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Volumn 287, Issue 17, 2012, Pages 13731-13742

Activated apoptotic cells induce dendritic cell maturation via engagement of toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)- grabbing nonintegrin (DC-SIGN), and β2 integrins

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELLS; APOPTOTIC; APOPTOTIC CELLS; COCULTURE; COMPLEX INTERACTION; DENDRITIC CELLS; FUNCTIONAL CHANGES; HUMAN SERUM ALBUMINS; INTEGRINS; INTERCELLULAR ADHESION MOLECULES; NEUTRALIZING ANTIBODIES; PERIPHERAL LYMPHOCYTES; SIGNALING PATHWAYS; SPLENOCYTES; SRC-FAMILY KINASE; SUPERNATANT FRACTIONS; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTORS; UP-REGULATION;

EID: 84859952564     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.336545     Document Type: Article
Times cited : (36)

References (62)
  • 1
    • 17644370329 scopus 로고    scopus 로고
    • Cell biology of antigen processing in vitro and in vivo
    • DOI 10.1146/annurev.immunol.22.012703.104538
    • Trombetta, E. S., and Mellman, I. (2005) Cell biology of antigen processing in vitro and in vivo. Annu. Rev. Immunol. 23, 975-1028 (Pubitemid 40563191)
    • (2005) Annual Review of Immunology , vol.23 , pp. 975-1028
    • Trombetta, E.S.1    Mellman, I.2
  • 3
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar, H., Kawai, T., and Akira, S. (2011) Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30, 16-34
    • (2011) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 4
    • 67649840704 scopus 로고    scopus 로고
    • Signaling through C-type lectin receptors: Shaping immune responses
    • Geijtenbeek, T. B., and Gringhuis, S. I. (2009) Signaling through C-type lectin receptors: shaping immune responses. Nat. Rev. Immunol. 9, 465-479
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 465-479
    • Geijtenbeek, T.B.1    Gringhuis, S.I.2
  • 5
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • DOI 10.1038/nri2215, PII NRI2215
    • Kono, H., and Rock, K. L. (2008) How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8, 279-289 (Pubitemid 351432799)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.4 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 9
    • 0002440574 scopus 로고    scopus 로고
    • Antigen-induced death of T-lymphocytes
    • Kabelitz, D., and Janssen, O. (1997) Antigen-induced death of T-lymphocytes. Front. Biosci. 2, d61-d77
    • (1997) Front. Biosci. , vol.2
    • Kabelitz, D.1    Janssen, O.2
  • 10
    • 0034614886 scopus 로고    scopus 로고
    • The induction of tolerance by dendritic cells that have captured apoptotic cells
    • Steinman, R. M., Turley, S., Mellman, I., and Inaba, K. (2000) The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191, 411-416
    • (2000) J. Exp. Med. , vol.191 , pp. 411-416
    • Steinman, R.M.1    Turley, S.2    Mellman, I.3    Inaba, K.4
  • 11
    • 0034795821 scopus 로고    scopus 로고
    • Phagocyte receptors for apoptotic cells: Recognition, uptake, and consequences
    • DOI 10.1172/JCI200114122
    • Fadok, V. A., Bratton, D. L., and Henson, P. M. (2001) Phagocyte receptors for apoptotic cells. Recognition, uptake, and consequences. J. Clin. Invest. 108, 957-962 (Pubitemid 32946068)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.7 , pp. 957-962
    • Fadok, V.A.1    Bratton, D.L.2    Henson, P.M.3
  • 12
    • 0037438495 scopus 로고    scopus 로고
    • Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells. Dependence on complement receptors and effect on cytokine production
