Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16356-16364

  Xue, Meilang ^a   Dervish, Suat ^a   Harrison, Leonard C ^b   Fulcher, Gregory ^a   Jackson, Christopher J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANTI-INFLAMMATORIES; APC MECHANISM; CYTOKINES; ENDOTHELIAL PROTEINS; IMMUNOSTAINING; IN-CONTROL; INFLAMMATORY CYTOKINES; INTERLEUKIN1; INTRAPERITONEALLY; MATRIX METALLOPROTEINASES; NOD MOUSE; NON-OBESE DIABETICS; PANCREATIC ISLET; PANCREATIC LYMPH NODES; SALINE CONTROL; SPLEEN CELLS; TRANSFORMING GROWTH FACTORS; TYPE 1 DIABETES;

CELL CULTURE; CELLS; DRUG PRODUCTS; ENZYME INHIBITION; GLYCOPROTEINS; PATHOLOGY;

MAMMALS;

ACTIVATED PROTEIN C; DROTRECOGIN; ENDOTHELIAL PROTEIN C RECEPTOR; GAMMA INTERFERON; GELATINASE A; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 2; PROTEIN C; TRANSFORMING GROWTH FACTOR BETA1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REGULATORY T LYMPHOCYTE; SPLEEN; SPLEEN CELL; TREATMENT DURATION;

ANIMALS; ANTICOAGULANTS; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; INFLAMMATION; ISLETS OF LANGERHANS; LYMPH NODES; MICE; MICE, INBRED NOD; MICE, SCID; PROTEIN C; SPLEEN; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 84860848748     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.325951     Document Type: Article

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