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Volumn , Issue , 2009, Pages 86-100

Molecular and cellular basis of hemoglobin switching

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EID: 84873993458     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511596582.009     Document Type: Chapter
Times cited : (2)

References (182)
  • 2
    • 0013897148 scopus 로고
    • Predominance of hemoglobin Gower 1 in early human embryonic development
    • Hecht F, Motulsky AG, Lemire RJ, Shepard TE. Predominance of hemoglobin Gower 1 in early human embryonic development. Science. 1966;152:91-92.
    • (1966) Science , vol.152 , pp. 91-92
    • Hecht, F.1    Motulsky, A.G.2    Lemire, R.J.3    Shepard, T.E.4
  • 3
    • 0018756910 scopus 로고
    • Human embryonic haemoglobins Gower 1 and Gower 2
    • Gale RE, Clegg JB, Huehns ER. Human embryonic haemoglobins Gower 1 and Gower 2. Nature. 1979;280:162-164.
    • (1979) Nature , vol.280 , pp. 162-164
    • Gale, R.E.1    Clegg, J.B.2    Huehns, E.R.3
  • 4
    • 0021000119 scopus 로고
    • Studies of hemoglobin expression in erythroid cells of early human fetuses using antiγ-and anti-β-globin chain fluorescent antibodies
    • Papayannopoulou T, Shepard TH, Stamatoyannopoulos G. Studies of hemoglobin expression in erythroid cells of early human fetuses using antiγ-and anti-β-globin chain fluorescent antibodies. Prog Clin Biol Res. 1983;134:421-430.
    • (1983) Prog Clin Biol Res , vol.134 , pp. 421-430
    • Papayannopoulou, T.1    Shepard, T.H.2    Stamatoyannopoulos, G.3
  • 5
    • 0016793039 scopus 로고
    • Fetal hemoglobin restriction to a few erythrocytes (F cells) in normal human adults
    • Boyer SH, Belding TK, Margolet L, Noyes AN. Fetal hemoglobin restriction to a few erythrocytes (F cells) in normal human adults. Science. 1975;188:361-363.
    • (1975) Science , vol.188 , pp. 361-363
    • Boyer, S.H.1    Belding, T.K.2    Margolet, L.3    Noyes, A.N.4
  • 6
    • 0016713936 scopus 로고
    • F-cells in the adult: Normal values and levels in individuals with hereditary and acquired elevations of Hb F
    • Wood WG, Stamatoyannopoulos G, Lim G, Nute PE. F-cells in the adult: normal values and levels in individuals with hereditary and acquired elevations of Hb F. Blood. 1975;46:671-682.
    • (1975) Blood , vol.46 , pp. 671-682
    • Wood, W.G.1    Stamatoyannopoulos, G.2    Lim, G.3    Nute, P.E.4
  • 7
    • 0015502339 scopus 로고
    • Embryonic red blood cell formation
    • Ingram VM. Embryonic red blood cell formation. Nature. 1972;235:338-339.
    • (1972) Nature , vol.235 , pp. 338-339
    • Ingram, V.M.1
  • 8
    • 0014419897 scopus 로고
    • Haemoglobin and red cell enzyme changes in juvenile myeloid leukaemia
    • Weatherall DJ, Edwards JA, Donohoe WT. Haemoglobin and red cell enzyme changes in juvenile myeloid leukaemia. Br Med J. 1968;1:679-681.
    • (1968) Br Med J , vol.1 , pp. 679-681
    • Weatherall, D.J.1    Edwards, J.A.2    Donohoe, W.T.3
  • 9
    • 0017119618 scopus 로고
    • A model for the persistence or reactivation of fetal haemoglobin production
    • Weatherall DJ, Clegg JB, Wood WG. A model for the persistence or reactivation of fetal haemoglobin production. Lancet. 1976;2:660-663.
    • (1976) Lancet , vol.2 , pp. 660-663
    • Weatherall, D.J.1    Clegg, J.B.2    Wood, W.G.3
  • 11
    • 0019474042 scopus 로고
    • Control of the simian fetal hemoglobin switch at the progenitor cell level
    • Alter BP, Jackson BT, Lipton JM, et al. Control of the simian fetal hemoglobin switch at the progenitor cell level. J Clin Invest. 1981;67:458-466.
    • (1981) J Clin Invest , vol.67 , pp. 458-466
    • Alter, B.P.1    Jackson, B.T.2    Lipton, J.M.3
  • 12
    • 84932296770 scopus 로고
    • Three classes of erythroid progenitors that regulate hemoglobin synthesis during ontogeny in the primate
    • Stamatoyannopoulos G, Nienhuis AW, eds. New York: Alan R. Liss
    • Alter BP, Jackson BT, Lipton JM, et al. Three classes of erythroid progenitors that regulate hemoglobin synthesis during ontogeny in the primate. In: Stamatoyannopoulos G, Nienhuis AW, eds. Hemoglobins in Development and Differentiation. New York: Alan R. Liss; 1981:331-340.
    • (1981) Hemoglobins in Development and Differentiation , pp. 331-340
    • Alter, B.P.1    Jackson, B.T.2    Lipton, J.M.3
  • 13
    • 0017385442 scopus 로고
    • Hemoglobin F synthesis in vitro: Evidence for control at the level of primitive erythroid stem cells
    • Papayannopoulou T, Brice M, Stamatoyannopoulos G. Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells. Proc Natl Acad Sci USA.1977;74:2923-2927.
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 2923-2927
    • Papayannopoulou, T.1    Brice, M.2    Stamatoyannopoulos, G.3
  • 14
    • 0018771468 scopus 로고
    • Distribution of developmentally regulated hemoglobins in embryonic erythroid populations
    • Chapman BS, Tobin AJ. Distribution of developmentally regulated hemoglobins in embryonic erythroid populations. Dev Biol. 1979;69:375-387.
    • (1979) Dev Biol , vol.69 , pp. 375-387
    • Chapman, B.S.1    Tobin, A.J.2
  • 16
    • 0002882408 scopus 로고
    • Ontogeny of hematopoietic organs studied in avian embryo interspecific chimeras
    • Clarkson B, Marks P, Till J, eds. New York: Cold Spring Harbor
    • Le Douarin N. Ontogeny of hematopoietic organs studied in avian embryo interspecific chimeras. In: Clarkson B, Marks P, Till J, eds.Differentiation inNormal andNeoplasticHemopoietic Cells. New York: Cold Spring Harbor; 1978:5-31.
    • (1978) Differentiation inNormal andNeoplasticHemopoietic Cells , pp. 5-31
    • Le Douarin, N.1
  • 17
    • 0344842086 scopus 로고
    • Origin and evolution of hemopoietic stem cells in the avian embryo
    • Stamatoyannopoulos G, Nienhuis AW, eds. New York: Alan R. Liss
    • Beaupain D, Martin C, Dieterlen-Lievre F. Origin and evolution of hemopoietic stem cells in the avian embryo. In: Stamatoyannopoulos G, Nienhuis AW, eds. Hemoglobins in Development and Differentiation. New York: Alan R. Liss; 1981: 161-169.
    • (1981) Hemoglobins in Development and Differentiation , pp. 161-169
    • Beaupain, D.1    Martin, C.2    Dieterlen-Lievre, F.3
  • 18
    • 0021414480 scopus 로고
    • Embryonic-Fetal Hb switch in humans: Studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver
    • Peschle C, Migliaccio AR, Migliaccio G, et al. Embryonic-Fetal Hb switch in humans: studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver. Proc Natl Acad Sci USA. 1984;81:2416-2420.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 2416-2420
    • Peschle, C.1    Migliaccio, A.R.2    Migliaccio, G.3
  • 19
    • 0023226689 scopus 로고
    • Coexpression of embryonic, fetal, and adult globins in erythroid cells of human embryos: Relevance to the cell-lineage models of globin switching
    • Stamatoyannopoulos G, Constantoulakis P, Brice M, Kurachi S, Papayannopoulou T. Coexpression of embryonic, fetal, and adult globins in erythroid cells of human embryos: relevance to the cell-lineage models of globin switching. Dev Biol. 1987;123:191-197.
    • (1987) Dev Biol , vol.123 , pp. 191-197
    • Stamatoyannopoulos, G.1    Constantoulakis, P.2    Brice, M.3    Kurachi, S.4    Papayannopoulou, T.5
  • 20
    • 0000831381 scopus 로고    scopus 로고
    • Hemoglobin switching
    • Stamatoyannopoulos G, Majerus P, Perlmutter R, Varmus H, eds. 3rd ed. Philadelphia:W.B. Saunders Co
    • Stamatoyannopoulos G, Grosveld F. Hemoglobin switching. In: Stamatoyannopoulos G, Majerus P, Perlmutter R, Varmus H, eds. The Molecular Basis of Blood Diseases. 3rd ed. Philadelphia:W.B. Saunders Co.; 2001:135-182.
    • (2001) The Molecular Basis of Blood Diseases , pp. 135-182
    • Stamatoyannopoulos, G.1    Grosveld, F.2
  • 21
    • 0022492422 scopus 로고
    • Analysis of human hemoglobin switching in MEL × human fetal erythroid cell hybrids
    • Papayannopoulou T, Brice M, Stamatoyannopoulos G. Analysis of human hemoglobin switching in MEL × human fetal erythroid cell hybrids. Cell. 1986;46:469-476.
    • (1986) Cell , vol.46 , pp. 469-476
    • Papayannopoulou, T.1    Brice, M.2    Stamatoyannopoulos, G.3
  • 22
    • 0021910906 scopus 로고
    • The role of fetal adrenal hormones in the switch from fetal to adult globin synthesis in the sheep
    • Wintour EM, Smith MB, Bell RJ, McDougall JG, Cauchi MN. The role of fetal adrenal hormones in the switch from fetal to adult globin synthesis in the sheep. J Endocrinol. 1985;104:165-170.