    • Morelli, A. E., Larregina, A. T., Shufesky, W. J., Zahorchak, A. F., Logar, A. J., Papworth, G. D., Wang, Z., Watkins, S. C., Falo, L. D., Jr., and Thomson, A. W. (2003) Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells. Dependence on complement receptors and effect on cytokine production. Blood 101, 611-620
    • (2003) Blood , vol.101 , pp. 611-620
    • Morelli, A.E.1    Larregina, A.T.2    Shufesky, W.J.3    Zahorchak, A.F.4    Logar, A.J.5    Papworth, G.D.6    Wang, Z.7    Watkins, S.C.8    Falo Jr., L.D.9    Thomson, A.W.10
  • 13
    • 0037083280 scopus 로고    scopus 로고
    • Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    • Stuart, L. M., Lucas, M., Simpson, C., Lamb, J., Savill, J., and Lacy-Hulbert, A. (2002) Inhibitory effects of apoptotic cell ingestion upon endotoxindriven myeloid dendritic cell maturation. J. Immunol. 168, 1627-1635 (Pubitemid 34135757)
    • (2002) Journal of Immunology , vol.168 , Issue.4 , pp. 1627-1635
    • Stuart, L.M.1    Lucas, M.2    Simpson, C.3    Lamb, J.4    Savill, J.5    Lacy-Hulbert, A.6
  • 17
    • 0041592513 scopus 로고    scopus 로고
    • Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells
    • DOI 10.1002/ijc.11243
    • Buttiglieri, S., Galetto, A., Forno, S., De Andrea, M., and Matera, L. (2003) Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells. Int. J. Cancer. 106, 516-520 (Pubitemid 36966207)
    • (2003) International Journal of Cancer , vol.106 , Issue.4 , pp. 516-520
    • Buttiglieri, S.1    Galetto, A.2    Forno, S.3    De Andrea, M.4    Matera, L.5
  • 18
    • 0036892577 scopus 로고    scopus 로고
    • Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells
    • DOI 10.1182/blood-2002-05-1389
    • Feng, H., Zeng, Y., Graner, M. W., and Katsanis, E. (2002) Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells. Blood 100, 4108-4115 (Pubitemid 35396879)
    • (2002) Blood , vol.100 , Issue.12 , pp. 4108-4115
    • Feng, H.1    Zeng, Y.2    Graner, M.W.3    Katsanis, E.4
  • 20
    • 0034235599 scopus 로고    scopus 로고
    • Generation of tumor-specific T lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells
    • Hoffmann, T. K., Meidenbauer, N., Dworacki, G., Kanaya, H., and Whiteside, T. L. (2000) Generation of tumor-specific T-lymphocytes by crosspriming with human dendritic cells ingesting apoptotic tumor cells. Cancer Res. 60, 3542-3549 (Pubitemid 30482175)
    • (2000) Cancer Research , vol.60 , Issue.13 , pp. 3542-3549
    • Hoffmann, T.K.1    Meidenbauer, N.2    Dworacki, G.3    Kanaya, H.4    Whiteside, T.L.5
  • 22
    • 0042807616 scopus 로고    scopus 로고
    • Dendritic cell maturation induced by delivery of ultraviolet-mediated apoptotic colorectal cancer cell lines
    • Ishii, S., Hiroishi, K., Eguchi, J., and Mitamura, K. (2003) Dendritic cell maturation induced by delivery of ultraviolet-mediated apoptotic colorectal cancer cell lines. Anticancer Res. 23, 2457-2463 (Pubitemid 36897115)
    • (2003) Anticancer Research , vol.23 , Issue.3 B , pp. 2457-2463
    • Ishii, S.1    Hiroishi, K.2    Eguchi, J.-I.3    Mitamura, K.4
  • 25
    • 34548654130 scopus 로고    scopus 로고
    • Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs
    • Johansson, U., Walther-Jallow, L., Smed-Sörensen, A., and Spetz, A. L. (2007) Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs. J. Immunol. 179, 1711-1720
    • (2007) J. Immunol. , vol.179 , pp. 1711-1720
    • Johansson, U.1    Walther-Jallow, L.2    Smed-Sörensen, A.3    Spetz, A.L.4
  • 26
