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Volumn 5, Issue 5, 2013, Pages 603-612

Quantitative imaging of a therapeutic peptide in biological tissue sections by MALDI MS

Author keywords

[No Author keywords available]

Indexed keywords

GENTISIC ACID; OCTREOTIDE; PEPTIDE;

EID: 84874167570     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.13     Document Type: Article
Times cited : (29)

References (48)
  • 1
    • 79959458959 scopus 로고    scopus 로고
    • The application of MALDI TOF MS in biopharmaceutical research
    • Kafka AP, Kleffmann T, Rades T, McDowell A. The application of MALDI TOF MS in biopharmaceutical research. Int. J. Pharm. 417(1-2), 70-82 (2011).
    • (2011) Int. J. Pharm. , vol.417 , Issue.1-2 , pp. 70-82
    • Kafka, A.P.1    Kleffmann, T.2    Rades, T.3    McDowell, A.4
  • 2
    • 84863218474 scopus 로고    scopus 로고
    • Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars
    • Berkowitz SA, Engen JR, Mazzeo JR, Jones GB. Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nat. Rev. Drug Discov. 11(7), 527-540 (2012).
    • (2012) Nat. Rev. Drug Discov. , vol.11 , Issue.7 , pp. 527-540
    • Berkowitz, S.A.1    Engen, J.R.2    Mazzeo, J.R.3    Jones, G.B.4
  • 3
    • 0028237535 scopus 로고
    • Are routine tissue distribution studies justifiable for approval of human drugs?
    • Monro AM. Are routine tissue distribution studies justifiable for approval of human drugs? Drug Metab. Dispos. 22(3), 341-342 (1994). (Pubitemid 24158529)
    • (1994) Drug Metabolism and Disposition , vol.22 , Issue.3 , pp. 341-342
    • Monro, A.M.1
  • 4
    • 0028007628 scopus 로고
    • Are we doing too many animal biodisposition investigations before Phase I studies in man? A re-evaluation of the timing and extent of ADME studies
    • Campbell DB. Are we doing too many animal biodisposition investigations before phase I studies in man? A re-evaluation of the timing and extent of ADME studies. Eur. J. Drug Metab. Pharmacokinet. 19(3), 283-293 (1994). (Pubitemid 24331199)
    • (1994) European Journal of Drug Metabolism and Pharmacokinetics , vol.19 , Issue.3 , pp. 283-293
    • Campbell, D.B.1
  • 5
    • 0030497430 scopus 로고    scopus 로고
    • The possibility of predicting tissue accumulation after repeated dosing using a single-dose tissue distribution study
    • Mizojiri K, Shindo H, Ohno Y. The possibility of predicting tissue accumulation after repeated dosing using a single-dose tissue distribution study. J. Toxicol. Sci. 21(5), 523-527 (1996). (Pubitemid 27044252)
    • (1996) Journal of Toxicological Sciences , vol.21 , Issue.5 , pp. 523-527
    • Mizojiri, K.1    Shindo, H.2    Ohno, Y.3
  • 6
    • 0034122973 scopus 로고    scopus 로고
    • Quantitative distribution studies in animals: Cross-validation of radioluminography versus liquid-scintillation measurement
    • DOI 10.1006/rtph.2000.1384
    • Steinke W, Archimbaud Y, Becka M et al. Quantitative distribution studies in animals: Cross-validation of radioluminography versus liquid-scintillation measurement. Regul. Toxicol. Pharmacol. 31(2 Pt 2), S33-S43 (2000). (Pubitemid 30314339)
    • (2000) Regulatory Toxicology and Pharmacology , vol.31 , Issue.2
    • Steinke, W.1    Archimbaud, Y.2    Becka, M.3    Binder, R.4    Busch, U.5    Dupont, P.6    Maas, J.7
  • 7
    • 0034082680 scopus 로고    scopus 로고
