AW00179 potentiates TRAIL-mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun-mediated up-regulation of DR5 and down-regulation of anti-Apoptotic molecules

Amino Acids

Volumn 43, Issue 4, 2012, Pages 1679-1687

  Hwang, Mi Kyung ^a   Ryu, Byung Jun ^a   Kim, Seong Hwan ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

c Jun; DR5; ROS; Sensitization; TRAIL

Indexed keywords

1 (4 TRIFLUOROMETHOXYPHENYL) 3 [4 (5 TRIFLUOROMETHYL 2,5 DIHYDRO PYRAZOL 1 YL)PHENYL]UREA; AW 00179; CARBANILAMIDE DERIVATIVE; CASPASE 8; DEATH RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL STRAIN H1299; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG POTENTIATION; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG NEOPLASMS; MAP KINASE KINASE 4; PHENYLUREA COMPOUNDS; PROTO-ONCOGENE PROTEINS C-JUN; PYRAZOLES; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UP-REGULATION;

EID: 84867577106     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1249-3     Document Type: Article

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