    • 76949089970 scopus 로고    scopus 로고
    • Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes
    • Brave, A., Johansson, U., Hallengärd, D., Heidari, S., Gullberg, H., Wahren, B., Hinkula, J., and Spetz, A. L. (2010) Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes. Vaccine 28, 2080-2087
    • (2010) Vaccine , vol.28 , pp. 2080-2087
    • Brave, A.1    Johansson, U.2    Hallengärd, D.3    Heidari, S.4    Gullberg, H.5    Wahren, B.6    Hinkula, J.7    Spetz, A.L.8
  • 28
    • 33644913374 scopus 로고    scopus 로고
    • Differential role of MAPK signaling in human dendritic cell maturation and Th1/Th2 engagement
    • DOI 10.1016/j.jdermsci.2005.11.004, PII S092318110500318X
    • Nakahara, T., Moroi, Y., Uchi, H., and Furue, M. (2006) Differential role of MAPK signaling in human dendritic cell maturation and Th1/Th2 engagement. J. Dermatol. Sci. 42, 1-11 (Pubitemid 43384125)
    • (2006) Journal of Dermatological Science , vol.42 , Issue.1 , pp. 1-11
    • Nakahara, T.1    Moroi, Y.2    Uchi, H.3    Furue, M.4
  • 29
    • 0242335086 scopus 로고    scopus 로고
    • Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation
    • DOI 10.1002/eji.200324073
    • Napolitani, G., Bortoletto, N., Racioppi, L., Lanzavecchia, A., and D'Oro, U. (2003) Activation of Src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. Eur. J. Immunol. 33, 2832-2841 (Pubitemid 37337149)
    • (2003) European Journal of Immunology , vol.33 , Issue.10 , pp. 2832-2841
    • Napolitani, G.1    Bortoletto, N.2    Racioppi, L.3    Lanzavecchia, A.4    D'Oro, U.5
  • 31
    • 17844375379 scopus 로고    scopus 로고
    • Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells
    • DOI 10.1016/j.exphem.2005.03.001
    • Xie, J., Qian, J., Yang, J., Wang, S., Freeman, M. E., 3rd, and Yi, Q. (2005) Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38MAPkinase in the differentiation and survival of monocyte-derived immature dendritic cells. Exp. Hematol. 33, 564-572 (Pubitemid 40592173)
    • (2005) Experimental Hematology , vol.33 , Issue.5 , pp. 564-572
    • Xie, J.1    Qian, J.2    Yang, J.3    Wang, S.4    Freeman III, M.E.5    Yi, Q.6
  • 32
    • 55549115035 scopus 로고    scopus 로고
    • Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-α and PGE2
    • Hu, Y., Park-Min, K. H., Yarilina, A., and Ivashkiv, L. B. (2008) Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-α and PGE2. J. Leukoc. Biol. 84, 1353-1360
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 1353-1360
    • Hu, Y.1    Park-Min, K.H.2    Yarilina, A.3    Ivashkiv, L.B.4
  • 33
  • 34
    • 0037111306 scopus 로고    scopus 로고
    • Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells
    • Spetz, A. L., Sörensen, A. S., Walther-Jallow, L., Wahren, B., Andersson, J., Holmgren, L., and Hinkula, J. (2002) Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells. J. Immunol. 169, 5771-5779 (Pubitemid 35291679)
    • (2002) Journal of Immunology , vol.169 , Issue.10 , pp. 5771-5779
    • Spetz, A.-L.1    Sorensen, A.S.2    Walther-Jallow, L.3    Wahren, B.4    Andersson, J.5    Holmgren, L.6    Hinkula, J.7
  • 35
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • DOI 10.1038/nature00858
    • Scaffidi, P., Misteli, T., and Bianchi, M. E. (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195 (Pubitemid 34773774)
    • (2002) Nature , vol.418 , Issue.6894 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 41
    • 77952888926 scopus 로고    scopus 로고
    • Dendritic cell activation by sensing Mycobacterium tuberculosis- induced apoptotic neutrophils via DC-SIGN
