Toxicity studies of Asahi Kasei PI, purified phosphatidylinositol from soy lecithin

Journal of Toxicological Sciences

Volumn 34, Issue 3, 2009, Pages 265-280

  Honda, Kumiko ^a   Enoshima, Teruhiko ^a   Oshikata, Takafumi ^a   Kamiya, Koichi ^a   Hamamura, Masao ^a   Yamaguchi, Noriko ^b   Nakamura, Kaori ^b   Oguma, Yoshihiro ^b   Fujiwara, Sho ^b   Takabe, Michihito ^b   Sono, Akira ^b   Kawasaki, Tsuneshirou ^c   Nasu, Masaaki ^c   Otsubo, Kazumasa ^c   Wakigawa, Koichi ^c  

^a Panapharm Laboratories Co   (Japan)

^b BoZo Research Center Inc   (Japan)

^c ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

Acute toxicity; Asahi Kasei PI; Genotoxicity; Phosphatidylinositol; Rats; Subchronic toxicology

Indexed keywords

PHOSPHATIDYLINOSITIDE;

AMES TEST; ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BLOOD CHEMISTRY; BODY WEIGHT; CONTROLLED STUDY; DRUG SAFETY; FEMALE; FOOD INTAKE; GENOTOXICITY; HISTOPATHOLOGY; MALE; NONHUMAN; OPHTHALMOSCOPY; ORGAN WEIGHT; RAT; SINGLE DRUG DOSE; SOYBEAN; TOXICITY TESTING; TREATMENT DURATION;

ANIMALIA; BACTERIA (MICROORGANISMS); RATTUS;

EID: 67649231344     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.265     Document Type: Article

References (31)

