Ed.), pp.673-684, Verlag Chemie (Weinheim).
3. Aiba, I., Hossain, A. and Kuo, M.T. (2008): Elevated GSH level increases cadmium resistance through down-regulation of Sp1-dependent expression of the cadmium transporter ZIP8. Mol. Pharmacol., 74, 823-833.
4. Amer, J., Atlas, D. and Fibach, E. (2008): N-acetyl-cysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells. Biochim. Biophys. Acta, 1780, 249-255.
5. Bradford, M.M. (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
6. Carlberg, I. and Mannervik, B. (1977): Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione. Biochim. Biophys. Acta, 484, 268-274.
7. Clark, R.B., Su, Y.F., Ortmann, R., Cubeddu, L., Johnson, G.L. and Perkins, J.P. (1975): Factors influencing the effect of hormones on the accumulation of cyclic AMP in cultured human astrocytoma cells. Metabolism, 24, 343-358.
8. Decker, T. and Lohmann-Matthes, M.L. (1988): A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J. Immunol. Methods, 115, 61-69.
9. Durnam, D.M. and Palmiter, R.D. (1981): Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J. Biol. Chem., 256, 5712-5716.
10. Ellis, E.M. (2007): Reactive carbonyls and oxidative stress: Potential for therapeutic intervention. Pharmacol. Ther., 115, 13-24.
11. Esterbauer, H., Cheeseman, K., Dianzani, M., Poli, G. and Slater, T. (1982): Separation and characterization of the aldehydic products of lipidperoxidation stimulated by ADP-Fe2+ in ratliver microsomes. Biochem. J., 208, 129-140.
12. Fotakis, G., Cemeli, E., Anderson, D. and Timbrell, J.A. (2005): Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line. Toxicol. in Vitro, 19, 481-489.
13. Fotakis, G. and Timbrell, J.A. (2006): In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett., 160, 171-177.
14. Friberg, L., Kjellstrom, T. and Nordberg, G. (1986): Cadmium in Handbook on the Toxicology of Metals (L. Friberg, G.F. Nordberg and V.B. Voul, Ed.), Elsevier, Oxford.
15. Gabbiani, G., Baic, D. and Déziel, C. (1967): Toxicity of cadmium for the central nervous system. Exp. Neurol., 18, 154-160.
16. Galán, A., García-Bermejo, L., Troyano, A., Vilaboa, N.E., Fernández, C., de Blas, E. and Aller, P. (2001): The role of intracellular oxidation in death induction (apoptosis and necrosis) in human promonocytic cells treated with stress inducers (camium, heat, X-rays). Eur. J. Cell Biol., 80, 312-320.
17. Gamalei, I.A., Efremova, T.N., Kirpichnikova, K.M., Komissarchik, Y.Y., Kever, L.V., Polozov, Y.V. and Khaitlina, S.Y. (2006): Decreased sensitivity of transformed 3T3-SV40 cells treated with N-acetylcysteine to bacterial invasion. Bull. Exp. Biol. Med., 142, 90-93.
18. Graham, F.L., Smiley, J., Russell, W.C. and Nairn, R. (1977): Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol., 36, 59-74.
19. Griffith, O.W. (1980): Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem., 106, 207-212.
20. Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1974): Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249, 7130-7139.
21. Hart, B.A., Lee, C.H., Shukla, G.S., Shukla, A., Osier, M., Eneman, J.D. and Chiu, J.F. (1999): Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress. Toxicology, 133, 43-58.
22. Hayes, J.D., Flanagan, J.U. and Jowsey, I.R. (2005): Glutathione transferases. Annu. Rev. Pharmacol. Toxicol., 45, 51-88.
23. He, X., Chen, M.G. and Ma, Q. (2008): Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem. Res. Toxicol., 21, 1375-1383.
24. Hempel, S.L., Buettner, G.R., O'Malley, Y.Q., Wessels, D.A. and Flaherty, D.M. (1999): Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′- dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′- dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic. Biol. Med., 27, 146-159.
25. Hinshelwood, A., McGarvie, G. and Ellis, E. (2002): Characterisation of a novel mouse liver aldo-keto reductase AKR7A5. FEBS Lett., 523, 213-218.
26. IARC (1993): Berrylium, cadmium, mercury and exposures in the glass manufacturing industry. IARC Scientific Publications, Lyon.
