HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency

Journal of Leukocyte Biology

Volumn 87, Issue 6, 2010, Pages 1133-1143

  Hoshino, Shigeki ^a,b   Konishi, Mitsuru ^c   Mori, Masako ^d   Shimura, Mari ^a   Nishitani, Chiaki ^e   Kuroki, Yoshio ^e   Koyanagi, Yoshio ^f   Kano, Shigeyuki ^a,b   Itabe, Hiroyuki ^g   Ishizaka, Yukihito ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d NOGUCHI INSTITUTE   (Japan)

^e SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f KYOTO UNIVERSITY   (Japan)

^g SHOWA UNIVERSITY   (Japan)

Author keywords

Oxidative stress; Oxidized phosphatidylcholine

Indexed keywords

INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLCHOLINE; TOLL LIKE RECEPTOR 4; VPR PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CEBPB PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MYD88 PROTEIN, HUMAN; PHOSPHOLIPID; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TLR4 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INNATE IMMUNITY; MONOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS REPLICATION; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PROMOTER REGION; PROTEIN MICROARRAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS ACTIVATION; WESTERN BLOTTING;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-6; MAP KINASE SIGNALING SYSTEM; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; OXIDATION-REDUCTION; PHOSPHOLIPIDS; PROMOTER REGIONS, GENETIC; PROTEIN ARRAY ANALYSIS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 4; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 77953977025     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0809547     Document Type: Article

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