Phosphatidylcholine biosynthesis and lipoprotein metabolism

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1821, Issue 5, 2012, Pages 754-761

  Cole, Laura K ^a   Vance, Jean E ^a   Vance, Dennis E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Apo B; Lipoprotein; Liver; Phosphatidylcholine

Indexed keywords

ABC TRANSPORTER A1; ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHOLINE KINASE; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; CHOLINEPHOSPHOTRANSFERASE; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; PHOSPHOLIPID TRANSFER PROTEIN; SCAVENGER RECEPTOR BI; VERY LOW DENSITY LIPOPROTEIN;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CATALYSIS; CELL FRACTIONATION; DEGRADATION KINETICS; DISEASE COURSE; ENDOPLASMIC RETICULUM; ENZYME PHOSPHORYLATION; GOLGI COMPLEX; LIPID COMPOSITION; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; LIPOPROTEIN SECRETION; LIVER; LIVER CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; RISK ASSESSMENT; SECRETORY PATHWAY; TRANSLATION REGULATION;

ANIMALS; APOLIPOPROTEINS E; CARDIOVASCULAR DISEASES; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HUMANS; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; LIVER; METABOLIC NETWORKS AND PATHWAYS; PHOSPHATIDYLCHOLINES; RECEPTORS, LDL;

EID: 84859157638     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.09.009     Document Type: Review

References (111)

