Hypermutation in bacteria and other cellular systems

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 355, Issue 1405, 2001, Pages 29-39

  Bridges, B A ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Adaptive mutation; Bacteria, hypermutation in; DNA polymerases; Mismatch correction; Transcription, effect on mutation; Translesion synthesis

Indexed keywords

BACTERIUM MUTANT; DNA POLYMERASE; GERM CELL; IONIZING RADIATION; MALE; MAMMAL CELL; MITOTIC RECOMBINATION; MOUSE; SOMATIC MUTATION;

ANIMAL; BACTERIAL GENOME; BACTERIUM; DNA DAMAGE; DNA REPAIR; ESCHERICHIA COLI; GENE REARRANGEMENT; GENETIC SELECTION; GENETIC TRANSCRIPTION; GENETICS; MAMMAL; MUTATION; PHYSIOLOGY; REVIEW; STRESS;

ANIMALS; BACTERIA; DNA DAMAGE; ESCHERICHIA COLI; GENE REARRANGEMENT; GENOME, BACTERIAL; MAMMALS; MUTATION; SELECTION (GENETICS); SOS RESPONSE (GENETICS); STRESS; TRANSCRIPTION, GENETIC;

EID: 0035966784     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (111)

1. Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development
2. Mutation drift and repertoire shift in the maturation of the immune response
3. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region
4. Fidelity of Escherichia coli DNA polymerase III holoenzyme
5. Concomitant induction of signal transduction pathways and genetic instability by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate
6. Stress response induced by DNA damage leads to specific delayed and untargeted mutations
7. Inefficient mismatch repair: Genetic defects and down regulation
8. Spontaneous mutation in stationary-phase Escherichia coli WP2 carrying various DNA repair alleles
9. Starvation-associated mutation in Escherichia coli: A spontaneous lesion hypothesis for 'directed' mutation
10. mutY 'directs' mutation?
11. Starvation-associated mutation in E. coli strains with and without reverse transcriptase
12. Elevated mutation rate in mutT bacteria during starvation: Evidence of DNA turnover?
13. Mutation in resting cells: The role of endogenous DNA damage
14. The role of DNA damage in stationary phase ('adaptive') mutation
15. Mutagenic repair in Escherichia coli: Products of the recA gene and of the umuD and umuC genes act at different steps in UV-induced mutagenesis
16. Effect of mutY and mutM/fpg-1 mutations on starvation-associated mutation in Escherichia coli: Implications for the role of 7,8-dihydro-8-oxoguanine
17. Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: Evidence for the requirement for the dinB gene
18. Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination
19. Adaptive reversion of a frameshift mutation in Escherichia coli
20. The origin of mutants
21. Persistently elevated frequency of spontaneous mutation in progeny of CHO clones surviving X-irradiation - Association with delayed reproductive death phenoptype
22. Association of increased spontaneous mutation rates with high levels of transcription in yeast
23. Singlet oxygen-induced mutations in M13 lacZ phage DNA
24. DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells
25. A constant rate of spontaneous mutation in DNA-based microbes
26. Rates of spontaneous mutation
27. Mouse minisatellite mutations induced by ionizing radiation
28. Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation
29. Radiation-induced germline instability at minisatellite loci
30. Transgenerational mutation by radiation
31. Involvement of Escherichia coli DNA polymerase II in response to oxidative damage and adaptive mutation
32. Dose-response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus
33. Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary phase Escherichia coli K-12 cells
34. Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: Spontaneous mutation by misincorporation
35. DNA polymerase accuracy and spontaneous mutation rates: Frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication
36. Contribution of 3′-5′ exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity
37. Fidelity of replication of bacteriophage phi X174 DNA in vitro and in vivo
38. Kinetic basis of spontaneous mutation. Misinsertion frequencies, proofreading specificities and cost of proofreading by DNA polymerases of Escherichia coli
39. Adaptive mutation: The uses of adversity
40. Nonadaptive mutations occur on the F episome during adaptive mutation conditions in Escherichia coli
41. Mechanisms of stationary phase mutation: A decade of adaptive mutation
42. Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs
43. Adaptive reversion of a episomal frameshift mutation in Escherichia coli requires conjugal functions but not actual conjugation
44. Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli
45. DNA replication errors produced by the replicative apparatus of Escherichia coli
46. Evidence that F plasmid transfer replication underlies apparent adaptive mutation
47. A search for a general phenomenon of adaptive mutability
