Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice

American Journal of Physiology - Renal Physiology

Volumn 284, Issue 2 53-2, 2003, Pages

  Schneider, André ^a   Zhang, Yahua ^b   Guan, Youfei ^b   Davis, Linda S ^b   Breyer, Matthew D ^b,c,d  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Collecting duct; Cre recombinase; Glomerulus; Interstitium; Liver; Spleen

Indexed keywords

BETA GALACTOSIDASE; CRE RECOMBINASE; DNA; GALACTOSIDASE; INTERFERON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE DELETION; GENE TARGETING; GENETIC RECOMBINATION; GENOTYPE; GLOMERULUS; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY EPITHELIUM; LIVER; MESANGIUM; MOUSE; NONHUMAN; PODOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPLEEN; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM;

EID: 0037302877     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00235.2002     Document Type: Article

References (23)

1. Arnheiter H, Skuntz S, Noteborn M, Chang S, and Meier E. Transgenic mice with intracellular immunity to influenza virus. Cell 62: 51-61, 1990.
2. Ave P, Colucci-Guyon E, Babinet C, and Huerre MR. An improved method to detect beta-galactosidase activity in transgenic mice: a post-staining procedure on paraffin embedded tissue sections. Transgenic Res 6: 37-40, 1997.
3. Betz U, Block W, van den Broek M, Yoshida K, Taga T, Kishimoto T, Addicks K, Rajewsky K, and Müller W. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic and pulmonary defects. J Exp Med 188: 1955-1965, 1998.
4. Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, and Sigmund CD. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 272: 28142-28148, 1997.
5. Floege J, Burg M, Al Masri AN, Grone HJ, and von Wussow P. Expression of interferon-inducible Mx-proteins in patients with IgA nephropathy or Henoch-Schonlein purpura. Am J Kidney Dis 33: 434-440, 1999.
6. 2 receptor in acute regulation of aquaporin-2. Kidney Blood Press Res 19: 32-37, 1996.
7. Horisberger MA and De Staritzky K. Expression and stability of the Mx protein in different tissues of mice, in response to interferon inducers or to influenza virus infection. J Interferon Res 9: 583-590, 1989.
8. Hoyer JR, Sisson SP, and Vernier RL. Tamm-Horsfall glycoprotein: ultrastructural immunoperoxidase localization in rat kidney. Lab Invest 41: 168-173, 1979.
9. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, and Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
10. Kuhn R, Schwenk F, Aguet M, and Rajewsky K. Inducible gene targeting in mice. Science 269: 1427-1429, 1995.
11. Laitinen L, Virtanen I, and Saxen L. Changes in the glycosylation pattern during embryonic development of mouse kidney as revealed with lectin conjugates. J Histochem Cytochem 35: 55-65, 1987.
12. Nelson RD, Stricklett P, Gustafson C, Stevens A, Ausiello D, Brown D, and Kohan DE. Expression of an AQP2 Cre recombinase transgene in kidney and male reproductive system of transgenic mice. Am J Physiol Cell Physiol 275: C216-C226, 1998.
13. Robert B, St John PL, and Abrahamson DR. Direct visualization of renal vascular morphogenesis in Flk1 heterozygous mutant mice. Am J Physiol Renal Physiol 275: F164-F172, 1998.
14. Rohlmann A, Gotthardt M, Hammer RE, and Herz J. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest 101: 689-695, 1998.
15. Sauer B and Henderson N. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci USA 85: 5166-5170, 1988.
16. Sepulveda AR, Huang SL, Lebovitz RM, and Lieberman MW. A 346-base pair region of the mouse gamma-glutamyl transpeptidase type II promoter contains sufficient cis-acting elements for kidney-restricted expression in transgenic mice. J Biol Chem 272: 11959-11967, 1997.
17. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71, 1999.
18. Stec DE and Sigmund CD. Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. Exp Nephrol 6: 568-575, 1998.
19. Sternberg N and Hamilton D. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J Mol Biol 150:467-486, 1981.
20. St-Onge L, Furth PA, and Gruss P. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic Acids Res 24: 3875-3877, 1996.
21. Stricklett PK, Nelson RD, and Kohan DE. The Cre/loxP system and gene targeting in the kidney. Am J Physiol Renal Physiol 276: F651-F657, 1999.
22. Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, and Soriano P. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci USA 94: 3789-3794, 1997.
23. Zhu X, Cheng J, Gao J, Lepor H, Zhang ZT, Pak J, and Wu XR. Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic mice. Am J Physiol Renal Physiol 282: F608-F617, 2002.