Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate

Journal of Theoretical Biology

Volumn 322, Issue , 2013, Pages 58-71

  Al Husari, Maymona ^a   Webb, Steven D ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Lactate H+ symporter; Modelling; Na+ H+ antiporter; PH gradient; Tumour microenvironment

Indexed keywords

CARRIER PROTEIN; LACTATE PROTON SYMPORTER; LACTIC ACID; PROTON; UNCLASSIFIED DRUG;

CONCENTRATION (COMPOSITION); MEMBRANE; NUMERICAL METHOD; NUMERICAL MODEL; PERTURBATION; PH; TUMOR;

ARTICLE; CELL PH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOSOME; GOLGI COMPLEX; LINEAR STABILITY ANALYSIS; LYSOSOME; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MEMBRANE VESICLE; NEOPLASM; PARAMETER SENSITIVITY ANALYSIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SENSITIVITY ANALYSIS;

HUMANS; HYDROGEN; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; LACTIC ACID; MODELS, BIOLOGICAL; NEOPLASMS; TUMOR MICROENVIRONMENT;

EID: 84874392391     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2013.01.007     Document Type: Article

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