Immunosuppressive effects of an ethyl acetate extract from Urtica dentata Hand on skin allograft rejection

Journal of Ethnopharmacology

Volumn 126, Issue 1, 2009, Pages 57-63

  Xiang, Ming ^a   Hou, Wen Rui ^a   Xie, Sheng Nan ^a   Zhang, Wei Dong ^b   Wang, Xin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Allograft rejection; Immunological tolerance; Immunosuppression; Laportea bulbifera Wedd; Urtica dentata Hand

Indexed keywords

ACETIC ACID ETHYL ESTER; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; PLANT EXTRACT; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; URTICA DENTATA HAND EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BACK; C57BL 6 MOUSE; CD4+ CD25+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGHER PLANT; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; SKIN ALLOGRAFT; SKIN TRANSPLANTATION; SPLEEN LYMPHOCYTE; TH1 CELL; TH2 CELL; URTICA DENTATA HAND; WOUND;

ACETATES; ANIMALS; CYTOKINES; DENDRITIC CELLS; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, ANIMAL; PHYTOTHERAPY; PLANT ROOTS; SKIN TRANSPLANTATION; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, REGULATORY; URTICACEAE;

ANIMALIA; LAPORTEA; MURINAE; MUS; URTICA;

EID: 70349783019     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.08.011     Document Type: Article

References (33)