1. Brook, J.G., Linn, S. and Aviram, M. (1986): Dietary soya lecithin decreases plasma triglyceride levels and inhibits collagen- and ADP-induced platelet aggregation. Biochem. Med. Metab. Biol., 35, 31-39.
2. Buang, Y., Wang, Y.M., Cha, J.Y., Nagao, K. and Yanagita, T. (2005): Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid. Nutrition, 21, 867-873. (Pubitemid 40828812)
3. Burgess, J.W., Boucher, J., Neville, T.A., Rouillard, P., Stamler, C., Zachariah, S. and Sparks, D.L. (2003): Phosphatidylinositol promotes cholesterol transport and excretion. J. Lipid Res., 44, 1355-1363. (Pubitemid 37279617)
4. Burgess, J.W., Neville, T.A., Rouillard, P., Harder, Z., Beanlands, D.S. and Sparks, D.L. (2005): Phosphatidylinositol increases HDL-C levels in humans. J. Lipid Res., 46, 350-355. (Pubitemid 40271099)
5. Di Paolo, G. and De Camilli, P. (2006): Phosphoinositides in cell regulation and membrane dynamics. Nature, 443, 651-657. (Pubitemid 44564702)
6. Erdahl, W.L., Stolywo, A. and Privett, O.S. (1973): Analysis of Soybean lecithin by thin layer and analytical liquid chromatography. J. Am. Oil Chem. Soc., 50, 513-515.
7. Fiume, Z. (2001): Final report on the safety assessment of lecithin and hydrogenated lecithin. Int. J. Toxicol., 20, 21-45.
8. Fukui, Y. (2003): PI3-kinase and phosphoinositide signaling. Cell Technology, 22, 828-830.
9. Hammond, G.R. and Schiavo, G. (2007): Polyphosphoinositol lipids: under-PPInning synaptic function in health and disease. Dev. Neurobiol., 67, 1232-1247.
10. Holub, B.J. (1986): Metabolism and function of myo-inositol and inositol phospholipids. Annu. Rev. Nutr., 6, 563-597.
11. Imaizumi, K., Mawatari, K., Murata, M., Ikeda, I. and Sugano, M. (1983): The contrasting effect of dietary phosphatidylethanolamine and phosphatidylcholine on serum lipoproteins and liver lipids in rats. J. Nutr., 113, 2403-2411. (Pubitemid 14222059)
12. Ishidate, M.Jr. (1982): Screening Trial to Detect Possible Chemical Mutagens and/or Carcinogens in the Environment - Mammalian Cell Systems. Journal of the Japan Cosmetic Science Association, 6, 31-43.
13. Koga, S. and Imamura, S. (2007): Novel phospholipid processing agent. International Application Patent, WO/2007/010892.
14. Logothetis, D.E., Jin, T., Lupyan, D. and Rosenhouse-Dantsker, A. (2007): Phosphoinositide-mediated gating of inwardly rectifying K(+) channels. Pflugers Arch., 455, 83-95. (Pubitemid 47403981)
15. Maron, D.M. and Ames, B.N. (1983): Revised methods for the Salmonella mutagenicity test. Mutat. Res., 113, 173-215.
16. Matsunaga, N., Shimazawa, M., Otsubo, K. and Hara, H. (2008): Phosphatidylinositol inhibits vascular endothelial growth factor-A - Induced migration of human umbilical vein endothelial cells. J. Pharmacol. Sci., 106, 128-135.
17. McDaniel, M.A., Maier, S.F. and Einstein, G.O. (2003): "Brain-specific" nutrients: a memory cure. Nutrition, 19, 957-975.
18. MHW (Ministry of Health and Welfare, Japan) (1989): The Guidelines of Toxicity Studies of Drugs (Notification No. Yakushin-1- 24 dated September 11, 1989).
19. MHW (Ministry of Health and Welfare, Japan) (1993): Amendments to the Guidelines of single Dose and Repeated Dose Toxicity Studies (Notification No. Yakushinyaku-88 dated August 10, 1993).
20. Michell, R.H. (2008): Inositol derivatives: evolution and functions. Nat. Rev. Mol. Cell. Biol., 9, 151-161.
21. OECD (1997a): OECD Guidelines for Testing of Chemicals, Test 471, Bacterial Reverse Mutation Test.
22. OECD (1997b): OECD Guidelines for Testing of Chemicals, Test 473, In vitro, Mammalian Chromosome Aberration Test.
23. OECD (1998): OECD Guidelines for Testing of Chemicals, Test 408, Repeated Dose 90-day Oral Toxicity Study in Rodents.
24. Parkinson, T.L. (1966): The chemical composition of eggs. J. Sci. Food Agric., 17, 101-111.
25. Shi, Y., Azab, A.N., Thompson, M.N. and Greenberg, M.L. (2006): Inositol phosphates and phosphoinositides in health and disease. In: Biology of inositols and Phosphoinositides (Majumder, A.L. and Biswas, B.B. eds.), pp.263-290, Springer, Netherlands.
26. Shirouchi, B., Nagao, K., Inoue, N., Ohkubo, T., Hibino, H. and Yanagita, T. (2007): Effect of dietary omega 3 phosphatidylcholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima Fatty rats. J. Agric. Food Chem., 55, 7170-7176.
27. Shirouchi, B., Nagao, K., Inoue, N., Furuya, K., Koga, S., Matsumoto, H. and Yanagita, T. (2008): Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats. J. Agric. Food Chem., 56, 2375-2379.
28. Shirouchi, B., Nagao, K., Furuya, K., Inoue, N., Inafuku, M., Nasu, M., Otsubo, K., Koga, S., Matsumoto, H. and Yanagita, T. (2009): Effect of Dietary phosphatidylinositol on cholesterol metabolism in Zucker (fa/fa) rats. J. Oleo Sci., 58, 111-115.
29. Tompkins, R.K. and Parkin, L.G. (1980): Effects of long-term ingestion of soya phospholipids on serum lipids in humans. Am. J. Surg., 140, 360-364.
30. Weihrauch, J.L. and Son, Y.S. (1983): The phospholipid content of foods. J. Am. Oil Chem. Soc., 60, 1971-1978.
31. Yang, X., Ongusaha, P.P., Miles, P.D., Havstad, J.C., Zhang, F., So, W.V., Kudlow, J.E., Michell, R.H., Olefsky, J.M., Field, S.J. and Evans, R.M. (2008): Phosphoinositide signalling links O-Glc- NAc transferase to insulin resistance. Nature, 451, 964-969. (Pubitemid 351301737)