1. M. Gobley J. Pharm. Chim. 17 1850 401 407
2. C. Diakonow Zbl. Med. Wiss. 2 1868 434 435
3. A. Strecker Ann. Chem. Pharm. 148 1868 77 90
4. E. Baer, and M. Kates Migration during hydrolysis of esters of glycerophosphoric acid. II. The acid and alkaline hydrolysis of L-alpha-lecithins J. Biol. Chem. 185 2 1950 615 623
5. A. Yamashita, T. Sugiura, and K. Waku Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells J. Biochem. 122 1 1997 1 16
6. G. van Meer, D.R. Voelker, and G.W. Feigenson Membrane lipids: where they are and how they behave Nat. Rev. Mol. Cell Biol. 9 2 2008 112 124
7. B.S. Robinson Lysophosphatidylcholine metabolism and lipoprotein secretion by cultured rat hepatocytes deficient in choline Biochem. J. 260 1 1989 207 214
8. V.P. Skipski Lipid composition of human serum lipoproteins Biochem. J. 104 2 1967 340 352
9. D. Alvaro Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species Comp. Biochem. Physiol. B 83 3 1986 551 554
10. J. Perez-Gil Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions Biochim. Biophys. Acta 1778 7-8 2008 1676 1695
11. J. Goerke Pulmonary surfactant: functions and molecular composition Biochim. Biophys. Acta 1408 2-3 1998 79 89
12. A. Jonas, and M.A. Phillips Lipoprotein structure D.E. Vance, J.E. Vance, Biochemistry of Lipids, Lipoproteins and Membranes 2008 Elsevier New York 485 506
13. J.J. Agren, J.P. Kurvinen, and A. Kuksis Isolation of very low density lipoprotein phospholipids enriched in ethanolamine phospholipids from rats injected with Triton WR 1339 Biochim. Biophys. Acta 1734 1 2005 34 43
14. D.G. Fast, and D.E. Vance Nascent VLDL phospholipid composition is altered when phosphatidylcholine biosynthesis is inhibited: evidence for a novel mechanism that regulates VLDL secretion Biochim. Biophys. Acta 1258 2 1995 159 168
15. H.J. Verkade Impaired biosynthesis of phosphatidylcholine causes a decrease in the number of very low density lipoprotein particles in the Golgi but not in the endoplasmic reticulum of rat liver J. Biol. Chem. 268 33 1993 24990 24996
16. P.S. Vermeulen Phosphatidylcholine biosynthesis is required for secretion of truncated apolipoprotein Bs from McArdle RH7777 cells only when a neutral lipid core is formed J. Lipid Res. 38 3 1997 447 458
17. Z.M. Yao, and D.E. Vance The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes J. Biol. Chem. 263 6 1988 2998 3004
18. A.A. Noga, Y. Zhao, and D.E. Vance An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins J. Biol. Chem. 277 44 2002 42358 42365
19. R.L. Jacobs Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein J. Biol. Chem. 283 4 2008 2147 2155
20. Z.M. Yao, and D.E. Vance Reduction in VLDL, but not HDL, in plasma of rats deficient in choline Biochem. Cell Biol. 68 2 1990 552 558
21. P.J. Raubenheimer, M.J. Nyirenda, and B.R. Walker A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet Diabetes 55 7 2006 2015 2020
22. R.L. Jacobs Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins J. Biol. Chem. 279 45 2004 47402 47410
23. M.E. Rinella Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet J. Lipid Res. 49 5 2008 1068 1076
24. P.E. Fielding, and C.J. Fielding Dynamics of lipoprotein transport in the human circulatory system D.E. Vance, J.E. Vance, Biochemistry of Lipids, Lipoproteins and Membranes 2008 Elsevier New York 533 553
25. E.P. Kennedy, and S.B. Weiss The function of cytidine coenzymes in the biosynthesis of phospholipides J. Biol. Chem. 222 1 1956 193 214
26. D.E. Vance, and J.E. Vance Phospholipid biosynthesis in eukaryotes D.E. Vance, J.E. Vance, Biochemistry of Lipids, Lipoproteins and Membranes 2008 Elsevier New York 214 244
27. R. Sundler, and B. Akesson Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates J. Biol. Chem. 250 9 1975 3359 3367
28. D.J. Shields Membrane topography of human phosphatidylethanolamine N-methyltransferase J. Biol. Chem. 278 5 2003 2956 2962
29. J.E. Vance Phospholipid synthesis in a membrane fraction associated with mitochondria J. Biol. Chem. 265 13 1990 7248 7256
30. C.H. Best, and M.E. Huntsman The effects of the components of lecithine upon deposition of fat in the liver J. Physiol. 75 4 1932 405 412
31. S. Mookerjea, C.E. Park, and A. Kuksis Lipid profiles of plasma lipoproteins of fasted and fed normal and choline-deficient rats Lipids 10 7 1975 374 382
32. Z.M. Yao, and D.E. Vance Head group specificity in the requirement of phosphatidylcholine biosynthesis for very low density lipoprotein secretion from cultured hepatocytes J. Biol. Chem. 264 19 1989 11373 11380
33. D.R. Hoffman S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of l-methionine, L-homocystein, and adenosine J. Biol. Chem. 255 22 1980 10822 10827
34. P.K. Chiang, and G.L. Cantoni Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo Biochem. Pharmacol. 28 12 1979 1897 1902
35. P.K. Chiang, H.H. Richards, and G.L. Cantoni S-Adenosyl-L-homocysteine hydrolase: analogues of S-adenosyl-L-homocysteine as potential inhibitors Mol. Pharmacol. 13 5 1977 939 947
36. A.A. Noga, and D.E. Vance A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice J. Biol. Chem. 278 24 2003 21851 21859
