Accurate determination of succinimide degradation products using high fidelity trypsin digestion peptide map analysis

Analytical Chemistry

Volumn 83, Issue 15, 2011, Pages 5912-5919

  Yu, X Christopher ^a   Joe, Koman ^a   Zhang, Yu ^a   Adriano, Andrea ^a   Wang, Yaning ^a   Gazzano Santoro, Helene ^a   Keck, Rodney G ^a   Deperalta, Galahad ^a   Ling, Victor ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFTER-TREATMENT; ALKALINE PH; ANTIGEN BINDING; CAPILLARY ISOELECTRIC FOCUSING; CHARGE INTERACTIONS; COCRYSTAL STRUCTURE; DEGRADATION MECHANISM; DEGRADATION PRODUCTS; DENATURING CONDITIONS; HIGH FIDELITY; HYDROLYSIS PRODUCTS; LIGHT CHAIN; MAP ANALYSIS; MASS SPECTROMETRIC ANALYSIS; NEGATIVE CHARGE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SAMPLE PREPARATION; SUCCINIMIDE; TRYPSIN DIGESTION;

ALKALINITY; ANTIGENS; BIOACTIVITY; ELECTROPHORESIS; LIQUID CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; PEPTIDES;

DEGRADATION;

MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; SUCCINIMIDE; SUCCINIMIDE DERIVATIVE; TRYPSIN;

ANIMAL; ARTICLE; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ISOELECTRIC FOCUSING; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PEPTIDE MAPPING; PH; SWINE;

ANIMALS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; ISOELECTRIC FOCUSING; MASS SPECTROMETRY; PEPTIDE MAPPING; RECOMBINANT PROTEINS; SUCCINIMIDES; SWINE; TRYPSIN;

EID: 79961009713     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac200750u     Document Type: Article

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