Fat lowers fat: Purified phospholipids as emerging therapies for dyslipidemia

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 4, 2013, Pages 887-893

  Sahebkar, Amirhossein ^a,b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cardiovascular disease; Cholesterol; Lipoprotein; Phospholipid; Reverse cholesterol transport; Triglyceride

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER G5; APOLIPOPROTEIN A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; SOY LECITHIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ATHEROGENESIS; BIOCOMPATIBILITY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CHOLESTEROL LIVER LEVEL; CHOLESTEROL TRANSPORT; DIET SUPPLEMENTATION; DRUG MEGADOSE; DRUG SAFETY; DYSLIPIDEMIA; FOLLOW UP; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; LIPID METABOLISM; LIPOPROTEIN METABOLISM; LOW DRUG DOSE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CHOLESTEROL; DYSLIPIDEMIAS; HUMANS; LIPID METABOLISM; PHOSPHOLIPIDS; TRIGLYCERIDES;

EID: 84874011234     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.01.013     Document Type: Review

References (93)

1. World Health Organization World Health Statistics Department of Measurement & Health Information Systems of the Information, Evidence and Research Cluster 2008 WHO Press Geneva 29 31
2. I. Ford, H. Murray, C.J. Packard, J. Shepherd, P.W. Macfarlane, and S.M. Cobbe Long-term follow-up of the West of Scotland Coronary Prevention Study N. Engl. J. Med. 357 2007 1477 1486
3. J. Shepherd, S.M. Cobbe, I. Ford, C.G. Isles, A.R. Lorimer, P.W. MacFarlane, J.H. McKillop, and C.J. Packard Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group N. Engl. J. Med. 333 1995 1301 1307
4. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial Lancet 360 2002 7 22
5. C.P. Cannon, E. Braunwald, C.H. McCabe, D.J. Rader, J.L. Rouleau, R. Belder, S.V. Joyal, K.A. Hill, M.A. Pfeffer, and A.M. Skene Intensive versus moderate lipid lowering with statins after acute coronary syndromes N. Engl. J. Med. 350 2004 1495 1504
6. H.R. Superko, and S. King III Lipid management to reduce cardiovascular risk: a new strategy is required Circulation 117 2008 560 568 (discussion 568)
7. T.R. Joy Novel HDL-based therapeutic agents Pharmacol. Ther. 135 2012 18 30
8. S. Redondo, J. Martinez-Gonzalez, C. Urraca, and T. Tejerina Emerging therapeutic strategies to enhance HDL function Lipids Health Dis. 10 2011 175
9. E.M. Degoma, and D.J. Rader Novel HDL-directed pharmacotherapeutic strategies Nat. Rev. Cardiol. 8 2011 266 277
10. M. Florentin, E.N. Liberopoulos, D.P. Mikhailidis, and M.S. Elisaf Emerging options in the treatment of dyslipidemias: a bright future? Expert Opin. Emerg. Drugs 16 2011 247 270
11. J.R. Colca, and R.F. Kletzien Current and emerging strategies for treating dyslipidemia and macrovascular disease Adv. Pharmacol. 57 2009 237 251
12. R.L. Pollex, T.R. Joy, and R.A. Hegele Emerging antidyslipidemic drugs Expert Opin. Emerg. Drugs 13 2008 363 381
13. Espinosa-Salinas, A. Rodríguez-Casado, S. Molina, A. Rodríguez-González, J.M. de Ordovás, and A.R. de Molina Molina, Beneficial effects of bioactive phospholipids: Genomic bases Curr. Nutr. Food Sci. 7 2011 145 154
14. J.S. Cohn, E. Wat, A. Kamili, and S. Tandy Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease Curr. Opin. Lipidol. 19 2008 257 262
15. M. Ishinaga, S. Sugiyama, and T. Mochizuki Daily intakes of fatty acids, sterols, and phospholipids by Japanese women and serum cholesterol J. Nutr. Sci. Vitaminol. (Tokyo) 40 1994 557 567
16. B. Akesson Content of phospholipids in human diets studied by the duplicate-portion technique Br. J. Nutr. 47 1982 223 229
