Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-κB and c-Jun NH2-terminal kinase

European Journal of Pharmacology

Volumn 494, Issue 1, 2004, Pages 1-9

  Kim, Young Ho ^a,b   Lee, Sang Han ^c   Lee, Jai Youl ^b   Choi, Sang Won ^d   Park, Jong Wook ^a   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Catholic University of Daegu   (South Korea)

Author keywords

iNOS; JNK; NF B; NO (Nitric oxide); Triptolide

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRIPTOLIDE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE; DITERPENES; DOWN-REGULATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHENANTHRENES;

EID: 2942609150     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.04.040     Document Type: Article

References (33)

1. Ajizian S.J., English B.K., Meals E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with LPS and interferon-gamma. J. Infect. Dis. 179:1999;939-944
2. Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357:2001;593-615
3. Baek W.K., Park J.W., Lim J.H., Suh S.I., Suh M.H., Kwon T.K. Molecular cloning and characterization of human BUB3 promoter. Gene. 295:2002;117-123
4. Baeuerle P.A., Baltimore D. NF-kappa B: ten years after. Cell. 87:1996;13-20
5. Caivano M. Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages. FEBS Lett. 429:1998;249-253
6. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159
7. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126:1982;131-138
8. Guo F.H., Comhair S.A., Zheng S., Dweik R.A., Eissa N.T., Thomassen M.J., Calhoun W., Erzurum S.C. Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis. J. Immunol. 164:2000;5970-5980
9. Jiang X. Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome. Pediatr. Nephrol. 8:1994;343-344
10. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 298:2002;1911-1912
11. Kleinert H., Euchenhofer C., Ihrig-Biedert I., Forstermann U. In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB. J. Biol. Chem. 271:1996;6039-6044
12. Kupchan S.M., Court W.A., Dailey R.G., Gilmore C.J., Bryan R.F. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J. Am. Chem. Soc. 94:1972;7194-7195
13. Liu R.H., Hotchkiss J.H. Potential genotoxicity of chronically elevated nitric oxide: a review. Mutat. Res. 339:1995;73-89
14. Lowenstein C.J., Alley E.W., Raval P., Snowman A.M., Snyder S.H., Russell S.W., Murphy W.J. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and LPS. Proc. Natl. Acad. Sci. 90:1993;9730-9734
15. MacMicking J., Xie Q.W., Nathan C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15:1997;323-350
16. Marks-Konczalik J., Chu S.C., Moss J. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites. J. Biol. Chem. 273:1998;22201-22208
17. Martin E., Nathan C., Xie Q.W. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:1994;977-984
18. Meydan N., Grunberger T., Dadi H., Shahar M., Arpaia E., Lapidot Z., Leeder J.S., Freedman M., Cohen A., Gazit A., Levitzki A., Roifman C.M. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature. 379:1996;645-648
19. Meyer C.F., Wang X., Chang C., Templeton D., Tan T.H. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. J. Biol. Chem. 271:1996;8971-8976
20. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:1991;109-142
21. Nathan C. Inducible nitric oxide synthase: what difference does it make? J. Clin. Invest. 100:1997;2417-2423
22. Ohmori Y., Hamilton T.A. Requirement for STAT1 in LPS-induced gene expression in macrophages. J. Leukoc. Biol. 69:2001;598-604
23. Prabhu K.S., Zamamiri-Davis F., Stewart J.B., Thompson J.T., Sordillo L.M., Reddy C.C. Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-kappaB in up-regulation. Biochem. J. 366:2002;203-209
24. Pu L.X., Zhang T.M. Effects of triptolide on T lymphocyte functions in mice. Acta Pharm. Sin. 11:1990;76-79
25. Qin W.Z., Zhu G.D., Yang S.M., Han K.Y., Wang J. Clinical observations on Tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus. J. Tradit. Chin. Med. 3:1983;131-132
26. Tak P.P., Firestein G.S. NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 107:2001;7-11
27. Tao X.L., Sun Y., Dong Y., Xiao Y.L., Hu D.W., Shi Y.P., Zhu Q.L., Dai H., Zhang H.Z. A prospective, controlled, double-blind, cross-over study of Tripterygium wilfodii Hook F in treatment of rheumatoid arthritis. Chin. Med. J. (Engl.). 102:1989;327-332
28. Taylor B.S., de Vera M.E., Ganster R.W., Wang Q., Shapiro R.A., Morris S.M. Jr., Billiar T.R., Geller D.A. Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J. Biol. Chem. 273:1998;15148-15156
29. Vodovotz Y., Lucia M.S., Flanders K.C., Chesler L., Xie Q.W., Smith T.W., Weidner J., Mumford R., Webber R., Nathan C., Roberts A.B., Lippa C.F., Sporn M.B. Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J. Exp. Med. 184:1996;1425-1433
30. Wei Y.S., Adachi I. Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines. Acta Pharm. Sin. 12:1991;406-410
31. Xie Q.W., Whisnant R., Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial LPS. J. Exp. Med. 177:1993;1779-1784
32. Xie Q.W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:1994;4705-4708
33. Yang Y., Liu Z., Tolosa E., Yang J., Li L. Triptolide induces apoptotic death of T lymphocyte. Immunopharmacology. 40:1998;139-149