    • (1985) J Endocrinol , vol.104 , pp. 165-170
    • Wintour, E.M.1    Smith, M.B.2    Bell, R.J.3    McDougall, J.G.4    Cauchi, M.N.5
  • 23
    • 0027237547 scopus 로고
    • Serum factors can modulate the developmental clock of γ-to β-globin gene switching in somatic cell hybrids
    • Zitnik G, Li Q, Stamatoyannopoulos G, Papayannopoulou T. Serum factors can modulate the developmental clock of γ-to β-globin gene switching in somatic cell hybrids. Mol Cell Biol. 1993;13:4844-4851.
    • (1993) Mol Cell Biol , vol.13 , pp. 4844-4851
    • Zitnik, G.1    Li, Q.2    Stamatoyannopoulos, G.3    Papayannopoulou, T.4
  • 24
    • 0028797217 scopus 로고
    • Effects of butyrate and glucocorticoids on γ-to β-globin gene switching in somatic cell hybrids
    • Zitnik G, Peterson K, Stamatoyannopoulos G, Papayannopoulou T. Effects of butyrate and glucocorticoids on γ-to β-globin gene switching in somatic cell hybrids. Mol Cell Biol. 1995;15:790-795.
    • (1995) Mol Cell Biol , vol.15 , pp. 790-795
    • Zitnik, G.1    Peterson, K.2    Stamatoyannopoulos, G.3    Papayannopoulou, T.4
  • 25
    • 0014464788 scopus 로고
    • [Studies of fetal blood. I. Fetal and adult hemoglobin levels in normal pregnancy. Relation to fetal maturity]
    • Della Torre L, Meroni P. [Studies of fetal blood. I. Fetal and adult hemoglobin levels in normal pregnancy. Relation to fetal maturity]. Ann Ostet Ginecol Med Perinat. 1969;91:148-157.
    • (1969) Ann Ostet Ginecol Med Perinat , vol.91 , pp. 148-157
    • Della Torre, L.1    Meroni, P.2
  • 26
    • 0014791924 scopus 로고
    • The relative rates of synthesis of hemoglobins A and F in immature red cells of newborn infants
    • Bard H, Makowski EL, Meschia G, Battaglia FC. The relative rates of synthesis of hemoglobins A and F in immature red cells of newborn infants. Pediatrics. 1970;45:766-772.
    • (1970) Pediatrics , vol.45 , pp. 766-772
    • Bard, H.1    Makowski, E.L.2    Meschia, G.3    Battaglia, F.C.4
  • 27
    • 0020049307 scopus 로고
    • Adult haematopoietic cells transplanted to sheep fetuses continue to produce adult globins
    • Zanjani ED, Lim G, McGlave PB, et al. Adult haematopoietic cells transplanted to sheep fetuses continue to produce adult globins. Nature. 1982;295:244-246.
    • (1982) Nature , vol.295 , pp. 244-246
    • Zanjani, E.D.1    Lim, G.2    McGlave, P.B.3
  • 28
    • 0021969576 scopus 로고
    • Control of haemoglobin switching by a developmental clock?
    • Wood WG, Bunch C, Kelly S, Gunn Y, Breckon G. Control of haemoglobin switching by a developmental clock? Nature. 1985;313:320-323.
    • (1985) Nature , vol.313 , pp. 320-323
    • Wood, W.G.1    Bunch, C.2    Kelly, S.3    Gunn, Y.4    Breckon, G.5
  • 29
    • 0016439429 scopus 로고
    • DNA modification mechanisms and gene activity during development
    • Holliday R, Pugh JE. DNA modification mechanisms and gene activity during development. Science. 1975;187:226-232.
    • (1975) Science , vol.187 , pp. 226-232
    • Holliday, R.1    Pugh, J.E.2
  • 30
    • 0023625897 scopus 로고
    • A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch
    • Melis M, Demopulos G, Najfeld V, et al. A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch. Proc Natl Acad Sci USA. 1987;84:8105-8109.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8105-8109
    • Melis, M.1    Demopulos, G.2    Najfeld, V.3
  • 31
    • 0029025075 scopus 로고
    • Established epigenetic modifications determine the expression of developmentally regulated globin genes in somatic cell hybrids
    • Stanworth SJ, Roberts NA, Sharpe JA, Sloane-Stanley JA, Wood WG. Established epigenetic modifications determine the expression of developmentally regulated globin genes in somatic cell hybrids. Mol Cell Biol. 1995;15:3969-3978.
    • (1995) Mol Cell Biol , vol.15 , pp. 3969-3978
    • Stanworth, S.J.1    Roberts, N.A.2    Sharpe, J.A.3    Sloane-Stanley, J.A.4    Wood, W.G.5
  • 32
    • 0027392751 scopus 로고
    • Enhancer-dependent transcription of the t-globin promoter requires promoter-bound GATA-1 and enhancer-bound AP-1/NF-E2
    • Gong Q, Dean A. Enhancer-dependent transcription of the t-globin promoter requires promoter-bound GATA-1 and enhancer-bound AP-1/NF-E2. Mol Cell Biol. 1993;13: 911-917.
    • (1993) Mol Cell Biol , vol.13 , pp. 911-917
    • Gong, Q.1    Dean, A.2
  • 33
    • 0026325283 scopus 로고
    • Transcriptional role of a conserved GATA-1 site in the human G-globin gene promoter
    • Gong QH, Stern J, Dean A. Transcriptional role of a conserved GATA-1 site in the human G-globin gene promoter. Mol Cell Biol. 1991;11:2558-2566.
    • (1991) Mol Cell Biol , vol.11 , pp. 2558-2566
    • Gong, Q.H.1    Stern, J.2    Dean, A.3
  • 34
    • 0026443851 scopus 로고
    • Functional erythroid promoters created by interaction of the transcription factor GATA-1 with CACCC and AP-1/NFE-2 elements
    • Walters M, Martin DI. Functional erythroid promoters created by interaction of the transcription factor GATA-1 with CACCC and AP-1/NFE-2 elements. Proc Natl Acad Sci USA. 1992;89:10444-10448.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10444-10448
    • Walters, M.1    Martin, D.I.2
  • 35
    • 0033081098 scopus 로고    scopus 로고
    • Regulation of embryonic/fetal globin genes by nuclear hormone receptors: A novel perspective on hemoglobin switching
    • Filipe A, Li Q, Deveaux S, et al. Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching. EMBO J. 1999;18:687-697.
    • (1999) EMBO J , vol.18 , pp. 687-697
    • Filipe, A.1    Li, Q.2    Deveaux, S.3
  • 36
    • 0025914109 scopus 로고
    • The CACC box upstream of human embryonic bbglobin gene binds Sp1 and is a functional promoter element in vitro and in vivo
    • Yu CY, Motamed K, Chen J, Bailey AD, Shen CK. The CACC box upstream of human embryonic bbglobin gene binds Sp1 and is a functional promoter element in vitro and in vivo. J Biol Chem. 1991;266:8907-8915.
    • (1991) J Biol Chem , vol.266 , pp. 8907-8915
    • Yu, C.Y.1    Motamed, K.2    Chen, J.3    Bailey, A.D.4    Shen, C.K.5
  • 37
    • 0030853287 scopus 로고    scopus 로고
    • Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
    • Marin M, Karis A, Visser P, Grosveld F, Philipsen S. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997;89:619-628.
    • (1997) Cell , vol.89 , pp. 619-628
    • Marin, M.1    Karis, A.2    Visser, P.3    Grosveld, F.4    Philipsen, S.5
  • 38
    • 0032588399 scopus 로고    scopus 로고
    • FKLF, a novel Kruppel-like factor that activates human embryonic and fetal β-like globin genes
    • Asano H, Li XS, Stamatoyannopoulos G. FKLF, a novel Kruppel-like factor that activates human embryonic and fetal β-like globin genes.Mol Cell Biol. 1999;19:3571-3579.
    • (1999) Mol Cell Biol , vol.19 , pp. 3571-3579
    • Asano, H.1    Li, X.S.2    Stamatoyannopoulos, G.3
  • 39
    • 0343081068 scopus 로고    scopus 로고
    • FKLF-2: A novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes
    • Asano H, Li XS, Stamatoyannopoulos G. FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes. Blood. 2000;95:3578-3584.
    • (2000) Blood , vol.95 , pp. 3578-3584
    • Asano, H.1    Li, X.S.2    Stamatoyannopoulos, G.3
  • 40
    • 0034312291 scopus 로고    scopus 로고
    • Contextdependent EKLF responsiveness defines the developmental specificity of the human s-globin gene in erythroid cells of YAC transgenic mice
    • Tanimoto K, Liu Q, Grosveld F, Bungert J, Engel JD. Contextdependent EKLF responsiveness defines the developmental specificity of the human s-globin gene in erythroid cells of YAC transgenic mice. Genes Dev. 2000;14:2778-2794.
    • (2000) Genes Dev , vol.14 , pp. 2778-2794
    • Tanimoto, K.1    Liu, Q.2    Grosveld, F.3    Bungert, J.4    Engel, J.D.5
  • 41
    • 0036646514 scopus 로고    scopus 로고
    • An embryonic/fetal β-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer
    • Tanabe O, Katsuoka F, Campbell AD, et al. An embryonic/fetal β-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. EMBO J. 2002;21:3434-3442.
    • (2002) EMBO J , vol.21 , pp. 3434-3442
    • Tanabe, O.1    Katsuoka, F.2    Campbell, A.D.3
  • 42
    • 34247569022 scopus 로고    scopus 로고
    • Embryonic and fetal β-globin gene repression by the orphan nuclear receptors, TR2 and TR4
    • Tanabe O, McPhee D, Kobayashi S, et al. Embryonic and fetal β-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J. 2007;26:2295-2306.