    • Quantitative whole-body radioluminography - Future strategy for balance and tissue distribution studies
    • DOI 10.1006/rtph.2000.1387
    • D'Argy R, Sundwall A. Quantitative whole-body radioluminography-future strategy for balance and tissue distribution studies. Regul. Toxicol. Pharmacol. 31(2 Pt 2), S57-S62 (2000). (Pubitemid 30314342)
    • (2000) Regulatory Toxicology and Pharmacology , vol.31 , Issue.2
    • D'Argy, R.1    Sundwall, A.2
  • 8
    • 0035527670 scopus 로고    scopus 로고
    • Quantitative whole-body autoradiography in the pharmaceutical industry - Survey results on study design, methods, and regulatory compliance
    • DOI 10.1016/S1056-8719(02)00161-2, PII S1056871902001612
    • Solon EG, Kraus L. Quantitative whole-body autoradiography in the pharmaceutical industry. Survey results on study design, methods, and regulatory compliance. J. Pharmacol. Toxicol. Methods 46(2), 73-81 (2001). (Pubitemid 34680996)
    • (2001) Journal of Pharmacological and Toxicological Methods , vol.46 , Issue.2 , pp. 73-81
    • Solon, E.G.1    Kraus, L.2
  • 9
    • 1542268974 scopus 로고    scopus 로고
    • Study on the practical use of quantitative whole-body auto- radioluminography
    • DOI 10.1016/j.yexmp.2003.11.002, PII S0014480003001394
    • Inazawa K, Koike M, Yamaguchi T. Study on the practical use of quantitative whole-body auto-radioluminography. Exp. Mol. Pathol. 76(2), 153-165 (2004). (Pubitemid 38316930)
    • (2004) Experimental and Molecular Pathology , vol.76 , Issue.2 , pp. 153-165
    • Inazawa, K.1    Koike, M.2    Yamaguchi, T.3
  • 10
    • 0031304362 scopus 로고    scopus 로고
    • Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS
    • Caprioli RM, Farmer TB, Gile J. Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 69(23), 4751-4760 (1997).
    • (1997) Anal. Chem. , vol.69 , Issue.23 , pp. 4751-4760
    • Caprioli, R.M.1    Farmer, T.B.2    Gile, J.3
  • 11
    • 0242606377 scopus 로고    scopus 로고
    • Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry
    • DOI 10.1002/jms.525
    • Reyzer ML, Hsieh Y, Ng K, Korfmacher WA, Caprioli RM. Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry. J. Mass Spectrom. 38(10), 1081-1092 (2003). (Pubitemid 37407703)
    • (2003) Journal of Mass Spectrometry , vol.38 , Issue.10 , pp. 1081-1092
    • Reyzer, M.L.1    Hsieh, Y.2    Ng, K.3    Korfmacher, W.A.4    Caprioli, R.M.5
  • 12
    • 77956606489 scopus 로고    scopus 로고
    • Correlation of skin blanching and percutaneous absorption for glucocorticoid receptor agonists by matrix-assisted laser desorption ionization mass spectrometry imaging and liquid extraction surface analysis with nanoelectrospray ionization mass spectrometry
    • Marshall P, Toteu-Djomte V, Bareille P et al. Correlation of skin blanching and percutaneous absorption for glucocorticoid receptor agonists by matrix-assisted laser desorption ionization mass spectrometry imaging and liquid extraction surface analysis with nanoelectrospray ionization mass spectrometry. Anal. Chem. 82(18), 7787-7794 (2010).
    • (2010) Anal. Chem. , vol.82 , Issue.18 , pp. 7787-7794
    • Marshall, P.1    Toteu-Djomte, V.2    Bareille, P.3
  • 13
    • 79960697624 scopus 로고    scopus 로고
    • Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions
    • Zaima N, Sasaki T, Tanaka H et al. Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions. Atherosclerosis 217(2), 427-432 (2011).