17. A.R. Tall, C.B. Blum, and S.M. Grundy Incorporation of radioactive phospholipid into subclasses of high-density lipoproteins Am. J. Physiol. 244 1983 E513 E516
18. K. Wehrmuller Impact of dietary phospholipids on human health ALP Sci. 524 2008 1 15
19. C.S. Lieber, S.J. Robins, J. Li, L.M. DeCarli, K.M. Mak, J.M. Fasulo, and M.A. Leo Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon Gastroenterology 106 1994 152 159
20. Y. Buang, Y.M. Wang, J.Y. Cha, K. Nagao, and T. Yanagita Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid Nutrition 21 2005 867 873
21. E. Feige, I. Mendel, J. George, N. Yacov, and D. Harats Modified phospholipids as anti-inflammatory compounds Curr. Opin. Lipidol. 21 2010 525 529
22. J.M. van Dieren, Y. Simons-Oosterhuis, H.C. Raatgeep, D.J. Lindenbergh-Kortleve, M.E. Lambers, C.J. van der Woude, E.J. Kuipers, G.T. Snoek, R. Potman, H. Hammad, B.N. Lambrecht, J.N. Samsom, and E.E. Nieuwenhuis Anti-inflammatory actions of phosphatidylinositol Eur. J. Immunol. 41 2011 1047 1057
23. R.A. Chaurio, C. Janko, L.E. Munoz, B. Frey, M. Herrmann, and U.S. Gaipl Phospholipids: key players in apoptosis and immune regulation Molecules 14 2009 4892 4914
24. B. Shirouchi, K. Nagao, N. Inoue, T. Ohkubo, H. Hibino, and T. Yanagita Effect of dietary omega 3 phosphatidylcholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima fatty rats J. Agric. Food Chem. 55 2007 7170 7176
25. A. Blokland, W. Honig, F. Brouns, and J. Jolles Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS Nutrition 15 1999 778 783
26. A.A. Farooqui, L. Liss, and L.A. Horrocks Neurochemical aspects of Alzheimer's disease: involvement of membrane phospholipids Metab. Brain Dis. 3 1988 19 35
27. G. Pepeu, I.M. Pepeu, and L. Amaducci A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacol. Res. 33 1996 73 80
28. M.A. McDaniel, S.F. Maier, and G.O. Einstein "Brain-specific" nutrients: a memory cure? Nutrition 19 2003 957 975
29. H. Ichihara, Y. Matsuoka, Y. Matsumoto, and R. Ueoka Therapeutic effects of hybrid liposomes on gastric carcinoma involve apoptosis Anticancer. Res. 30 2010 2011 2016
30. H. Ichihara, K. Funamoto, T. Matsushita, Y. Matsumoto, and R. Ueoka Histological bioanalysis for therapeutic effects of hybrid liposomes on the hepatic metastasis of colon carcinoma in vivo Int. J. Pharm. 394 2010 174 178
31. N.R. Pandey, and D.L. Sparks Phospholipids as cardiovascular therapeutics Curr. Opin. Investig. Drugs 9 2008 281 285
32. J.G. Brook, S. Linn, and M. Aviram Dietary soya lecithin decreases plasma triglyceride levels and inhibits collagen- and ADP-induced platelet aggregation Biochem. Med. Metab. Biol. 35 1986 31 39
33. M.T. Childs, J.A. Bowlin, J.T. Ogilvie, W.R. Hazzard, and J.J. Albers The contrasting effects of a dietary soya lecithin product and corn oil on lipoprotein lipids in normolipidemic and familial hypercholesterolemic subjects Atherosclerosis 38 1981 217 228
34. R.K. Tompkins, and L.G. Parkin Effects of long-term ingestion of soya phospholipids on serum lipids in humans Am. J. Surg. 140 1980 360 364
35. T.A. Wilson, C.M. Meservey, and R.J. Nicolosi Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: beyond linoleate Atherosclerosis 140 1998 147 153
36. J.L. Weihrauch, and Y.S. Son The phospholipid content of foods JAOCS 60 1983 1971 1978
37. E. Polichetti, N. Diaconescu, P.L. De La Porte, L. Malli, H. Portugal, A.M. Pauli, H. Lafont, B. Tuchweber, I. Yousef, and F. Chanussot Cholesterol-lowering effect of soyabean lecithin in normolipidaemic rats by stimulation of biliary lipid secretion Br. J. Nutr. 75 1996 471 478
