Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways

Journal of Ethnopharmacology

Volumn 146, Issue 1, 2013, Pages 379-392

  Wang, Jun ^a,b   Lu, Jingli ^a   Lan, Yan ^a   Zhou, Hong ^a   Li, Weijie ^a   Xiang, Ming ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Autoimmune diabetes; Dendritic cell; Regulatory T cell; TLR4 signaling pathways; Total coumarins; Urtica dentata Hand

Indexed keywords

BETA INTERFERON; COUMARIN DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; SODIUM CHLORIDE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; DIABETES MELLITUS; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ISOLATION; DRUG MEGADOSE; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; IMMUNOREGULATION; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LOW DRUG DOSE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLANT ROOT; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; THYMUS; TREATMENT DURATION; URTICA; URTICA DENTATA;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; COUMARINS; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOLOGIC FACTORS; MICE; MICE, INBRED NOD; PANCREAS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND; TOLL-LIKE RECEPTOR 4; URTICACEAE;

LAPORTEA; MURINAE; MUS; URTICA;

EID: 84874105384     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.01.009     Document Type: Article

References (61)

1. S. Abdollahi-Roodsaz, L.A. Joosten, M.F. Roelofs, T.R. Radstake, G. Matera, C. Popa, J.W. van der Meer, M.G. Netea, and W.B. van den Berg Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis Arthritis & Rheumatism 56 2007 2957 2967
2. M. Battaglia, and M.G. Roncarolo Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes Seminars in Immunology 23 2011 182 194
3. H. Björkbacka, K.A. Fitzgerald, F. Huet, X. Li, J.A. Gregory, M.A. Lee, C.M. Ordija, N.E. Dowley, D.T. Golenbock, and M.W. Freeman The induction of macrophage gene expression by LPS predominantly utilizes Myd88- independentsignaling cascades Physiological Genomics 19 2004 319 330
4. J.A. Bluestone, K. Herold, and G. Eisenbarth Genetics, pathogenesis and clinical interventions in type 1 diabetes Nature 464 2010 1293 1300
5. I. Caramalho, T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide Journal of Experimental Medicine 197 2003 403 411
6. S. Carpenter, and L.A. O'Neill Recent insights into the structure of toll-like receptors and post-translational modifications of their associated signalling proteins Biochemical Journal 422 2009 1 10
7. D. Cheatem, B.B. Ganesh, E. Gangi, C. Vasu, and B.S. Prabhakar Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function. Clinical Immunology 131 2009 260 270
8. J. Dai, B. Liu, and Z. Li Regulatory T cells and toll-like receptors: what is the missing link? International Immunopharmacology 9 2009 528 533
9. J. Dai, B. Liu, S.M. Ngoi, S. Sun, A.T. Vella, and Z. Li TLR4 hyper responsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells. Journal of Immunology 178 2007 3219 3225
10. S. Devaraj, M.R. Dasu, S.H. Park, and I. Jialal Increased levels of ligands of toll-like receptors 2 and 4 in type 1 diabetes Diabetologia 52 2009 1665 1668
11. S. Devaraj, M.R. Dasu, J. Rockwood, W. Winter, S.C. Griffen, and I. Jialal Increased toll like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state Journal of Clinical Endocrinology & Metabolism 93 2008 578 583
12. S. Devaraj, I. Jialal, J.M. Yun, and A. Bremer Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications Metabolism 60 2010 256 259
13. S. Devaraj, P. Tobias, and I. Jialal Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes Cytokine 55 2011 441 445
14. J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nature Immunology 4 2003 330 336
15. M. Gambuzza, N. Licata, E. Palella, D. Celi, V. Foti Cuzzola, D. Italiano, S. Marino, and P. Bramanti Targeting toll-like receptors: emerging therapeutics for multiple sclerosis management Journal of Neuroimmunology 239 2011 1 12
16. Y. Gao, X. Fang, H. Sun, Y. Wang, L.J. Yao, J.P. Li, Y. Tong, B. Zhang, and Y. Liu Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice Biological and Pharmaceutical Bulletin 32 2009 1665 1671
