-
1
-
-
0025931005
-
Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527)
-
Cobb BS, Payne DM, Reynolds AB, Parsons JT, (1991) Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527). Mol Cell Biol 11: 5832-5838.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 5832-5838
-
-
Cobb, B.S.1
Payne, D.M.2
Reynolds, A.B.3
Parsons, J.T.4
-
2
-
-
0032054723
-
Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
-
Ip YT, Davis RJ, (1998) Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr Opin Cell Biol 10: 205-219.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 205-219
-
-
Ip, Y.T.1
Davis, R.J.2
-
3
-
-
0031817208
-
The p38 MAP kinase pathway and its biological function
-
New L, Han J, (1998) The p38 MAP kinase pathway and its biological function. Trends Cardiovasc Med 8: 220-228.
-
(1998)
Trends Cardiovasc Med
, vol.8
, pp. 220-228
-
-
New, L.1
Han, J.2
-
4
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
-
Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, et al. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22: 153-183.
-
(2001)
Endocr Rev
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
-
5
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
-
Johnson GL, Lapadat R, (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298: 1911-1912.
-
(2002)
Science
, vol.298
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
6
-
-
0027424403
-
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14
-
Han J, Lee JD, Tobias PS, Ulevitch RJ, (1993) Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem 268: 25009-25014.
-
(1993)
J Biol Chem
, vol.268
, pp. 25009-25014
-
-
Han, J.1
Lee, J.D.2
Tobias, P.S.3
Ulevitch, R.J.4
-
7
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han J, Lee JD, Bibbs L, Ulevitch RJ, (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811.
-
(1994)
Science
, vol.265
, pp. 808-811
-
-
Han, J.1
Lee, J.D.2
Bibbs, L.3
Ulevitch, R.J.4
-
8
-
-
0029790656
-
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
-
Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, et al. (1996) FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J 15: 4629-4642.
-
(1996)
EMBO J
, vol.15
, pp. 4629-4642
-
-
Tan, Y.1
Rouse, J.2
Zhang, A.3
Cariati, S.4
Cohen, P.5
-
9
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739-746.
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
-
10
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta), J Biol Chem
-
Jiang Y, Chen C, Li Z, Guo W, Gegner JA, et al. (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta), J Biol Chem. 271: 17920-17926.
-
(1996)
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
Chen, C.2
Li, Z.3
Guo, W.4
Gegner, J.A.5
-
11
-
-
0029911710
-
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation
-
Lechner C, Zahalka MA, Giot JF, Moller NP, Ullrich A, (1996) ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc Natl Acad Sci U S A 93: 4355-4359.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 4355-4359
-
-
Lechner, C.1
Zahalka, M.A.2
Giot, J.F.3
Moller, N.P.4
Ullrich, A.5
-
12
-
-
0030581626
-
The primary structure of p38 gamma: a new member of p38 group of MAP kinases
-
Li Z, Jiang Y, Ulevitch RJ, Han J, (1996) The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun 228: 334-340.
-
(1996)
Biochem Biophys Res Commun
, vol.228
, pp. 334-340
-
-
Li, Z.1
Jiang, Y.2
Ulevitch, R.J.3
Han, J.4
-
13
-
-
0030828701
-
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases
-
Jiang Y, Gram H, Zhao M, New L, Gu J, et al. (1997) Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases. p38delta, J Biol Chem 272: 30122-30128.
-
(1997)
P38delta, J Biol Chem
, vol.272
, pp. 30122-30128
-
-
Jiang, Y.1
Gram, H.2
Zhao, M.3
New, L.4
Gu, J.5
-
14
-
-
0031587929
-
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
-
Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, et al. (1997) Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun 235: 533-538.
-
(1997)
Biochem Biophys Res Commun
, vol.235
, pp. 533-538
-
-
Kumar, S.1
McDonnell, P.C.2
Gum, R.J.3
Hand, A.T.4
Lee, J.C.5
-
15
-
-
27944461325
-
Generation and characterization of p38beta (MAPK11) gene-targeted mice
-
Beardmore VA, Hinton HJ, Eftychi C, Apostolaki M, Armaka M, et al. (2005) Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol 25: 10454-10464.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10454-10464
-
-
Beardmore, V.A.1
Hinton, H.J.2
Eftychi, C.3
Apostolaki, M.4
Armaka, M.5
-
16
-
-
20244365497
-
p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
-
Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, et al. (2005) p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J 24: 1134-1145.
-
(2005)
EMBO J
, vol.24
, pp. 1134-1145
-
-
Sabio, G.1
Arthur, J.S.2
Kuma, Y.3
Peggie, M.4
Carr, J.5
-
17
-
-
0034641614
-
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
-
Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, et al. (2000) Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A 97: 10454-10459.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10454-10459
-
-
Mudgett, J.S.1
Ding, J.2
Guh-Siesel, L.3
Chartrain, N.A.4
Yang, L.5
-
18
-
-
0034610981
-
Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
-
Allen M, Svensson L, Roach M, Hambor J, McNeish J, et al. (2000) Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med 191: 859-870.