    • Hedlund, S., Persson, A., Vujic, A., Che, K. F., Stendahl, O., and Larsson, M. (2010) Dendritic cell activation by sensing Mycobacterium tuberculosis- induced apoptotic neutrophils via DC-SIGN. Hum. Immunol. 71, 535-540
    • (2010) Hum. Immunol. , vol.71 , pp. 535-540
    • Hedlund, S.1    Persson, A.2    Vujic, A.3    Che, K.F.4    Stendahl, O.5    Larsson, M.6
  • 42
    • 77950627537 scopus 로고    scopus 로고
    • Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    • van Stijn, C. M., Meyer, S., van den Broek, M., Bruijns, S. C., van Kooyk, Y., Geyer, R., and van Die, I. (2010) Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN. Mol. Immunol. 47, 1544-1552
    • (2010) Mol. Immunol. , vol.47 , pp. 1544-1552
    • Van Stijn, C.M.1    Meyer, S.2    Van Den Broek, M.3    Bruijns, S.C.4    Van Kooyk, Y.5    Geyer, R.6    Van Die, I.7
  • 43
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation. Sensing and reacting to damage
    • Chen, G. Y., and Nuñez, G. (2010) Sterile inflammation. Sensing and reacting to damage. Nat. Rev. Immunol. 10, 826-837
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nuñez, G.2
  • 45
    • 77955359472 scopus 로고    scopus 로고
    • Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists
    • Kuka, M., Baronio, R., Valentini, S., Monaci, E., Muzzi, A., Aprea, S., De Gregorio, E., and D'Oro, U. (2010) Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. PLoS One 5, e11491
    • (2010) PLoS One , vol.5
    • Kuka, M.1    Baronio, R.2    Valentini, S.3    Monaci, E.4    Muzzi, A.5    Aprea, S.6    De Gregorio, E.7    D'Oro, U.8
  • 46
    • 33646001132 scopus 로고    scopus 로고
    • NF-κB and the regulation of hematopoiesis
    • Bottero, V., Withoff S., and Verma, I. M. (2006) NF-κB and the regulation of hematopoiesis. Cell Death Differ. 13, 785-797
    • (2006) Cell Death Differ. , vol.13 , pp. 785-797
    • Bottero, V.1    Withoff, S.2    Verma, I.M.3
  • 47
    • 0141844653 scopus 로고    scopus 로고
    • Reciprocal modulation of toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
    • DOI 10.1074/jbc.M305213200
    • Lee, J. Y., Ye, J., Gao, Z., Youn, H. S., Lee, W. H., Zhao, L., Sizemore, N., and Hwang, D. H. (2003) Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J. Biol. Chem. 278, 37041-37051 (Pubitemid 37175218)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.39 , pp. 37041-37051
    • Lee, J.Y.1    Ye, J.2    Gao, Z.3    Youn, H.S.4    Lee, W.H.5    Zhao, L.6    Sizemore, N.7    Hwang, D.H.8
  • 48
    • 34248544993 scopus 로고    scopus 로고
    • C-Type Lectin DC-SIGN Modulates Toll-like Receptor Signaling via Raf-1 Kinase-Dependent Acetylation of Transcription Factor NF-κB
    • DOI 10.1016/j.immuni.2007.03.012, PII S1074761307002191
    • Gringhuis, S. I., den Dunnen, J., Litjens, M., van Het Hof, B., van Kooyk, Y., and Geijtenbeek, T. B. (2007) C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-κB. Immunity 26, 605-616 (Pubitemid 46756345)
    • (2007) Immunity , vol.26 , Issue.5 , pp. 605-616
    • Gringhuis, S.I.1    Den, D.J.2    Litjens, M.3    Van Het, H.B.4    Van Kooyk, Y.5    Geijtenbeek, T.B.H.6
  • 49
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • DOI 10.1038/32588
    • Banchereau, J., and Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252 (Pubitemid 28155090)
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 50
    • 0036715411 scopus 로고    scopus 로고
    • Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity?
