Curcumin regulates low-linear energy transfer γ-radiation-induced NFκB-dependent telomerase activity in human neuroblastoma cells

International Journal of Radiation Oncology Biology Physics

Volumn 79, Issue 4, 2011, Pages 1206-1215

  Aravindan, Natarajan ^a   Veeraraghavan, Jamunarani ^a   Madhusoodhanan, Rakhesh ^a   Herman, Terence S ^a   Natarajan, Mohan ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Curcumin; Neuroblastoma; NF B; Radiosensitization; Telomerase activity

Indexed keywords

AMPLIFICATION PROTOCOLS; CELL SURVIVAL; CLONOGENIC ASSAYS; CURCUMIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTHELIAL SYSTEMS; HUMAN NEUROBLASTOMA; LINEAR ENERGY TRANSFER; LUCIFERASE REPORTER ASSAYS; NEUROBLASTOMA CELLS; NEUROBLASTOMAS; PROMOTER REGION; QUANTITATIVE POLYMERASE CHAIN REACTION; RADIATION-INDUCED; RADIO-SENSITIZATION; RECOGNITION SITE; TELOMERASE; TELOMERASE ACTIVITY; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTIONAL LEVELS; TRANSFECTED CELLS; UP-REGULATION;

ASSAYS; BINDING ENERGY; BROMINE COMPOUNDS; CELLS; ELECTROPHORETIC MOBILITY; ENERGY TRANSFER; IONIZING RADIATION; NUCLEIC ACIDS; POLYMERASE CHAIN REACTION; TRANSCRIPTION;

CYTOLOGY;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CURCUMIN; I KAPPA B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; PROTEIN P50; PROTEIN SUBUNIT; SMALL INTERFERING RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; ASSAY; CELL SURVIVAL; CLONOGENIC ASSAY; ELECTROPHORETIC MOBILITY; GAMMA RADIATION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IONIZING RADIATION; LINEAR ENERGY TRANSFER; MUTANT; NEUROBLASTOMA CELL; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; TRANSCRIPTION INITIATION; UPREGULATION;

CELL LINE, TUMOR; CELL SURVIVAL; CURCUMIN; GAMMA RAYS; HUMANS; LINEAR ENERGY TRANSFER; NEUROBLASTOMA; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RADIATION TOLERANCE; RNA, MESSENGER; TELOMERASE;

EID: 79951946518     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.10.058     Document Type: Article

References (37)