48. Metastable phenotype of bacteria
49. Spontaneous point mutations that occur more often when advantageous than when neutral
50. Recombination in adaptive mutation
51. A direct role of DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli
52. Mismatch repair protein MutL becomes limiting during stationary-phase mutation
53. Endogenous cellular contributions to mammalian mutagenesis
54. Escherichia coli mutator genes
55. Indirect mutagenesis in phage lambda by ultraviolet pre-irradiation of host bacteria
56. Mutation d'un bactériophage induite par l'irradiation des seules bactéries-hôtes avant l'infection
57. Leakiness of genetic markers and susceptibility to post-plating mutagenesis in Escherichia coli
58. Replication errors: Cha(lle)nging the genome
59. The human DINB1 gene encodes the DNA polymerase Poltheta
60. Biochemistry and genetics of eukaryotic mismatch repair
61. On the dependence of spontaneous mutation rates on the functional state of genes
62. Mutagenesis by proximity to the recA gene of Escherichia coli
63. c: Possible involvement of interfilament association in proteolytic and recombination activities
64. Preferential mutagenesis of lacZ integrated at unique sites in the Escherichia coli chromosome
65. Adaptive mutation sequences reproduced by mismatch repair deficiency
66. The SOS response regulates adaptive mutation
67. Somatic hypermutation: How many mechanisms diversify V region sequences?
68. Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis
69. Biological function for 6-methyladenine residues in the DNA of Escherichia coli K12
70. Accurate translesion synthesis by human DNA polymerase η
71. Low fidelity DNA synthesis by human DNA polymerase-η
72. Experimental evidence for an alternative to directed mutation in the bgl operon
73. Fidelity and error specificity of the alpha catalytic subunit of Escherichia coli DNA polymerase III
74. Genetic analysis of transcription-associated mutation in Saccharomyces cerevisiae
75. Adaptive evolution of highly mutable loci in pathogenic bacteria
76. Transient mutators: A semiquantitative analysis of the influence of translation and transcription errors on mutation rates
77. Induction of a germline mutation at a hypervariable mouse minisatellite locus by 252Cf radiation
78. Adaptive mutation and slow-growing revertants of an Escherichia coli lacZ amber mutant
79. Adaptive mutation in Escherichia coli: A role for conjugation
80. Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase
81. The mutagenesis protein UmuC is a DNA polymerase activated by UmuD, RecA, and SSB and Is specialized for translesion replication
82. Adaptive mutations produce resistance to ciprofloxacin
83. Adaptive mutation by deletions in small mononucleotide repeats
84. Mutagenic DNA repair in Escherichia coli XIV. Influence of two DNA polymerase III mutator alleles on spontaneous and UV mutagenesis
85. Is DNA replication a necessary condition for spontaneous mutation?
86. Radiation induction of germline mutation at a hypervariable mouse minisatellite locus
87. Genetic mechanisms of bacterial antigenic variation
88. The fidelity of base selection by the polymerase subunit of DNA polymerase III holoenzyme
89. Mutator tRNAs are encoded by the Escherichia coli mutator genes mutA and mutC: A novel pathway for mutagenesis
90. Delayed mutation in Chinese hamster cells
91. A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript
92. Genetic analysis of mutagenesis in aging Escherichia coli colonies
93. 2 C mutagenic complex and RecA protein
94. UmuD′(2)C is an error-prone DNA polymerase, Escherichia coli pol V
95. Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis
96. Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli
97. Plaque color method for rapid isolation of novel recA mutants of Escherichia coli K-12: New classes of protease-constitutive recA mutants
98. Reversion of the tyrosine ochre strain Escherichia coli WU3610 under starvation conditions depends on a new gene tas
99. A UmuD, C-dependent pathway for spontaneous G:C to C:G transversions in stationary phase Escherichia coli mutY
100. Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation
101. The formation of one-G deletions as a consequence of singlet-oxygen-induced DNA damage
102. Mutagenesis of lambda phage by tif-expression or host-irradiation functions is largely independent of damage in the phage DNA
103. The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis
104. The infuence of somatic mutation on the immune response
105. Non-targeted mutagenesis of unirradiated lambda phage in Escherichia coli host cells irradiated with ultraviolet light
106. Does selective gene activation direct evolution?
107. Hypermutation in derepressed operons of E. coli K12
108. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
109. Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine:guanine mispair to prevent spontaneous G:C-C:G transversions