    • (2011) Atherosclerosis , vol.217 , Issue.2 , pp. 427-432
    • Zaima, N.1    Sasaki, T.2    Tanaka, H.3
  • 15
    • 33748865022 scopus 로고    scopus 로고
    • Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry
    • DOI 10.1021/ac060788p
    • Khatib-Shahidi S, Andersson M, Herman JL, Gillespie TA, Caprioli RM. Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal. Chem. 78(18), 6448-6456 (2006). (Pubitemid 44418954)
    • (2006) Analytical Chemistry , vol.78 , Issue.18 , pp. 6448-6456
    • Khatib-Shahidi, S.1    Andersson, M.2    Herman, J.L.3    Gillespie, T.A.4    Caprioli, R.M.5
  • 16
    • 34047187431 scopus 로고    scopus 로고
    • Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry
    • DOI 10.1002/rcm.2952
    • Atkinson SJ, Loadman PM, Sutton C, Patterson LH, Clench MR. Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry. Rapid Commun. Mass Spectrom. 21(7), 1271-1276 (2007). (Pubitemid 46509403)
    • (2007) Rapid Communications in Mass Spectrometry , vol.21 , Issue.7 , pp. 1271-1276
    • Atkinson, S.J.1    Loadman, P.M.2    Sutton, C.3    Patterson, L.H.4    Clench, M.R.5
  • 17
    • 79957933802 scopus 로고    scopus 로고
    • MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections
    • Li F, Hsieh Y, Kang L, Sondey C, Lachowicz J, Korfmacher WA. MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections. Bioanalysis 1(2), 299-307 (2009).
    • (2009) Bioanalysis , vol.1 , Issue.2 , pp. 299-307
    • Li, F.1    Hsieh, Y.2    Kang, L.3    Sondey, C.4    Lachowicz, J.5    Korfmacher, W.A.6
  • 18
    • 81055144381 scopus 로고    scopus 로고
    • MALDI imaging mass spectrometry: Bridging biology and chemistry in drug development
    • Castellino S, Groseclose MR, Wagner D. MALDI imaging mass spectrometry: Bridging biology and chemistry in drug development. Bioanalysis 3(21), 2427-2441 (2011).
    • (2011) Bioanalysis , vol.3 , Issue.21 , pp. 2427-2441
    • Castellino, S.1    Groseclose, M.R.2    Wagner, D.3
  • 19
    • 24644432436 scopus 로고    scopus 로고
    • Characterization and performance of MALDI on a triple quadrupole mass spectrometer for analysis and quantification of small molecules
    • DOI 10.1021/ac0506130
    • Gobey J, Cole M, Janiszewski J et al. Characterization and performance of MALDI on a triple quadrupole mass spectrometer for analysis and quantification of small molecules. Anal. Chem. 77(17), 5643-5654 (2005). (Pubitemid 41266060)
    • (2005) Analytical Chemistry , vol.77 , Issue.17 , pp. 5643-5654
    • Gobey, J.1    Cole, M.2    Janiszewski, J.3    Covey, T.4    Chau, T.5    Kovarik, P.6    Corr, J.7
  • 20
    • 0029397819 scopus 로고
    • Structural characterization of phospholipids by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry
    • Marto JA, White FM, Seldomridge S, Marshall AG. Structural characterization of phospholipids by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry. Anal. Chem. 67(21), 3979-3984 (1995).
    • (1995) Anal. Chem. , vol.67 , Issue.21 , pp. 3979-3984
    • Marto, J.A.1    White, F.M.2    Seldomridge, S.3    Marshall, A.G.4
  • 21
    • 33645841960 scopus 로고    scopus 로고
    • Matrix-suppressed laser desorption/ionisation mass spectrometry and its suitability for metabolome analyses
    • Vaidyanathan S, Gaskell S, Goodacre R. Matrix-suppressed laser desorption/ionisation mass spectrometry and its suitability for metabolome analyses. Rapid Commun. Mass Spectrom. 20(8), 1192-1198 (2006).