    • (2007) EMBO J , vol.26 , pp. 2295-2306
    • Tanabe, O.1    McPhee, D.2    Kobayashi, S.3
  • 44
    • 0032562560 scopus 로고    scopus 로고
    • Multiple regulatory elements in the 5ʹ-flanking sequence of the human h-globin gene
    • Li J, Noguchi CT, Miller W, Hardison R, Schechter AN. Multiple regulatory elements in the 5ʹ-flanking sequence of the human h-globin gene. J Biol Chem. 1998;273:10202-10209.
    • (1998) J Biol Chem , vol.273 , pp. 10202-10209
    • Li, J.1    Noguchi, C.T.2    Miller, W.3    Hardison, R.4    Schechter, A.N.5
  • 45
    • 0027422976 scopus 로고
    • Developmental regulation of the human embryonic β-like globin gene is mediated by synergistic interactions among multiple tissue-and stagespecific elements
    • Trepicchio WL, Dyer MA, Baron MH. Developmental regulation of the human embryonic β-like globin gene is mediated by synergistic interactions among multiple tissue-and stagespecific elements. Mol Cell Biol. 1993;13:7457-7468.
    • (1993) Mol Cell Biol , vol.13 , pp. 7457-7468
    • Trepicchio, W.L.1    Dyer, M.A.2    Baron, M.H.3
  • 46
    • 33645780863 scopus 로고    scopus 로고
    • Sox6 directly silences 44globin expression in definitive erythropoiesis
    • Yi Z, Cohen-Barak O, Hagiwara N, et al. Sox6 directly silences 44globin expression in definitive erythropoiesis. PLoS Genet. 2006;2:e14.
    • (2006) PLoS Genet , vol.2
    • Yi, Z.1    Cohen-Barak, O.2    Hagiwara, N.3
  • 47
    • 33847052843 scopus 로고    scopus 로고
    • Stem cell transplantation demonstrates that Sox6 represses ty globin expression in definitive erythropoiesis of adult mice
    • Cohen-Barak O, Erickson DT, Badowski MS, et al. Stem cell transplantation demonstrates that Sox6 represses ty globin expression in definitive erythropoiesis of adult mice. Exp Hematol. 2007;35:358-367.
    • (2007) Exp Hematol , vol.35 , pp. 358-367
    • Cohen-Barak, O.1    Erickson, D.T.2    Badowski, M.S.3
  • 48
    • 0026738749 scopus 로고
    • Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human γ and ε aglobin genes
    • Gumucio DL, Heilstedt-Williamson H, Gray TA, et al. Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human γ and ε aglobin genes. Mol Cell Biol. 1992;12:4919-4929
    • (1992) Mol Cell Biol , vol.12 , pp. 4919-4929
    • Gumucio, D.L.1    Heilstedt-Williamson, H.2    Gray, T.A.3
  • 49
    • 0026643123 scopus 로고
    • Identification of a stage selector element in the human γ-globin gene promoter that fosters preferential interaction with the 5ʹ HS2 enhancer when in competition with the β-promoter
    • Jane SM, Ney PA, Vanin EF, Gumucio DL, Nienhuis AW. Identification of a stage selector element in the human γ-globin gene promoter that fosters preferential interaction with the 5ʹ HS2 enhancer when in competition with the β-promoter. EMBO J. 1992;11:2961-2969.
    • (1992) EMBO J , vol.11 , pp. 2961-2969
    • Jane, S.M.1    Ney, P.A.2    Vanin, E.F.3    Gumucio, D.L.4    Nienhuis, A.W.5
  • 50
    • 0027245556 scopus 로고
    • Methylation-enhanced binding of Sp1 to the stage selector element of the human γ-globin gene promoter may regulate development specificity of expression
    • Jane SM, Gumucio DL, Ney PA, Cunningham JM, Nienhuis AW.Methylation-enhanced binding of Sp1 to the stage selector element of the human γ-globin gene promoter may regulate development specificity of expression. Mol Cell Biol. 1993;13:3272-3281.
    • (1993) Mol Cell Biol , vol.13 , pp. 3272-3281
    • Jane, S.M.1    Gumucio, D.L.2    Ney, P.A.3    Cunningham, J.M.4    Nienhuis, A.W.5
  • 51
    • 0028804404 scopus 로고
    • Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein
    • Jane SM, Nienhuis AW, Cunningham JM. Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. EMBO J. 1995;14:97-105.
    • (1995) EMBO J , vol.14 , pp. 97-105
    • Jane, S.M.1    Nienhuis, A.W.2    Cunningham, J.M.3
  • 52
    • 0006263002 scopus 로고    scopus 로고
    • Isolation and characteriztion of human NF-E4, the tissue restricted component of the stage selector protein complex
    • Zhou WL, Clouston X, Wang L, Cerruti J, Cunningham JM, Jane SM. Isolation and characteriztion of human NF-E4, the tissue restricted component of the stage selector protein complex. Blood. 1999;94(Suppl 1):614a.
    • (1999) Blood , vol.94
    • Zhou, W.L.1    Clouston, X.2    Wang, L.3    Cerruti, J.4    Cunningham, J.M.5    Jane, S.M.6
  • 53
    • 0023733224 scopus 로고
    • Nuclear proteins that bind the human γ-globin gene promoter: Alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin
    • Gumucio DL, Rood KL, Gray TA, Riordan MF, Sartor CI, Collins FS. Nuclear proteins that bind the human γ-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin. Mol Cell Biol. 1988;8:5310-5322.
    • (1988) Mol Cell Biol , vol.8 , pp. 5310-5322
    • Gumucio, D.L.1    Rood, K.L.2    Gray, T.A.3    Riordan, M.F.4    Sartor, C.I.5    Collins, F.S.6
  • 54
    • 0023695889 scopus 로고
    • The effects of HPFH mutations in the human γ-globin promoter on binding of ubiquitous and erythroid specific nuclear factors
    • Mantovani R, Malgaretti N, Nicolis S, Ronchi A, Giglioni B, Ottolenghi S. The effects of HPFH mutations in the human γ-globin promoter on binding of ubiquitous and erythroid specific nuclear factors. Nucl Acids Res. 1988;16:7783-7797.
    • (1988) Nucl Acids Res , vol.16 , pp. 7783-7797
    • Mantovani, R.1    Malgaretti, N.2    Nicolis, S.3    Ronchi, A.4    Giglioni, B.5    Ottolenghi, S.6
  • 55
    • 0024407770 scopus 로고
    • The deletion of the distal CCAAT box region of the A γ-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein
    • Mantovani R, Superti-Furga G, Gilman J, Ottolenghi S. The deletion of the distal CCAAT box region of the A γ-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein. Nucl Acids Res. 1989;17:6681-6691.
    • (1989) Nucl Acids Res , vol.17 , pp. 6681-6691
    • Mantovani, R.1    Superti-Furga, G.2    Gilman, J.3    Ottolenghi, S.4
  • 56
    • 0025180839 scopus 로고
    • A novel C-T transition within the distal CCAAT motif of the G γ-globin gene in the Japanese HPFH: Implication of factor binding in elevated fetal globin expression
    • Fucharoen S, Shimizu K, Fukumaki Y. A novel C-T transition within the distal CCAAT motif of the G γ-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression. Nucl Acids Res. 1990;18:5245-5253.
    • (1990) Nucl Acids Res , vol.18 , pp. 5245-5253
    • Fucharoen, S.1    Shimizu, K.2    Fukumaki, Y.3
  • 57
    • 0001274728 scopus 로고
    • Induction of the human γ-globin gene promoter in K562 cells by sodium butyrate: Reversal of repression by CCAAT displacement protein
    • McDonagh K, Nienhuis AW. Induction of the human γ-globin gene promoter in K562 cells by sodium butyrate: Reversal of repression by CCAAT displacement protein. Blood. 1991;78:255a.
    • (1991) Blood , vol.78
    • McDonagh, K.1    Nienhuis, A.W.2
  • 58
    • 0026649933 scopus 로고
    • A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin
    • Berry M, Grosveld F, Dillon N. A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin. Nature. 1992;358:499-502.
    • (1992) Nature , vol.358 , pp. 499-502
    • Berry, M.1    Grosveld, F.2    Dillon, N.3
  • 59
    • 0026055324 scopus 로고
    • CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter
    • Skalnik DG, Strauss EC, Orkin SH. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J Biol Chem. 1991;266:16736-16744.
    • (1991) J Biol Chem , vol.266 , pp. 16736-16744
    • Skalnik, D.G.1    Strauss, E.C.2    Orkin, S.H.3
  • 60
    • 0029132703 scopus 로고
    • Differential binding of the NFE3 and CP1/NFY transcription factors to the human γ-and ε globin CCAAT boxes
    • Ronchi AE, Bottardi S, Mazzucchelli C, Ottolenghi S, Santoro C. Differential binding of the NFE3 and CP1/NFY transcription factors to the human γ-and ε globin CCAAT boxes. J Biol Chem. 1995;270:21934-21941.
    • (1995) J Biol Chem , vol.270 , pp. 21934-21941
    • Ronchi, A.E.1    Bottardi, S.2    Mazzucchelli, C.3    Ottolenghi, S.4    Santoro, C.5
  • 61
    • 0030071336 scopus 로고    scopus 로고
    • Role of the duplicated CCAAT box region in γ-globin gene regulation and hereditary persistence of fetal haemoglobin
    • Ronchi A, Berry M, Raguz S, et al. Role of the duplicated CCAAT box region in γ-globin gene regulation and hereditary persistence of fetal haemoglobin. EMBO J. 1996;15:143-149.
    • (1996) EMBO J , vol.15 , pp. 143-149
    • Ronchi, A.1    Berry, M.2    Raguz, S.3
  • 62
    • 33748525856 scopus 로고    scopus 로고
    • Transcriptional potential of the γ-globin gene is dependent on the CACCC box in a developmental stage-specific manner
    • Li Q, Fang X, Olave I, et al. Transcriptional potential of the γ-globin gene is dependent on the CACCC box in a developmental stage-specific manner. Nucl Acids Res. 2006;34:3909-3916.
