Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies

Biotechnology and Bioengineering

Volumn 110, Issue 4, 2013, Pages 1087-1097

  Feeney, Lauren ^a   Carvalhal, Veronica ^a   Yu, X Christopher ^a   Chan, Betty ^a   Michels, David A ^a   Wang, Yajun Jennifer ^a   Shen, Amy ^a   Ressl, Jan ^a   Dusel, Brendon ^a   Laird, Michael W ^a  

^a GENENTECH INC   (United States)

Author keywords

CHO; MAb; Sequence variant; Tyrosine

Indexed keywords

AMINO ACID SEQUENCE; CELL CULTURE PROCESS; CHINESE HAMSTER OVARY CELLS; CHO; CHO CELL; DATA SUPPORT; DNA MUTATION; IMMUNOGENICITY; LOW LEVEL; MAB; MONOCLONAL ANTIBODIES (MABS); MOST LIKELY; POTENTIAL IMPACTS; PRODUCT SAFETY; PRODUCT VARIATIONS; PRODUCTION OF; RECOMBINANT MONOCLONAL ANTIBODY; SEQUENCE VARIANTS; STRUCTURAL SIMILARITY; THERAPEUTIC PRODUCTS; THERAPEUTIC USE; TYROSINE; TYROSINE RESIDUES;

CELL CULTURE; MONOCLONAL ANTIBODIES; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE;

AMINO ACIDS;

HISTIDINE; MONOCLONAL ANTIBODY; PHENYLALANINE; PROTEIN VARIANT; RECOMBINANT ANTIBODY; TYROSINE;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CHO CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; NONHUMAN; PROTEIN DEPLETION;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; HISTIDINE; PHENYLALANINE; RECOMBINANT PROTEINS; TYROSINE;

CRICETULUS GRISEUS;

EID: 84874203862     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24759     Document Type: Article

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