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , Issue.8 , pp. 1192-1198
    • Vaidyanathan, S.1    Gaskell, S.2    Goodacre, R.3
  • 22
    • 0024289037 scopus 로고
    • Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons
    • Karas M, Hillenkamp F. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal. Chem. 60(20), 2299-2301 (1988).
    • (1988) Anal. Chem. , vol.60 , Issue.20 , pp. 2299-2301
    • Karas, M.1    Hillenkamp, F.2
  • 23
    • 0025677738 scopus 로고
    • Mass spectrometry of peptides and proteins by matrix-assisted ultraviolet laser desorption/ionization
    • Hillenkamp F, Karas M. Mass spectrometry of peptides and proteins by matrix-assisted ultraviolet laser desorption/ionization. Methods Enzymol. 193, 280-295 (1990).
    • (1990) Methods Enzymol , vol.193 , pp. 280-295
    • Hillenkamp, F.1    Karas, M.2
  • 24
    • 84866944321 scopus 로고    scopus 로고
    • Quantitation by MS imaging: needs and challenges in pharmaceuticals
    • Stauber J. Quantitation by MS imaging: needs and challenges in pharmaceuticals. Bioanalysis 4(17), 2095-2098 (2012).
    • (2012) Bioanalysis , vol.4 , Issue.17 , pp. 2095-2098
    • Stauber, J.1
  • 25
    • 77950322164 scopus 로고    scopus 로고
    • Quantitative MALDI-MS(n) analysis of cocaine in the autopsied brain of a human cocaine user employing a wide isolation window and internal standards
    • Reich RF, Cudzilo K, Levisky JA, Yost RA. Quantitative MALDI-MS(n) analysis of cocaine in the autopsied brain of a human cocaine user employing a wide isolation window and internal standards. J. Am. Soc. Mass Spectrom. 21(4), 564-571 (2010).
    • (2010) J. Am. Soc. Mass Spectrom. , vol.21 , Issue.4 , pp. 564-571
    • Reich, R.F.1    Cudzilo, K.2    Levisky, J.A.3    Yost, R.A.4
  • 26
    • 77955372862 scopus 로고    scopus 로고
    • Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry
    • Nilsson A, Fehniger TE, Gustavsson L et al. Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry. PLoS ONE 5(7), e11411 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.7
    • Nilsson, A.1    Fehniger, T.E.2    Gustavsson, L.3
  • 27
    • 83655182569 scopus 로고    scopus 로고
    • Determination of loperamide in mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis
    • Shin YG, Dong T, Chou B, Menghrajani K. Determination of loperamide in mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis. Arch. Pharm. Res. 34(11), 1983-1988 (2011).
    • (2011) Arch. Pharm. Res. , vol.34 , Issue.11 , pp. 1983-1988
    • Shin, Y.G.1    Dong, T.2    Chou, B.3    Menghrajani, K.4
  • 28
    • 84865185551 scopus 로고    scopus 로고
    • Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation
    • Goodwin RJ, Nilsson A, Borg D et al. Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation. J. Proteomics 75(16), 4912-4920 (2012).
    • (2012) J. Proteomics , vol.75 , Issue.16 , pp. 4912-4920
    • Goodwin, R.J.1    Nilsson, A.2    Borg, D.3
  • 29
    • 84865169841 scopus 로고    scopus 로고
    • Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor
    • Hamm G, Bonnel D, Legouffe R et al. Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor. J. Proteomics 75(16), 4952-4961 (2012).
    • (2012) J. Proteomics , vol.75 , Issue.16 , pp. 4952-4961
    • Hamm, G.1    Bonnel, D.2    Legouffe, R.3
  • 30
    • 84861647273 scopus 로고    scopus 로고
    • Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry
    • Takai N, Tanaka Y, Inazawa K, Saji H. Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry. Rapid Commun. Mass Spectrom. 26(13), 1549-1556 (2012).
    • (2012) Rapid Commun. Mass Spectrom. , vol.26 , Issue.13 , pp. 1549-1556
    • Takai, N.1    Tanaka, Y.2    Inazawa, K.3    Saji, H.4
  • 32
    • 0033794877 scopus 로고    scopus 로고
    • Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry
    • Tamvakopoulos CS, Colwell LF, Barakat K et al. Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 14(19), 1729-1735 (2000).