1. A. Ahmed, and T.O. Tollefsbol Telomerase, telomerase inhibition, and cancer J Anti Aging Med 6 2003 315 325 (Pubitemid 38580425)
2. J. Feng, W.D. Funk, and S.S. Wang The RNA component of human telomerase Science 269 1995 1236 1241
3. L. Harrington, T. McPhail, and V. Mar A mammalian telomerase-associated protein Science 275 1997 973 977 (Pubitemid 27087712)
4. M. Meyerson, C.M. Counter, and E.N. Eaton hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization Cell 90 1997 785 795 (Pubitemid 27357969)
5. M. Takakura, S. Kyo, and T. Kanaya Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells Cancer Res 59 1999 551 557 (Pubitemid 29076049)
6. N.W. Kim, M.A. Piatyszek, and K.R. Prowse Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
7. C. Poremba, H. Willenbring, and B. Hero Telomerase activity distinguishes between neuroblastomas with good and poor prognosis Ann Oncol 10 1999 715 721 (Pubitemid 29342378)
8. M.L. Bernstein, J.M. Leclerc, and G. Bunin A population-based study of neuroblastoma incidence, survival, and mortality in North America J Clin Oncol 10 1992 323 329
9. B.H. Kushner Neuroblastoma: A disease requiring a multitude of imaging studies J Nucl Med 45 2004 1172 1188 (Pubitemid 47611663)
10. C.J. Streutker, P. Thorner, and N. Fabricius Telomerase activity as a prognostic factor in neuroblastomas Pediatr Dev Pathol 4 2001 62 67 (Pubitemid 32155690)
11. C. Poremba, C. Scheel, and B. Hero Telomerase activity and telomerase subunits gene expression patterns in neuroblastoma: A molecular and immunohistochemical study establishing prognostic tools for fresh-frozen and paraffin-embedded tissues J Clin Oncol 18 2000 2582 2592 (Pubitemid 30432525)
12. R.P. Castleberry, L.E. Kun, and J.J. Shuster Radiotherapy improves the outlook for patients older than 1 year with Pediatric Oncology Group stage C neuroblastoma J Clin Oncol 9 1991 789 795
13. P. Finnon, A.R. Silver, and S.D. Bouffler Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription Carcinogenesis 21 2000 573 578 (Pubitemid 30214009)
14. L. Yin, A.K. Hubbard, and C. Giardina NF-kappa B regulates transcription of the mouse telomerase catalytic subunit J Biol Chem 275 2000 36671 36675 (Pubitemid 32002070)
15. N. Aravindan, R. Madhusoodhanan, and S. Ahmad Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells Cancer Biol Ther 7 2008 569 576 (Pubitemid 351847033)
16. N. Aravindan, R. Madhusoodhanan, and M. Natarajan Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells Mol Cell Biochem 310 2008 167 179
17. M. Natarajan, S. Mohan, and R. Konopinski Induced telomerase activity in primary aortic endothelial cells by low-LET gamma-radiation is mediated through NF-kappaB activation Br J Radiol 81 2008 711 720
18. A.B. Kunnumakkara, P. Diagaradjane, and S. Guha Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products Clin Cancer Res 14 2008 2128 2136 (Pubitemid 351551125)
19. P. Javvadi, A.T. Segan, and S.W. Tuttle The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway Mol Pharmacol 73 2008 1491 1501 (Pubitemid 351574839)
20. H. Narang, and M. Krishna Inhibition of radiation induced nitration by curcumin and nicotinamide in mouse macrophages Mol Cell Biochem 276 2005 7 13 (Pubitemid 41236203)
21. A.L. Cheng, C.H. Hsu, and J.K. Lin Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions Anticancer Res 21 2001 2895 2900
22. F. Yang, G.P. Lim, and A.N. Begum Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo J Biol Chem 280 2005 5892 5901 (Pubitemid 40280072)
23. S.X. Cui, X.J. Qu, and Y.Y. Xie Curcumin inhibits telomerase activity in human cancer cell lines Int J Mol Med 18 2006 227 231
24. N. Aravindan, S. Mohan, and T.S. Herman Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis J Cell Biochem 106 2009 999 1009
25. R. Madhusoodhanan, M. Natarajan, and J. Veeraraghavan NFkappaB signaling related molecular alterations in human neuroblastoma cells after fractionated irradiation J Radiat Res (Tokyo) 50 2009 311 324
26. M. Natarajan, N. Aravindan, and M.L. Meltz Post-translational modification of I-kappa B alpha activates NF-kappa B in human monocytes exposed to 56Fe ions Radiat Environ Biophys 41 2002 139 144 (Pubitemid 36988777)
27. J.A. Brockman, D.C. Scherer, and T.A. McKinsey Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation Mol Cell Biol 15 1995 2809 2818
28. Y.H. Hsu, and J.J. Lin Telomere and telomerase as targets for anti-cancer and regeneration therapies Acta Pharmacol Sin 26 2005 513 518
29. L. Boldrini, P. Faviana, and S. Gisfredi Regulation of telomerase and its hTERT messenger in colorectal cancer Oncol Rep 11 2004 395 400
30. J. Xing, Y. Zhu, and H. Zhao Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation Cancer Epidemiol Biomarkers Prev 16 2007 606 609 (Pubitemid 46548667)
31. M. Agarwal, S. Pandita, and C.R. Hunt Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization Cancer Res 68 2008 3370 3378
32. C.H. Huang, Z.K. Liao, and F.X. Zhou [hTERT promoter enhances the radiosensitivity to gene-radiation therapy of human laryngeal carcinoma transplanted in nude mice] Zhonghua Zhong Liu Za Zhi 30 2008 733 736
33. Y.S. Cong, W.E. Wright, and J.W. Shay Human telomerase and its regulation Microbiol Mol Biol Rev 66 2002 407 425 table of contents (Pubitemid 35001137)
34. R. Buser, R. Montesano, and I. Garcia Bovine microvascular endothelial cells immortalized with human telomerase J Cell Biochem 98 2006 267 286
35. B.B. Aggarwal, and S. Shishodia Molecular targets of dietary agents for prevention and therapy of cancer Biochem Pharmacol 71 2006 1397 1421
36. N. Chainani-Wu Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa) J Altern Complement Med 9 2003 161 168 (Pubitemid 36297021)
37. S. Mukherjee Nee Chakraborty, U. Ghosh, and N.P. Bhattacharyya Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity Mol Cell Biochem 297 2007 31 39 (Pubitemid 46443527)