-
(2000)
J Exp Med
, vol.191
, pp. 859-870
-
-
Allen, M.1
Svensson, L.2
Roach, M.3
Hambor, J.4
McNeish, J.5
-
19
-
-
0033622470
-
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
-
Adams RH, Porras A, Alonso G, Jones M, Vintersten K, et al. (2000) Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 6: 109-116.
-
(2000)
Mol Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
Porras, A.2
Alonso, G.3
Jones, M.4
Vintersten, K.5
-
20
-
-
18844383961
-
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
-
Engel FB, Schebesta M, Duong MT, Lu G, Ren S, et al. (2005) p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 19: 1175-1187.
-
(2005)
Genes Dev
, vol.19
, pp. 1175-1187
-
-
Engel, F.B.1
Schebesta, M.2
Duong, M.T.3
Lu, G.4
Ren, S.5
-
21
-
-
0031934170
-
Pharmacological effects of SB 220025, a selective inhibitor of p38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
-
Jackson JR, Bolognese B, Hillegass L, Kassis S, Adams J, et al. (1998) Pharmacological effects of SB 220025, a selective inhibitor of p38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J Pharmacol Exp Ther 284: 687-692.
-
(1998)
J Pharmacol Exp Ther
, vol.284
, pp. 687-692
-
-
Jackson, J.R.1
Bolognese, B.2
Hillegass, L.3
Kassis, S.4
Adams, J.5
-
22
-
-
0034121690
-
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
-
Badger AM, Griswold DE, Kapadia R, Blake S, Swift BA, et al. (2000) Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis Rheum 43: 175-183.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 175-183
-
-
Badger, A.M.1
Griswold, D.E.2
Kapadia, R.3
Blake, S.4
Swift, B.A.5
-
23
-
-
0034651730
-
Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation
-
Nick JA, Young SK, Brown KK, Avdi NJ, Arndt PG, et al. (2000) Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J Immunol 164: 2151-2159.
-
(2000)
J Immunol
, vol.164
, pp. 2151-2159
-
-
Nick, J.A.1
Young, S.K.2
Brown, K.K.3
Avdi, N.J.4
Arndt, P.G.5
-
24
-
-
13844288120
-
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
-
Underwood DC, Osborn RR, Bochnowicz S, Webb EF, Rieman DJ, et al. (2000) SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am J Physiol Lung Cell Mol Physiol 279: 895-902.
-
(2000)
Am J Physiol Lung Cell Mol Physiol
, vol.279
, pp. 895-902
-
-
Underwood, D.C.1
Osborn, R.R.2
Bochnowicz, S.3
Webb, E.F.4
Rieman, D.J.5
-
25
-
-
77953236170
-
The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss
-
Bohm C, Hayer S, Kilian A, Zaiss MM, Finger S, et al. (2009) The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol 183: 5938-5947.
-
(2009)
J Immunol
, vol.183
, pp. 5938-5947
-
-
Bohm, C.1
Hayer, S.2
Kilian, A.3
Zaiss, M.M.4
Finger, S.5
-
26
-
-
0037307476
-
Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis
-
Stambe C, Atkins RC, Tesch GH, Kapoun AM, Hill PA, et al. (2003) Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis. J Am Soc Nephrol 14: 338-351.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 338-351
-
-
Stambe, C.1
Atkins, R.C.2
Tesch, G.H.3
Kapoun, A.M.4
Hill, P.A.5
-
27
-
-
34047205066
-
Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6
-
Sheryanna A, Bhangal G, McDaid J, Smith J, Manning A, et al. (2007) Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6. J Am Soc Nephrol 18: 1167-1179.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1167-1179
-
-
Sheryanna, A.1
Bhangal, G.2
McDaid, J.3
Smith, J.4
Manning, A.5
-
28
-
-
66049086274
-
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies
-
Damjanov N, Kauffman RS, Spencer-Green GT, (2009) Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum 60: 1232-1241.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1232-1241
-
-
Damjanov, N.1
Kauffman, R.S.2
Spencer-Green, G.T.3
-
29
-
-
34347211015
-
Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium
-
Asgeirsdottir SA, Kamps JA, Bakker HI, Zwiers PJ, Heeringa P, et al. (2007) Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium. Mol Pharmacol 72: 121-131.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 121-131
-
-
Asgeirsdottir, S.A.1
Kamps, J.A.2
Bakker, H.I.3
Zwiers, P.J.4
Heeringa, P.5
-
30
-
-
0346103699
-
Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis
-
Moeller MJ, Soofi A, Hartmann I, Le Hir M, Wiggins R, et al. (2004) Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis. J Am Soc Nephrol 15: 61-67.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 61-67
-
-
Moeller, M.J.1
Soofi, A.2
Hartmann, I.3
Le Hir, M.4
Wiggins, R.5
-
31
-
-
32644455295
-
Podocyte involvement in human immune crescentic glomerulonephritis
-
Bariety J, Bruneval P, Meyrier A, Mandet C, Hill G, et al. (2005) Podocyte involvement in human immune crescentic glomerulonephritis. Kidney Int 68: 1109-1119.
