Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 37, 2011, Pages 15242-15247

  Guney, Michelle A ^a   Petersen, Christine P ^b   Boustani, Andre ^b   Duncan, Matthew R ^c   Gunasekaran, Uma ^b   Menon, Renuka ^b   Warfield, Courtney ^b   Grotendorst, Gary R ^c   Means, Anna L ^a,b   Economides, Aris N ^d   Gannon, Maureen ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c Lovelace Respiratory Institute   (United States)

^d REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIVISION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENDOCRINE CELL; ENDOTHELIUM CELL; MALE; MORPHOGENESIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; VASCULARIZATION;

ANIMALS; AUTOCRINE COMMUNICATION; CELL LINEAGE; CELL PROLIFERATION; CELL SIZE; CONNECTIVE TISSUE GROWTH FACTOR; EMBRYONIC DEVELOPMENT; ENDOTHELIAL CELLS; INSULIN-SECRETING CELLS; MICE; MODELS, BIOLOGICAL; MORPHOGENESIS; RATS;

EID: 80053059611     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100072108     Document Type: Article

References (39)

1. Apelqvist A, et al. (1999) Notch signalling controls pancreatic cell differentiation. Nature 400:877-881. (Pubitemid 29406724)
2. Jensen J, et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation. Diabetes 49(2):163-176. (Pubitemid 30070993)
3. Gradwohl G, Dierich A, LeMeur M, Guillemot F (2000) Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611. (Pubitemid 30118489)
4. Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457. (Pubitemid 34863851)
5. Bhushan A, et al. (2001) Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128: 5109-5117. (Pubitemid 34083036)
6. Norgaard GA, Jensen JN, Jensen J (2003) FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol 264:323-338. (Pubitemid 37490972)
7. Jacquemin P, et al. (2006) An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol 290(1):189-199. (Pubitemid 43083614)
8. Lammert E, Cleaver O, Melton D (2001) Induction of pancreatic differentiation by signals from blood vessels. Science 294:564-567. (Pubitemid 32999547)
9. Guney MA, Gannon M (2009) Pancreas cell fate. Birth Defects Res C Embryo Today 87: 232-248.
10. Yoshitomi H, Zaret KS (2004) Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 131: 807-817. (Pubitemid 38263196)
11. Edsbagge J, et al. (2005) Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development 132:1085-1092. (Pubitemid 40484941)
12. Brissova M, et al. (2006) Pancreatic islet production of vascular endothelial growth factor-A is essential for islet vascularization, revascularization, and function. Diabetes 55:2974-2985. (Pubitemid 44923633)
13. Christofori G, Naik P, Hanahan D (1995) Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 9:1760-1770.
14. Zhang W, et al. (2006) PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab 4: 491-497. (Pubitemid 44817351)
15. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609. (Pubitemid 24315741)
16. Offield MF, et al. (1996) PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122(6):983-995. (Pubitemid 26096002)
17. Gannon M, et al. (2008) pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314(2):406-417.
18. Desgraz R, Herrera PL (2009) Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development 136:3567-3574.
19. Ivkovic S, et al. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130:2779-2791. (Pubitemid 37069592)
20. Crawford LA, et al. (2009) Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol 23:324-336.
21. Gressner OA, Gressner AM (2008) Connective tissue growth factor: A fibrogenic master switch in fibrotic liver diseases. Liver Int 28:1065-1079.
22. Canalis E, Zanotti S, Beamer WG, Economides AN, Smerdel-Ramoya A (2010) Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology 151:3490-3501.
23. Gustafsson E, Brakebusch C, Hietanen K, Fässler R (2001) Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice. J Cell Sci 114:671-676. (Pubitemid 32237139)
24. Bjarnegard M, et al. (2004) Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnromalities. Development 131(8): 1847-1857. (Pubitemid 38559851)
25. Umans L, et al. (2007) Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am J Pathol 170(5): 1460-1472. (Pubitemid 47339293)
26. Song L, et al. (2007) Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol 301(1):276-286. (Pubitemid 44958389)
27. Zhang H, et al. (2007) Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injuury in mice. Am J Pathol 171(4):1113-1126. (Pubitemid 47582887)
28. Schonhoff SE, Giel-Moloney M, Leiter AB (2004) Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol 270:443-454. (Pubitemid 38748564)
29. Artner I, et al. (2010) MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes 59:2530-2539.
30. Brigstock DR (2002) Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis 5 (3):153-165.
31. Sand FW, et al. (2011) Growth-limiting role of endothelial cells in endoderm development. Dev Biol 352:267-277.
32. Pierreux CE, et al. (2010) Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas. Dev Biol 347:216-227.
33. Nikolova G, et al. (2006) The vascular basement membrane: A niche for insulin gene expression and Beta cell proliferation. Dev Cell 10:397-405.
34. Parsons JA, Brelje TC, Sorenson RL (1992) Adaptation of islets of Langerhans to pregnancy: Increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130:1459-1466.
35. JohanssonM, Mattsson G, Andersson A, Jansson L, Carlsson PO (2006) Islet endothelial cells and pancreatic beta-cell proliferation: Studies in vitro and during pregnancy in adult rats. Endocrinology 147:2315-2324.
36. D'Amour KA, et al. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24:1392-1401. (Pubitemid 44722103)
37. Borowiak M, et al. (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4:348-358.
38. Ackermann Misfeldt A, Costa RH, Gannon M (2008) β-Cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1. Diabetes 57:3069-3077.
39. Milo-Landesman D, et al. (2001) Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system. Cell Transplant 10:645-650. (Pubitemid 34241692)