Human immunodeficiency virus type 1 replication in the absence of integrase-mediated DNA recombination: Definition of permissive and nonpermissive T-cell lines

Journal of Virology

Volumn 75, Issue 17, 2001, Pages 7944-7955

  Nakajima, N ^a   Lu, R ^a   Engelman, A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE;

ARTICLE; CHROMOSOME; CONTROLLED STUDY; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIFE CYCLE; PRIORITY JOURNAL; RNA RECOMBINATION; T LYMPHOCYTE; VIROGENESIS; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS REPLICATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; DNA, VIRAL; HIV INTEGRASE; HIV-1; HUMANS; MUTATION; RECOMBINATION, GENETIC; VIRUS REPLICATION;

EID: 0034863355     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.17.7944-7955.2001     Document Type: Article

References (62)

1. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
2. Analysis of human immunodeficiency virus type 1 integrase mutants
3. Modified Hirt procedure for rapid purification of extrachromosomal DNA from mammalian cells
4. Rapid isolation of eukaryotic DNA
5. Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: Effects on integration and cDNA synthesis
6. Integration
7. Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutations at highly conserved residues
8. Self-limiting, cell-type dependent replication of an integrase-defective human immunodeficiency virus type 1 mutant in human primary macrophages but not T lymphocytes
9. Chromosome structure and human immunodeficiency virus type 1 cDNA integration: Centromeric alphoid repeats are a disfavored target
10. Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)
11. Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type 1 intasome
12. Pac gene as efficient dominant marker and reporter gene in mammalian cells
13. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens
14. In vivo analysis of retroviral integrase structure and function
15. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
16. Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase
17. Integration is required for productive infection of monocyte-derived macrophage by human immunodeficiency virus type 1
18. Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions
19. Mutations in the human immunodeficiency virus type 1 integrase D, D(35)E motif do not eliminate provirus formation
20. Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants
21. Selective extraction of polyoma DNA from infected mouse cell cultures
22. Species-specific, postentry barriers to primate immunodeficiency virus infection
23. Expression status of Tax protein in human T-cell leukemia virus type 1-transformed MT-4 cells: Recall of MT-4 cells distributed by the NIH AIDS Research and Reference Reagent Program
24. Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking
25. An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat
26. Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemia T-cell line Molt-4
27. Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene
28. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells
29. Quantitative HIV culture
30. Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate DNA efficiently during infection
31. Human immunodeficiency virus infection of cells arrested in the cell cycle
32. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands
33. The Epstein-Barr virus BZLF1 gene product activates the human immunodeficiency virus type 1 5′ long terminal repeat
34. Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: Unusual phenotype of mutants in the zinc finger-like domain
35. Type-C virus-producing cell lines derived from adult T-cell leukemia
36. The long cytoplasmic tail of gp41 is required in a cell type-dependent manner for HIV-1 envelope glycoprotein incorporation into virions
37. High levels of unintegrated DNA in brain tissue of AIDS dementia patients
38. Use of cis- and trans-acting viral regulatory sequences to improve expression of human immunodeficiency virus vectors in human lymphocytes
39. Production of high-titer helper-free retroviruses by transient transfection
40. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
41. Efficient HIV-1 replication can occur in the absence of the viral matrix protein
42. Intrabody-mediated knockout of the high-affinity IL-2 receptor in primary human T cells using a bicistronic lentivirus vector
43. Contribution of NF-κB and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: Distinct patterns of viral growth are determined by T-cell types
44. Integration is essential for efficient gene expression of human immunodeficiency virus type 1
45. Restricted expression of human T-cell leukemia-lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes
46. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
47. Epstein-Barr virus nuclear antigen 2 transactivates the long terminal repeat of human immunodeficiency virus type 1
48. Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: Potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia
49. Genetic analysis of the human immunodeficiency virus type 1 integrase protein
50. Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-1
51. Human immunodeficiency virus type 1 NL4-L3 replication in four T-cell lines: Rate and efficiency of entry, a major determinant of permissiveness
52. Integration is not necessary for expression of human immunodeficiency virus type 1 protein products
53. Control selection for RNA quantitation
54. The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells
55. Circular forms of unintegrated human immunodeficiency virus type 1 DNA and high levels of viral protein expression: Association with dementia and multinucleated giant cells in the brains of patients with AIDS
56. Host sequences flanking the HIV provirus
57. Analysis of the junctions between human immunodeficiency virus type 1 proviral DNA and human DNA
58. The role of T3 surface molecules in the activation of human T cells: A two-stimulus requirement for IL 2 production reflects events occurring at a pretranslational level
59. Human immunodeficiency virus type 1 integrase: Effects of mutations on viral ability to integrate, direct gene expression from unintegrated viral DNA templates, and sustain propagation in primary cells
60. Distribution of targets for avian retrovirus DNA integration in vivo
61. A general method for the generation of high-titer, pantropic retroviral vectors: Highly efficient infection of primary lymphocytes