    • DOI 10.1016/S1471-4906(02)02281-0, PII S1471490602022810
    • Lutz, M. B., and Schuler, G. (2002) Immature, semimature, and fully mature dendritic cells. Which signals induce tolerance or immunity? Trends Immunol. 23, 445-449 (Pubitemid 35015188)
    • (2002) Trends in Immunology , vol.23 , Issue.9 , pp. 445-449
    • Lutz, M.B.1    Schuler, G.2
  • 51
    • 33747362224 scopus 로고    scopus 로고
    • Dendritic cells matured with TNF can be further activated in vitro and after subcutaneous injection in vivo which converts their tolerogenicity into immunogenicity
    • DOI 10.1097/01.cji.0000210081.60178.b4, PII 0000237120060700000007
    • Voigtländer, C., Rössner, S., Cierpka, E., Theiner, G., Wiethe, C., Menges, M., Schuler, G., and Lutz, M. B. (2006) Dendritic cells matured with TNF can be further activated in vitro and after subcutaneous injection in vivo, which converts their tolerogenicity into immunogenicity. J. Immunother. 29, 407-415 (Pubitemid 44288953)
    • (2006) Journal of Immunotherapy , vol.29 , Issue.4 , pp. 407-415
    • Voigtlander, C.1    Rossner, S.2    Cierpka, E.3    Theiner, G.4    Wiethe, C.5    Menges, M.6    Schuler, G.7    Lutz, M.B.8
  • 54
    • 78649760576 scopus 로고    scopus 로고
    • The role of integrins in the recognition and response of dendritic cells to biomaterials
    • Rogers, T. H., and Babensee, J. E. (2011) The role of integrins in the recognition and response of dendritic cells to biomaterials. Biomaterials 32, 1270-1279
    • (2011) Biomaterials , vol.32 , pp. 1270-1279
    • Rogers, T.H.1    Babensee, J.E.2
  • 55
    • 57649142987 scopus 로고    scopus 로고
    • Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes
    • Scott, M. J., and Billar, T. R. (2008) Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J. Biol. Chem. 283, 29433-29446
    • (2008) J. Biol. Chem. , vol.283 , pp. 29433-29446
    • Scott, M.J.1    Billar, T.R.2
  • 56
    • 77954946392 scopus 로고    scopus 로고
    • Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
    • Han, C., Jin, J., Xu, S., Liu, H., Li, N., and Cao, X. (2010) Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat. Immunol. 11, 734-742
    • (2010) Nat. Immunol. , vol.11 , pp. 734-742
    • Han, C.1    Jin, J.2    Xu, S.3    Liu, H.4    Li, N.5    Cao, X.6
  • 57
    • 0034254811 scopus 로고    scopus 로고
    • The PI3 kinase, p38 SAP kinase, and NF-κb signal transduction pathways are involved in the survival and maturation of lipopolysaccharide- stimulated human monocyte-derived dendritic cells
    • Ardeshna, K. M., Pizzey, A. R., Devereux, S., and Khwaja, A. (2000) The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96, 1039-1046 (Pubitemid 30616871)
    • (2000) Blood , vol.96 , Issue.3 , pp. 1039-1046
    • Ardeshna, K.M.1    Pizzey, A.R.2    Devereux, S.3    Khwaja, A.4
  • 58
    • 33845709678 scopus 로고    scopus 로고
    • An essential role for Akt1 in dendritic cell function and tumor immunotherapy
    • DOI 10.1038/nbt1262, PII NBT1262
    • Park, D., Lapteva, N., Seethammagari, M., Slawin, K. M., and Spencer, D. M. (2006) An essential role for Akt1 in dendritic cell function and tumor immunotherapy. Nat. Biotechnol. 24, 1581-1590 (Pubitemid 44967484)
    • (2006) Nature Biotechnology , vol.24 , Issue.12 , pp. 1581-1590
    • Park, D.1    Lapteva, N.2    Seethammagari, M.3    Slawin, K.M.4    Spencer, D.M.5
  • 60
    • 78650195216 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase/ Akt and impairment of nuclear factor-κB. Molecular mechanisms behind the arrested maturation/activation state of Leishmania infantum-infected dendritic cells
    • Neves, B. M., Silvestre, R., Resende, M., Ouaissi, A., Cunha, J., Tavares, J., Loureiro, I., Santarém, N., Silva, A. M., Lopes, M. C., Cruz, M. T., and Cordeiro da Silva, A. (2010) Activation of phosphatidylinositol 3-kinase/ Akt and impairment of nuclear factor-κB. Molecular mechanisms behind the arrested maturation/activation state of Leishmania infantum-infected dendritic cells. Am. J. Pathol. 177, 2898-2911
    • (2010) Am. J. Pathol. , vol.177 , pp. 2898-2911
    • Neves, B.M.1    Silvestre, R.2    Resende, M.3    Ouaissi, A.4    Cunha, J.5    Tavares, J.6    Loureiro, I.7    Santarém, N.8    Silva, A.M.9    Lopes, M.C.10    Cruz, M.T.11    Cordeiro Da Silva, A.12
  • 61
    • 79958737483 scopus 로고    scopus 로고
    • Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IκB kinase activity
    • Singhal, E., and Sen, P. (2011) Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IκB kinase activity. Int. J. Biochem. Cell Biol. 43, 1134-1146
    • (2011) Int. J. Biochem. Cell Biol. , vol.43 , pp. 1134-1146
    • Singhal, E.1    Sen, P.2


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