38. E. Polichetti, A. Janisson, P.L. de la Porte, H. Portugal, J. Leonardi, A. Luna, P. La Droitte, and F. Chanussot Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits: role of the hepato-biliary axis Life Sci. 67 2000 2563 2576
39. M. Zeman, A. Zak, and P. Stolba The effect of polyene phosphatidylcholine administration on lipid metabolism and glucose tolerance in patients with hyperlipoproteinemia IIB Sb. Lek. 96 1995 43 48
40. B.H. Chung, F. Franklin, P. Liang, S. Doran, B.H. Cho, and C.A. Curcio Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaques Biochim. Biophys. Acta 1733 2005 76 89
41. W.V. Rodrigueza, S.K. Klimuk, P.H. Pritchard, and M.J. Hope Cholesterol mobilization and regression of atheroma in cholesterol-fed rabbits induced by large unilamellar vesicles Biochim. Biophys. Acta 1368 1998 306 320
42. W.V. Rodrigueza, K.D. Mazany, A.D. Essenburg, M.E. Pape, T.J. Rea, C.L. Bisgaier, and K.J. Williams Large versus small unilamellar vesicles mediate reverse cholesterol transport in vivo into two distinct hepatic metabolic pools. Implications for the treatment of atherosclerosis Arterioscler. Thromb. Vasc. Biol. 17 1997 2132 2139
43. J.A. Gazzara, M.C. Phillips, S. Lund-Katz, M.N. Palgunachari, J.P. Segrest, G.M. Anantharamaiah, W.V. Rodrigueza, and J.W. Snow Effect of vesicle size on their interaction with class A amphipathic helical peptides J. Lipid Res. 38 1997 2147 2154
44. K.J. Williams, V.P. Werth, and J.A. Wolff Intravenously administered lecithin liposomes: a synthetic antiatherogenic lipid particle Perspect. Biol. Med. 27 1984 417 431
45. M. Friedman, S.O. Byers, and R.H. Rosenman Resolution of aortic atherosclerotic infiltration in the rabbit by phosphatide infusion Proc. Soc. Exp. Biol. Med. 95 1957 586 588
46. K.J. Williams, M.C. Phillips, and W.V. Rodrigueza Structural and metabolic consequences of liposome-lipoprotein interactions Adv. Drug Deliv. Rev. 32 1998 31 43
47. S. Tandy, R.W. Chung, A. Kamili, E. Wat, J.M. Weir, P.J. Meikle, and J.S. Cohn Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet Atherosclerosis 213 2010 142 147
48. Y. Jiang, S.K. Noh, and S.I. Koo Egg phosphatidylcholine decreases the lymphatic absorption of cholesterol in rats J. Nutr. 131 2001 2358 2363
49. K. Mackay, J.R. Starr, R.M. Lawn, and J.L. Ellsworth Phosphatidylcholine hydrolysis is required for pancreatic cholesterol esterase- and phospholipase A2-facilitated cholesterol uptake into intestinal Caco-2 cells J. Biol. Chem. 272 1997 13380 13389
50. R. Homan, and K.L. Hamelehle Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2 J. Lipid Res. 39 1998 1197 1209
51. D.E. Cohen, and M.C. Carey Acyl chain unsaturation modulates distribution of lecithin molecular species between mixed micelles and vesicles in model bile. Implications for particle structure and metastable cholesterol solubilities J. Lipid Res. 32 1991 1291 1302
52. L.K. Cole, J.E. Vance, and D.E. Vance Phosphatidylcholine biosynthesis and lipoprotein metabolism Biochim. Biophys. Acta 1821 2012 754 761
53. S. Kar, M.A. Patel, R.K. Tripathy, P. Bajaj, U.V. Suvarnakar, and A.H. Pande Oxidized phospholipid content destabilizes the structure of reconstituted high density lipoprotein particles and changes their function Biochim. Biophys. Acta 1821 2012 1200 1210
54. D. Hollander, and D. Morgan Effect of plant sterols, fatty acids and lecithin on cholesterol absorption in vivo in the rat Lipids 15 1980 395 400
55. A.J. Rampone The effect of lecithin on intestinal cholesterol uptake by rat intestine in vitro J. Physiol. 229 1973 505 514