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , Issue.19 , pp. 1729-1735
    • Tamvakopoulos, C.S.1    Colwell, L.F.2    Barakat, K.3
  • 33
    • 37649012006 scopus 로고    scopus 로고
    • Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up
    • Murao N, Ishigai M, Yasuno H, Shimonaka Y, Aso Y. Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up. Rapid Commun. Mass Spectrom. 21(24), 4033-4038 (2007).
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , Issue.24 , pp. 4033-4038
    • Murao, N.1    Ishigai, M.2    Yasuno, H.3    Shimonaka, Y.4    Aso, Y.5
  • 34
    • 38949163071 scopus 로고    scopus 로고
    • Insulins in equine urine: Qualitative analysis by immunoaffinity purification and liquid chromatography/tandem mass spectrometry for doping control purposes in horse-racing
    • DOI 10.1002/rcm.3360
    • Kuuranne T, Thomas A, Leinonen A et al. Insulins in equine urine: qualitative analysis by immunoaffinity purification and liquid chromatography/tandem mass spectrometry for doping control purposes in horse-racing. Rapid Commun. Mass Spectrom. 22(3), 355-362 (2008). (Pubitemid 351212861)
    • (2008) Rapid Communications in Mass Spectrometry , vol.22 , Issue.3 , pp. 355-362
    • Kuuranne, T.1    Thomas, A.2    Leinonen, A.3    Delahaut, P.4    Bosseloir, A.5    Schanzer, W.6    Thevis, M.7
  • 35
    • 80054747827 scopus 로고    scopus 로고
    • Bioanalytical strategies for developing highly sensitive liquid chromatography/tandem mass spectrometry based methods for the peptide GLP-1 agonists in support of discovery PK/PD studies
    • Zhang H, Xin B, Caporuscio C, Olah TV. Bioanalytical strategies for developing highly sensitive liquid chromatography/tandem mass spectrometry based methods for the peptide GLP-1 agonists in support of discovery PK/PD studies. Rapid Commun. Mass Spectrom. 25(22), 3427-3435 (2011).
    • (2011) Rapid Commun. Mass Spectrom. , vol.25 , Issue.22 , pp. 3427-3435
    • Zhang, H.1    Xin, B.2    Caporuscio, C.3    Olah, T.V.4
  • 36
    • 84863012569 scopus 로고    scopus 로고
    • General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies
    • Li H, Ortiz R, Tran L et al. General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies. Anal. Chem. 84(3), 1267-1273 (2012).
    • (2012) Anal. Chem. , vol.84 , Issue.3 , pp. 1267-1273
    • Li, H.1    Ortiz, R.2    Tran, L.3
  • 38
    • 37648999140 scopus 로고    scopus 로고
    • Determination of long-acting release octreotide, an octapeptide analog of somatostation, in human plasma by liquid chromatography/tandem mass spectrometry
    • Jiang Y, Wang J, Wang Y et al. Determination of long-acting release octreotide, an octapeptide analog of somatostation, in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 21(24), 3982-3986 (2007).
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , Issue.24 , pp. 3982-3986
    • Jiang, Y.1    Wang, J.2    Wang, Y.3
  • 39
    • 79959880412 scopus 로고    scopus 로고
    • Determination of octreotide and assessment of matrix effects in human plasma using ultra high performance liquid chromatography-tandem mass spectrometry
    • Ismaiel OA, Zhangb T, Jenkinsb R, Karnesc HT. Determination of octreotide and assessment of matrix effects in human plasma using ultra high performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879(22), 2081-2088 (2011).