37. K.A. Waite, N.R. Cabilio, and D.E. Vance Choline deficiency-induced liver damage is reversible in Pemt(-/-) mice J. Nutr. 132 1 2002 68 71
38. R.L. Jacobs Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity J. Biol. Chem. 285 29 2010 22403 22413
39. J.E. Vance, T.M. Nguyen, and D.E. Vance The biosynthesis of phosphatidylcholine by methylation of phosphatidylethanolamine derived from ethanolamine is not required for lipoprotein secretion by cultured rat hepatocytes Biochim. Biophys. Acta 875 3 1986 501 509
40. J.E. Vance, and D.E. Vance Specific pools of phospholipids are used for lipoprotein secretion by cultured rat hepatocytes J. Biol. Chem. 261 10 1986 4486 4491
41. Y. Zhao Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice Arterioscler. Thromb. Vasc. Biol. 29 9 2009 1349 1355
42. A. Rusinol, H. Verkade, and J.E. Vance Assembly of rat hepatic very low density lipoproteins in the endoplasmic reticulum J. Biol. Chem. 268 5 1993 3555 3562
43. J. Yamaguchi The conversion of apoB100 low density lipoprotein/high density lipoprotein particles to apoB100 very low density lipoproteins in response to oleic acid occurs in the endoplasmic reticulum and not in the Golgi in McA RH7777 cells J. Biol. Chem. 278 43 2003 42643 42651
44. V. Gusarova, J.L. Brodsky, and E.A. Fisher Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER J. Biol. Chem. 278 48 2003 48051 48058
45. C.R. Pullinger The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life J. Lipid Res. 30 7 1989 1065 1077
46. N.O. Davidson, and G.S. Shelness APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation Annu. Rev. Nutr. 20 2000 169 193
47. D.A. Blasiole, R.A. Davis, and A.D. Attie The physiological and molecular regulation of lipoprotein assembly and secretion Mol. Biosyst. 3 9 2007 608 619
48. A.C. Rutledge, Q. Su, and K. Adeli Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly Biochem. Cell Biol. 88 2 2010 251 267
49. R.A. Borchardt, and R.A. Davis Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretion J. Biol. Chem. 262 34 1987 16394 16402
50. M. Zhou, E.A. Fisher, and H.N. Ginsberg Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein J. Biol. Chem. 273 38 1998 24649 24653
51. E.A. Fisher The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70 J. Biol. Chem. 272 33 1997 20427 20434
52. W. Liao, S.C. Yeung, and L. Chan Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulum J. Biol. Chem. 273 42 1998 27225 27230
53. M. Pan Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production J. Clin. Invest. 113 9 2004 1277 1287
54. M. Pan Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control Proc. Natl. Acad. Sci. U. S. A. 105 15 2008 5862 5867
55. D.A. Blasiole, A.T. Oler, and A.D. Attie Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB J. Biol. Chem. 283 17 2008 11374 11381
56. J. Twisk The role of the LDL receptor in apolipoprotein B secretion J. Clin. Invest. 105 4 2000 521 532
57. W. Qiu Overexpression of the endoplasmic reticulum 60 protein ER-60 downregulates apoB100 secretion by inducing its intracellular degradation via a nonproteasomal pathway: evidence for an ER-60-mediated and pCMB-sensitive intracellular degradative pathway Biochemistry 43 16 2004 4819 4831
58. M. Manchekar Apolipoprotein B-containing lipoprotein particle assembly: lipid capacity of the nascent lipoprotein particle J. Biol. Chem. 279 38 2004 39757 39766
59. M. Pan The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis J. Biol. Chem. 277 6 2002 4413 4421
60. Y. Liu Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice Biochim. Biophys. Acta 1781 3 2008 97 104
61. E.A. Fisher The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways J. Biol. Chem. 276 30 2001 27855 27863
62. K.J. Williams, and E.A. Fisher Atherosclerosis: cell biology and lipoproteins-three distinct processes that control apolipoprotein-B secretion Curr. Opin. Lipidol. 12 2 2001 235 237
63. R.S. McLeod Carboxyl-terminal truncation impairs lipid recruitment by apolipoprotein B100 but does not affect secretion of the truncated apolipoprotein B-containing lipoproteins J. Biol. Chem. 269 4 1994 2852 2862
64. E. Wong, and A.M. Cuervo Integration of clearance mechanisms: the proteasome and autophagy Cold Spring Harb. Perspect. Biol. 2 12 2010 a006734
65. H.N. Ginsberg, and E.A. Fisher The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism J. Lipid Res. 50 Suppl. 2009 S162 S166
66. J.D. Sparks, and C.E. Sparks Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes J. Biol. Chem. 265 15 1990 8854 8862
67. S.B. Biddinger Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis Cell Metab. 7 2 2008 125 134
68. A.M. Cuervo Autophagy: many paths to the same end Mol. Cell. Biochem. 263 1-2 2004 55 72
69. X.C. Jiang Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency Nat. Med. 7 7 2001 847 852
70. X.C. Jiang Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants J. Biol. Chem. 280 18 2005 18336 18340
71. P. Rava Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins J. Biol. Chem. 281 16 2006 11019 11027