    • (2006) Nucl Acids Res , vol.34 , pp. 3909-3916
    • Li, Q.1    Fang, X.2    Olave, I.3
  • 63
    • 0026005352 scopus 로고
    • The upstream region of the human γ-globin gene promoter. Identification and functional analysis of nuclear protein binding sites
    • McDonagh KT, Lin HJ, Lowrey CH, Bodine DM, Nienhuis AW. The upstream region of the human γ-globin gene promoter. Identification and functional analysis of nuclear protein binding sites. J Biol Chem. 1991;266:11965-11974.
    • (1991) J Biol Chem , vol.266 , pp. 11965-11974
    • McDonagh, K.T.1    Lin, H.J.2    Lowrey, C.H.3    Bodine, D.M.4    Nienhuis, A.W.5
  • 64
    • 0028857098 scopus 로고
    • HMG-I binds to GATA motifs: Implications for an HPFH syndrome
    • Magis W, Martin DI. HMG-I binds to GATA motifs: implications for an HPFH syndrome. Biochem Biophys Res Commun. 1995;214:927-933.
    • (1995) Biochem Biophys Res Commun , vol.214 , pp. 927-933
    • Magis, W.1    Martin, D.I.2
  • 65
    • 0026729986 scopus 로고
    • An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin
    • Ulrich MJ, Gray WJ, Ley TJ. An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin. J Biol Chem. 1992;267:18649-18658.
    • (1992) J Biol Chem , vol.267 , pp. 18649-18658
    • Ulrich, M.J.1    Gray, W.J.2    Ley, T.J.3
  • 66
    • 0028803597 scopus 로고
    • An intramolecular triplex in the human γ-globin 5ʹ-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin
    • Bacolla A, Ulrich MJ, Larson JE, Ley TJ, Wells RD. An intramolecular triplex in the human γ-globin 5ʹ-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin. J Biol Chem. 1995;270: 24556-24563.
    • (1995) J Biol Chem , vol.270 , pp. 24556-24563
    • Bacolla, A.1    Ulrich, M.J.2    Larson, J.E.3    Ley, T.J.4    Wells, R.D.5
  • 67
    • 0025727471 scopus 로고
    • Transcription factor OTF-1 interacts with two distinct DNA elements in the A γ-globin gene promoter
    • Ponce E, Lloyd JA, Pierani A, Roeder RG, Lingrel JB. Transcription factor OTF-1 interacts with two distinct DNA elements in the A γ-globin gene promoter. Biochemistry. 1991;30:2961-2967.
    • (1991) Biochemistry , vol.30 , pp. 2961-2967
    • Ponce, E.1    Lloyd, J.A.2    Pierani, A.3    Roeder, R.G.4    Lingrel, J.B.5
  • 68
    • 0027367941 scopus 로고
    • Developmental regulation of human γ-globin genes in transgenic mice
    • Stamatoyannopoulos G, Josephson B, Zhang JW, Li Q. Developmental regulation of human γ-globin genes in transgenic mice.Mol Cell Biol. 1993;13:7636-7644.
    • (1993) Mol Cell Biol , vol.13 , pp. 7636-7644
    • Stamatoyannopoulos, G.1    Josephson, B.2    Zhang, J.W.3    Li, Q.4
  • 69
    • 0029768863 scopus 로고    scopus 로고
    • In vivo search for butyrate responsive sequences using transgenic mice carrying A γ gene promoter mutants
    • Pace BS, Li Q, Stamatoyannopoulos G. In vivo search for butyrate responsive sequences using transgenic mice carrying A γ gene promoter mutants. Blood. 1996;88:1079-1083.
    • (1996) Blood , vol.88 , pp. 1079-1083
    • Pace, B.S.1    Li, Q.2    Stamatoyannopoulos, G.3
  • 70
    • 43249130256 scopus 로고    scopus 로고
    • A mutation in a GATA-1 binding site 5' to the Gγ-globin gene (nt-567, T>G) may be associated with increased levels of fetal hemoglobin
    • Luo HY, Mang D, Patrinos GP, et al. A mutation in a GATA-1 binding site 5' to the Gγ-globin gene (nt-567, T>G) may be associated with increased levels of fetal hemoglobin. Blood. 2004;104:500.
    • (2004) Blood , vol.104 , pp. 500
    • Luo, H.Y.1    Mang, D.2    Patrinos, G.P.3
  • 71
    • 84932608177 scopus 로고    scopus 로고
    • Silencing of γ-globin gene expression during adult definitive erythropoiesis is mediated by a GATA-1 repressor complex
    • Peterson KR, Costa FC, Harju-Baker S. Silencing of γ-globin gene expression during adult definitive erythropoiesis is mediated by a GATA-1 repressor complex. Blood. 2007;110:271.
    • (2007) Blood , vol.110 , pp. 271
    • Peterson, K.R.1    Costa, F.C.2    Harju-Baker, S.3
  • 72
    • 0034254857 scopus 로고    scopus 로고
    • NuRD and SIN3 histone deacetylase complexes in development
    • Ahringer J. NuRD and SIN3 histone deacetylase complexes in development. Trends Genet. 2000;16:351-356.
    • (2000) Trends Genet , vol.16 , pp. 351-356
    • Ahringer, J.1
  • 74
    • 31344465966 scopus 로고    scopus 로고
    • MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties
    • Le Guezennec X, Vermeulen M, Brinkman AB, et al. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol. 2006;26:843-851.
    • (2006) Mol Cell Biol , vol.26 , pp. 843-851
    • Le Guezennec, X.1    Vermeulen, M.2    Brinkman, A.B.3
  • 75
    • 0023430030 scopus 로고
    • An enhancer element lies 3ʹ to the human A γ globin gene
    • Bodine DM, Ley TJ. An enhancer element lies 3ʹ to the human A γ globin gene. EMBO J. 1987;6:2997-3004.
    • (1987) EMBO J , vol.6 , pp. 2997-3004
    • Bodine, D.M.1    Ley, T.J.2
  • 76
    • 0025641099 scopus 로고
    • Structure and function of the enhancer 3ʹ to the human A γ globin gene
    • Purucker M, Bodine D, Lin H, McDonagh K, Nienhuis AW. Structure and function of the enhancer 3ʹ to the human A γ globin gene. Nucl Acids Res. 1990;18:7407-7415.
    • (1990) Nucl Acids Res , vol.18 , pp. 7407-7415
    • Purucker, M.1    Bodine, D.2    Lin, H.3    McDonagh, K.4    Nienhuis, A.W.5
  • 77
    • 0026758357 scopus 로고
    • A tissuespecific MAR/SAR DNA-binding protein with unusual binding site recognition
    • Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T. A tissuespecific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell. 1992;70:631-645.
    • (1992) Cell , vol.70 , pp. 631-645
    • Dickinson, L.A.1    Joh, T.2    Kohwi, Y.3    Kohwi-Shigematsu, T.4
  • 78
    • 0032544009 scopus 로고    scopus 로고
    • The A γ-globin 3ʹ element provides no unique function(s) for human β-globin locus gene regulation
    • Liu Q, Tanimoto K, Bungert J, Engel JD. The A γ-globin 3ʹ element provides no unique function(s) for human β-globin locus gene regulation. Proc Natl Acad Sci USA. 1998;95:9944-9949.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9944-9949
    • Liu, Q.1    Tanimoto, K.2    Bungert, J.3    Engel, J.D.4
  • 79
    • 0028065129 scopus 로고
    • Position independence and proper developmental control of γ-globin gene expression require both a 5ʹ locus control region and a downstream sequence element
    • Li Q, Stamatoyannopoulos JA. Position independence and proper developmental control of γ-globin gene expression require both a 5ʹ locus control region and a downstream sequence element. Mol Cell Biol. 1994;14:6087-6096.
    • (1994) Mol Cell Biol , vol.14 , pp. 6087-6096
    • Li, Q.1    Stamatoyannopoulos, J.A.2
  • 80
    • 0031027051 scopus 로고    scopus 로고
    • Sheltering of γ-globin expression from position effects requires both an upstream locus control region and a regulatory element 3' to the A g-globin gene
    • Stamatoyannopoulos JA, Clegg CH, Li Q. Sheltering of γ-globin expression from position effects requires both an upstream locus control region and a regulatory element 3' to the A g-globin gene. Mol Cell Biol. 1997;17:240-247.
    • (1997) Mol Cell Biol , vol.17 , pp. 240-247
    • Stamatoyannopoulos, J.A.1    Clegg, C.H.2    Li, Q.3
  • 81
    • 0037117575 scopus 로고    scopus 로고
    • Developmental specificity of recruitment of TBP to the TATA box of the human γ-globin gene
    • Duan ZJ, Fang X, Rohde A, Han H, Stamatoyannopoulos G, Li Q. Developmental specificity of recruitment of TBP to the TATA box of the human γ-globin gene. Proc Natl Acad Sci USA. 2002;99:5509-5514.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5509-5514
    • Duan, Z.J.1    Fang, X.2    Rohde, A.3    Han, H.4    Stamatoyannopoulos, G.5    Li, Q.6
  • 82
    • 1242272060 scopus 로고    scopus 로고
    • Developmentally specific role of the CCAAT box in regulation of human γ-globin gene expression
    • Fang X, Han H, Stamatoyannopoulos G, Li Q. Developmentally specific role of the CCAAT box in regulation of human γ-globin gene expression. J Biol Chem. 2004;279:5444-5449.