    • (2011) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.879 , Issue.22 , pp. 2081-2088
    • Ismaiel, O.A.1    Zhangb, T.2    Jenkinsb, R.3    Karnesc, H.T.4
  • 40
    • 0032909925 scopus 로고    scopus 로고
    • Automated strategies for obtaining standardized collisionally induced dissociation spectra on a benchtop ion trap mass spectrometer
    • DOI 10.1002/(SICI)1097-0231(19990430)13:8<663::AID-RCM538>3.0.CO;2- H
    • Lopez LL, Tiller PR, Senko MW, Schwartz JC. Automated strategies for obtaining standardized collisionally induced dissociation spectra on a benchtop ion trap mass spectrometer. Rapid Commun. Mass Spectrom. 13(8), 663-668 (1999). (Pubitemid 29194452)
    • (1999) Rapid Communications in Mass Spectrometry , vol.13 , Issue.8 , pp. 663-668
    • Lopez, L.L.1    Tiller, P.R.2    Senko, M.W.3    Schwartz, J.C.4
  • 42
    • 0026720422 scopus 로고
    • Somatostatin receptor scintigraphy with indium-111-DTPA-D-Phe-1- octreotide in man: Metabolism, dosimetry and comparison with iodine-123-Tyr-3-octreotide
    • Krenning EP, Bakker WH, Kooij PPM et al. Somatostatin receptor scintigraphy with indium-111-DTPA-D-Phe-1-octreotide in man: Metabolism, dosimetry and comparison with iodine-123-Tyr-3-octreotide. J. Nucl. Med. 33(5), 652-658 (1992).
    • (1992) J. Nucl. Med. , vol.33 , Issue.5 , pp. 652-658
    • Krenning, E.P.1    Bakker, W.H.2    Kooij, P.P.M.3
  • 44
    • 0031593941 scopus 로고    scopus 로고
    • Renal metabolism of 111In-DTPA-D-Phe1-octreotide in vivo
    • Akizawa H, Arano Y, Uezono T et al. Renal metabolism of 111In-DTPA-D-Phe1-octreotide in vivo. Bioconjug. Chem. 9(6), 662-670 (1998).
    • (1998) Bioconjug. Chem. , vol.9 , Issue.6 , pp. 662-670
    • Akizawa, H.1    Arano, Y.2    Uezono, T.3
  • 45
    • 84870229925 scopus 로고    scopus 로고
    • Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD
    • Neubert H, Fountain S, King L et al. Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD. Bioanalysis 4(21), 2589-2604 (2012).
    • (2012) Bioanalysis , vol.4 , Issue.21 , pp. 2589-2604
    • Neubert, H.1    Fountain, S.2    King, L.3
  • 46
    • 79954595692 scopus 로고    scopus 로고
    • High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions
    • Prideaux B, Dartois V, Staab D et al. High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions. Anal. Chem. 83(6), 2112-2118 (2011).
    • (2011) Anal. Chem. , vol.83 , Issue.6 , pp. 2112-2118
    • Prideaux, B.1    Dartois, V.2    Staab, D.3
  • 47
    • 84857858396 scopus 로고    scopus 로고
    • 3D imaging by mass spectrometry: A new frontier
    • Seeley EH, Caprioli RM. 3D imaging by mass spectrometry: A new frontier. Anal. Chem. 84(5), 2105-2110 (2012).
    • (2012) Anal. Chem. , vol.84 , Issue.5 , pp. 2105-2110
    • Seeley, E.H.1    Caprioli, R.M.2
  • 48
    • 84863954470 scopus 로고    scopus 로고
    • Exploring three-dimensional matrix-assisted laser desorption/ionization imaging mass spectrometry data: Three-dimensional spatial segmentation of mouse kidney
    • Trede D, Schiffler S, Becker M et al. Exploring three-dimensional matrix-assisted laser desorption/ionization imaging mass spectrometry data: Three-dimensional spatial segmentation of mouse kidney. Anal. Chem. 84(14), 6079-6087 (2012).
    • (2012) Anal. Chem. , vol.84 , Issue.14 , pp. 6079-6087
    • Trede, D.1    Schiffler, S.2    Becker, M.3


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