General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies

Analytical Chemistry

Volumn 84, Issue 3, 2012, Pages 1267-1273

  Li, Hongyan ^a   Ortiz, Robert ^a   Tran, Linh ^a   Hall, Michael ^a   Spahr, Chris ^b   Walker, Ken ^b   Laudemann, John ^b   Miller, Sterling ^b   Salimi Moosavi, Hossein ^a   Lee, Jean W ^a  

^a PKDM ^*  (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE APPROACH; BIOLOGICAL SAMPLES; INTERNAL STANDARDS; LC-MS/MS; LIGAND BINDING; MATRIX EFFECTS; METHOD DEVELOPMENT; METHOD QUALIFICATIONS; PRECLINICAL STUDIES; PROCESSING STEPS; SAMPLE PROCESSING; STABLE ISOTOPES; THERAPEUTIC MONOCLONAL ANTIBODIES;

ISOTOPES; PEPTIDES;

MONOCLONAL ANTIBODIES;

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; QUALITY CONTROL; STANDARD; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOGLOBULIN G; ISOTOPE LABELING; PEPTIDES; QUALITY CONTROL; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY;

EID: 84863012569     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac202792n     Document Type: Article

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