27. Jin, Y. and Penning, T.M. (2007): Aldo-keto reductases and bioactivation/detoxication. Annu. Rev. Pharmacol. Toxicol., 47, 263-292.
28. Kamiyama, T., Miyakawa, H., Li, J.P., Akiba, T., Liu, J.H., Liu, J., Marumo, F. and Sato, C. (1995): Effects of one-year cadmium exposure on livers and kidneys and their relation to glutathione levels. Res. Commun. Mol. Pathol. Pharmacol., 88, 177-186.
29. Koizumi, N., Murata, K., Hayashi, C., Nishio, H. and Goji, J. (2008): High cadmium accumulation among humans and primates: comparison across various mammalian species - a study from Japan. Biol. Trace Elem. Res., 121, 205-214.
30. Leach, F.R. (1981): ATP Determination with Firefly Luciferase. J. Appl. Biochem., 3, 473-517.
31. Liu, J., Kadiiska, M.B., Corton, J.C., Qu, W., Waalkes, M.P., Mason, R.P., Liu, Y. and Klaassen, C.D. (2002): Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein- I/II-null mice. Free Radic. Biol. Med., 32, 525-535.
32. Liu, J., Qu, W. and Kadiiska, M.B. (2009): Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol. Appl. Pharmacol., 238, 209-214.
33. Lyon, R.C., Johnston, S.M., Watson, D.G., McGarvie, G. and Ellis, E.M. (2007): Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldoketo reductase AKR7A2. J. Biol. Chem., 282, 25986-25992.
34. Mao, W.P., Ye, J.L., Guan, Z.B., Zhao, J.M., Zhang, C., Zhang, N.N., Jiang, P. and Tian, T. (2007): Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria. Toxicol. in Vitro, 21, 343-354.
35. Mosmann, T. (1983): Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
36. Nzengue, Y., Steiman, R., Garrel, C., Lefèbvre, E. and Guiraud, P. (2008): Oxidative stress and DNA damage induced by cadmium in the human keratinocyte HaCaT cell line: role of glutathione in the resistance to cadmium. Toxicology, 243, 193-206.
37. Oh, S.H. and Lim, S.C. (2006): A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine- mediated catalase upregulation. Toxicol. Appl. Pharmacol., 212, 212-223.
38. Ohkawa, H., Ohishi, N. and Yagi, K. (1979): Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358.
39. Robertson, J.D. and Orrenius, S. (2000): Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit. Rev. Toxicol., 30, 609-627.
40. Satarug, S., Baker, J.R., Urbenjapol, S., Haswell-Elkins, M., Reilly, P.E., Williams, D.J. and Moore, M.R. (2003): A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett., 137, 65-83.
41. Satarug, S. and Moore, M.R. (2004): Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect., 112, 1099-1103.
42. Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, E.L. (1988): A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res., 175, 184-191.
43. Sugita, M. and Tsuchiya, K. (1995): Estimation of variation among individuals of biological half-time of cadmium calculated from accumulation data. Environ. Res., 68, 31-37.
44. Waalkes, M.P. (2000): Cadmium carcinogenesis in review. J. Inorg. Biochem., 79, 241-244.
45. Wendel, A. (1980): in Enzymatic Basis of Detoxification, Ed., pp.333-353. Academic Press New York, NY.
46. Williams, G.T. and Morimoto, R.I. (1990): Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Mol. Cell Biol., 10, 3125-3136.
47. Yang, C.S., Tzou, B.C., Liu, Y.P., Tsai, M.J., Shyue, S.K. and Tzeng, S.F. (2008): Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium. J. Cell Biochem., 103, 825-834.
48. Yang, P.M., Chen, H.C., Tsai, J.S. and Lin, L.Y. (2007a): Cadmium induces Ca2+-dependent necrotic cell death through calpain-triggered mitochondrial depolarization and reactive oxygen species-mediated inhibition of nuclear factor-kappaB activity. Chem. Res. Toxicol., 20, 406-415.
49. Yang, Z., Yang, S., Qian, S.Y., Hong, J.S., Kadiiska, M.B., Tennant, R.W., Waalkes, M.P. and Liu, J. (2007b): Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia. Toxicol. Sci., 98, 488-494.