(E)-2,4-bis(p-hydroxyphenyl)-2-butenal has an antiproliferative effect on NSCLC cells induced by p38 MAPK-mediated suppressionof NF-κB and up-regulation of TNFRSF10B (DR5)

British Journal of Pharmacology

Volumn 168, Issue 6, 2013, Pages 1471-1484

  Kollipara, Pushpa Saranya ^a   Jeong, Heon Sang ^a   Han, Sang Bae ^a   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

Author keywords

apoptosis; death receptor 5; lung cancer; NF B; p38 MAPK

Indexed keywords

2,4 BIS(4 HYDROXYPHENYL) 2 BUTENAL; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYTOKINE RECEPTOR; DEATH RECEPTOR 5; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN P53; PROTEIN TNFRSF12; PROTEIN TNFRSF21; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TNFRSF10B GENE; TRANSCRIPTION TERMINATION;

ALDEHYDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITORY CONCENTRATION 50; LUNG; MAP KINASE SIGNALING SYSTEM; NEOPLASM PROTEINS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOLS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA INTERFERENCE; RNA, MESSENGER;

EID: 84874413050     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12024     Document Type: Article

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