72. Y. Luo Pharmacologic inhibition of phospholipid transfer protein activity reduces apolipoprotein-B secretion from hepatocytes J. Pharmacol. Exp. Ther. 332 3 2010 1100 1106
73. Y. Luo Identification and characterization of dual inhibitors for phospholipid transfer protein and microsomal triglyceride transfer protein J. Pharmacol. Exp. Ther. 335 3 2010 653 658
74. J.D. Horton Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL J. Clin. Invest. 103 7 1999 1067 1076
75. A.A. Noga, and D.E. Vance Insights into the requirement of phosphatidylcholine synthesis for liver function in mice J. Lipid Res. 44 10 2003 1998 2005
76. B. Teusink Stimulation of the in vivo production of very low density lipoproteins by apolipoprotein E is independent of the presence of the low density lipoprotein receptor J. Biol. Chem. 276 44 2001 40693 40697
77. F. Kuipers Impaired secretion of very low density lipoprotein- triglycerides by apolipoprotein E-deficient mouse hepatocytes J. Clin. Invest. 100 11 1997 2915 2922
78. A.R. Mensenkamp The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice J. Hepatol. 40 4 2004 599 606
79. M. Miyata, and J.D. Smith Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides Nat. Genet. 14 1 1996 55 61
80. D.M. Hatters, C.A. Peters-Libeu, and K.H. Weisgraber Apolipoprotein E structure: insights into function Trends Biochem. Sci. 31 8 2006 445 454
81. L.K. Cole Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- mice Circ. Res. 108 6 2011 686 694
82. G.M. Dallinga-Thie The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight Atherosclerosis 211 1 2010 1 8
83. J.M. Timmins Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I J. Clin. Invest. 115 5 2005 1333 1342
84. R.P. de Crom High density lipoprotein-binding proteins in porcine liver. Isolation and histological localization Arterioscler. Thromb. 12 3 1992 325 331
85. D. Duffy, and D.J. Rader Update on strategies to increase HDL quantity and function Nat. Rev. Cardiol. 6 7 2009 455 463
86. C. Tang, and J.F. Oram The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes Biochim. Biophys. Acta 1791 7 2009 563 572
87. A. Brooks-Wilson Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency Nat. Genet. 22 4 1999 336 345
88. M. Bodzioch The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease Nat. Genet. 22 4 1999 347 351
89. S. Rust Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 Nat. Genet. 22 4 1999 352 355
90. Y. Wang, and J.F. Oram Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway J. Biol. Chem. 280 43 2005 35896 35903
91. Y. Wang, and J.F. Oram Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway J. Lipid Res. 48 5 2007 1062 1068
92. J.C. Robichaud, G.A. Francis, and D.E. Vance A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase J. Biol. Chem. 283 51 2008 35496 35506
93. S.M. Watkins, X. Zhu, and S.H. Zeisel Phosphatidylethanolamine-N- methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice J. Nutr. 133 11 2003 3386 3391
94. M. Hoekstra, T.J. Van Berkel, and M. Van Eck Scavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism World J. Gastroenterol. 16 47 2010 5916 5924
95. C.K. Glass, and J.L. Witztum Atherosclerosis. the road ahead Cell 104 4 2001 503 516
96. D. Lloyd-Jones Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics subcommittee Circulation 119 3 2009 e21 e181
97. D.N. Brindley Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization Am. J. Physiol. Endocrinol. Metab. 298 5 2010 E897 E908
98. N.M. de Alwis, and C.P. Day Non-alcoholic fatty liver disease: the mist gradually clears J. Hepatol. 48 Suppl. 1 2008 S104 S112
99. S. Saadeh Nonalcoholic fatty liver disease and obesity Nutr. Clin. Pract. 22 1 2007 1 10
100. O. James, and C. Day Non-alcoholic steatohepatitis: another disease of affluence Lancet 353 9165 1999 1634 1636
101. C.J. Walkey Biochemical and evolutionary significance of phospholipid methylation J. Biol. Chem. 273 42 1998 27043 27046
102. Z. Li, L.B. Agellon, and D.E. Vance Phosphatidylcholine homeostasis and liver failure J. Biol. Chem. 280 45 2005 37798 37802
103. Z. Li The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis Cell Metab. 3 5 2006 321 331
104. J. Song Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD) FASEB J. 19 10 2005 1266 1271
105. D.W. Jun Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans Eur. J. Gastroenterol. Hepatol. 21 6 2009 667 672
106. K.A. da Costa Common genetic polymorphisms affect the human requirement for the nutrient choline FASEB J. 20 9 2006 1336 1344
107. H. Dong The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population J. Hepatol. 46 5 2007 915 920
108. S. Romeo, J.C. Cohen, and H.H. Hobbs No association between polymorphism in PEMT (V175M) and hepatic triglyceride content in the Dallas Heart Study FASEB J. 20 12 2006 2180 author reply 2181-2
109. C. Minahk Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes J. Biol. Chem. 283 10 2008 6449 6458
110. J.C. Robichaud Hepatic uptake and metabolism of phosphatidylcholine associated with high density lipoproteins Biochim. Biophys. Acta 1790 6 2009 538 551
111. J.S. Millar Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339 J. Lipid Res. 46 9 2005 2023 2028