17. E.A. Green, L. Gorelik, C.M. McGregor, E.H. Tran, and R.A. Flavell CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes Proceedings of the National Academy of Sciences of the United States of America 100 2003 10878 10883
18. R.K. Gregg, R. Jain, S.J. Schoenleber, R. Divekar, J.J. Bell, H.H. Lee, P. Yu, and H. Zaghouani A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes Journal of Immunology 173 2004 7308 7316
19. S. Gregori Dendritic cells in networks of immunological tolerance Tissue Antigens 77 2011 89 99
20. B. Han, P. Serra, A. Amrani, J. Yamanouchi, A.F. Marée, L. Edelstein-Keshet, and P. Santamaria Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide Nature Medicine 11 2005 645 652
21. Y.J. Hong, N. Kim, K. Lee, C. Hee Sonn, J. Eun Lee, S. Tae Kim, I. Ho Baeg, and K.M. Lee Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments Journal of Ethnopharmacology 144 2012 225 233
22. W.R. Hou, Z.Q. Su, H.F. Pi, G.M. Yao, P. Zhang, X. Luo, S.N. Xie, and M. Xiang Immunosuppressive constituents from Urtica dentata Hand Journal of Asian Natural Products Research 12 2010 707 713
23. Y. Huang, M. Parker, C. Xia, R. Peng, C. Wasserfall, T. Clarke, L. Wu, T. Chowdhry, M. Campbell-Thompson, J. Williams, M. Clare-Salzler, M.A. Atkinson, and K.L. Womer Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses Journal of Immunology 182 2009 4608 4615
24. A. Iwasaki, and R. Medzhitov Toll-like receptor control of the adaptive immune responses Nature Immunology 5 2004 987 995
25. M. Knip, and H. Siljander Autoimmune mechanisms in type 1 diabetes Autoimmunity Reviews 7 2008 550 557
26. M. Knip Pathogenesis of type 1 diabetes: implications for incidence trends Hormone Research in Paediatrics 76 2011 57 64
27. T. Krueger, U. Wohlrab, M. Klucken, M. Schott, and J. Seissler Autoantigenspecific protection of non-obese diabetic mice from cyclophosphamideaccelerated diabetes by vaccination with dendritic cells Diabetologia 46 2003 1357 1365
28. M. Li, L. Song, X. Gao, W. Chang, and X. Qin Toll-like receptor 4 on β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes Experimental and Molecular Medicine 44 2012 260 267
29. S. Lindley, C.M. Dayan, A. Bishop, B.O. Roep, M. Peakman, and T.I. Tree Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes Diabetes 54 2005 92 99
30. X. Luo, L.L. Li, S.S. Zhang, J.L. Lu, Y. Zeng, H.Y. Zhang, and M. Xiang Therapeutic effects of total coumarins from Urtica dentata Hand on collagen-induced arthritis in Balb/c mice Journal of Ethnopharmacology 138 2011 523 529
31. D. Ly, R. Tohn, B. Rubin, H. Blumenfeld, G.S. Besra, N. Veerapen, S.A. Porcelli, and T.L. Delovitch An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes Clinical & Experimental Immunology 160 2010 185 198
32. R. Medzhitov, P. Preston-Hurlburt, and C.A. Janeway Jr A human homologue of the Drosophila toll protein signals activation of adaptive immunity Nature 388 1997 394 397
33. A.F. McGettrick, and L.A. O'Neill Localisation and trafficking of toll-like receptors: an important mode of regulation Current Opinion in Immunology 22 2010 20 27
34. O. Odumosu, D. Nicholas, K. Payne, and W. Langridge Cholera toxin B subunit linked to glutamic acid decarboxylase suppresses dendritic cell maturation and function Vaccine 29 2011 8451 8458
35. S.K. Pathak, A.E. Sköld, V. Mohanram, C. Persson, U. Johansson, and A.L. Spetz Activated apoptotic cells induce dendritic cell maturation via engagement of toll-like receptor 4 (TLR4), DC-SIGN and beta-2 integrins Journal of Biological Chemistry 287 2012 13731 13742
36. M.J. Perone, S. Bertera, W.J. Shufesky, S.J. Divito, A. Montecalvo, A.R. Mathers, A.T. Larregina, M. Pang, N. Seth, K.W. Wucherpfennig, M. Trucco, L.G. Baum, and A.E. Morelli Suppression of autoimmune diabetes by soluble galectin-1 Journal of Immunology 182 2009 2641 2653
37. C. Petzold, J. Riewaldt, T. Koenig, S. Schallenberg, and K. Kretschmer Dendritic cell-targeted pancreatic beta-cell antigen leads to conversion of self-reactive CD4(+) T cells into regulatory T cells and promotes immunotolerance in NOD mice Review of Diabetic Studies 7 2010 47 61
38. B.E. Phillips, and M. Trucco Immunotherapy-based strategies for the treatment of autoimmune diabetes: searching for the cure Current Pharmaceutical Design 17 2011 3217 3223