-
(2005)
Kidney Int
, vol.68
, pp. 1109-1119
-
-
Bariety, J.1
Bruneval, P.2
Meyrier, A.3
Mandet, C.4
Hill, G.5
-
32
-
-
0031563832
-
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
-
Mundel P, Reiser J, Zuniga Mejia Borja A, Pavenstadt H, Davidson GR, et al. (1997) Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236: 248-258.
-
(1997)
Exp Cell Res
, vol.236
, pp. 248-258
-
-
Mundel, P.1
Reiser, J.2
Zuniga Mejia Borja, A.3
Pavenstadt, H.4
Davidson, G.R.5
-
33
-
-
0033048645
-
Expression of interferon-inducible Mx-proteins in patients with IgA nephropathy or Henoch-Schonlein purpura
-
Floege J, Burg M, Al Masri AN, Grone HJ, von Wussow P, (1999) Expression of interferon-inducible Mx-proteins in patients with IgA nephropathy or Henoch-Schonlein purpura. Am J Kidney Dis 33: 434-440.
-
(1999)
Am J Kidney Dis
, vol.33
, pp. 434-440
-
-
Floege, J.1
Burg, M.2
Al Masri, A.N.3
Grone, H.J.4
von Wussow, P.5
-
34
-
-
0037302877
-
Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice
-
Schneider A, Zhang Y, Guan Y, Davis LS, Breyer MD, (2003) Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice. Am J Physiol Renal Physiol 284: 411-417.
-
(2003)
Am J Physiol Renal Physiol
, vol.284
, pp. 411-417
-
-
Schneider, A.1
Zhang, Y.2
Guan, Y.3
Davis, L.S.4
Breyer, M.D.5
-
35
-
-
0026066556
-
Initiation and evolution of interstitial leukocytic infiltration in experimental glomerulonephritis
-
Lan HY, Paterson DJ, Atkins RC, (1991) Initiation and evolution of interstitial leukocytic infiltration in experimental glomerulonephritis. Kidney Int 40: 425-433.
-
(1991)
Kidney Int
, vol.40
, pp. 425-433
-
-
Lan, H.Y.1
Paterson, D.J.2
Atkins, R.C.3
-
36
-
-
42449162927
-
Selective p38MAPK isoform expression and activation in antineutrophil cytoplasmatic antibody-associated crescentic glomerulonephritis: role of p38MAPKalpha
-
Polzer K, Soleiman A, Baum W, Axmann R, Distler J, et al. (2008) Selective p38MAPK isoform expression and activation in antineutrophil cytoplasmatic antibody-associated crescentic glomerulonephritis: role of p38MAPKalpha. Ann Rheum Dis 67: 602-608.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 602-608
-
-
Polzer, K.1
Soleiman, A.2
Baum, W.3
Axmann, R.4
Distler, J.5
-
37
-
-
0942298030
-
p38 Mitogen-activated protein kinase activation and cell localization in human glomerulonephritis: correlation with renal injury
-
Stambe C, Nikolic-Paterson DJ, Hill PA, Dowling J, Atkins RC, (2004) p38 Mitogen-activated protein kinase activation and cell localization in human glomerulonephritis: correlation with renal injury. J Am Soc Nephrol 15: 326-336.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 326-336
-
-
Stambe, C.1
Nikolic-Paterson, D.J.2
Hill, P.A.3
Dowling, J.4
Atkins, R.C.5
-
38
-
-
0942287102
-
The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis
-
Stambe C, Atkins RC, Tesch GH, Masaki T, Schreiner GF, et al. (2004) The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis. J Am Soc Nephrol 15: 370-379.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 370-379
-
-
Stambe, C.1
Atkins, R.C.2
Tesch, G.H.3
Masaki, T.4
Schreiner, G.F.5
-
39
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs WH, Treiber DK, Atteridge CE, Azimioara MD, et al. (2005) A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol 23: 329-336.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs, W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
-
40
-
-
0035229054
-
Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis
-
Song GY, Chung CS, Jarrar D, Chaudry IH, Ayala A, (2001) Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis. Shock 15: 42-48.
-
(2001)
Shock
, vol.15
, pp. 42-48
-
-
Song, G.Y.1
Chung, C.S.2
Jarrar, D.3
Chaudry, I.H.4
Ayala, A.5
-
41
-
-
78751702875
-
Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo
-
2011 Feb
-
van der Veen BS, Chen M, Müller R, van Timmeren MM, Petersen AH, et al. (2011) Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo. Ann Rheum Dis. 2011 Feb 70(2): 356-65.
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.2
, pp. 356-365
-
-
van der Veen, B.S.1
Chen, M.2
Müller, R.3
van Timmeren, M.M.4
Petersen, A.H.5
|