Structure of a glycomimetic ligand in the carbohydrate recognition domain of C-type lectin DC-SIGN. Structural requirements for selectivity and ligand design

Journal of the American Chemical Society

Volumn 135, Issue 7, 2013, Pages 2518-2529

  Thépaut, Michel ^a,b,c   Guzzi, Cinzia ^e   Sutkeviciute, Ieva ^a,b,c   Sattin, Sara ^d   Ribeiro Viana, Renato ^e   Varga, Norbert ^d   Chabrol, Eric ^a,b,c   Rojo, Javier ^e   Bernardi, Anna ^d   Angulo, Jesus ^e   Nieto, Pedro M ^e   Fieschi, Franck ^a,b,f  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b CNRS   (France)

^c CEA GRENOBLE   (France)

^d UNIVERSITY OF MILAN   (Italy)

^e INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

^f INSTITUT UNIVERSITAIRE DE FRANCE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-HIV; BINDING EPITOPES; BINDING MODES; BINDING ORIENTATION; C-TYPE LECTINS; CARBOHYDRATE-RECOGNITION DOMAINS; CONFORMATIONAL PROPERTIES; DC SIGNS; DENDRITIC CELLS (DCS); DENDRONS; GLYCOMIMETIC; HIGH-RESOLUTION STRUCTURES; HIV INFECTION; HIV TRANSMISSION; LANGERHANS CELLS; LEWIS X; LIGAND BINDING; LIGAND DESIGN; NATURAL LIGANDS; NMR EXPERIMENTS; SELECTIVE INTERACTION; STRUCTURAL REQUIREMENTS; SURFACE PLASMONS; T LYMPHOCYTES;

BINDING ENERGY; CARBOHYDRATES; DENDRIMERS; LEAD COMPOUNDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SELF ASSEMBLY; X RAY CRYSTALLOGRAPHY;

LIGANDS;

CARBOHYDRATE; LECTIN;

ARTICLE; CRYSTAL STRUCTURE; DENDRITIC CELL; LIGAND BINDING; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BIOMIMETICS; CARBOHYDRATE SEQUENCE; CELL ADHESION MOLECULES; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANECARBOXYLIC ACIDS; DRUG DESIGN; LECTINS, C-TYPE; LIGANDS; MANNOSIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE;

EID: 84874097948     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3053305     Document Type: Article

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