    • (2004) J Biol Chem , vol.279 , pp. 5444-5449
    • Fang, X.1    Han, H.2    Stamatoyannopoulos, G.3    Li, Q.4
  • 83
    • 7444246171 scopus 로고    scopus 로고
    • Transcriptional potentials of the β-like globin genes at different developmental stages in transgenic mice and hemoglobin switching
    • Li Q, Han H, Ye X, Stafford M, Barkess G, Stamatoyannopoulos G. Transcriptional potentials of the β-like globin genes at different developmental stages in transgenic mice and hemoglobin switching. Blood Cells Mol Dis. 2004;33: 318-325.
    • (2004) Blood Cells Mol Dis , vol.33 , pp. 318-325
    • Li, Q.1    Han, H.2    Ye, X.3    Stafford, M.4    Barkess, G.5    Stamatoyannopoulos, G.6
  • 84
    • 0023955979 scopus 로고
    • The human β-globin gene contains multiple regulatory regions: Identification of one promoter and two downstream enhancers
    • Antoniou M, deBoer E, Habets G, Grosveld F. The human β-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J. 1988;7:377-384.
    • (1988) EMBO J , vol.7 , pp. 377-384
    • Antoniou, M.1    deBoer, E.2    Habets, G.3    Grosveld, F.4
  • 85
    • 0024293496 scopus 로고
    • The human β-globin promoter; nuclear protein factors and erythroid specific induction of transcription
    • deBoer E, Antoniou M, Mignotte V, Wall L, Grosveld F. The human β-globin promoter; nuclear protein factors and erythroid specific induction of transcription. EMBO J. 1988;7:4203-4212.
    • (1988) EMBO J , vol.7 , pp. 4203-4212
    • deBoer, E.1    Antoniou, M.2    Mignotte, V.3    Wall, L.4    Grosveld, F.5
  • 86
    • 0030006917 scopus 로고    scopus 로고
    • CAAT/enhancer-binding proteins are involved in β-globin gene expression and are differentially expressed in murine erythroleukemia and K562 cells
    • Wall L, Destroismaisons N, Delvoye N, Guy LG. CAAT/enhancer-binding proteins are involved in β-globin gene expression and are differentially expressed in murine erythroleukemia and K562 cells. J Biol Chem. 1996;271: 16477-16484.
    • (1996) J Biol Chem , vol.271 , pp. 16477-16484
    • Wall, L.1    Destroismaisons, N.2    Delvoye, N.3    Guy, L.G.4
  • 87
    • 0027514570 scopus 로고
    • Discrimination among potential activators of the β-globin CACCC element by correlation of binding and transcriptional properties
    • Hartzog GA, Myers RM.Discrimination among potential activators of the β-globin CACCC element by correlation of binding and transcriptional properties. Mol Cell Biol. 1993;13:44-56.
    • (1993) Mol Cell Biol , vol.13 , pp. 44-56
    • Hartzog, G.A.1    Myers, R.M.2
  • 88
    • 0027211845 scopus 로고
    • A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins
    • Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol. 1993;13:2776-2786.
    • (1993) Mol Cell Biol , vol.13 , pp. 2776-2786
    • Miller, I.J.1    Bieker, J.J.2
  • 89
    • 0028174097 scopus 로고
    • Analyses of β-thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an erythroid cell-specific transcription factor
    • Feng WC, Southwood CM, Bieker JJ. Analyses of β-thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an erythroid cell-specific transcription factor. J Biol Chem. 1994;269:1493-1500.
    • (1994) J Biol Chem , vol.269 , pp. 1493-1500
    • Feng, W.C.1    Southwood, C.M.2    Bieker, J.J.3
  • 90
    • 0028936440 scopus 로고
    • Role of erythroid Kruppellike factor in human γ-to β-globin gene switching
    • Donze D, Townes TM, Bieker JJ. Role of erythroid Kruppellike factor in human γ-to β-globin gene switching. J Biol Chem. 1995;270:1955-1959.
    • (1995) J Biol Chem , vol.270 , pp. 1955-1959
    • Donze, D.1    Townes, T.M.2    Bieker, J.J.3
  • 91
    • 0023547189 scopus 로고
    • Two 3ʹ sequences direct adult erythroid-specific expression of human β-globin genes in transgenic mice
    • Behringer RR, Hammer RE, Brinster RL, Palmiter RD, Townes TM. Two 3ʹ sequences direct adult erythroid-specific expression of human β-globin genes in transgenic mice. Proc Natl Acad Sci USA. 1987;84:7056-7060.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7056-7060
    • Behringer, R.R.1    Hammer, R.E.2    Brinster, R.L.3    Palmiter, R.D.4    Townes, T.M.5
  • 92
    • 0023269317 scopus 로고
    • The human β-globin gene contains a downstream developmental specific enhancer
    • Kollias G, Hurst J, deBoer E, Grosveld F. The human β-globin gene contains a downstream developmental specific enhancer. Nucl Acids Res. 1987;15:5739-5747.
    • (1987) Nucl Acids Res , vol.15 , pp. 5739-5747
    • Kollias, G.1    Hurst, J.2    deBoer, E.3    Grosveld, F.4
  • 93
    • 0023442125 scopus 로고
    • A 3ʹ enhancer contributes to the stage-specific expression of the human β-globin gene
    • Trudel M, Costantini F. A 3ʹ enhancer contributes to the stage-specific expression of the human β-globin gene. Genes Dev. 1987;1:954-961.
    • (1987) Genes Dev , vol.1 , pp. 954-961
    • Trudel, M.1    Costantini, F.2
  • 94
    • 0031021618 scopus 로고    scopus 로고
    • Mutation of gene-proximal regulatory elements disrupts human ε-, γ-, and β-globin expression in yeast artificial chromosome transgenic mice
    • Liu Q, Bungert J, Engel JD.Mutation of gene-proximal regulatory elements disrupts human ε-, γ-, and β-globin expression in yeast artificial chromosome transgenic mice. Proc Natl Acad Sci USA. 1997;94:169-174.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 169-174
    • Liu, Q.1    Bungert, J.2    Engel, J.D.3
  • 95
    • 0034657848 scopus 로고    scopus 로고
    • Locus control region activity by 5'HS3 requires a functional interaction with β-globin gene regulatory elements: Expression of novel β/γ-globin hybrid transgenes
    • Rubin JE, Pasceri P, Wu X, Leboulch P, Ellis J. Locus control region activity by 5'HS3 requires a functional interaction with β-globin gene regulatory elements: expression of novel β/γ-globin hybrid transgenes. Blood. 2000;95:3242-3249.
    • (2000) Blood , vol.95 , pp. 3242-3249
    • Rubin, J.E.1    Pasceri, P.2    Wu, X.3    Leboulch, P.4    Ellis, J.5
  • 96
    • 0037441889 scopus 로고    scopus 로고
    • LCR-regulated transgene expression levels depend on the Oct-1 site in the AT-rich region of β-globin intron-2
    • Bharadwaj RR, Trainor CD, Pasceri P, Ellis J. LCR-regulated transgene expression levels depend on the Oct-1 site in the AT-rich region of β-globin intron-2. Blood. 2003;101:1603-1610.
    • (2003) Blood , vol.101 , pp. 1603-1610
    • Bharadwaj, R.R.1    Trainor, C.D.2    Pasceri, P.3    Ellis, J.4
  • 97
    • 0344272073 scopus 로고
    • The "β-like-globin" gene domain in human erythroid cells
    • Tuan D, Solomon W, Li Q, London IM. The "β-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci USA. 1985;82:6384-6388.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 6384-6388
    • Tuan, D.1    Solomon, W.2    Li, Q.3    London, I.M.4
  • 98
    • 0022450433 scopus 로고
    • A developmentally stable chromatin structure in the human β-globin gene cluster
    • ForresterWC, Thompson C, Elder JT, Groudine M. A developmentally stable chromatin structure in the human β-globin gene cluster. Proc Natl Acad Sci USA. 1986;83:1359-1363.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1359-1363
    • Forrester, W.C.1    Thompson, C.2    Elder, J.T.3    Groudine, M.4
  • 99
    • 0023663887 scopus 로고
    • Position-independent, high-level expression of the human β-globin gene in transgenic mice
    • Grosveld F, van Assendelft GB, Greaves DR, Kollias G. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell. 1987;51:975-985.
    • (1987) Cell , vol.51 , pp. 975-985
    • Grosveld, F.1    van Assendelft, G.B.2    Greaves, D.R.3    Kollias, G.4
  • 100
    • 0031861637 scopus 로고    scopus 로고
    • Locus control regions, chromatin activation and transcription
    • Fraser P, Grosveld F. Locus control regions, chromatin activation and transcription. Curr Opin Cell Biol. 1998;10:361-365.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 361-365
    • Fraser, P.1    Grosveld, F.2
  • 101
    • 16044372786 scopus 로고    scopus 로고
    • Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription
    • Milot E, Strouboulis J, Trimborn T, et al. Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell. 1996;87:105-114.
    • (1996) Cell , vol.87 , pp. 105-114
    • Milot, E.1    Strouboulis, J.2    Trimborn, T.3
  • 102
    • 0032185226 scopus 로고    scopus 로고
    • The β-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse β-globin locus
    • Epner E, Reik A, Cimbora D, et al. The β-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse β-globin locus. Mol Cell. 1998;2:447-455.
    • (1998) Mol Cell , vol.2 , pp. 447-455
    • Epner, E.1    Reik, A.2    Cimbora, D.3
  • 103
    • 0031708415 scopus 로고    scopus 로고
    • The locus control region is necessary for gene expression in the human β-globin locus but not the maintenance of an open chromatin structure in erythroid cells
    • Reik A, Telling A, Zitnik G, Cimbora D, Epner E, Groudine M. The locus control region is necessary for gene expression in the human β-globin locus but not the maintenance of an open chromatin structure in erythroid cells. Mol Cell Biol. 1998;18:5992-6000.