39. S.M. Pop, C.P. Wong, D.A. Culton, S.H. Clarke, and R. Tisch Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes Journal of Experimental Medicine 201 2005 1333 1346
40. I.R. Rifkin, E.A. Leadbetter, L. Busconi, G. Viglianti, and A. Marshak-Rothstein Toll-like receptors, endogenous ligands, and systemic autoimmune disease Immunological Reviews 204 2005 27 42
41. S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono Regulatory T cells and immune tolerance Cell 133 2008 775 787
42. K. Sato, and S. Fujita Dendritic cells: nature and classification Allergology International 56 2007 183 191
43. E. Sgouroudis, and C.A. Piccirillo Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease Diabetes/Metabolism Research and Reviews 25 2009 208 218
44. J. Tellier, J.P. van Meerwijk, and P. Romagnoli An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes International Immunology 18 2006 1509 1519
45. K.E. Thomas, C.L. Galligan, R.D. Newman, E.N. Fish, and S.N. Vogel Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide Journal of Biological Chemistry 281 2006 31119 31130
46. V. Verhasselt, W. Vanden Berghe, N. Vanderheyde, F. Willems, G. Haegeman, and M. Goldman N-acetyl-l-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition Journal of Immunology 162 1999 2569 2574
47. D.A. Vignali, L.W. Collison, and C.J. Workman How regulatory T cells work Nature Reviews Immunology 8 2008 523 532
48. F.A. Villa, K. Lieske, and L. Gerwick Selective MyD88-dependent pathway inhibition by the cyanobacterial natural product malyngamide F acetate European Journal of Pharmacology 629 2010 140 146
49. H. Waldner, M. Collins, and V.K. Kuchroo Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease Journal of Clinical Investigation 113 2004 990 997
50. D.R. Wan, J.C. Chen, and H.H. Yu Urtica dentata Hand S.X. Fu, Flora Hupehensis Tomus second ed. 2002 Hubei Science and Technology Publisher Wuhan 234 238
51. X. Wang, A. Zhang, Y. Liu, S. Chen, Z. Feng, W. Shang, M. Maziarz, J. Radtke, and C.S. Hampe Anti-idiotypic antibody specific to GAD65 autoantibody prevents type 1 diabetes in the NOD mouse PLoS One 7 2012 e32515
52. L. Williams, and A. Rudensky Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 Nature Immunology 8 2007 277 284
53. M. Xiang, W.R. Hou, S.N. Xie, W.D. Zhang, and X. Wang Immunosuppressive effects of an ethyl acetate extract from Urtica dentata Hand onskin allograft rejection Journal of Ethnopharmacology 126 2009 57 63
54. M. Xiang, S. Zhang, J. Lu, L. Li, W. Hou, M. Xie, and Y. Zeng Antilithic effects of extracts from Urtica dentata Hand on calcium oxalate urinarystones in rats Journal of Huazhong University of Science and Technology 31 2011 673 677
55. M. Xue, S. Dervish, L.C. Harrison, G. Fulcher, and C.J. Jackson Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells and prevents diabetes in NOD mice Journal of Biological Chemistry 287 2012 16356 16364
56. M. Yamamoto, S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, T. Kaisho, O. Takeuchi, K. Takeda, and S. Akira TRAM is specifically involved in the toll-like receptor 4-mediated MyD88-independent signaling pathway Nature Immunology 4 2003 1144 1150
57. Y. Yi, S.T. Liao, M.W. Zhang, J. Shi, R.F. Zhang, Y.Y. Deng, and Z.C. Wei Physicochemical characteristics and immunomodulatory activities of three polysaccharide protein complexes of longan pulp Molecules 16 2011 6148 6164
58. S. You, M. Belghith, S. Cobbold, M.A. Alyanakian, C. Gouarin, S. Barriot, C. Garcia, H. Waldmann, J.F. Bach, and L. Chatenoud Autoimmune diabetes onset results from qualitative rather than quantitative age dependent changes in pathogenic T-cells Diabetes 54 2005 1415 1422
59. H.S. Youn, J.Y. Lee, K.A. Fitzgerald, H.A. Young, S. Akira, and D.H. Hwang Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex Journal of Immunology 175 2005 3339 3346
60. N. Zhang, B. Krüger, G. Lal, Y. Luan, A. Yadav, W. Zang, M. Grimm, A.M. Waaga-Gasser, B. Murphy, J.S. Bromberg, and B. Schröppel Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival Immunology Letters 127 2010 119 125
61. X. Zhou, S.L. Bailey-Bucktrout, L.T. Jeker, C. Penaranda, M. Martínez-Llordella, M. Ashby, M. Nakayama, W. Rosenthal, and J.A. Bluestone Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo Nature Immunology 10 2009 1000 1007