56. A.B. Thomson, and L. Cleland Intestinal cholesterol uptake from phospholipid vesicles and from simple and mixed micelles Lipids 16 1981 881 887
57. P. Proulx, H. Aubry, I. Brglez, and D.G. Williamson Factors influencing the uptake of cholesterol by isolated brush border membranes from rabbit small intestine Exp. Biol. 45 1986 335 343
58. J.W. Burgess, T.A. Neville, P. Rouillard, Z. Harder, D.S. Beanlands, and D.L. Sparks Phosphatidylinositol increases HDL-C levels in humans J. Lipid Res. 46 2005 350 355
59. C.J. Stamler, D. Breznan, T.A. Neville, F.J. Viau, E. Camlioglu, and D.L. Sparks Phosphatidylinositol promotes cholesterol transport in vivo J. Lipid Res. 41 2000 1214 1221
60. H.I. Nishida, H. Kato, and T. Nishida Affinity of lipid transfer protein for lipid and lipoprotein particles as influenced by lecithin-cholesterol acyltransferase J. Biol. Chem. 265 1990 4876 4883
61. D. Masson, A. Athias, and L. Lagrost Evidence for electronegativity of plasma high density lipoprotein-3 as one major determinant of human cholesteryl ester transfer protein activity J. Lipid Res. 37 1996 1579 1590
62. J.G. Boucher, T. Nguyen, and D.L. Sparks Lipoprotein electrostatic properties regulate hepatic lipase association and activity Biochem. Cell Biol. 85 2007 696 708
63. D.L. Sparks, C. Chatterjee, E. Young, J. Renwick, and N.R. Pandey Lipoprotein charge and vascular lipid metabolism Chem. Phys. Lipids 154 2008 1 6
64. J.W. Burgess, J. Boucher, T.A. Neville, P. Rouillard, C. Stamler, S. Zachariah, and D.L. Sparks Phosphatidylinositol promotes cholesterol transport and excretion J. Lipid Res. 44 2003 1355 1363
65. S. Hopewell, N.R. Pandey, A. Misquith, E. Twomey, and D.L. Sparks Phosphatidylinositol acts through mitogen-activated protein kinase to stimulate hepatic apolipoprotein A-I secretion Metabolism 57 2008 1677 1684
66. N.R. Pandey, J. Renwick, A. Misquith, K. Sokoll, and D.L. Sparks Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion Biochemistry 47 2008 1579 1587
67. B. Shirouchi, K. Nagao, N. Inoue, K. Furuya, S. Koga, H. Matsumoto, and T. Yanagita Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats J. Agric. Food Chem. 56 2008 2375 2379
68. D.L. Sparks, P.G. Frank, and T.A. Neville Effect of the surface lipid composition of reconstituted LPA-I on apolipoprotein A-I structure and lecithin: cholesterol acyltransferase activity Biochim. Biophys. Acta 1390 1998 160 172
69. D.L. Sparks, G.M. Anantharamaiah, J.P. Segrest, and M.C. Phillips Effect of the cholesterol content of reconstituted LpA-I on lecithin:cholesterol acyltransferase activity J. Biol. Chem. 270 1995 5151 5157
70. L. Lagrost The role of cholesteryl ester transfer protein and phospholipid transfer protein in the remodeling of plasma high-density lipoproteins Trends Cardiovasc. Med. 7 1997 218 224
71. S. Amr, P. Hamosh, and M. Hamosh Effect of intralipid infusion on lecithin:cholesterol acyltransferase and lipoprotein lipase in young rats Biochim. Biophys. Acta 1001 1989 145 149
72. H.I. Nishida, H. Arai, and T. Nishida Cholesterol ester transfer mediated by lipid transfer protein as influenced by changes in the charge characteristics of plasma lipoproteins J. Biol. Chem. 268 1993 16352 16360
73. D.E. Vance Physiological roles of phosphatidylethanolamine N-methyltransferase Biochim. Biophys. Acta 2012 10.1016/j.bbalip.2012.07.017
74. K. Imaizumi, K. Mawatari, M. Murata, I. Ikeda, and M. Sugano The contrasting effect of dietary phosphatidylethanolamine and phosphatidylcholine on serum lipoproteins and liver lipids in rats J. Nutr. 113 1983 2403 2411
75. K. Imaizumi, K. Sekihara, and M. Sugano Hypocholesterolemic action of dietary phosphatidylethanolamine in rats sensitive to exogenous cholesterol J. Nutr. Biochem. 2 1991 251 254