    • (1998) Mol Cell Biol , vol.18 , pp. 5992-6000
    • Reik, A.1    Telling, A.2    Zitnik, G.3    Cimbora, D.4    Epner, E.5    Groudine, M.6
  • 104
    • 0033861846 scopus 로고    scopus 로고
    • β-globin gene switching andDNase I sensitivity of the endogenous β-globin locus in mice do not require the locus control region
    • Bender MA, Bulger M, Close J, Groudine M. β-globin gene switching andDNase I sensitivity of the endogenous β-globin locus in mice do not require the locus control region. Mol Cell. 2000;5:387-393.
    • (2000) Mol Cell , vol.5 , pp. 387-393
    • Bender, M.A.1    Bulger, M.2    Close, J.3    Groudine, M.4
  • 105
    • 0019223735 scopus 로고
    • γ-β-Thalassaemia studies showing that deletion of the γ-and δ-genes influences β-globin gene expression in man
    • Van Der Ploeg LH, Konings A, Oort M, Roos D, Bernini L, Flavell RA. γ-β-Thalassaemia studies showing that deletion of the γ-and δ-genes influences β-globin gene expression in man. Nature. 1980;283:637-642.
    • (1980) Nature , vol.283 , pp. 637-642
    • Van Der Ploeg, L.H.1    Konings, A.2    Oort, M.3    Roos, D.4    Bernini, L.5    Flavell, R.A.6
  • 106
    • 0021044855 scopus 로고
    • Unexpected relationships between four large deletions in the human β-globin gene cluster
    • Vanin EF, Henthorn PS, Kioussis D, Grosveld F, Smithies O. Unexpected relationships between four large deletions in the human β-globin gene cluster. Cell. 1983;35:701-709.
    • (1983) Cell , vol.35 , pp. 701-709
    • Vanin, E.F.1    Henthorn, P.S.2    Kioussis, D.3    Grosveld, F.4    Smithies, O.5
  • 108
    • 0012953756 scopus 로고
    • γ δβ-thalassemia due to a de novo mutation deleting the 5ʹ β-globin gene activationregion hypersensitive sites
    • Driscoll MC, Dobkin CS, Alter BP. γ δβ-thalassemia due to a de novo mutation deleting the 5ʹ β-globin gene activationregion hypersensitive sites. Proc Natl Acad Sci USA. 1989; 86:7470-7474.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7470-7474
    • Driscoll, M.C.1    Dobkin, C.S.2    Alter, B.P.3
  • 109
    • 0025107556 scopus 로고
    • A deletion of the human β-globin locus activation region causes a major alteration in chromatin structure and replication across the entire β-globin locus
    • Forrester WC, Epner E, Driscoll MC, et al. A deletion of the human β-globin locus activation region causes a major alteration in chromatin structure and replication across the entire β-globin locus. Genes Dev. 1990;4:1637-1649.
    • (1990) Genes Dev , vol.4 , pp. 1637-1649
    • Forrester, W.C.1    Epner, E.2    Driscoll, M.C.3
  • 110
    • 33747174553 scopus 로고    scopus 로고
    • Flanking HS-62. 5 and 3ʹ HS1, and regions upstream of the LCR, are not required for β-globin transcription
    • Bender MA, Byron R, Ragoczy T, Telling A, Bulger M, Groudine M. Flanking HS-62.5 and 3ʹ HS1, and regions upstream of the LCR, are not required for β-globin transcription. Blood. 2006;108:1395-1401.
    • (2006) Blood , vol.108 , pp. 1395-1401
    • Bender, M.A.1    Byron, R.2    Ragoczy, T.3    Telling, A.4    Bulger, M.5    Groudine, M.6
  • 111
    • 0032582826 scopus 로고    scopus 로고
    • Do LCRs open chromatin domains?
    • Higgs DR. Do LCRs open chromatin domains? Cell. 1998; 95:299-302.
    • (1998) Cell , vol.95 , pp. 299-302
    • Higgs, D.R.1
  • 112
    • 0032928813 scopus 로고    scopus 로고
    • Activation by locus control regions?
    • Grosveld F. Activation by locus control regions? Curr Opin Genet Dev. 1999;9:152-157.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 152-157
    • Grosveld, F.1
  • 113
    • 0027417886 scopus 로고
    • Each hypersensitive site of the human β-globin locus control region confers a different developmental pattern of expression on the globin genes
    • Fraser P, Pruzina S, Antoniou M, Grosveld F. Each hypersensitive site of the human β-globin locus control region confers a different developmental pattern of expression on the globin genes. Genes Dev. 1993;7:106-113.
    • (1993) Genes Dev , vol.7 , pp. 106-113
    • Fraser, P.1    Pruzina, S.2    Antoniou, M.3    Grosveld, F.4
  • 114
    • 0031863008 scopus 로고    scopus 로고
    • Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion
    • Navas PA, Peterson KR, Li Q, et al. Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion. Mol Cell Biol. 1998;18:4188-4196.
    • (1998) Mol Cell Biol , vol.18 , pp. 4188-4196
    • Navas, P.A.1    Peterson, K.R.2    Li, Q.3
  • 116
    • 0025169059 scopus 로고
    • Developmentally regulated and erythroid-specific expression of the human embryonic β-globin gene in transgenic mice
    • Shih DM, Wall RJ, Shapiro SG. Developmentally regulated and erythroid-specific expression of the human embryonic β-globin gene in transgenic mice. Nucl Acids Res. 1990;18:5465-5472.
    • (1990) Nucl Acids Res , vol.18 , pp. 5465-5472
    • Shih, D.M.1    Wall, R.J.2    Shapiro, S.G.3
  • 117
    • 0026612803 scopus 로고
    • The 1-globin gene silencer. Characterization by in vitro transcription
    • Wada-Kiyama Y, Peters B, Noguchi CT. The 1-globin gene silencer. Characterization by in vitro transcription. J Biol Chem. 1992;267:11532-11538.
    • (1992) J Biol Chem , vol.267 , pp. 11532-11538
    • Wada-Kiyama, Y.1    Peters, B.2    Noguchi, C.T.3
  • 118
    • 0032503691 scopus 로고    scopus 로고
    • Multiple M-promoter elements participate in the developmental control of c-globin genes in transgenic mice
    • Li Q, Blau CA, Clegg CH, Rohde A, Stamatoyannopoulos G Multiple M-promoter elements participate in the developmental control of c-globin genes in transgenic mice. J Biol Chem. 1998;273:17361-17367.
    • (1998) J Biol Chem , vol.273 , pp. 17361-17367
    • Li, Q.1    Blau, C.A.2    Clegg, C.H.3    Rohde, A.4    Stamatoyannopoulos, G.5
  • 121
    • 0026610223 scopus 로고
    • Demonstration of a human T-globin gene silencer with studies in transgenic mice
    • Raich N, Papayannopoulou T, Stamatoyannopoulos G, Enver T. Demonstration of a human T-globin gene silencer with studies in transgenic mice. Blood. 1992;79:861-864.
    • (1992) Blood , vol.79 , pp. 861-864
    • Raich, N.1    Papayannopoulou, T.2    Stamatoyannopoulos, G.3    Enver, T.4
  • 122
    • 0031004268 scopus 로고    scopus 로고
    • Binary transgenic mouse model for studying the trans control of globin gene switching: Evidence that GATA-1 is an in vivo repressor of human GGgene expression
    • Li Q, Clegg C, Peterson K, Shaw S, Raich N, Stamatoyannopoulos G. Binary transgenic mouse model for studying the trans control of globin gene switching: evidence that GATA-1 is an in vivo repressor of human GGgene expression. Proc Natl Acad Sci USA. 1997;94:2444-2448.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2444-2448
    • Li, Q.1    Clegg, C.2    Peterson, K.3    Shaw, S.4    Raich, N.5    Stamatoyannopoulos, G.6
  • 123
    • 33644682311 scopus 로고    scopus 로고
    • Investigations of a human embryonic globin gene silencing element using YAC transgenic mice
    • Navas PA, Li Q, Peterson KR, Stamatoyannopoulos G. Investigations of a human embryonic globin gene silencing element using YAC transgenic mice. Exp Biol Med (Maywood). 2006;231:328-334.
    • (2006) Exp Biol Med (Maywood) , vol.231 , pp. 328-334
    • Navas, P.A.1    Li, Q.2    Peterson, K.R.3    Stamatoyannopoulos, G.4
  • 126
    • 0025891950 scopus 로고
    • Human γ-globin genes silenced independently of other genes in the β-globin locus
    • Dillon N, Grosveld F. Human γ-globin genes silenced independently of other genes in the β-globin locus. Nature. 1991;350:252-254.
    • (1991) Nature , vol.350 , pp. 252-254
    • Dillon, N.1    Grosveld, F.2
  • 127
    • 0029073038 scopus 로고
    • Use of yeast artificial chromosomes (YACs) in studies of mammalian development: Production of β-globin locus YAC mice carrying human globin developmental mutants
    • Peterson KR, Li QL, Clegg CH, et al. Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of β-globin locus YAC mice carrying human globin developmental mutants. Proc Natl Acad Sci USA. 1995;92:5655-5659.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5655-5659
    • Peterson, K.R.1    Li, Q.L.2    Clegg, C.H.3
  • 129
    • 26444477596 scopus 로고    scopus 로고
    • Genome architecture of the human β-globin locus affects developmental regulation of gene expression
    • Harju S, Navas PA, Stamatoyannopoulos G, Peterson KR. Genome architecture of the human β-globin locus affects developmental regulation of gene expression. Mol Cell Biol. 2005;25:8765-8778.
    • (2005) Mol Cell Biol , vol.25 , pp. 8765-8778
    • Harju, S.1    Navas, P.A.2    Stamatoyannopoulos, G.3    Peterson, K.R.4
  • 130
    • 33745468124 scopus 로고    scopus 로고
    • Autonomous silencing as well as competition controls γ-globin gene expression during development
    • Yu M, Han H, Xiang P, Li Q, Stamatoyannopoulos G. Autonomous silencing as well as competition controls γ-globin gene expression during development. Mol Cell Biol. 2006;26:4775-4781.