1. Abe M., Hackstein H., and Thomson A.W. Manipulation of dendritic cells in organ transplantation: a major step towards graft tolerance. Current Opinion in Organ Transplantation 9 (2004) 294-300
2. Bani S., Kaul A., Khan B., Ahmad S.F., Suri K.A., Satti N.K., Amina M., and Qazi G.N. Immunosuppressive properties of an ethyl acetate fraction from Euphorbia royleana. Journal of Ethnopharmacology 99 (2005) 185-192
3. Chatila T.A. Role of regulatory T cells in human diseases. Journal of Allergy and Clinical Immunology 116 (2005) 949-959
4. Cyndi C., Wen-Hui L., Pen Y., Peter S., and Chih-Pin Liu. Induction of autoantigen-specific Th2 and Th1 regulatory T cells and modulation of autoimmune diabetes. The Journal of Immunology 171 (2003) 733-744
5. Davis W.C., Mckenzie I.F., and Mevold R.W. A comparison of skin and heart graft rejection patterns in H-2 mutant mice. Transplantation 29 (1980) 189-192
6. Emmanouilidis N., Guo Z., Dong Y., Newton-West M., Adams A.B., Lee Eun D.H., et al. Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells. Transplantation 81 (2006) 455-462
7. Finkelman F.D., Lees A., Birnbaum R., Gause W.C., and Morris S.C. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. The Journal of Immunology 157 (1996) 1406-1414
8. Guo L., Fujino M., Kimura H., Funeshima N., Kitazawa Y., Harihara Y., et al. Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Transplant Immunology 12 (2003) 41-48
9. Hall B.M., Pearce N.W., Gurley K.E., and Dorsch S.E. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action. Journal of Experimental Medicine 171 (1990) 141-157
10. + T cells. Advances in Immunology 81 (2003) 331-371
11. Krueger T., Wohlrab U., Klucken M., Schott M., and Seissler J. Autoantigen-specific protection of non-obese diabetic mice from cyclophosphamide-accelerated diabetes by vaccination with dendritic cells. Diabetologia 46 (2003) 1357-1365
12. Kuo Y.R., Huang C.W., Shigeru G., Wang C.T., Hsu L.W., and Lin Y.C. Alloantigen-Pulsed host dendritic cells induced T-cell regulation and prolong allograft survival in a rat model of hindlimb allotransplantation. Journal of Surgical Research 5 (2008) 34-42
13. Lee Y.C., Kim S.H., Roh S.S., Choi H.Y., and Seo Y.B. Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice. Journal of Ethnopharmacology 112 (2007) 40-48
14. Lugo-Villarino G., Maldonado-Lopez R., Possemato R., Penaranda C., and Glimcher L.H. T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells. Proceedings of the National Academy of Sciences of the United States of America 100 (2003) 7749-7754
15. Lutz M.B., Kukutsch N., Ogilvie A.L., Rössner S., Koch F., Romani N., and Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. Journal of Immunological Methods 223 (1999) 77-92
16. Marcello M., Johannes R., Annalisa G., Luca M., Stefania C., Laura C., et al. Short-term cyclosporine therapy and cotransplantation of donor splenocytes: effects on graft rejection and survival rats in pigs subjected to renal transplantation. Journal of Surgical Research 150 (2008) 100-109
17. Matsumoto S., Marui S., Shiho O., Tsukamoto K., Yoshimura N., and Oka T. A novel immunosuppressant, IR-1116, which has a different biological mechanism from that of cyclosporine A. European Journal of Immnunology 23 (1993) 2121-2128
18. Morelli A.E., and Thomson A.W. Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunological Reviews 196 (2003) 125-146
19. Morgan M.E., Flierman R., van Duivenvoorde L.M., Witteveen H.J., vanEwijk W., van Laar J.M., et al. Effective treatment of collagen-induced arthritis by adoptive transfer of CD25 regulatory T cells. Arthritis and Rheumatism 52 (2005) 2212-2221
20. -T cells determines rejection or tolerance. Transplant Immunology 15 (2006) 311-318
21. Pascual D.W., Kiyono H., and Mcghee J.R. The enteric nervous and immune systems: interaction for mucosal immunity and inflammation. Immunomethods 5 (1994) 56-72
22. Rosenberg A., and Singer A. Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. Annual Reviews of Immunology 10 (1992) 333-358
23. Sansonetti P.J., and Phalipon A. M cells as ports of entry for entcroinvasive pathogens: mechanisms of interaction, consequences for the disease process. Seminar in Immunology 11 (1999) 193-203
24. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells. Annual Review of Immunology 21 (2003) 685-711
25. + thymocytes and peripheral T cells have immune suppressive activity in vitro. European Journal of Immunology 31 (2001) 1247-1254
26. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
27. Taner T., Hackstein H., Wang Z., Morelli A.E., and Thomson A.W. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce Ag-specific T cell regulation and prolong graft survival. American Journal of Transplantation 5 (2005) 228-236
28. Tung T.H., Mohanakumar T., and Mackinnon S.E. Th1/Th2 cytokine profile of the immune response in limb component transplantation. Plastic and Reconstructive Surgery 116 (2005) 557-566
29. Valujskikh A., Matesic D., Gilliam A., Anthony D., Haggi T.M., and Heeger P.S. T cells reactive to a single immunodominant self-restricted allopeptide induce skin graft rejection in mice. Journal of Clinical Investigation 101 (1998) 1398-1407
30. Wan D.R., Chen J.C., and Yu H.H. Urtica dentata Hand. In: Fu S.X. (Ed). Flora Hupehensis Tomus. 2nd ed. (2002), Hubei Science and Technology Publisher, Wuhan 234-238
31. Wang X., Zou X.L., Su Z.Q., Yao Y., and Xiang M. Efects of the immune inhibitory active component of traditional Chinese medicine on murine BM-DCs. Chinese Journal of Experimental Surgery 24 (2007) 1414-1416
32. Xiang M., Tao E., Chu T., and Yuan S.Y. Preliminary study on preventing effects of the active component of Honghuoma on CIA model. Chinese Journal of Hospital Pharmacy 10 (2006) 1201-1205
33. Xu J.F., Huang B.J., Yin H., Xiong P., Feng W., Xu Y., et al. A limited course of soluble CD83 delays acute cellular rejection of MHC-mismatched mouse skin allografts. Transplant International 20 (2007) 266-276