76. H. Muller, L.I. Hellgren, E. Olsen, and A. Skrede Lipids rich in phosphatidylethanolamine from natural gas-utilizing bacteria reduce plasma cholesterol and classes of phospholipids: a comparison with soybean oil Lipids 39 2004 833 841
77. M. Murata, K. Imaizumi, and M. Sugano Effect of dietary phospholipids and their constituent bases on serum lipids and apolipoproteins in rats J. Nutr. 112 1982 1805 1808
78. K. Honda, T. Enoshima, T. Oshikata, K. Kamiya, M. Hamamura, N. Yamaguchi, K. Nakamura, Y. Oguma, S. Fujiwara, M. Takabe, A. Sono, T. Kawasaki, M. Nasu, K. Otsubo, and K. Wakigawa Toxicity studiesof Asahi Kasei PI, purified phosphatidylinositol from soy lecithin J. Toxicol. Sci. 34 2009 265 280
79. F.M. Sacks Clinical usefulness of HDL cholesterol as a target to lower risk or coronary heart disease Br. J. Cardiol. 10 2003 297 304
80. F.M. Sacks The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart disease: expert group recommendations Am. J. Cardiol. 90 2002 139 143
81. V.G. Athyros, D.P. Mikhailidis, A.A. Papageorgiou, A.N. Symeonidis, B.R. Mercouris, A. Pehlivanidis, V.I. Bouloukos, and M. Elisaf Effect of atorvastatin on high density lipoprotein cholesterol and its relationship with coronary events: a subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study Curr. Med. Res. Opin. 20 2004 627 637
82. L.A. Carlson Nicotinic acid and other therapies for raising high-density lipoprotein Curr. Opin. Cardiol. 21 2006 336 344
83. M.A. Al-Mohaissen, S.C. Pun, and J.J. Frohlich Niacin: from mechanisms of action to therapeutic uses Mini Rev. Med. Chem. 10 2010 204 217
84. M. Navab, I. Shechter, G.M. Anantharamaiah, S.T. Reddy, B.J. Van Lenten, and A.M. Fogelman Structure and function of HDL mimetics Arterioscler. Thromb. Vasc. Biol. 30 2010 164 168
85. M. Navab, G.M. Anantharamaiah, S.T. Reddy, B.J. Van Lenten, and A.M. Fogelman Apo A-1 mimetic peptides as atheroprotective agents in murine models Curr. Drug Targets 9 2008 204 209
86. M. Navab, G.M. Anantharamaiah, S.T. Reddy, B.J. Van Lenten, G.M. Buga, and A.M. Fogelman Peptide mimetics of apolipoproteins improve HDL function J. Clin. Lipidol. 1 2007 142 147
87. W.S. Davidson, D.L. Sparks, S. Lund-Katz, and M.C. Phillips The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins J. Biol. Chem. 269 1994 8959 8965
88. K. Amin, K.M. Wasan, R.M. Albrecht, and T.D. Heath Cell association of liposomes with high fluid anionic phospholipid content is mediated specifically by LDL and its receptor, LDLr J. Pharm. Sci. 91 2002 1233 1244
89. S. Lauraeus, J.M. Holopainen, M. Taskinen, and P.K.J. Kinnunen Aggregation of dimyristoylphosphatidylglycerol liposomes by human plasma low density lipoprotein Biochim. Biophys. Acta 1373 1998 147 162
90. P. Greenspan, B. Rye, F. Mao, and R.L. Gutman Association of negatively charged phospholipids with low-density lipoprotein (LDL) increases its uptake and the deposition of cholesteryl esters by macrophages Biochim. Biophys. Acta 1257 1995 257 264
91. G. Zuliani, M. Galvani, E. Leitersdorf, S. Volpato, M. Cavalieri, and R. Fellin The role of polyunsaturated fatty acids (PUFA) in the treatment of dyslipidemias Curr. Pharm. Des. 15 2009 4087 4093
92. M.J. LeBlanc, S. Brunet, G. Bouchard, T. Lamireau, I.M. Yousef, V. Gavino, E. Levy, and B. Tuchweber Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats J. Nutr. Biochem. 14 2003 40 48
93. Y.B. Lombardo, and A.G. Chicco Effects of dietary polyunsaturated n - 3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review J. Nutr. Biochem. 17 2006 1 13