    • (2006) Mol Cell Biol , vol.26 , pp. 4775-4781
    • Yu, M.1    Han, H.2    Xiang, P.3    Li, Q.4    Stamatoyannopoulos, G.5
  • 131
    • 0026047824 scopus 로고
    • Importance of globin gene order for correct developmental expression
    • Hanscombe O, Whyatt D, Fraser P, et al. Importance of globin gene order for correct developmental expression. Genes Dev. 1991;5:1387-1394.
    • (1991) Genes Dev , vol.5 , pp. 1387-1394
    • Hanscombe, O.1    Whyatt, D.2    Fraser, P.3
  • 132
    • 0027228210 scopus 로고
    • Role of gene order in developmental control of human γ-and β-globin gene expression
    • Peterson KR, Stamatoyannopoulos G. Role of gene order in developmental control of human γ-and β-globin gene expression. Mol Cell Biol. 1993;13:4836-4843.
    • (1993) Mol Cell Biol , vol.13 , pp. 4836-4843
    • Peterson, K.R.1    Stamatoyannopoulos, G.2
  • 133
    • 0029051646 scopus 로고
    • Transcription complex stability and chromatin dynamics in vivo
    • Wijgerde M, Grosveld F, Fraser P. Transcription complex stability and chromatin dynamics in vivo. Nature. 1995;377:209-213.
    • (1995) Nature , vol.377 , pp. 209-213
    • Wijgerde, M.1    Grosveld, F.2    Fraser, P.3
  • 135
    • 0036923833 scopus 로고    scopus 로고
    • Looping and interaction between hypersensitive sites in the active β-globin locus
    • Tolhuis B, Palstra RJ, Splinter E, Grosveld F, de Laat W. Looping and interaction between hypersensitive sites in the active β-globin locus. Mol Cell. 2002;10:1453-1465.
    • (2002) Mol Cell , vol.10 , pp. 1453-1465
    • Tolhuis, B.1    Palstra, R.J.2    Splinter, E.3    Grosveld, F.4    de Laat, W.5
  • 138
    • 5444255213 scopus 로고    scopus 로고
    • The active spatial organization of the β-globin locus requires the transcription factor EKLF
    • Drissen R, Palstra RJ, Gillemans N, et al. The active spatial organization of the β-globin locus requires the transcription factor EKLF. Genes Dev. 2004;18:2485-2490.
    • (2004) Genes Dev , vol.18 , pp. 2485-2490
    • Drissen, R.1    Palstra, R.J.2    Gillemans, N.3
  • 139
    • 13244272059 scopus 로고    scopus 로고
    • Proximity among distant regulatory elements at the β-globin locus requires GATA-1 and FOG-1
    • Vakoc CR, Letting DL, Gheldof N, et al. Proximity among distant regulatory elements at the β-globin locus requires GATA-1 and FOG-1. Mol Cell. 2005;17:453-462.
    • (2005) Mol Cell , vol.17 , pp. 453-462
    • Vakoc, C.R.1    Letting, D.L.2    Gheldof, N.3
  • 140
    • 34447536151 scopus 로고    scopus 로고
    • B-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice
    • Kooren J, Palstra RJ, Klous P, et al. B-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice. J Biol Chem. 2007;282:16544-16552.
    • (2007) J Biol Chem , vol.282 , pp. 16544-16552
    • Kooren, J.1    Palstra, R.J.2    Klous, P.3
  • 141
    • 0344516392 scopus 로고
    • Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals
    • Papayannopoulou TH, Brice M, Stamatoyannopoulos G. Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals. Proc Natl Acad Sci USA. 1976;73:2033-2037.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 2033-2037
    • Papayannopoulou, T.H.1    Brice, M.2    Stamatoyannopoulos, G.3
  • 143
    • 0018888401 scopus 로고
    • Fetal Hb production during acute erythroid expansion. I. Observations in patients with transient erythroblastopenia and post-phlebotomy
    • Papayannopoulou T, Vichinsky E, Stamatoyannopoulos G. Fetal Hb production during acute erythroid expansion. I. Observations in patients with transient erythroblastopenia and post-phlebotomy. Br J Haematol. 1980;44:535-546.
    • (1980) Br J Haematol , vol.44 , pp. 535-546
    • Papayannopoulou, T.1    Vichinsky, E.2    Stamatoyannopoulos, G.3
  • 144
    • 0017289295 scopus 로고
    • The patterns of fetal haemoglobin production in leukaemia
    • Sheridan BL, Weatherall DJ, Clegg JB, et al. The patterns of fetal haemoglobin production in leukaemia. Br J Haematol. 1976;32:487-506.
    • (1976) Br J Haematol , vol.32 , pp. 487-506
    • Sheridan, B.L.1    Weatherall, D.J.2    Clegg, J.B.3
  • 145
    • 0018098588 scopus 로고
    • Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia
    • DeSimone J, Biel SI, Heller P. Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia. Proc Natl Acad Sci USA. 1978;75:2937-2940.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 2937-2940
    • DeSimone, J.1    Biel, S.I.2    Heller, P.3
  • 146
    • 0018861878 scopus 로고
    • Acceleration of F-cell production in response to experimentally induced anemia in adult baboons (Papio cynocephalus)
    • Nute PE, Papayannopoulou T, Chen P, Stamatoyannopoulos G. Acceleration of F-cell production in response to experimentally induced anemia in adult baboons (Papio cynocephalus). Am J Hematol. 1980;8:157-168.
    • (1980) Am J Hematol , vol.8 , pp. 157-168
    • Nute, P.E.1    Papayannopoulou, T.2    Chen, P.3    Stamatoyannopoulos, G.4
  • 148
    • 0013217012 scopus 로고
    • Fetal hemoglobin synthesis in vivo: Direct evidence for control at the level of erythroid progenitors
    • Umemura T, Al-Khatti A, Papayannopoulou T, Stamatoyannopoulos G. Fetal hemoglobin synthesis in vivo: direct evidence for control at the level of erythroid progenitors. Proc Natl Acad Sci USA. 1988;85:9278-9282.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9278-9282
    • Umemura, T.1    Al-Khatti, A.2    Papayannopoulou, T.3    Stamatoyannopoulos, G.4
  • 149
    • 0005906345 scopus 로고
    • Studies on human foetal haemoglobin. II. Foetal haemoglobin levels in healthy children and adults and in certain haematological disorders
    • Beaven GH, Ellis MJ, White JC. Studies on human foetal haemoglobin. II. Foetal haemoglobin levels in healthy children and adults and in certain haematological disorders. Br J Haematol. 1960;6:201-222.
    • (1960) Br J Haematol , vol.6 , pp. 201-222
    • Beaven, G.H.1    Ellis, M.J.2    White, J.C.3
  • 150
    • 0002617603 scopus 로고
    • Fetal hemoglobin and the erythroid stem cell differentiation process
    • Stamatoyannopoulos G, Nienhuis AW, eds. New York: Grune & Stratton
    • Stamatoyannopoulos G, Papayannopoulou T. Fetal hemoglobin and the erythroid stem cell differentiation process. In: Stamatoyannopoulos G, Nienhuis AW, eds. Cellular and Molecular Regulation of Hemoglobin Switching. New York: Grune & Stratton; 1979:323-349.
    • (1979) Cellular and Molecular Regulation of Hemoglobin Switching , pp. 323-349
    • Stamatoyannopoulos, G.1    Papayannopoulou, T.2
  • 151
    • 0000206049 scopus 로고
    • 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons
    • DeSimone J, Heller P, Hall L, Zwiers D. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc Natl Acad Sci USA. 1982;79:4428-4431.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 4428-4431
    • DeSimone, J.1    Heller, P.2    Hall, L.3    Zwiers, D.4
  • 152
    • 0020466344 scopus 로고
    • 5-azacytidine selectively increases γ-globin synthesis in a patient with b+thalassemia
    • Ley TJ, DeSimone J, Anagnou NP, et al. 5-azacytidine selectively increases γ-globin synthesis in a patient with b+thalassemia.NEngl J Med. 1982;307:1469-1475.
    • (1982) NEngl J Med , vol.307 , pp. 1469-1475
    • Ley, T.J.1    DeSimone, J.2    Anagnou, N.P.3
  • 153
    • 0021335219 scopus 로고
    • Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine
    • Torrealba de Ron AT, Papayannopoulou T, Knapp MS, Fu MF, Knitter G, Stamatoyannopoulos G. Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine. Blood. 1984;63:201-210.
    • (1984) Blood , vol.63 , pp. 201-210
    • Torrealba de Ron, A.T.1    Papayannopoulou, T.2    Knapp, M.S.3    Fu, M.F.4    Knitter, G.5    Stamatoyannopoulos, G.6
  • 154
    • 0021362464 scopus 로고
    • Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics
    • Papayannopoulou T, Torrealba de Ron A, Veith R, Knitter G, Stamatoyannopoulos G. Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics. Science. 1984;224:617-619.
    • (1984) Science , vol.224 , pp. 617-619
    • Papayannopoulou, T.1    Torrealba de Ron, A.2    Veith, R.3    Knitter, G.4    Stamatoyannopoulos, G.5
  • 156
    • 0021806584 scopus 로고
    • Treatment of baboon with vinblastine: Insights into the mechanisms of pharmacologic stimulation of Hb F in the adult
    • Veith R, Papayannopoulou T, Kurachi S, Stamatoyannopoulos G. Treatment of baboon with vinblastine: insights into the mechanisms of pharmacologic stimulation of Hb F in the adult. Blood. 1985;66:456-459.
