Correlation of skin blanching and percutaneous absorption for glucocorticoid receptor agonists by matrix-assisted laser desorption ionization mass spectrometry imaging and liquid extraction surface analysis with nanoelectrospray ionization mass spectrometry

Analytical Chemistry

Volumn 82, Issue 18, 2010, Pages 7787-7794

  Marshall, Peter ^a   Toteu Djomte, Valerie ^a   Bareille, Philippe ^a   Perry, Hayley ^a   Brown, Gillian ^b   Baumert, Mark ^b   Biggadike, Keith ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Advion BioSciences Ltd UK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORY ACTIVITY; ETHANOL SOLUTIONS; GLUCOCORTICOID RECEPTOR; HEALTHY HUMANS; HUMAN VOLUNTEERS; IN-VITRO; LIQUID EXTRACTION; LOW DOSE; MATRIX ASSISTED LASER DESORPTION/IONIZATION; MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY; NANOELECTROSPRAY IONIZATION MASS SPECTROMETRY; PERCUTANEOUS ABSORPTION; PORCINE SKIN; TIME COURSE;

ABSORPTION; BLANCHING; DESORPTION; ETHANOL; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETRY; PARTICLE DETECTORS; SOLVENT EXTRACTION; SURFACE ANALYSIS;

ABSORPTION SPECTROSCOPY;

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ADOLESCENT; ADULT; ANIMAL; ARTICLE; ATMOSPHERIC PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; EAR; ELECTROSPRAY MASS SPECTROMETRY; FRACTIONATION; HUMAN; MALE; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; NANOTECHNOLOGY; RANDOMIZED CONTROLLED TRIAL; SKIN; SKIN ABSORPTION; SURFACE PROPERTY;

ADOLESCENT; ADULT; ANIMALS; ATMOSPHERIC PRESSURE; CHEMICAL FRACTIONATION; EAR; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; NANOTECHNOLOGY; RECEPTORS, GLUCOCORTICOID; SKIN; SKIN ABSORPTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SURFACE PROPERTIES; YOUNG ADULT;

EID: 77956606489     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac1017524     Document Type: Article

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