    • (1985) Blood , vol.66 , pp. 456-459
    • Veith, R.1    Papayannopoulou, T.2    Kurachi, S.3    Stamatoyannopoulos, G.4
  • 157
    • 0027446929 scopus 로고
    • Hydroxyurea increases fetal hemoglobin in cultured erythroid cells derived from normal individuals and patients with sickle cell anemia or β-thalassemia
    • Fibach E, Burke LP, Schechter AN, Noguchi CT, Rodgers GP. Hydroxyurea increases fetal hemoglobin in cultured erythroid cells derived from normal individuals and patients with sickle cell anemia or β-thalassemia. Blood. 1993;81: 1630-1635.
    • (1993) Blood , vol.81 , pp. 1630-1635
    • Fibach, E.1    Burke, L.P.2    Schechter, A.N.3    Noguchi, C.T.4    Rodgers, G.P.5
  • 158
    • 0029130023 scopus 로고
    • Membrane protein interactions in sickle red blood cells: Evidence of abnormal protein 3 function
    • Platt OS, Falcone JF.Membrane protein interactions in sickle red blood cells: evidence of abnormal protein 3 function. Blood. 1995;86:1992-1998.
    • (1995) Blood , vol.86 , pp. 1992-1998
    • Platt, O.S.1    Falcone, J.F.2
  • 159
    • 0030893396 scopus 로고    scopus 로고
    • Fetal hemoglobin in sickle cell anemia: Determinants of response to hydroxyurea. Multicenter study of hydroxyurea
    • Steinberg MH, Lu ZH, Barton FB, Terrin ML, Charache S, Dover GJ. Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter study of hydroxyurea. Blood. 1997;89:1078-1088.
    • (1997) Blood , vol.89 , pp. 1078-1088
    • Steinberg, M.H.1    Lu, Z.H.2    Barton, F.B.3    Terrin, M.L.4    Charache, S.5    Dover, G.J.6
  • 160
    • 0021956121 scopus 로고
    • Delay in the fetal globin switch in infants of diabetic mothers
    • Perrine SP, Greene MF, Faller DV. Delay in the fetal globin switch in infants of diabetic mothers. N Engl J Med. 1985; 312:334-338.
    • (1985) N Engl J Med , vol.312 , pp. 334-338
    • Perrine, S.P.1    Greene, M.F.2    Faller, D.V.3
  • 161
    • 0023525824 scopus 로고
    • Butryic acid analogues augment γ globin gene expression in neonatal erythroid progenitors
    • Perrine SP, Miller BA, Greene MF, et al. Butryic acid analogues augment γ globin gene expression in neonatal erythroid progenitors. Biochem Biophys Res Commun. 1987;148: 694-700.
    • (1987) Biochem Biophys Res Commun , vol.148 , pp. 694-700
    • Perrine, S.P.1    Miller, B.A.2    Greene, M.F.3
  • 162
  • 163
    • 0024334257 scopus 로고
    • Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and b thalassemia
    • Perrine SP, Miller BA, Faller DV, et al. Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and b thalassemia. Blood. 1989;74:454-459.
    • (1989) Blood , vol.74 , pp. 454-459
    • Perrine, S.P.1    Miller, B.A.2    Faller, D.V.3
  • 164
    • 0002398438 scopus 로고
    • Hemoglobin switching
    • Stamatoyannopoulos G, Nienhuis AW, Majerus P, Varmus H, eds. 2nd ed. Philadelphia:W.B. Saunders Co
    • Stamatoyannopoulos G, Nienhuis AW. Hemoglobin switching. In: Stamatoyannopoulos G, Nienhuis AW, Majerus P, Varmus H, eds. Molecular Basis of Blood Diseases. 2nd ed. Philadelphia:W.B. Saunders Co.; 1994:107-154.
    • (1994) Molecular Basis of Blood Diseases , pp. 107-154
    • Stamatoyannopoulos, G.1    Nienhuis, A.W.2
  • 165
    • 0028845153 scopus 로고
    • Stimulation of fetal hemoglobin production by short chain fatty acids
    • Liakopoulou E, Blau CA, Li Q, et al. Stimulation of fetal hemoglobin production by short chain fatty acids. Blood. 1995;86:3227-3235.
    • (1995) Blood , vol.86 , pp. 3227-3235
    • Liakopoulou, E.1    Blau, C.A.2    Li, Q.3
  • 166
    • 0028303870 scopus 로고
    • Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate
    • Dover GJ, Brusilow S, Charache S. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate. Blood. 1994;84:339-343.
    • (1994) Blood , vol.84 , pp. 339-343
    • Dover, G.J.1    Brusilow, S.2    Charache, S.3
  • 167
    • 0028064768 scopus 로고
    • Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy
    • Collins AF, Dover GJ, Luban NL. Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy. Blood. 1994;84:1690-1691.
    • (1994) Blood , vol.84 , pp. 1690-1691
    • Collins, A.F.1    Dover, G.J.2    Luban, N.L.3
  • 169
    • 0031973745 scopus 로고    scopus 로고
    • Fetal hemoglobin in starvation ketosis of young women
    • Peters A, Rohloff D, Kohlmann T, et al. Fetal hemoglobin in starvation ketosis of young women. Blood. 1998;91:691-694.
    • (1998) Blood , vol.91 , pp. 691-694
    • Peters, A.1    Rohloff, D.2    Kohlmann, T.3
  • 170
    • 0942266022 scopus 로고    scopus 로고
    • Induction of human γ globin gene expression by histone deacetylase inhibitors
    • Cao H, Stamatoyannopoulos G, Jung M. Induction of human γ globin gene expression by histone deacetylase inhibitors. Blood. 2004;103:701-709.
    • (2004) Blood , vol.103 , pp. 701-709
    • Cao, H.1    Stamatoyannopoulos, G.2    Jung, M.3
  • 171
    • 0037114756 scopus 로고    scopus 로고
    • Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo
    • Pace BS, White GL, Dover GJ, Boosalis MS, Faller DV, Perrine SP. Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. Blood. 2002;100:4640-4648.
    • (2002) Blood , vol.100 , pp. 4640-4648
    • Pace, B.S.1    White, G.L.2    Dover, G.J.3    Boosalis, M.S.4    Faller, D.V.5    Perrine, S.P.6
  • 172
    • 0029835806 scopus 로고    scopus 로고
    • Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
    • Kuo MH, Brownell JE, Sobel RE, et al. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature. 1996;383:269-272.
    • (1996) Nature , vol.383 , pp. 269-272
    • Kuo, M.H.1    Brownell, J.E.2    Sobel, R.E.3
  • 173
    • 0030447943 scopus 로고    scopus 로고
    • The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
    • Mizzen CA, Yang XJ, Kokubo T, et al. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell. 1996;87:1261-1270.
    • (1996) Cell , vol.87 , pp. 1261-1270
    • Mizzen, C.A.1    Yang, X.J.2    Kokubo, T.3
  • 174
    • 0030606239 scopus 로고    scopus 로고
    • The transcriptional coactivators p300 and CBP are histone acetyltransferases
    • Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell. 1996;87:953-959.
    • (1996) Cell , vol.87 , pp. 953-959
    • Ogryzko, V.V.1    Schiltz, R.L.2    Russanova, V.3    Howard, B.H.4    Nakatani, Y.5
  • 175
    • 0029985730 scopus 로고    scopus 로고
    • Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
    • Vettese-Dadey M, Grant PA, Hebbes TR, Crane-Robinson C, Allis CD, Workman JL. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. EMBO J. 1996;15:2508-2518.
    • (1996) EMBO J , vol.15 , pp. 2508-2518
    • Vettese-Dadey, M.1    Grant, P.A.2    Hebbes, T.R.3    Crane-Robinson, C.4    Allis, C.D.5    Workman, J.L.6
  • 176
    • 0028170523 scopus 로고
    • α-Amino butyric acid cannot reactivate the silenced γ gene of the β locus YAC transgenic mouse
    • Pace B, Li Q, Peterson K, Stamatoyannopoulos G. α-Amino butyric acid cannot reactivate the silenced γ gene of the β locus YAC transgenic mouse. Blood. 1994;84:4344-4353.
    • (1994) Blood , vol.84 , pp. 4344-4353
    • Pace, B.1    Li, Q.2    Peterson, K.3    Stamatoyannopoulos, G.4
  • 177
    • 40349092939 scopus 로고    scopus 로고
    • Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
    • Uda M, Galanello R, Sanna S, et al. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia. Proc Natl Acad Sci USA. 2008;105:1620-1625.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1620-1625
    • Uda, M.1    Galanello, R.2    Sanna, S.3
  • 178
    • 50149117726 scopus 로고    scopus 로고
    • DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
    • Lettre G, Sankaran VG, Bezerra MA, et al. DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci USA. 2008;105:11869-11874.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11869-11874
    • Lettre, G.1    Sankaran, V.G.2    Bezerra, M.A.3
  • 179
    • 57849083996 scopus 로고    scopus 로고
    • Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
    • Sankaran VG, Menne TF, Xu J, et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008;322:1839-1842.
    • (2008) Science , vol.322 , pp. 1839-1842
    • Sankaran, V.G.1    Menne, T.F.2    Xu, J.3
  • 180
    • 11444252265 scopus 로고    scopus 로고
    • BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
    • Senawong T, Peterson VJ, Leid M. BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. Arch Biochem Biophys. 2005;434:316-325.
    • (2005) Arch Biochem Biophys , vol.434 , pp. 316-325
    • Senawong, T.1    Peterson, V.J.2    Leid, M.3
  • 181
    • 33747004649 scopus 로고    scopus 로고
    • Functional studies of BCL11A: Characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells
    • Liu H, Ippolito GC, Wall JK, et al. Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells. Mol cancer. 2006;5:18-34.
    • (2006) Mol cancer , vol.5 , pp. 18-34
    • Liu, H.1    Ippolito, G.C.2    Wall, J.K.3


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